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The map label for this gene is gcvPB

Identifier: 239617991

GI number: 239617991

Start: 1738023

End: 1739474

Strand: Reverse

Name: gcvPB

Synonym: Kole_1619

Alternate gene names: 239617991

Gene position: 1739474-1738023 (Counterclockwise)

Preceding gene: 239617992

Following gene: 239617989

Centisome position: 75.56

GC content: 43.11

Gene sequence:

>1452_bases
ATGACTATATTCGAAAAATCAGTCACTGGAAGAACAGGATACACACTACCCGAGGAGAAAAAAGACGAAATTCGTCCTTC
AGACTACATACCTGAACATCTTTTAAGGAAAGAATTACCAGGACTCCCTGAGTGCAGTGAAATAGATGTTGTTAGGCATT
ATACTGAGTTAACCAGAAAGAACTATTCAGTGGATAACGGATTCTATCCGTTAGGTTCATGTACCATGAAATACAACCCT
AAACTCAATGAAAAAATCGCCGCACTCGAAGGTTTTTCGTTGCTTCATCCTTACGAACCCATTGAAAAAGTTCAAGGCGC
TCTAGAGGTCATGTACAGGCTCCAAACTCTCCTTTCAGAGATTACTGGTATGGATGCCTTCACTCTTCAACCCGCTGCAG
GCGCCCACGGAGAATTGACAGGAATGCTTATAGTCAAAAAGTATTTCGAGGTAAAGGGTGAGAATCAAAGAACAAAGGTC
ATCGTCCCGGATTCGGCTCACGGTACAAATCCTGCATCGGCTTCTATGGCCGGATTCCAGGTAGTAGAAATCAAGTCCAA
CGATAATGGAATAATTGATCTCGATAACCTCGAGGCTGCTCTGGATGAAAGTGTCGCAGCTATAATGCTTACAAACCCGA
ACACCCTGGGTTTGTTTGAAAAGGACATTATAAAAATTGCTGAAATGGCCCATAAAAATGGCACCCTCCTCTATTATGAC
GGGGCTAACCTGAACGCTATTATGGGAAAGGTCAGGCCCGGCGACATGGGGTTCGATATAGTCCATCTCAACCTGCATAA
GACATTCTCCACACCGCACGGCATGGGAGGTCCAGGAAGCGGGCCGGTGGGCGTTAAAGGTCATTTGAAGGAGTTTCTCC
CGATACCTGTAGTGGATTTAACAGACGAGGGTTACATCCTGAAAACCGATCTCTCACATTCTATCGGAAGAATTAGGAGT
TTCTATGGAAATTTTGGCGTGGTTGTTAAGGCATTGGCTTATATTCTTATGCTTGGTAAAGATGGTCTAACCTATGCAAG
TGAGATAGCTGTTCTAAATGCTAACTATCTCAGGACAAGGCTCTCTGAATTGATACCAACAGCTTATCCAGGTTTGTGCA
AACACGAGTTTGTACTCGATGGCACAAAATTAGTCAAGGAATATGGGATCAAGACTCTCGACCTCGCTAAAAGGATGCTG
GACTACGGTGTACACCCACCAACTATATACTTCCCTCTTATCGTTCATGAAGCCTTAATGATAGAACCAACAGAAACAGA
AAACAAAGATAATCTTGACCATTTCGTTGAGGTGGTAAAAAAGATCCTTGAAGAAGCAAAAAAAGATCCGGAATTCGTTA
AAAATGCCCCGTACAACACACCTATAAAACGCCTTGATGAAGTTACGGCTTCCAGAAAGCCAAAGGTAAGATGGATACCC
AAAGAACAATAA

Upstream 100 bases:

>100_bases
AATGGTATCCAGAGATGAAAAGTTGTGCGCTTTTCTGCACCACGGAAGCTGTAAGAAATGCAGATATCGAGTTTCTTCTT
GGACGTCTGGAGGAGATATT

Downstream 100 bases:

>100_bases
CCCAGGATGACGGGTTGAAAGATTTTAAGGTCTATGATATTATACTCACTGAACGAGCAGGCGTAGCTTCAATCGGTGGA
GCGCCGCCTTGGTAAGGCGG

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2

Number of amino acids: Translated: 483; Mature: 482

Protein sequence:

