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The map label for this gene is dosT [H]

Identifier: 121637913

GI number: 121637913

Start: 2256439

End: 2258160

Strand: Reverse

Name: dosT [H]

Synonym: BCG_2046c

Alternate gene names: 121637913

Gene position: 2258160-2256439 (Counterclockwise)

Preceding gene: 121637914

Following gene: 121637912

Centisome position: 51.62

GC content: 65.45

Gene sequence:

>1722_bases
GTGACACACCCTGACAGGGCGAACGTTAACCCTGGCAGCCCGCCAGTGCGCGAGACACTGTCGCAGCTTCGGTTGCGAGA
GCTGCTGCTGGAAGTCCAAGACCGGATTGAACAGATCGTCGAAGGCCGCGACCGGCTGGATGGTCTGATCGACGCCATCT
TGGCGATCACATCGGGACTCAAGCTCGACGCCACCCTGCGCGCCATTGTGCATACCGCCGCCGAGTTGGTGGATGCCCGC
TACGGGGCGCTCGGGGTGCGCGGTTACGACCATAGATTGGTCGAATTCGTCTACGAGGGGATCGACGAAGAGACCCGGCA
CCTCATCGGCTCATTGCCGGAGGGGCGAGGTGTTCTCGGCGCGCTGATCGAGGAGCCAAAGCCGATCCGGCTGGACGATA
TCTCGCGGCATCCCGCATCGGTTGGATTTCCGCTGCACCATCCGCCGATGCGGACCTTCCTCGGGGTTCCAGTGCGCATC
CGCGACGAGGTGTTCGGCAATCTTTACTTGACCGAGAAGGCAGATGGCCAGCCGTTCAGCGATGACGACGAGGTGCTGGT
GCAGGCGCTGGCCGCCGCGGCCGGGATTGCCGTTGACAATGCCCGTCTCTTCGAGGAATCACGGACCCGGGAAGCGTGGA
TCGAGGCAACCCGCGACATCGGAACGCAGATGCTGGCCGGTGCGGACCCGGCCATGGTGTTTCGGCTCATCGCCGAGGAA
GCGTTGACGTTGATGGCTGGGGCAGCCACCTTGGTGGCGGTGCCGCTCGACGACGAAGCGCCGGCTTGCGAGGTCGACGA
CCTGGTCATCGTAGAGGTGGCCGGAGAGATCTCCCCGGCGGTCAAGCAAATGACGGTTGCCGTCAGCGGAACGTCGATCG
GGGGAGTCTTTCACGACCGTACGCCCCGCCGGTTCGACCGGCTTGACCTCGCGGTCGACGGCCCGGTGGAGCCCGGGCCC
GCCCTGGTGCTGCCGCTGCGTGCCGCCGACACTGTTGCCGGTGTGCTGGTCGCACTTCGCAGTGCCGATGAACAGCCGTT
CAGCGACAAACAGCTCGATATGATGGCCGCCTTCGCTGACCAGGCTGCGCTCGCCTGGCGGCTGGCGACCGCGCAGCGAC
AGATGCGAGAAGTGGAGATCCTGACCGATCGCGACCGGATCGCACGTGATCTGCATGACCACGTCATCCAGCGGCTCTTC
GCAGTCGGGCTCACCCTGCAGGGTGCCGCTCCGCGAGCACGTGTCCCCGCCGTCCGGGAATCCATCTACAGCAGCATCGA
CGATCTCCAGGAAATCATTCAGGAGATTCGATCTGCGATCTTCGACCTACACGCCGGGCCCTCCCGGGCGACGGGTCTGC
GCCACCGACTGGACAAGGTCATCGACCAACTCGCGATCCCCGCGCTGCACACCACGGTCCAGTACACGGGCCCGCTGTCC
GTTGTCGACACCGTCCTGGCCAACCACGCCGAAGCGGTTCTGCGGGAGGCGGTTAGCAACGCTGTCCGGCACGCGAACGC
GACCAGCCTGGCCATCAACGTCAGCGTCGAGGATGATGTGCGGGTCGAGGTCGTCGACGACGGTGTCGGCATCTCCGGCG
ACATCACCGAAAGCGGCCTGCGCAATCTCCGCCAGCGTGCCGACGACGCGGGCGGCGAATTCACAGTCGAGAACATGCCG
ACCGGAGGCACCTTGCTGCGGTGGTCTGCACCGCTGCGCTGA

Upstream 100 bases:

>100_bases
CGGCTGCACCCTGCTGGTCGTCGGTCAGCAGTATCTGTGACTGTGCCGCTGGGTAGCCAGACCAGTTGGTTGAGCGCAGC
TCCGGTGTCAACATAGCTAT

Downstream 100 bases:

>100_bases
TGGATTGATGGACTGTGTTCCGACCGCAAGGAGCGTGAAATGTCTGCTGCGACAGCGAAATACGGAATACTCGTTGGCGT
CGACGGATCAGCGCAATCCA

Product: histidine kinase response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 573; Mature: 572

Protein sequence:

>573_residues
MTHPDRANVNPGSPPVRETLSQLRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAITSGLKLDATLRAIVHTAAELVDAR
YGALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLGALIEEPKPIRLDDISRHPASVGFPLHHPPMRTFLGVPVRI
RDEVFGNLYLTEKADGQPFSDDDEVLVQALAAAAGIAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEE
ALTLMAGAATLVAVPLDDEAPACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVFHDRTPRRFDRLDLAVDGPVEPGP
ALVLPLRAADTVAGVLVALRSADEQPFSDKQLDMMAAFADQAALAWRLATAQRQMREVEILTDRDRIARDLHDHVIQRLF
AVGLTLQGAAPRARVPAVRESIYSSIDDLQEIIQEIRSAIFDLHAGPSRATGLRHRLDKVIDQLAIPALHTTVQYTGPLS
VVDTVLANHAEAVLREAVSNAVRHANATSLAINVSVEDDVRVEVVDDGVGISGDITESGLRNLRQRADDAGGEFTVENMP
TGGTLLRWSAPLR

Sequences:

>Translated_573_residues
MTHPDRANVNPGSPPVRETLSQLRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAITSGLKLDATLRAIVHTAAELVDAR
YGALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLGALIEEPKPIRLDDISRHPASVGFPLHHPPMRTFLGVPVRI
RDEVFGNLYLTEKADGQPFSDDDEVLVQALAAAAGIAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEE
ALTLMAGAATLVAVPLDDEAPACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVFHDRTPRRFDRLDLAVDGPVEPGP
ALVLPLRAADTVAGVLVALRSADEQPFSDKQLDMMAAFADQAALAWRLATAQRQMREVEILTDRDRIARDLHDHVIQRLF
AVGLTLQGAAPRARVPAVRESIYSSIDDLQEIIQEIRSAIFDLHAGPSRATGLRHRLDKVIDQLAIPALHTTVQYTGPLS
VVDTVLANHAEAVLREAVSNAVRHANATSLAINVSVEDDVRVEVVDDGVGISGDITESGLRNLRQRADDAGGEFTVENMP
TGGTLLRWSAPLR
>Mature_572_residues
THPDRANVNPGSPPVRETLSQLRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAITSGLKLDATLRAIVHTAAELVDARY
GALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLGALIEEPKPIRLDDISRHPASVGFPLHHPPMRTFLGVPVRIR
DEVFGNLYLTEKADGQPFSDDDEVLVQALAAAAGIAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEEA
LTLMAGAATLVAVPLDDEAPACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVFHDRTPRRFDRLDLAVDGPVEPGPA
LVLPLRAADTVAGVLVALRSADEQPFSDKQLDMMAAFADQAALAWRLATAQRQMREVEILTDRDRIARDLHDHVIQRLFA
VGLTLQGAAPRARVPAVRESIYSSIDDLQEIIQEIRSAIFDLHAGPSRATGLRHRLDKVIDQLAIPALHTTVQYTGPLSV
VDTVLANHAEAVLREAVSNAVRHANATSLAINVSVEDDVRVEVVDDGVGISGDITESGLRNLRQRADDAGGEFTVENMPT
GGTLLRWSAPLR

Specific function: Interacts with the two-component regulatory system devR/devS (dosR/dosS) involved in onset of the dormancy response. May act as a direct hypoxia sensor (rather than a redox sensor); the normal state is the oxygenated form, while the deoxy form is probably

COG id: COG2203

COG function: function code T; FOG: GAF domain

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788812, Length=270, Percent_Identity=27.037037037037, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1787474, Length=259, Percent_Identity=24.7104247104247, Blast_Score=66, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003018
- InterPro:   IPR011712 [H]

Pfam domain/function: PF01590 GAF; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: 2.7.3.- [C]

Molecular weight: Translated: 62155; Mature: 62024

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHPDRANVNPGSPPVRETLSQLRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAITSGL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
KLDATLRAIVHTAAELVDARYGALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLG
CHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHH
ALIEEPKPIRLDDISRHPASVGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFS
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCEEEHHHHCCCEEEEECCCCCCCC
DDDEVLVQALAAAAGIAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEE
CCHHHHHHHHHHHHCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
ALTLMAGAATLVAVPLDDEAPACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVFHDR
HHHHHHCCEEEEEEECCCCCCCCCCCCEEEEEECCCCCHHHHHEEEEEECCCCCCCCCCC
TPRRFDRLDLAVDGPVEPGPALVLPLRAADTVAGVLVALRSADEQPFSDKQLDMMAAFAD
CCCHHHHCCEEECCCCCCCCEEEEEECHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
QAALAWRLATAQRQMREVEILTDRDRIARDLHDHVIQRLFAVGLTLQGAAPRARVPAVRE
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCEECCCCCCCCCHHHHH
SIYSSIDDLQEIIQEIRSAIFDLHAGPSRATGLRHRLDKVIDQLAIPALHTTVQYTGPLS
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCHHHHHHEEECCCHH
VVDTVLANHAEAVLREAVSNAVRHANATSLAINVSVEDDVRVEVVDDGVGISGDITESGL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEEECCCCCCCCCCHHHH
RNLRQRADDAGGEFTVENMPTGGTLLRWSAPLR
HHHHHHHCCCCCEEEECCCCCCCEEEEECCCCC
>Mature Secondary Structure 
THPDRANVNPGSPPVRETLSQLRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAITSGL
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
KLDATLRAIVHTAAELVDARYGALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLG
CHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHH
ALIEEPKPIRLDDISRHPASVGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFS
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCEEEHHHHCCCEEEEECCCCCCCC
DDDEVLVQALAAAAGIAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEE
CCHHHHHHHHHHHHCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
ALTLMAGAATLVAVPLDDEAPACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVFHDR
HHHHHHCCEEEEEEECCCCCCCCCCCCEEEEEECCCCCHHHHHEEEEEECCCCCCCCCCC
TPRRFDRLDLAVDGPVEPGPALVLPLRAADTVAGVLVALRSADEQPFSDKQLDMMAAFAD
CCCHHHHCCEEECCCCCCCCEEEEEECHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
QAALAWRLATAQRQMREVEILTDRDRIARDLHDHVIQRLFAVGLTLQGAAPRARVPAVRE
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCEECCCCCCCCCHHHHH
SIYSSIDDLQEIIQEIRSAIFDLHAGPSRATGLRHRLDKVIDQLAIPALHTTVQYTGPLS
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCHHHHHHEEECCCHH
VVDTVLANHAEAVLREAVSNAVRHANATSLAINVSVEDDVRVEVVDDGVGISGDITESGL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEEECCCCCCCCCCHHHH
RNLRQRADDAGGEFTVENMPTGGTLLRWSAPLR
HHHHHHHCCCCCEEEECCCCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring phosphorus-containing groups; Phosphotransferases with a nitrogenous group as acceptor [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]