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The map label for this gene is serS

Identifier: 239617246

GI number: 239617246

Start: 902206

End: 903480

Strand: Reverse

Name: serS

Synonym: Kole_0854

Alternate gene names: 239617246

Gene position: 903480-902206 (Counterclockwise)

Preceding gene: 239617247

Following gene: 239617245

Centisome position: 39.25

GC content: 44.39

Gene sequence:

>1275_bases
ATGATAGATATCCGTCTTGTGCGTGAGAATCCGGAAAAAATAAGGGCGGCTTTGAAGAATAGATGTGTAGATGAATCTAT
ACTCGATGAATTGCTCGAGTTAGATAAGGCAAGACGCGAAGCTATAAGTACTTCCGATAGGAAAAAAGCGGAGAGGAACA
AGATATCTTCACAGATCGCAAAAGCAAAAGCTTCAGGTGATGAAGCTCTGGCTAAAGAGCTCATGGAAAAGGCAAAGGAC
ATCTCTGTTGAGGTAAAAGAACTTTCTGAAAAGGCGAAGAAACTCGATGAAGAAATGAGAAATAAATTGCTTTACATACC
GAACATTCCTCACGAGAGCGTTCCTGTGGGCGAAAGTGAGGAAGACAATGTTGTTGTTAGAAAATGGGGTGAGCCAAGAC
AATTTGATTTTGACTCCCTCGCACATTGGGATCTTGGTCCCAATCTTGGTATGATGGATTTCGAACGAGCAGCGAAGTTA
AGTGGTTCGAGATTTGTAATTCTAAGGAAAGAACTGGCCAGGCTCGAGCGCGCTCTCATTAACTTCATGCTCGATCTTCA
TACTAGAGAGCACGGTTACGAAGAAGTTGCTTTGCCACACCTCGTAAAAAGGGAAACAATGCAAGCCACAGGGCAGCTTC
CAAAATTCGAGGAAGAAGCTTATAAAACCGATCCGGACGATATGTTCCTGATACCAACAGCTGAAGTTCCTCTTGTAGCA
CAGCACAGGGACGAAATTCTTAACCTGAACGAACTTCCGAGGAAATATACAGCTTATACCCCGTGTTACAGAAGAGAAGC
TGGAAGCTATGGAAAAGACGTGAAGGGAATGATAAGGGTACACCAGTTTGACAAGGTGGAACTTGTCTGGTTTGTTCATC
CAGATGAATCTTACGAAGCCCTTGAAAAGCTTACCGCTGATGCGGAAGAGGTTCTCAAAAGACTCGGGCTTCCATACAGA
GTAGTGGCTTTGTGTACAGGGGACCTCGGTTTTGCTGCGGCTAAAACCTATGATATAGAAGTCTGGCTGCCATCTTACAA
CGCTTACAAAGAAATCTCGTCATGCAGTAATGTTGAGGATTTCCAGGCGAGAAGGGGAAATATGCGCTTTAGAGATAAAG
ACAATAAATTGAAATACGTCCACACCCTCAATGGGTCTGGGCTTGCTGTTGGAAGGACTCTGGTTGCCATCGTTGAGAAC
TATCAGCTTCCGGATGGAAGGATAAGAGTTCCAGAAGTCCTGGTTCCTTATATGGGAACGGAGGTAATAGGCTGA

Upstream 100 bases:

>100_bases
ATAGAACCATTACAGCTTCAGAATTGACTTATAATACCACCAACGATACATTCGAAGGTAAAGACGTTTACCTCGAAATA
ATACTTGAGGAGGGTGAGCA

Downstream 100 bases:

>100_bases
GTGCCAAACGCTTTCTTTGTCGAAAGGGTTGAAGAAAAACGACTTATATTTGATGAGATTGAAGCTCATCATATGAAGGT
TGTTCGTGTAAAACCAGGTG

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MIDIRLVRENPEKIRAALKNRCVDESILDELLELDKARREAISTSDRKKAERNKISSQIAKAKASGDEALAKELMEKAKD
ISVEVKELSEKAKKLDEEMRNKLLYIPNIPHESVPVGESEEDNVVVRKWGEPRQFDFDSLAHWDLGPNLGMMDFERAAKL
SGSRFVILRKELARLERALINFMLDLHTREHGYEEVALPHLVKRETMQATGQLPKFEEEAYKTDPDDMFLIPTAEVPLVA
QHRDEILNLNELPRKYTAYTPCYRREAGSYGKDVKGMIRVHQFDKVELVWFVHPDESYEALEKLTADAEEVLKRLGLPYR
VVALCTGDLGFAAAKTYDIEVWLPSYNAYKEISSCSNVEDFQARRGNMRFRDKDNKLKYVHTLNGSGLAVGRTLVAIVEN
YQLPDGRIRVPEVLVPYMGTEVIG

Sequences:

>Translated_424_residues
MIDIRLVRENPEKIRAALKNRCVDESILDELLELDKARREAISTSDRKKAERNKISSQIAKAKASGDEALAKELMEKAKD
ISVEVKELSEKAKKLDEEMRNKLLYIPNIPHESVPVGESEEDNVVVRKWGEPRQFDFDSLAHWDLGPNLGMMDFERAAKL
SGSRFVILRKELARLERALINFMLDLHTREHGYEEVALPHLVKRETMQATGQLPKFEEEAYKTDPDDMFLIPTAEVPLVA
QHRDEILNLNELPRKYTAYTPCYRREAGSYGKDVKGMIRVHQFDKVELVWFVHPDESYEALEKLTADAEEVLKRLGLPYR
VVALCTGDLGFAAAKTYDIEVWLPSYNAYKEISSCSNVEDFQARRGNMRFRDKDNKLKYVHTLNGSGLAVGRTLVAIVEN
YQLPDGRIRVPEVLVPYMGTEVIG
>Mature_424_residues
MIDIRLVRENPEKIRAALKNRCVDESILDELLELDKARREAISTSDRKKAERNKISSQIAKAKASGDEALAKELMEKAKD
ISVEVKELSEKAKKLDEEMRNKLLYIPNIPHESVPVGESEEDNVVVRKWGEPRQFDFDSLAHWDLGPNLGMMDFERAAKL
SGSRFVILRKELARLERALINFMLDLHTREHGYEEVALPHLVKRETMQATGQLPKFEEEAYKTDPDDMFLIPTAEVPLVA
QHRDEILNLNELPRKYTAYTPCYRREAGSYGKDVKGMIRVHQFDKVELVWFVHPDESYEALEKLTADAEEVLKRLGLPYR
VVALCTGDLGFAAAKTYDIEVWLPSYNAYKEISSCSNVEDFQARRGNMRFRDKDNKLKYVHTLNGSGLAVGRTLVAIVEN
YQLPDGRIRVPEVLVPYMGTEVIG

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=464, Percent_Identity=34.051724137931, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI8923421, Length=356, Percent_Identity=32.3033707865169, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI225579074, Length=336, Percent_Identity=33.0357142857143, Blast_Score=191, Evalue=8e-49,
Organism=Escherichia coli, GI1787120, Length=435, Percent_Identity=51.0344827586207, Blast_Score=423, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17539260, Length=466, Percent_Identity=32.4034334763949, Blast_Score=234, Evalue=8e-62,
Organism=Caenorhabditis elegans, GI17542084, Length=328, Percent_Identity=30.1829268292683, Blast_Score=155, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6320226, Length=447, Percent_Identity=37.1364653243848, Blast_Score=250, Evalue=3e-67,
Organism=Saccharomyces cerevisiae, GI6321799, Length=436, Percent_Identity=33.7155963302752, Blast_Score=219, Evalue=5e-58,
Organism=Drosophila melanogaster, GI24581334, Length=465, Percent_Identity=33.1182795698925, Blast_Score=224, Evalue=8e-59,
Organism=Drosophila melanogaster, GI17737985, Length=311, Percent_Identity=33.7620578778135, Blast_Score=165, Evalue=6e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_KOSOT (C5CGC3)

Other databases:

- EMBL:   CP001634
- RefSeq:   YP_002940568.1
- GeneID:   7968206
- GenomeReviews:   CP001634_GR
- KEGG:   kol:Kole_0854
- ProtClustDB:   PRK05431
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 48523; Mature: 48523

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 280-280 BINDING 287-287 BINDING 386-386

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDIRLVRENPEKIRAALKNRCVDESILDELLELDKARREAISTSDRKKAERNKISSQIA
CEEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
KAKASGDEALAKELMEKAKDISVEVKELSEKAKKLDEEMRNKLLYIPNIPHESVPVGESE
HHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCEEECCCCCCCCCCCCCCC
EDNVVVRKWGEPRQFDFDSLAHWDLGPNLGMMDFERAAKLSGSRFVILRKELARLERALI
CCCEEEEECCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHCCCCEEEEEHHHHHHHHHHHH
NFMLDLHTREHGYEEVALPHLVKRETMQATGQLPKFEEEAYKTDPDDMFLIPTAEVPLVA
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCEEEEECCCCCCHH
QHRDEILNLNELPRKYTAYTPCYRREAGSYGKDVKGMIRVHQFDKVELVWFVHPDESYEA
HHHHHHCCHHHCCHHHHCCCCHHHHHCCCCCCCHHHHHHHEECCCEEEEEEECCCCHHHH
LEKLTADAEEVLKRLGLPYRVVALCTGDLGFAAAKTYDIEVWLPSYNAYKEISSCSNVED
HHHHHCCHHHHHHHCCCCEEEEEEEECCCCCCEEEEEEEEEEECCCHHHHHHHHCCCCHH
FQARRGNMRFRDKDNKLKYVHTLNGSGLAVGRTLVAIVENYQLPDGRIRVPEVLVPYMGT
HHHHCCCCCEECCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCEECHHHHHHHCCH
EVIG
HCCC
>Mature Secondary Structure
MIDIRLVRENPEKIRAALKNRCVDESILDELLELDKARREAISTSDRKKAERNKISSQIA
CEEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
KAKASGDEALAKELMEKAKDISVEVKELSEKAKKLDEEMRNKLLYIPNIPHESVPVGESE
HHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCEEECCCCCCCCCCCCCCC
EDNVVVRKWGEPRQFDFDSLAHWDLGPNLGMMDFERAAKLSGSRFVILRKELARLERALI
CCCEEEEECCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHCCCCEEEEEHHHHHHHHHHHH
NFMLDLHTREHGYEEVALPHLVKRETMQATGQLPKFEEEAYKTDPDDMFLIPTAEVPLVA
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCEEEEECCCCCCHH
QHRDEILNLNELPRKYTAYTPCYRREAGSYGKDVKGMIRVHQFDKVELVWFVHPDESYEA
HHHHHHCCHHHCCHHHHCCCCHHHHHCCCCCCCHHHHHHHEECCCEEEEEEECCCCHHHH
LEKLTADAEEVLKRLGLPYRVVALCTGDLGFAAAKTYDIEVWLPSYNAYKEISSCSNVED
HHHHHCCHHHHHHHCCCCEEEEEEEECCCCCCEEEEEEEEEEECCCHHHHHHHHCCCCHH
FQARRGNMRFRDKDNKLKYVHTLNGSGLAVGRTLVAIVENYQLPDGRIRVPEVLVPYMGT
HHHHCCCCCEECCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCEECHHHHHHHCCH
EVIG
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA