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The map label for this gene is thlA [H]

Identifier: 239616998

GI number: 239616998

Start: 645969

End: 647174

Strand: Reverse

Name: thlA [H]

Synonym: Kole_0598

Alternate gene names: 239616998

Gene position: 647174-645969 (Counterclockwise)

Preceding gene: 239616999

Following gene: 239616997

Centisome position: 28.11

GC content: 45.11

Gene sequence:

>1206_bases
GTGAAAAGAAGAGTTTTTATTGTTGGAGCTAAAAGAACGGCTATTGGTGTATTCGGTGGAAGCCTTAAGAGTATTTCTGC
ACCAAAACTTGGTTCTATAGCGATTAAGGCGGCTATCGACCAGGCCGGTGTTGAACCTTCAGATATTAATGAAGTTATCG
TTGGTAATGTTCTTATGGCAGGTCAGGGTATGGGTCCGGCCAGACAGTCTTCTATTTATGCGGGAATTCCTGTGGAAGTT
CCAGCTTACACAGTTCATATGGTTTGTGGGAGCGGTATGAAGTCTATCATTATTGGTGCTAAAGATATCGCTTATGGTGA
GGCCGATCTTGTGGTAGCAGGCGGTATGGAAAACATGTCTCAGGCACCGTATCTGGTCGATTATAAGGCGAGGTTTGGAG
CTAAATTTGGCGATATGAAGATGACTGACCACATGGTGTTTGACGGTCTTACTGATATTTTTAACCAGGTTCACATGGGT
ATAACCGCCGAAGAAATCGCTTCCCGGTTCGAAATATCTCGTGAAGAACAGGATGAATATGCCCTTGAAAGCCAGAATCG
CGCTCGTGCGGCAATTGCTGCAGGGAAATTCAAAGACGAGATAGTACCCGTTGAGGTTGTTGAGAAAAAACAGACCAGGA
TTTTTGATACCGACGAAGGTCCCAGAGAAACCAGCATTGAAAAACTTGCAAGGTTAAGACCTGCTTTCAAGAAAGATGGA
ACAGTAACCGCTGGAAATTCCTCTACCATTAACGATGGAGCCAGTGCAGTTATTCTCGCAAGCGAGGATTACGTAAAAGC
TCACGGTTTGAAACCTCTGGCGGAAGTTATTGCCTGGGGACAGGGTGGAGTCGATCCGATGGTTATGGGGCTTGGGCCGG
TTCCCGCAACCGATAATGCCCTCAAATATGCAGGTCTAAAGTTCACAGATATCGATCTTATCGAGGCAAATGAAGCTTTT
GCTGTGCAAACACTCGGGGTTATCCGTAAATGGAATGAAATGTATGGAGTCAGCAAAGATTATGTAATTGAAAGAGCAAA
CGTCAATGGAGGTGCCATAGCTCTTGGACACCCGATAGGTTGTAGTGGAAACAGAATAGTTGTGACCTTGCTTTATGAAA
TGATGAAACGCGGAGTTGAACTCGGCCTTGCCACGCTGTGTATTGGTGGTGGAATGGGAACAGCCATTATTATAAAGAGA
ATCTGA

Upstream 100 bases:

>100_bases
TTCTCATTCCGTAAACCTGATTTTGTCATGTACAAAAACGCCCTGATAGAATAAATTGAATAAAACTTTTCAAGTATCTA
TAACAAATGGAGGGGTACAC

Downstream 100 bases:

>100_bases
GTTAGTCCGTTGTTCCTGATAAGGATCTAAGTAGTCCTAACCATGACTTGGAATCCGAAGGGAGGATCTAAGGTGAAGGT
CATCAAAAGTAAGGAAGTGG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MKRRVFIVGAKRTAIGVFGGSLKSISAPKLGSIAIKAAIDQAGVEPSDINEVIVGNVLMAGQGMGPARQSSIYAGIPVEV
PAYTVHMVCGSGMKSIIIGAKDIAYGEADLVVAGGMENMSQAPYLVDYKARFGAKFGDMKMTDHMVFDGLTDIFNQVHMG
ITAEEIASRFEISREEQDEYALESQNRARAAIAAGKFKDEIVPVEVVEKKQTRIFDTDEGPRETSIEKLARLRPAFKKDG
TVTAGNSSTINDGASAVILASEDYVKAHGLKPLAEVIAWGQGGVDPMVMGLGPVPATDNALKYAGLKFTDIDLIEANEAF
AVQTLGVIRKWNEMYGVSKDYVIERANVNGGAIALGHPIGCSGNRIVVTLLYEMMKRGVELGLATLCIGGGMGTAIIIKR
I

Sequences:

>Translated_401_residues
MKRRVFIVGAKRTAIGVFGGSLKSISAPKLGSIAIKAAIDQAGVEPSDINEVIVGNVLMAGQGMGPARQSSIYAGIPVEV
PAYTVHMVCGSGMKSIIIGAKDIAYGEADLVVAGGMENMSQAPYLVDYKARFGAKFGDMKMTDHMVFDGLTDIFNQVHMG
ITAEEIASRFEISREEQDEYALESQNRARAAIAAGKFKDEIVPVEVVEKKQTRIFDTDEGPRETSIEKLARLRPAFKKDG
TVTAGNSSTINDGASAVILASEDYVKAHGLKPLAEVIAWGQGGVDPMVMGLGPVPATDNALKYAGLKFTDIDLIEANEAF
AVQTLGVIRKWNEMYGVSKDYVIERANVNGGAIALGHPIGCSGNRIVVTLLYEMMKRGVELGLATLCIGGGMGTAIIIKR
I
>Mature_401_residues
MKRRVFIVGAKRTAIGVFGGSLKSISAPKLGSIAIKAAIDQAGVEPSDINEVIVGNVLMAGQGMGPARQSSIYAGIPVEV
PAYTVHMVCGSGMKSIIIGAKDIAYGEADLVVAGGMENMSQAPYLVDYKARFGAKFGDMKMTDHMVFDGLTDIFNQVHMG
ITAEEIASRFEISREEQDEYALESQNRARAAIAAGKFKDEIVPVEVVEKKQTRIFDTDEGPRETSIEKLARLRPAFKKDG
TVTAGNSSTINDGASAVILASEDYVKAHGLKPLAEVIAWGQGGVDPMVMGLGPVPATDNALKYAGLKFTDIDLIEANEAF
AVQTLGVIRKWNEMYGVSKDYVIERANVNGGAIALGHPIGCSGNRIVVTLLYEMMKRGVELGLATLCIGGGMGTAIIIKR
I

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=399, Percent_Identity=47.3684210526316, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI167614485, Length=400, Percent_Identity=49, Blast_Score=361, Evalue=1e-100,
Organism=Homo sapiens, GI4557237, Length=401, Percent_Identity=42.643391521197, Blast_Score=317, Evalue=9e-87,
Organism=Homo sapiens, GI4501853, Length=403, Percent_Identity=38.9578163771712, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI4504327, Length=426, Percent_Identity=33.5680751173709, Blast_Score=192, Evalue=3e-49,
Organism=Homo sapiens, GI194353979, Length=397, Percent_Identity=29.4710327455919, Blast_Score=137, Evalue=1e-32,
Organism=Escherichia coli, GI87082165, Length=401, Percent_Identity=52.1197007481297, Blast_Score=394, Evalue=1e-111,
Organism=Escherichia coli, GI1788554, Length=400, Percent_Identity=54, Blast_Score=393, Evalue=1e-110,
Organism=Escherichia coli, GI1787663, Length=406, Percent_Identity=39.9014778325123, Blast_Score=277, Evalue=1e-75,
Organism=Escherichia coli, GI48994986, Length=409, Percent_Identity=39.3643031784841, Blast_Score=243, Evalue=1e-65,
Organism=Escherichia coli, GI1788683, Length=409, Percent_Identity=32.2738386308068, Blast_Score=170, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI133906874, Length=398, Percent_Identity=44.9748743718593, Blast_Score=343, Evalue=9e-95,
Organism=Caenorhabditis elegans, GI25147385, Length=399, Percent_Identity=41.6040100250627, Blast_Score=310, Evalue=1e-84,
Organism=Caenorhabditis elegans, GI17535921, Length=401, Percent_Identity=41.3965087281795, Blast_Score=285, Evalue=3e-77,
Organism=Caenorhabditis elegans, GI17535917, Length=409, Percent_Identity=32.7628361858191, Blast_Score=201, Evalue=7e-52,
Organism=Caenorhabditis elegans, GI17551802, Length=422, Percent_Identity=30.8056872037915, Blast_Score=187, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI17537653, Length=390, Percent_Identity=23.8461538461538, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6325229, Length=407, Percent_Identity=43.4889434889435, Blast_Score=303, Evalue=4e-83,
Organism=Saccharomyces cerevisiae, GI6322031, Length=404, Percent_Identity=37.1287128712871, Blast_Score=212, Evalue=7e-56,
Organism=Drosophila melanogaster, GI24655093, Length=398, Percent_Identity=48.9949748743719, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24640423, Length=399, Percent_Identity=43.1077694235589, Blast_Score=325, Evalue=2e-89,
Organism=Drosophila melanogaster, GI17648125, Length=402, Percent_Identity=44.0298507462687, Blast_Score=314, Evalue=6e-86,
Organism=Drosophila melanogaster, GI17137578, Length=427, Percent_Identity=31.3817330210773, Blast_Score=181, Evalue=1e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 42705; Mature: 42705

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRRVFIVGAKRTAIGVFGGSLKSISAPKLGSIAIKAAIDQAGVEPSDINEVIVGNVLMA
CCCEEEEEECCCEEEEEECCCCCCCCCCCCCCEEEEEHHHHCCCCCCCCCHHHCCCEEEE
GQGMGPARQSSIYAGIPVEVPAYTVHMVCGSGMKSIIIGAKDIAYGEADLVVAGGMENMS
CCCCCCCHHCCEEECCCCCCCCEEEEEECCCCCHHEEEECHHHCCCCCCEEEECCCCCCC
QAPYLVDYKARFGAKFGDMKMTDHMVFDGLTDIFNQVHMGITAEEIASRFEISREEQDEY
CCCEEEEEHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHH
ALESQNRARAAIAAGKFKDEIVPVEVVEKKQTRIFDTDEGPRETSIEKLARLRPAFKKDG
HHHCCCCHHHHHECCCCCCCCCCHHHHCCCCCEEECCCCCCCHHHHHHHHHHCCCCCCCC
TVTAGNSSTINDGASAVILASEDYVKAHGLKPLAEVIAWGQGGVDPMVMGLGPVPATDNA
CEECCCCCCCCCCCCEEEEECCCHHHHCCCCHHHHHHHCCCCCCCCEEEECCCCCCCCCC
LKYAGLKFTDIDLIEANEAFAVQTLGVIRKWNEMYGVSKDYVIERANVNGGAIALGHPIG
CEECCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHEEEECCCCCCEEEECCCCC
CSGNRIVVTLLYEMMKRGVELGLATLCIGGGMGTAIIIKRI
CCCCEEHHHHHHHHHHHHHHHCEEHEEECCCCCEEEEEEEC
>Mature Secondary Structure
MKRRVFIVGAKRTAIGVFGGSLKSISAPKLGSIAIKAAIDQAGVEPSDINEVIVGNVLMA
CCCEEEEEECCCEEEEEECCCCCCCCCCCCCCEEEEEHHHHCCCCCCCCCHHHCCCEEEE
GQGMGPARQSSIYAGIPVEVPAYTVHMVCGSGMKSIIIGAKDIAYGEADLVVAGGMENMS
CCCCCCCHHCCEEECCCCCCCCEEEEEECCCCCHHEEEECHHHCCCCCCEEEECCCCCCC
QAPYLVDYKARFGAKFGDMKMTDHMVFDGLTDIFNQVHMGITAEEIASRFEISREEQDEY
CCCEEEEEHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHH
ALESQNRARAAIAAGKFKDEIVPVEVVEKKQTRIFDTDEGPRETSIEKLARLRPAFKKDG
HHHCCCCHHHHHECCCCCCCCCCHHHHCCCCCEEECCCCCCCHHHHHHHHHHCCCCCCCC
TVTAGNSSTINDGASAVILASEDYVKAHGLKPLAEVIAWGQGGVDPMVMGLGPVPATDNA
CEECCCCCCCCCCCCEEEEECCCHHHHCCCCHHHHHHHCCCCCCCCEEEECCCCCCCCCC
LKYAGLKFTDIDLIEANEAFAVQTLGVIRKWNEMYGVSKDYVIERANVNGGAIALGHPIG
CEECCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHEEEECCCCCCEEEECCCCC
CSGNRIVVTLLYEMMKRGVELGLATLCIGGGMGTAIIIKRI
CCCCEEHHHHHHHHHHHHHHHCEEHEEECCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7867955; 11075929; 11466286; 1685080 [H]