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The map label for this gene is fchA [H]

Identifier: 239618057

GI number: 239618057

Start: 1818464

End: 1819093

Strand: Reverse

Name: fchA [H]

Synonym: Kole_1686

Alternate gene names: 239618057

Gene position: 1819093-1818464 (Counterclockwise)

Preceding gene: 239618058

Following gene: 239618056

Centisome position: 79.02

GC content: 45.4

Gene sequence:

>630_bases
ATGGATCTTTGCTCGTTAAGCGTTAAGGACTTCATAAAGCGAGTTGCCGAGAAATCACCGACTCCAGGTGGAGGCGCTGT
TGGAGCTGTTGCGGCTGCTTTGGCCGCTGCACTTGGTGCTATGGTTTCGAACCTTACCATCGGCAAGAAAGGATACGAAG
ACGTTGAGAGTCAGATGGAAGCATGTCTCGAAATCTTCGGCAACGAGATGAGCTACCTTTGTGATCTCGTAAATAAGGAC
GTTCAAGCCTTCGATCAGGTAATGGCAGCTTACAGGCTTCCTAAAAATTCTGAAGAAGAAAAAGCCGTCAGAACAGTGAA
GATCCAACAAGCTTTAAAAACTGCCATCGAAGTGCCCTTCGATCTTGCCAGACGTTGTAAAAATGTCATAGTGAACGTGG
AAAGACTGGCAAAATGGGGCAATCTCAACGCTATTTCCGACGCTGAAAGTGCTGCACATTTGTTGTACGCAGTTTATTAT
GTCGCAAAGGCCAACGTAATGATCAACATGAAGTCACTGAAAGATCCACGGTACTGTAACTGGATCAAAGAAGAAATGGA
CCATCTCGAAAAGCAAATCGAAGCCTCCTACCGGAGGATACTCGAGGTGATAAAAAAGAGAAATGGTTAA

Upstream 100 bases:

>100_bases
GAAGATATGATAAGGATGTTGATTGCGGGCGCCGACAGAATTGGAACGAGTTCTGGAATGAAAATAATAGGCAAAAAATA
ATACAACAGGGGGGATTTGG

Downstream 100 bases:

>100_bases
ATTCACCGTCACAAAAAAAGACCCGGTAACATCCGCGAGAACTGGAAAGCTAGAAACAAAACACGGTGTTTTCGAAACAC
CTGTGTTTATGCCTGTGGGT

Product: Formimidoyltetrahydrofolate cyclodeaminase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MDLCSLSVKDFIKRVAEKSPTPGGGAVGAVAAALAAALGAMVSNLTIGKKGYEDVESQMEACLEIFGNEMSYLCDLVNKD
VQAFDQVMAAYRLPKNSEEEKAVRTVKIQQALKTAIEVPFDLARRCKNVIVNVERLAKWGNLNAISDAESAAHLLYAVYY
VAKANVMINMKSLKDPRYCNWIKEEMDHLEKQIEASYRRILEVIKKRNG

Sequences:

>Translated_209_residues
MDLCSLSVKDFIKRVAEKSPTPGGGAVGAVAAALAAALGAMVSNLTIGKKGYEDVESQMEACLEIFGNEMSYLCDLVNKD
VQAFDQVMAAYRLPKNSEEEKAVRTVKIQQALKTAIEVPFDLARRCKNVIVNVERLAKWGNLNAISDAESAAHLLYAVYY
VAKANVMINMKSLKDPRYCNWIKEEMDHLEKQIEASYRRILEVIKKRNG
>Mature_209_residues
MDLCSLSVKDFIKRVAEKSPTPGGGAVGAVAAALAAALGAMVSNLTIGKKGYEDVESQMEACLEIFGNEMSYLCDLVNKD
VQAFDQVMAAYRLPKNSEEEKAVRTVKIQQALKTAIEVPFDLARRCKNVIVNVERLAKWGNLNAISDAESAAHLLYAVYY
VAKANVMINMKSLKDPRYCNWIKEEMDHLEKQIEASYRRILEVIKKRNG

Specific function: Required for both C1 and C2 metabolism [H]

COG id: COG3404

COG function: function code E; Methenyl tetrahydrofolate cyclohydrolase

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cyclodeaminase/cyclohydrolase family [H]

Homologues:

Organism=Homo sapiens, GI46255035, Length=206, Percent_Identity=33.495145631068, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI11140815, Length=206, Percent_Identity=33.495145631068, Blast_Score=92, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007044 [H]

Pfam domain/function: PF04961 FTCD_C [H]

EC number: =3.5.4.9 [H]

Molecular weight: Translated: 23221; Mature: 23221

Theoretical pI: Translated: 8.18; Mature: 8.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLCSLSVKDFIKRVAEKSPTPGGGAVGAVAAALAAALGAMVSNLTIGKKGYEDVESQME
CCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
ACLEIFGNEMSYLCDLVNKDVQAFDQVMAAYRLPKNSEEEKAVRTVKIQQALKTAIEVPF
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCH
DLARRCKNVIVNVERLAKWGNLNAISDAESAAHLLYAVYYVAKANVMINMKSLKDPRYCN
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEHHHCCCCHHHH
WIKEEMDHLEKQIEASYRRILEVIKKRNG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDLCSLSVKDFIKRVAEKSPTPGGGAVGAVAAALAAALGAMVSNLTIGKKGYEDVESQME
CCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
ACLEIFGNEMSYLCDLVNKDVQAFDQVMAAYRLPKNSEEEKAVRTVKIQQALKTAIEVPF
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCH
DLARRCKNVIVNVERLAKWGNLNAISDAESAAHLLYAVYYVAKANVMINMKSLKDPRYCN
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEHHHCCCCHHHH
WIKEEMDHLEKQIEASYRRILEVIKKRNG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7961516; 10215859 [H]