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The map label for this gene is gcvPA [H]

Identifier: 239617992

GI number: 239617992

Start: 1739471

End: 1740820

Strand: Reverse

Name: gcvPA [H]

Synonym: Kole_1620

Alternate gene names: 239617992

Gene position: 1740820-1739471 (Counterclockwise)

Preceding gene: 239617993

Following gene: 239617991

Centisome position: 75.62

GC content: 41.04

Gene sequence:

>1350_bases
ATGAAAGAACGTCATTCTTACATTCCTCACACCCCGGAAGAAATAAAATCGATGTTAGAAACGATAGGAGTTCCCAGTAT
TGAGGAGCTTTTTTCAGATGTTCCGAAGGTTTTTGATTTTGAACTCGCTCTACCAAAAGGTTCGGATGAATTCAGTGTTT
ATCGTGAAATGAAATCTCTTGCCGAAAGAAATACAAATCTCGAACAACTGGCAGTGTTTCGTGGTGGTGGTATATATCAT
CATTACATTCCATTTGTAGTTCAAGCTCTCGCATCTCGAAGCGAATTTCTCACTGCTTACACGCCTTATCAGGCTGAGGT
TTCCCAGGGGACCTTGCAAGCTCTTTACGAGTTCCAGACGATGATCGTTGAGCTTACAGGAATGGAAGTCGCCAATTCTT
CTATGTATGATGGGGCAACAGCTGTCGCTGAAGCGGCTCTTATGGCCGTAAGGACAAATAGGAAAGATAAAATTATTGTT
GCAAAAAATGTGCATCCTGAATATAGGGAAGTCATCAGAACCTATTGTTCTGGACAAAACATAAAGGTTGAAGAAGTCAA
CTTTGATAAAAACAGCGGGAATATCGACCTTGAAACACTCAAATCAAAACTCACAGATGATGTTTCCGGAGTAATTGTTG
GTTATCCGAATTTTTTCGGAGTAATTGAGGATCTAAAAATTATTCGTGAGTTGCTTCCGGAAAAAGTTATGTTCATAGTT
GTAGCTAATCCGATTGCACTATCACTTCTTGAGGCCCCTGGAAAGCTTGGTGCCGATATCGTTGTCGGTGAAGGTCAGCC
ACTGGGAAACCCTCCAAACTTCGGTGGCCCTGGTTTTGGTTTCTTTGCTACTTTGGAAAAATACATCCGAAAGATGCCAG
GAAGAATCATTGGAGAGACAAAAGATACTGAAGGAAGAACAGGGTACGTTATGGTGCTTCAAACGAGGGAACAACATATC
AGGAGAAGTAAAGCAACATCTAATATTTGTTCCAATCATGCCCACAATGCTGTTACTGCTGCCATATATATGAGTGTTAT
GGGAAAAGAAGGGCTTCGTGAGGTAGCTGAACAATCCTTCGCCAAAGCGCATTCGTTGAAAGAAAGATTACTGAAGCTCG
AAGGAGTTACGGAGGTATTCAGTGGGCCATTCTTCCATGAATTCGTTATAAGTTTTAACAAAGATGTGGAATTTATTAAT
TCGGAACTCATGAAACATAAAATTCTCGGACCTTTGAATCTAGAGAAATGGTATCCAGAGATGAAAAGTTGTGCGCTTTT
CTGCACCACGGAAGCTGTAAGAAATGCAGATATCGAGTTTCTTCTTGGACGTCTGGAGGAGATATTATGA

Upstream 100 bases:

>100_bases
GAAGGCTGGCTTTTTAAGATAAAGCTTTCAAATTCTGATGAACTCAACGAGCTCATGGACGAAGAGGAGTACAAGGCTTT
TTGTAAAGAGGAGGAATGAC

Downstream 100 bases:

>100_bases
CTATATTCGAAAAATCAGTCACTGGAAGAACAGGATACACACTACCCGAGGAGAAAAAAGACGAAATTCGTCCTTCAGAC
TACATACCTGAACATCTTTT

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1 [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MKERHSYIPHTPEEIKSMLETIGVPSIEELFSDVPKVFDFELALPKGSDEFSVYREMKSLAERNTNLEQLAVFRGGGIYH
HYIPFVVQALASRSEFLTAYTPYQAEVSQGTLQALYEFQTMIVELTGMEVANSSMYDGATAVAEAALMAVRTNRKDKIIV
AKNVHPEYREVIRTYCSGQNIKVEEVNFDKNSGNIDLETLKSKLTDDVSGVIVGYPNFFGVIEDLKIIRELLPEKVMFIV
VANPIALSLLEAPGKLGADIVVGEGQPLGNPPNFGGPGFGFFATLEKYIRKMPGRIIGETKDTEGRTGYVMVLQTREQHI
RRSKATSNICSNHAHNAVTAAIYMSVMGKEGLREVAEQSFAKAHSLKERLLKLEGVTEVFSGPFFHEFVISFNKDVEFIN
SELMKHKILGPLNLEKWYPEMKSCALFCTTEAVRNADIEFLLGRLEEIL

Sequences:

>Translated_449_residues
MKERHSYIPHTPEEIKSMLETIGVPSIEELFSDVPKVFDFELALPKGSDEFSVYREMKSLAERNTNLEQLAVFRGGGIYH
HYIPFVVQALASRSEFLTAYTPYQAEVSQGTLQALYEFQTMIVELTGMEVANSSMYDGATAVAEAALMAVRTNRKDKIIV
AKNVHPEYREVIRTYCSGQNIKVEEVNFDKNSGNIDLETLKSKLTDDVSGVIVGYPNFFGVIEDLKIIRELLPEKVMFIV
VANPIALSLLEAPGKLGADIVVGEGQPLGNPPNFGGPGFGFFATLEKYIRKMPGRIIGETKDTEGRTGYVMVLQTREQHI
RRSKATSNICSNHAHNAVTAAIYMSVMGKEGLREVAEQSFAKAHSLKERLLKLEGVTEVFSGPFFHEFVISFNKDVEFIN
SELMKHKILGPLNLEKWYPEMKSCALFCTTEAVRNADIEFLLGRLEEIL
>Mature_449_residues
MKERHSYIPHTPEEIKSMLETIGVPSIEELFSDVPKVFDFELALPKGSDEFSVYREMKSLAERNTNLEQLAVFRGGGIYH
HYIPFVVQALASRSEFLTAYTPYQAEVSQGTLQALYEFQTMIVELTGMEVANSSMYDGATAVAEAALMAVRTNRKDKIIV
AKNVHPEYREVIRTYCSGQNIKVEEVNFDKNSGNIDLETLKSKLTDDVSGVIVGYPNFFGVIEDLKIIRELLPEKVMFIV
VANPIALSLLEAPGKLGADIVVGEGQPLGNPPNFGGPGFGFFATLEKYIRKMPGRIIGETKDTEGRTGYVMVLQTREQHI
RRSKATSNICSNHAHNAVTAAIYMSVMGKEGLREVAEQSFAKAHSLKERLLKLEGVTEVFSGPFFHEFVISFNKDVEFIN
SELMKHKILGPLNLEKWYPEMKSCALFCTTEAVRNADIEFLLGRLEEIL

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=351, Percent_Identity=35.3276353276353, Blast_Score=206, Evalue=4e-53,
Organism=Escherichia coli, GI1789269, Length=385, Percent_Identity=38.1818181818182, Blast_Score=198, Evalue=5e-52,
Organism=Caenorhabditis elegans, GI17535605, Length=356, Percent_Identity=38.4831460674157, Blast_Score=210, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6323843, Length=445, Percent_Identity=35.2808988764045, Blast_Score=228, Evalue=1e-60,
Organism=Drosophila melanogaster, GI24645648, Length=350, Percent_Identity=36.2857142857143, Blast_Score=229, Evalue=2e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 50253; Mature: 50253

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKERHSYIPHTPEEIKSMLETIGVPSIEELFSDVPKVFDFELALPKGSDEFSVYREMKSL
CCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHCHHHEEEEEECCCCCHHHHHHHHHHHH
AERNTNLEQLAVFRGGGIYHHYIPFVVQALASRSEFLTAYTPYQAEVSQGTLQALYEFQT
HHCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHH
MIVELTGMEVANSSMYDGATAVAEAALMAVRTNRKDKIIVAKNVHPEYREVIRTYCSGQN
HHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHCCCC
IKVEEVNFDKNSGNIDLETLKSKLTDDVSGVIVGYPNFFGVIEDLKIIRELLPEKVMFIV
EEEEEECCCCCCCCEEHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHCCHHEEEEE
VANPIALSLLEAPGKLGADIVVGEGQPLGNPPNFGGPGFGFFATLEKYIRKMPGRIIGET
EECHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEECCC
KDTEGRTGYVMVLQTREQHIRRSKATSNICSNHAHNAVTAAIYMSVMGKEGLREVAEQSF
CCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCHHHHHHHHHHHH
AKAHSLKERLLKLEGVTEVFSGPFFHEFVISFNKDVEFINSELMKHKILGPLNLEKWYPE
HHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHCHH
MKSCALFCTTEAVRNADIEFLLGRLEEIL
HHHHEEEEEHHHHHCCCHHHHHHHHHHHC
>Mature Secondary Structure
MKERHSYIPHTPEEIKSMLETIGVPSIEELFSDVPKVFDFELALPKGSDEFSVYREMKSL
CCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHCHHHEEEEEECCCCCHHHHHHHHHHHH
AERNTNLEQLAVFRGGGIYHHYIPFVVQALASRSEFLTAYTPYQAEVSQGTLQALYEFQT
HHCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHH
MIVELTGMEVANSSMYDGATAVAEAALMAVRTNRKDKIIVAKNVHPEYREVIRTYCSGQN
HHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHCCCC
IKVEEVNFDKNSGNIDLETLKSKLTDDVSGVIVGYPNFFGVIEDLKIIRELLPEKVMFIV
EEEEEECCCCCCCCEEHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHCCHHEEEEE
VANPIALSLLEAPGKLGADIVVGEGQPLGNPPNFGGPGFGFFATLEKYIRKMPGRIIGET
EECHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEECCC
KDTEGRTGYVMVLQTREQHIRRSKATSNICSNHAHNAVTAAIYMSVMGKEGLREVAEQSF
CCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCHHHHHHHHHHHH
AKAHSLKERLLKLEGVTEVFSGPFFHEFVISFNKDVEFINSELMKHKILGPLNLEKWYPE
HHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHCHH
MKSCALFCTTEAVRNADIEFLLGRLEEIL
HHHHEEEEEHHHHHCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]