>483_residues
MTIFEKSVTGRTGYTLPEEKKDEIRPSDYIPEHLLRKELPGLPECSEIDVVRHYTELTRKNYSVDNGFYPLGSCTMKYNP
KLNEKIAALEGFSLLHPYEPIEKVQGALEVMYRLQTLLSEITGMDAFTLQPAAGAHGELTGMLIVKKYFEVKGENQRTKV
IVPDSAHGTNPASASMAGFQVVEIKSNDNGIIDLDNLEAALDESVAAIMLTNPNTLGLFEKDIIKIAEMAHKNGTLLYYD
GANLNAIMGKVRPGDMGFDIVHLNLHKTFSTPHGMGGPGSGPVGVKGHLKEFLPIPVVDLTDEGYILKTDLSHSIGRIRS
FYGNFGVVVKALAYILMLGKDGLTYASEIAVLNANYLRTRLSELIPTAYPGLCKHEFVLDGTKLVKEYGIKTLDLAKRML
DYGVHPPTIYFPLIVHEALMIEPTETENKDNLDHFVEVVKKILEEAKKDPEFVKNAPYNTPIKRLDEVTASRKPKVRWIP
KEQ

Sequences:

>Translated_483_residues
MTIFEKSVTGRTGYTLPEEKKDEIRPSDYIPEHLLRKELPGLPECSEIDVVRHYTELTRKNYSVDNGFYPLGSCTMKYNP
KLNEKIAALEGFSLLHPYEPIEKVQGALEVMYRLQTLLSEITGMDAFTLQPAAGAHGELTGMLIVKKYFEVKGENQRTKV
IVPDSAHGTNPASASMAGFQVVEIKSNDNGIIDLDNLEAALDESVAAIMLTNPNTLGLFEKDIIKIAEMAHKNGTLLYYD
GANLNAIMGKVRPGDMGFDIVHLNLHKTFSTPHGMGGPGSGPVGVKGHLKEFLPIPVVDLTDEGYILKTDLSHSIGRIRS
FYGNFGVVVKALAYILMLGKDGLTYASEIAVLNANYLRTRLSELIPTAYPGLCKHEFVLDGTKLVKEYGIKTLDLAKRML
DYGVHPPTIYFPLIVHEALMIEPTETENKDNLDHFVEVVKKILEEAKKDPEFVKNAPYNTPIKRLDEVTASRKPKVRWIP
KEQ
>Mature_482_residues
TIFEKSVTGRTGYTLPEEKKDEIRPSDYIPEHLLRKELPGLPECSEIDVVRHYTELTRKNYSVDNGFYPLGSCTMKYNPK
LNEKIAALEGFSLLHPYEPIEKVQGALEVMYRLQTLLSEITGMDAFTLQPAAGAHGELTGMLIVKKYFEVKGENQRTKVI
VPDSAHGTNPASASMAGFQVVEIKSNDNGIIDLDNLEAALDESVAAIMLTNPNTLGLFEKDIIKIAEMAHKNGTLLYYDG
ANLNAIMGKVRPGDMGFDIVHLNLHKTFSTPHGMGGPGSGPVGVKGHLKEFLPIPVVDLTDEGYILKTDLSHSIGRIRSF
YGNFGVVVKALAYILMLGKDGLTYASEIAVLNANYLRTRLSELIPTAYPGLCKHEFVLDGTKLVKEYGIKTLDLAKRMLD
YGVHPPTIYFPLIVHEALMIEPTETENKDNLDHFVEVVKKILEEAKKDPEFVKNAPYNTPIKRLDEVTASRKPKVRWIPK
EQ

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily

Homologues:

Organism=Homo sapiens, GI108773801, Length=430, Percent_Identity=40.4651162790698, Blast_Score=291, Evalue=7e-79,
Organism=Escherichia coli, GI1789269, Length=407, Percent_Identity=41.7690417690418, Blast_Score=290, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI17535605, Length=410, Percent_Identity=43.6585365853659, Blast_Score=299, Evalue=3e-81,
Organism=Caenorhabditis elegans, GI32564013, Length=364, Percent_Identity=44.5054945054945, Blast_Score=276, Evalue=1e-74,
Organism=Saccharomyces cerevisiae, GI6323843, Length=472, Percent_Identity=40.6779661016949, Blast_Score=306, Evalue=4e-84,
Organism=Drosophila melanogaster, GI24645648, Length=410, Percent_Identity=42.4390243902439, Blast_Score=295, Evalue=4e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCSPB_KOSOT (C5CF44)

Other databases:

- EMBL:   CP001634
- RefSeq:   YP_002941313.1
- ProteinModelPortal:   C5CF44
- GeneID:   7967853
- GenomeReviews:   CP001634_GR
- KEGG:   kol:Kole_1619
- ProtClustDB:   PRK04366
- HAMAP:   MF_00713
- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421
- Gene3D:   G3DSA:3.40.640.10
- PANTHER:   PTHR11773

Pfam domain/function: PF02347 GDC-P; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =1.4.4.2

Molecular weight: Translated: 53758; Mature: 53627

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIFEKSVTGRTGYTLPEEKKDEIRPSDYIPEHLLRKELPGLPECSEIDVVRHYTELTRK
CCEECCCCCCCCCCCCCCCCHHCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHC
NYSVDNGFYPLGSCTMKYNPKLNEKIAALEGFSLLHPYEPIEKVQGALEVMYRLQTLLSE
CCCCCCCCEECCCEEEEECCCCCHHHHHHCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHH
ITGMDAFTLQPAAGAHGELTGMLIVKKYFEVKGENQRTKVIVPDSAHGTNPASASMAGFQ
HCCCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCEE
VVEIKSNDNGIIDLDNLEAALDESVAAIMLTNPNTLGLFEKDIIKIAEMAHKNGTLLYYD
EEEEECCCCCEEEECCHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEC
GANLNAIMGKVRPGDMGFDIVHLNLHKTFSTPHGMGGPGSGPVGVKGHLKEFLPIPVVDL
CCCCHHHEECCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHCCCCCEEEE
TDEGYILKTDLSHSIGRIRSFYGNFGVVVKALAYILMLGKDGLTYASEIAVLNANYLRTR
CCCCEEEEECHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHEEEECHHHHHHH
LSELIPTAYPGLCKHEFVLDGTKLVKEYGIKTLDLAKRMLDYGVHPPTIYFPLIVHEALM
HHHHCCCCCCCCCCCCEEECHHHHHHHHCCHHHHHHHHHHHCCCCCCCEEHHHHHHHHHE
IEPTETENKDNLDHFVEVVKKILEEAKKDPEFVKNAPYNTPIKRLDEVTASRKPKVRWIP
ECCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHCCCCCEECCC
KEQ
CCC
>Mature Secondary Structure 
TIFEKSVTGRTGYTLPEEKKDEIRPSDYIPEHLLRKELPGLPECSEIDVVRHYTELTRK
CEECCCCCCCCCCCCCCCCHHCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHC
NYSVDNGFYPLGSCTMKYNPKLNEKIAALEGFSLLHPYEPIEKVQGALEVMYRLQTLLSE
CCCCCCCCEECCCEEEEECCCCCHHHHHHCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHH
ITGMDAFTLQPAAGAHGELTGMLIVKKYFEVKGENQRTKVIVPDSAHGTNPASASMAGFQ
HCCCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCEE
VVEIKSNDNGIIDLDNLEAALDESVAAIMLTNPNTLGLFEKDIIKIAEMAHKNGTLLYYD
EEEEECCCCCEEEECCHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEC
GANLNAIMGKVRPGDMGFDIVHLNLHKTFSTPHGMGGPGSGPVGVKGHLKEFLPIPVVDL
CCCCHHHEECCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHCCCCCEEEE
TDEGYILKTDLSHSIGRIRSFYGNFGVVVKALAYILMLGKDGLTYASEIAVLNANYLRTR
CCCCEEEEECHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHEEEECHHHHHHH
LSELIPTAYPGLCKHEFVLDGTKLVKEYGIKTLDLAKRMLDYGVHPPTIYFPLIVHEALM
HHHHCCCCCCCCCCCCEEECHHHHHHHHCCHHHHHHHHHHHCCCCCCCEEHHHHHHHHHE
IEPTETENKDNLDHFVEVVKKILEEAKKDPEFVKNAPYNTPIKRLDEVTASRKPKVRWIP
ECCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHCCCCCEECCC
KEQ
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA