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The map label for this gene is glmU

Identifier: 239618102

GI number: 239618102

Start: 1861688

End: 1863028

Strand: Reverse

Name: glmU

Synonym: Kole_1734

Alternate gene names: 239618102

Gene position: 1863028-1861688 (Counterclockwise)

Preceding gene: 239618103

Following gene: 239618101

Centisome position: 80.93

GC content: 41.98

Gene sequence:

>1341_bases
ATGACCGCAATTATTTTAGCGGCAGGACTTGGAAAAAGGATGAAATCCGAAATCCCGAAGGTGGTACACTCCATTCTCGG
TTTACCAATGATAAATTGGGTTCTGAGAGCGGTCAAAAAAGCAGGAATAGAAAACATTATAGTAGTTACAGGATATAAAG
CCGAGATCGTCGAAGCACTGTTACCTGAGGATGTTAAGACCGTAAGACAGGTAAAACAGCTTGGAACCGGACACGCTGTC
ATGGTAGCCCAAGATGCTGTCATGGATGATGAGGTCATAGTACTCACGGGTGACGCACCGTTAATATCCCCTGAAACCCT
CATAAACCTATATAAAATAAGGCGCGAAAAAGATTACGACGTTGTCGTCGCAAGTACCTTTCAAGAGGACCCAACAGGAT
ACGGAAGAATAGTGAGGGAAAATGGTAAGCTCAGAATCATAGAAGAAAAAGACGCTTCTGAGGAAATAAAGAGAATCAAA
GAAATAAACAGCGGTATTTACGTTTTCAAAAGTGACTTTTTAAAAGACGCGTTGAAGAAAATTAACAATAACAACAACCA
AAAAGAATACTATCTAACTGATACAGTTGCCCTGGCTGAAAAAGCCACGGCACATGTGATCGAAGACCCAACGGAGGTCC
TTGGTGTTAACAACCGGGTACAACTCGCTGAGATCCAAAAGATAGCGCAAAAAAAGATAAATGAGAGGTTGATGCTAAAC
GGCATAACAATTGTGGATCCCGACACAACATATATTTCACCTGATGTTGAGATTGGACAGGATACGGTTATTGAACCCAT
GACCTTCATACTCGGGAAAACAAAAATAGGTAATAATTGCCTCATTGGACCAATGACCAGGATCATCGATTCAAGCATCG
ATGACAGCGTCTCAATCATAAGGTCTGAGGTGGAACAGGCTATCATAAAATCAGGAGCACGGGTAGGACCTTTTTCAAGA
TTGAGACCCGGAACAACGCTTCTGGAAAACACGAAGATAGGAAATTTTGTTGAAGTCAAGAAATCTACCATAGGTCGCAA
TAGTAAAGCACAGCACCTCACATATCTTGGAGACGCTACAATCGGAGAAGATGTAAATATTGGTGCTGGAACGATAACCT
GCAACTATGATGGTGTTCGCAAACATCAGACCATCATTGAAAATAACTCTTTCATAGGAAGTAACTGTTCTCTTGTCGCC
CCGGTAAAAATCGGCGAGGGTTCAGTTGTTGGTGCTGGTTCGGTTATTACCGATGATGTTCCACCATATTCTCTAGCCCT
TGGAAGAGGAAGGCAGGTAATCAAAGAAGGTAGATATAAAAACAAGGAGAAAGGGGAATAA

Upstream 100 bases:

>100_bases
TTGGTAAGGAAAGCTCTGAGAAAACTAAATAAGACCCGGTAAAACATCTGCTTCCGCTGATTTATCATTTGAATTATACT
GTTAATAGGGGGGATGTGAG

Downstream 100 bases:

>100_bases
TTATGCCTTTTCAGCCAAATGAAATGAAGGTTTTTTCCGGTTCCTCAAACCGGCAGCTTGCGGAGAAAATTGCGAAATAT
ATAGGAATAGACCTCGGAAA

Product: UDP-N-acetylglucosamine pyrophosphorylase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MTAIILAAGLGKRMKSEIPKVVHSILGLPMINWVLRAVKKAGIENIIVVTGYKAEIVEALLPEDVKTVRQVKQLGTGHAV
MVAQDAVMDDEVIVLTGDAPLISPETLINLYKIRREKDYDVVVASTFQEDPTGYGRIVRENGKLRIIEEKDASEEIKRIK
EINSGIYVFKSDFLKDALKKINNNNNQKEYYLTDTVALAEKATAHVIEDPTEVLGVNNRVQLAEIQKIAQKKINERLMLN
GITIVDPDTTYISPDVEIGQDTVIEPMTFILGKTKIGNNCLIGPMTRIIDSSIDDSVSIIRSEVEQAIIKSGARVGPFSR
LRPGTTLLENTKIGNFVEVKKSTIGRNSKAQHLTYLGDATIGEDVNIGAGTITCNYDGVRKHQTIIENNSFIGSNCSLVA
PVKIGEGSVVGAGSVITDDVPPYSLALGRGRQVIKEGRYKNKEKGE

Sequences:

>Translated_446_residues
MTAIILAAGLGKRMKSEIPKVVHSILGLPMINWVLRAVKKAGIENIIVVTGYKAEIVEALLPEDVKTVRQVKQLGTGHAV
MVAQDAVMDDEVIVLTGDAPLISPETLINLYKIRREKDYDVVVASTFQEDPTGYGRIVRENGKLRIIEEKDASEEIKRIK
EINSGIYVFKSDFLKDALKKINNNNNQKEYYLTDTVALAEKATAHVIEDPTEVLGVNNRVQLAEIQKIAQKKINERLMLN
GITIVDPDTTYISPDVEIGQDTVIEPMTFILGKTKIGNNCLIGPMTRIIDSSIDDSVSIIRSEVEQAIIKSGARVGPFSR
LRPGTTLLENTKIGNFVEVKKSTIGRNSKAQHLTYLGDATIGEDVNIGAGTITCNYDGVRKHQTIIENNSFIGSNCSLVA
PVKIGEGSVVGAGSVITDDVPPYSLALGRGRQVIKEGRYKNKEKGE
>Mature_445_residues
TAIILAAGLGKRMKSEIPKVVHSILGLPMINWVLRAVKKAGIENIIVVTGYKAEIVEALLPEDVKTVRQVKQLGTGHAVM
VAQDAVMDDEVIVLTGDAPLISPETLINLYKIRREKDYDVVVASTFQEDPTGYGRIVRENGKLRIIEEKDASEEIKRIKE
INSGIYVFKSDFLKDALKKINNNNNQKEYYLTDTVALAEKATAHVIEDPTEVLGVNNRVQLAEIQKIAQKKINERLMLNG
ITIVDPDTTYISPDVEIGQDTVIEPMTFILGKTKIGNNCLIGPMTRIIDSSIDDSVSIIRSEVEQAIIKSGARVGPFSRL
RPGTTLLENTKIGNFVEVKKSTIGRNSKAQHLTYLGDATIGEDVNIGAGTITCNYDGVRKHQTIIENNSFIGSNCSLVAP
VKIGEGSVVGAGSVITDDVPPYSLALGRGRQVIKEGRYKNKEKGE

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family

Homologues:

Organism=Escherichia coli, GI1790168, Length=445, Percent_Identity=42.6966292134831, Blast_Score=342, Evalue=2e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMU_KOSOT (C5CFS2)

Other databases:

- EMBL:   CP001634
- RefSeq:   YP_002941424.1
- ProteinModelPortal:   C5CFS2
- GeneID:   7968135
- GenomeReviews:   CP001634_GR
- KEGG:   kol:Kole_1734
- GO:   GO:0005737
- HAMAP:   MF_01631
- InterPro:   IPR005882
- InterPro:   IPR005835
- InterPro:   IPR011004
- TIGRFAMs:   TIGR01173

Pfam domain/function: PF00483 NTP_transferase; SSF51161 Trimer_LpxA_like

EC number: =2.7.7.23; =2.3.1.157

Molecular weight: Translated: 48821; Mature: 48690

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: ACT_SITE 352-352 BINDING 70-70 BINDING 135-135 BINDING 148-148 BINDING 163-163 BINDING 376-376 BINDING 394-394 BINDING 412-412 BINDING 429-429

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAIILAAGLGKRMKSEIPKVVHSILGLPMINWVLRAVKKAGIENIIVVTGYKAEIVEAL
CCEEEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHH
LPEDVKTVRQVKQLGTGHAVMVAQDAVMDDEVIVLTGDAPLISPETLINLYKIRREKDYD
CCHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCC
VVVASTFQEDPTGYGRIVRENGKLRIIEEKDASEEIKRIKEINSGIYVFKSDFLKDALKK
EEEEECCCCCCCCCCEEEEECCCEEEEECCCHHHHHHHHHHHCCCEEEEHHHHHHHHHHH
INNNNNQKEYYLTDTVALAEKATAHVIEDPTEVLGVNNRVQLAEIQKIAQKKINERLMLN
HCCCCCCEEEEEEHHHHHHHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHHHCCEEEEC
GITIVDPDTTYISPDVEIGQDTVIEPMTFILGKTKIGNNCLIGPMTRIIDSSIDDSVSII
CEEEECCCCCEECCCCCCCCCHHHHHHHHHHCCCCCCCCCEEHHHHHHHHCCCCHHHHHH
RSEVEQAIIKSGARVGPFSRLRPGTTLLENTKIGNFVEVKKSTIGRNSKAQHLTYLGDAT
HHHHHHHHHHCCCCCCCHHHCCCCCCEECCCCCCCEEEEHHHHCCCCCCCCEEEEECCCC
IGEDVNIGAGTITCNYDGVRKHQTIIENNSFIGSNCSLVAPVKIGEGSVVGAGSVITDDV
CCCCCCCCCEEEEECCCCCHHHHHHHCCCCEECCCCCEEEEEEECCCCEEECCCEEECCC
PPYSLALGRGRQVIKEGRYKNKEKGE
CCHHHHHHCCHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TAIILAAGLGKRMKSEIPKVVHSILGLPMINWVLRAVKKAGIENIIVVTGYKAEIVEAL
CEEEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHH
LPEDVKTVRQVKQLGTGHAVMVAQDAVMDDEVIVLTGDAPLISPETLINLYKIRREKDYD
CCHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCC
VVVASTFQEDPTGYGRIVRENGKLRIIEEKDASEEIKRIKEINSGIYVFKSDFLKDALKK
EEEEECCCCCCCCCCEEEEECCCEEEEECCCHHHHHHHHHHHCCCEEEEHHHHHHHHHHH
INNNNNQKEYYLTDTVALAEKATAHVIEDPTEVLGVNNRVQLAEIQKIAQKKINERLMLN
HCCCCCCEEEEEEHHHHHHHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHHHCCEEEEC
GITIVDPDTTYISPDVEIGQDTVIEPMTFILGKTKIGNNCLIGPMTRIIDSSIDDSVSII
CEEEECCCCCEECCCCCCCCCHHHHHHHHHHCCCCCCCCCEEHHHHHHHHCCCCHHHHHH
RSEVEQAIIKSGARVGPFSRLRPGTTLLENTKIGNFVEVKKSTIGRNSKAQHLTYLGDAT
HHHHHHHHHHCCCCCCCHHHCCCCCCEECCCCCCCEEEEHHHHCCCCCCCCEEEEECCCC
IGEDVNIGAGTITCNYDGVRKHQTIIENNSFIGSNCSLVAPVKIGEGSVVGAGSVITDDV
CCCCCCCCCEEEEECCCCCHHHHHHHCCCCEECCCCCEEEEEEECCCCEEECCCEEECCC
PPYSLALGRGRQVIKEGRYKNKEKGE
CCHHHHHHCCHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA