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The map label for this gene is 15595030

Identifier: 15595030

GI number: 15595030

Start: 726458

End: 727753

Strand: Direct

Name: 15595030

Synonym: BB0685

Alternate gene names: NA

Gene position: 726458-727753 (Clockwise)

Preceding gene: 15595029

Following gene: 15595031

Centisome position: 79.77

GC content: 29.24

Gene sequence:

>1296_bases
ATGAACTTGGAGTCTTTAAGCAGTTTTATGGAACTTAGTAAAAATTTTAGACATAAAAGCGTTTTAGAAAAAAGGCAAGA
GATAAAAAGTTTTTTGGAATTATCTTATAAAGATTTTTTTTATAATAATGCCAATGAAGATTTTCTTTTTAATATGATAG
AAAATTATATTGGATATTTATCTTTTCCTATTGGAATTGTAAAAAATTTGAAAATAAATGGCAAATACTATTCTTTGCCA
ATTGCAACAGAAGAATCTTCTGTTGTTGCTGCCCTAAATTTTGCGGCAAAGATTCTTGAAAATGCTGATTTAAGGTATTC
TTTGGGTGAAGTGTTGGGAATTTCGCAAATTTATATAAAATCGGAAAAAGATTTAAGTAAAATTTTTGTTGACCTTGGTG
ATAAAATTAAGACTTGGATTGAACCTCTTTTAACCAATATGAATCAAAGGGGGGGTGGATTTAGAAGGTTGTCAACTAGG
CACATTAAAGAATTAGGTATTCAAAAATTAAATATTTATGTGGATACTTGTGATGCTATGGGTGCTAATTTGCTAAACTC
AATTGCAGAGCGTGTAGCAGAATTTATTTTTTTAGAATTCGGATATGAGTGTGTTTTAAAAGTTTTAAGCAATGATATTA
GTGAATTTACAGCCAAAGCCCGTTTTGTTTTAGATTTTAAGCATTTGCTACCGGGTAAAGAGGATTCTTGGAATTTGGCT
AAAAAAATTGAACTTATTTCTAGTATAGGTTTTTACGAAGAGGAGCGAGCTGTTACTAATAATAAAGGTATTATGAATGG
AATTACAGGGGTGTGTCTTGCAACTTTTAATGACACAAGAGCTCTTGAGGCCTCTGTTCATAAATTTGCTTCAAAAAGCG
GCAAATATTTTCCCCTTAGTAAATTTTATACTACTGACAATGCTTTAGTTGGAGAAATTGAAATTCCTTTGCAAGTTGGA
ACTAAAGGTGGGGTTATATCTTTTAATGAAGCTTCAATTTTAAGTTTTAAAATTATGAATGTAAATAGTAAGAGCGAATT
TATTGGTATTCTCTCTTGTGTTGGACTTGCTAGTAATTTTGCAGCATTAAGGGCTCTTGCATTTAATGGGATTCAAAAGG
GTCATATGAGATTGCATGTTAATAAAATACTCCATCTTTTAAAGACAAAATATAATATTTCTGATTTTGAAAAAGACAAA
TTATTATTGGAAATGGAAAGAATGAATATTTATTCTTTTGATTTTGCTTTTAAAATTTTGAAGAAAATAAGGTTAGAGAA
TGAAAATAAAGTGTAA

Upstream 100 bases:

>100_bases
GATTATGAACATATTTTAAAAATGTCTATGTTTTTAAGTGGAAGCAAAAGTTTATTAGAGTTTAGAAATAATAAGTATTT
TTTAAGTAGTTATTTGCTTG

Downstream 100 bases:

>100_bases
AGTTCATGCAAGCTTAGCTTTAATTAAATATTGGGGGAAAAAGGATGTTTTTTTAAACATTCCAGCTACTTCCAGTCTTG
CTGTTAGTGTTGACAAGTTT

Product: 3-hydroxy-3-methylglutaryl-CoA reductase

Products: NA

Alternate protein names: HMG-CoA reductase

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MNLESLSSFMELSKNFRHKSVLEKRQEIKSFLELSYKDFFYNNANEDFLFNMIENYIGYLSFPIGIVKNLKINGKYYSLP
IATEESSVVAALNFAAKILENADLRYSLGEVLGISQIYIKSEKDLSKIFVDLGDKIKTWIEPLLTNMNQRGGGFRRLSTR
HIKELGIQKLNIYVDTCDAMGANLLNSIAERVAEFIFLEFGYECVLKVLSNDISEFTAKARFVLDFKHLLPGKEDSWNLA
KKIELISSIGFYEEERAVTNNKGIMNGITGVCLATFNDTRALEASVHKFASKSGKYFPLSKFYTTDNALVGEIEIPLQVG
TKGGVISFNEASILSFKIMNVNSKSEFIGILSCVGLASNFAALRALAFNGIQKGHMRLHVNKILHLLKTKYNISDFEKDK
LLLEMERMNIYSFDFAFKILKKIRLENENKV

Sequences:

>Translated_431_residues
MNLESLSSFMELSKNFRHKSVLEKRQEIKSFLELSYKDFFYNNANEDFLFNMIENYIGYLSFPIGIVKNLKINGKYYSLP
IATEESSVVAALNFAAKILENADLRYSLGEVLGISQIYIKSEKDLSKIFVDLGDKIKTWIEPLLTNMNQRGGGFRRLSTR
HIKELGIQKLNIYVDTCDAMGANLLNSIAERVAEFIFLEFGYECVLKVLSNDISEFTAKARFVLDFKHLLPGKEDSWNLA
KKIELISSIGFYEEERAVTNNKGIMNGITGVCLATFNDTRALEASVHKFASKSGKYFPLSKFYTTDNALVGEIEIPLQVG
TKGGVISFNEASILSFKIMNVNSKSEFIGILSCVGLASNFAALRALAFNGIQKGHMRLHVNKILHLLKTKYNISDFEKDK
LLLEMERMNIYSFDFAFKILKKIRLENENKV
>Mature_431_residues
MNLESLSSFMELSKNFRHKSVLEKRQEIKSFLELSYKDFFYNNANEDFLFNMIENYIGYLSFPIGIVKNLKINGKYYSLP
IATEESSVVAALNFAAKILENADLRYSLGEVLGISQIYIKSEKDLSKIFVDLGDKIKTWIEPLLTNMNQRGGGFRRLSTR
HIKELGIQKLNIYVDTCDAMGANLLNSIAERVAEFIFLEFGYECVLKVLSNDISEFTAKARFVLDFKHLLPGKEDSWNLA
KKIELISSIGFYEEERAVTNNKGIMNGITGVCLATFNDTRALEASVHKFASKSGKYFPLSKFYTTDNALVGEIEIPLQVG
TKGGVISFNEASILSFKIMNVNSKSEFIGILSCVGLASNFAALRALAFNGIQKGHMRLHVNKILHLLKTKYNISDFEKDK
LLLEMERMNIYSFDFAFKILKKIRLENENKV

Specific function: Converts HMG-CoA to mevalonate

COG id: COG1257

COG function: function code I; Hydroxymethylglutaryl-CoA reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA reductase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HMDH_BORBU (O51628)

Other databases:

- EMBL:   AE000783
- PIR:   D70185
- RefSeq:   NP_212819.1
- ProteinModelPortal:   O51628
- SMR:   O51628
- EnsemblBacteria:   EBBORT00000008443
- GeneID:   1195537
- GenomeReviews:   AE000783_GR
- KEGG:   bbu:BB0685
- NMPDR:   fig|224326.1.peg.1069
- TIGR:   BB_0685
- GeneTree:   EBGT00050000007361
- HOGENOM:   HBG477902
- OMA:   GIQRGHM
- ProtClustDB:   CLSK507761
- BioCyc:   BBUR224326:BB_0685-MONOMER
- BRENDA:   1.1.1.88
- InterPro:   IPR002202
- InterPro:   IPR004553
- InterPro:   IPR023074
- InterPro:   IPR009023
- InterPro:   IPR009029
- Gene3D:   G3DSA:3.90.770.10
- PANTHER:   PTHR10572
- PRINTS:   PR00071
- TIGRFAMs:   TIGR00532

Pfam domain/function: PF00368 HMG-CoA_red; SSF55035 HMG_CoA_NAD_bind; SSF56542 HMG_CoA_sub_bind

EC number: =1.1.1.88

Molecular weight: Translated: 48922; Mature: 48922

Theoretical pI: Translated: 8.92; Mature: 8.92

Prosite motif: PS00066 HMG_COA_REDUCTASE_1; PS00318 HMG_COA_REDUCTASE_2; PS01192 HMG_COA_REDUCTASE_3; PS50065 HMG_COA_REDUCTASE_4

Important sites: ACT_SITE 85-85 ACT_SITE 278-278 ACT_SITE 375-375

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLESLSSFMELSKNFRHKSVLEKRQEIKSFLELSYKDFFYNNANEDFLFNMIENYIGYL
CCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
SFPIGIVKNLKINGKYYSLPIATEESSVVAALNFAAKILENADLRYSLGEVLGISQIYIK
HHHHHHHHCEEECCEEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHHHCCHHEEEE
SEKDLSKIFVDLGDKIKTWIEPLLTNMNQRGGGFRRLSTRHIKELGIQKLNIYVDTCDAM
CCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEEEECHHHH
GANLLNSIAERVAEFIFLEFGYECVLKVLSNDISEFTAKARFVLDFKHLLPGKEDSWNLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHCCCCCCCCHHH
KKIELISSIGFYEEERAVTNNKGIMNGITGVCLATFNDTRALEASVHKFASKSGKYFPLS
HHHHHHHHCCCCHHHHHHCCCCCCHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCH
KFYTTDNALVGEIEIPLQVGTKGGVISFNEASILSFKIMNVNSKSEFIGILSCVGLASNF
HEEECCCCEEEEEEEEEEECCCCCEEEECCCEEEEEEEEECCCHHHHHHHHHHHHHHHHH
AALRALAFNGIQKGHMRLHVNKILHLLKTKYNISDFEKDKLLLEMERMNIYSFDFAFKIL
HHHHHHHHHCCCCCHHEEEHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCEEHHHHHHHHH
KKIRLENENKV
HHHHCCCCCCC
>Mature Secondary Structure
MNLESLSSFMELSKNFRHKSVLEKRQEIKSFLELSYKDFFYNNANEDFLFNMIENYIGYL
CCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
SFPIGIVKNLKINGKYYSLPIATEESSVVAALNFAAKILENADLRYSLGEVLGISQIYIK
HHHHHHHHCEEECCEEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHHHCCHHEEEE
SEKDLSKIFVDLGDKIKTWIEPLLTNMNQRGGGFRRLSTRHIKELGIQKLNIYVDTCDAM
CCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEEEECHHHH
GANLLNSIAERVAEFIFLEFGYECVLKVLSNDISEFTAKARFVLDFKHLLPGKEDSWNLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHCCCCCCCCHHH
KKIELISSIGFYEEERAVTNNKGIMNGITGVCLATFNDTRALEASVHKFASKSGKYFPLS
HHHHHHHHCCCCHHHHHHCCCCCCHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCH
KFYTTDNALVGEIEIPLQVGTKGGVISFNEASILSFKIMNVNSKSEFIGILSCVGLASNF
HEEECCCCEEEEEEEEEEECCCCCEEEECCCEEEEEEEEECCCHHHHHHHHHHHHHHHHH
AALRALAFNGIQKGHMRLHVNKILHLLKTKYNISDFEKDKLLLEMERMNIYSFDFAFKIL
HHHHHHHHHCCCCCHHEEEHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCEEHHHHHHHHH
KKIRLENENKV
HHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9403685