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The map label for this gene is 15595031

Identifier: 15595031

GI number: 15595031

Start: 727737

End: 728675

Strand: Direct

Name: 15595031

Synonym: BB0686

Alternate gene names: NA

Gene position: 727737-728675 (Clockwise)

Preceding gene: 15595030

Following gene: 15595032

Centisome position: 79.91

GC content: 29.5

Gene sequence:

>939_bases
ATGAAAATAAAGTGTAAAGTTCATGCAAGCTTAGCTTTAATTAAATATTGGGGGAAAAAGGATGTTTTTTTAAACATTCC
AGCTACTTCCAGTCTTGCTGTTAGTGTTGACAAGTTTTATTCAATAAGTGAGCTTGAACTTTCAAATCGAGATGAAATAA
TTTTAAATTCAAAGCCAGTTATATTAAAAAATAGAGAAAAGGTGTTTTTTGATTATGCAAGAAAAATTCTTAATGAACCA
AATGTTAGATTTAAAATTAAAAGTAAAAACAATTTCCCGACAGCAGCAGGCCTTGCAAGTTCAAGTTCAGGTTTTGCTTC
TATTGCTGCTTGTATTTTGAAATATTTTAATAAATATTCTTGTAATAGCGCATCTAATCTTGCAAGAGTAGGATCGGCTT
CTGCGGCAAGGGCTATTTACGGGGGGTTTACTATTTTAAAAGAGGGTTCAAAAGAATCTTTTCAATTAAGAGATCAATCT
TATTTTAATGATTTGCGAATAATATTTGCCATAATTGATAGTAATGAAAAAGAATTGTCTTCAAGAGCCGCAATGAATAT
TTGCAAACGGCATAAATTTTATTATGATGCTTGGATTGCCTCTAGTAAAAAGATTTTTAAAGACGCTTTATATTTTTTTT
TAAAAAAAGATTTTATACATTTTGGAGCAACTATTGTAAAAAGTTATCAGAATATGTTTGCCTTAATGTTTGCATCTTCT
ATTTTTTATTTTAAAAATAGTACAATAGATTTAATTAGGTATGCTGCTGATTTGAGAAATGAGGGGATTTTTGTATTTGA
GACGATGGATGCAGGCCCCCAAGTAAAGTTTCTTTGTTTGGAGGAAAATTTAAATACTATTTTAAAAGGACTTAAGCAAA
ATTTTACTGGCATTGATTTTATTGTTTCAAAGGTTGGGTGTGACTTAGAATGGATTTGA

Upstream 100 bases:

>100_bases
TCTGATTTTGAAAAAGACAAATTATTATTGGAAATGGAAAGAATGAATATTTATTCTTTTGATTTTGCTTTTAAAATTTT
GAAGAAAATAAGGTTAGAGA

Downstream 100 bases:

>100_bases
TTAGTTTTTCTGTACCCGGAAATTTACTTTTAATGGGGGAGTATACTATTTTAGAGGAAAAGGGATTGGGGTTGGCAATT
GCCATCAACAAGAGAGCATT

Product: mevalonate pyrophosphate decarboxylase

Products: ADP; phosphate; isopentenyl diphosphate; CO2

Alternate protein names: Mevalonate Diphosphate Decarboxylase; Mevalonate Pyrophosphate Decarboxylase; Phosphomevalonate Kinase

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MKIKCKVHASLALIKYWGKKDVFLNIPATSSLAVSVDKFYSISELELSNRDEIILNSKPVILKNREKVFFDYARKILNEP
NVRFKIKSKNNFPTAAGLASSSSGFASIAACILKYFNKYSCNSASNLARVGSASAARAIYGGFTILKEGSKESFQLRDQS
YFNDLRIIFAIIDSNEKELSSRAAMNICKRHKFYYDAWIASSKKIFKDALYFFLKKDFIHFGATIVKSYQNMFALMFASS
IFYFKNSTIDLIRYAADLRNEGIFVFETMDAGPQVKFLCLEENLNTILKGLKQNFTGIDFIVSKVGCDLEWI

Sequences:

>Translated_312_residues
MKIKCKVHASLALIKYWGKKDVFLNIPATSSLAVSVDKFYSISELELSNRDEIILNSKPVILKNREKVFFDYARKILNEP
NVRFKIKSKNNFPTAAGLASSSSGFASIAACILKYFNKYSCNSASNLARVGSASAARAIYGGFTILKEGSKESFQLRDQS
YFNDLRIIFAIIDSNEKELSSRAAMNICKRHKFYYDAWIASSKKIFKDALYFFLKKDFIHFGATIVKSYQNMFALMFASS
IFYFKNSTIDLIRYAADLRNEGIFVFETMDAGPQVKFLCLEENLNTILKGLKQNFTGIDFIVSKVGCDLEWI
>Mature_312_residues
MKIKCKVHASLALIKYWGKKDVFLNIPATSSLAVSVDKFYSISELELSNRDEIILNSKPVILKNREKVFFDYARKILNEP
NVRFKIKSKNNFPTAAGLASSSSGFASIAACILKYFNKYSCNSASNLARVGSASAARAIYGGFTILKEGSKESFQLRDQS
YFNDLRIIFAIIDSNEKELSSRAAMNICKRHKFYYDAWIASSKKIFKDALYFFLKKDFIHFGATIVKSYQNMFALMFASS
IFYFKNSTIDLIRYAADLRNEGIFVFETMDAGPQVKFLCLEENLNTILKGLKQNFTGIDFIVSKVGCDLEWI

Specific function: Unknown

COG id: COG3407

COG function: function code I; Mevalonate pyrophosphate decarboxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4505289, Length=327, Percent_Identity=26.2996941896024, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17537201, Length=325, Percent_Identity=26.4615384615385, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324371, Length=303, Percent_Identity=28.3828382838284, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI28571205, Length=327, Percent_Identity=24.1590214067278, Blast_Score=71, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.1.1.33

Molecular weight: Translated: 35413; Mature: 35413

Theoretical pI: Translated: 9.88; Mature: 9.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIKCKVHASLALIKYWGKKDVFLNIPATSSLAVSVDKFYSISELELSNRDEIILNSKPV
CEEEEEEHHHEEEEEECCCCCEEEECCCCCCEEEEHHHHCCEEEEECCCCCEEEECCCCE
ILKNREKVFFDYARKILNEPNVRFKIKSKNNFPTAAGLASSSSGFASIAACILKYFNKYS
EEECCHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHCCCCCCCCHHHHHHHHHHHHHCCC
CNSASNLARVGSASAARAIYGGFTILKEGSKESFQLRDQSYFNDLRIIFAIIDSNEKELS
CCCHHHHHHHCCCHHHHHHHCCEEEEECCCCCCEEECHHHHHCCEEEEEEEECCCHHHHH
SRAAMNICKRHKFYYDAWIASSKKIFKDALYFFLKKDFIHFGATIVKSYQNMFALMFASS
HHHHHHHHHHCCHHEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFYFKNSTIDLIRYAADLRNEGIFVFETMDAGPQVKFLCLEENLNTILKGLKQNFTGIDF
HHEEECCHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEECCCHHHHHHHHHHCCCHHHH
IVSKVGCDLEWI
HHHHHCCCEECC
>Mature Secondary Structure
MKIKCKVHASLALIKYWGKKDVFLNIPATSSLAVSVDKFYSISELELSNRDEIILNSKPV
CEEEEEEHHHEEEEEECCCCCEEEECCCCCCEEEEHHHHCCEEEEECCCCCEEEECCCCE
ILKNREKVFFDYARKILNEPNVRFKIKSKNNFPTAAGLASSSSGFASIAACILKYFNKYS
EEECCHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHCCCCCCCCHHHHHHHHHHHHHCCC
CNSASNLARVGSASAARAIYGGFTILKEGSKESFQLRDQSYFNDLRIIFAIIDSNEKELS
CCCHHHHHHHCCCHHHHHHHCCEEEEECCCCCCEEECHHHHHCCEEEEEEEECCCHHHHH
SRAAMNICKRHKFYYDAWIASSKKIFKDALYFFLKKDFIHFGATIVKSYQNMFALMFASS
HHHHHHHHHHCCHHEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFYFKNSTIDLIRYAADLRNEGIFVFETMDAGPQVKFLCLEENLNTILKGLKQNFTGIDF
HHEEECCHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEECCCHHHHHHHHHHCCCHHHH
IVSKVGCDLEWI
HHHHHCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; (R)-5-diphosphomevalonate

Specific reaction: ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA