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The map label for this gene is uvrC [H]

Identifier: 239616736

GI number: 239616736

Start: 349204

End: 350928

Strand: Direct

Name: uvrC [H]

Synonym: Kole_0329

Alternate gene names: 239616736

Gene position: 349204-350928 (Clockwise)

Preceding gene: 239616735

Following gene: 239616738

Centisome position: 15.17

GC content: 40.29

Gene sequence:

>1725_bases
TTGAAAAATAAGCTCCTGGCAAAGGTTCGGGAACTTCCCGAGAAACCCGGGATTTACTTATTCAAAAACAAAAAGGGAGA
AATTATATACATTGGAAAAGCAAAAAAACTAAGAAAGAGGGTTTCTTCATATTTTCGTGCTTCAACACACGAACAAAATG
GAAAAACCAGAGAACTTTATCAGGAGATTGACGATCTAGAATTCATAGTCGTTCCCACTGAGAAAGAAGCTCTGCTGCTT
GAGGCAAATTTGATTTATCAACACAAACCGAAATTCAATGTTCTTCTCAAGGATTCCAAACGTTATCCCTATATTTTTAT
CTCTGATGATGAATTTCCATACATCTCCATAACAAGAATACGGGATAGAAAAGGTTTTTATTACGGTCCATACACCAGCA
TAACCCTCGTAAGGAATCTGTTGGACCTTCTCCAGAGAATCTTCAAACTCCGATCCTGTATGGATAATAGAGACTGTAAA
AAAGGACGTCCGTGCTTCCTGTATCATTTGAAGATGTGTTCCGCCCCTCTCGCCGGGGAAATTTCCCACGCAGAATACCA
GAAGCAGGTTCGTGGATTCATGGACTTTCTCGATGGAAAAACGCTGGATGTCAGAAGACAACTGGAAAGAAGTATGCAAA
GACTTGCTGAGAACCTGCAATTTGAGAAAGCAAAAGAGATCCGCGATGTTCTTGTTTCCTTCGATCGTCTTTACAGCAAG
CAAGCTGTGGATGTTTCAGAGAGTTATACCGCTGATTTTATTGTTCTTGATTCTGGAATTGTAACATTATTGGAAGTCAG
GGGTGGCCTATTGCTCGGTAAATTGACCTTCGATTTTCCCGAAGGAAATTTAAAGGATTTCATTCAACAATTTTATTATG
GCCAGAATCACAGAAAACCTCCCGTTTTAATCGTCCCTGGACTGAATAAATCCGAAATCAAAGAAATAGCAGAAGATTTT
GAATACATAGGAAATCCAAGGAGCGAAGAGGAAAAACGTTTATTGCTGATAGCCAGTGACAATACCATAGAAGAACTGAG
AATTCGATTAAAAGTACAACAATCGTTGAAAATGGCAAAAGAGCTATTGGGGTTGAACAAAATTCCAAGAATTATTGAAG
GAGTAGATATTTCACATACGCAGGGGGTTTATACCGTTGCCTCCGTTGTTGTGTTTCGAAATGGCCAACCCGACAAGATT
AGTTACCGCAGGTACAGAATCACCGAGCTTAATGAACCTAATGATTTCGAGGCTTTAAAAATACTAATGAGACGTAGATA
TTCCAAACACCCACCACCGGATCTGCTGCTCGTTGATGGAGGGGCTCCACAACTTGCAGCGGTTCGTGAGTCACTTGAAG
AGCTCGGACTGAAGAAGATAGATTTCATTGGATTAGCAAAAGAAGAAGAGGAAATAGTTTTTCCTGACAACAGAGGAAGA
TTGAAACTTTCACCCGATCATCCCGTTTTGCGATTGTTGACAACGATTAGAGATGAATCACACAGATTCGCAGTGAACTA
CCACAGAGTCTTAAGAGAGCGAAAGTTTTCAACATCAAGACTCGATGACATTCCCGGTATTGGGCCAAAAAGAAAAAGGG
CACTGGTTAGAGCCTTCGGAAGTGTGACAAACATAAAAAAGGCCAGCAAAGAGGAACTCATGAAGGTAATAAAAAATCGA
AAAGTTGTTGAACAGATACTTGCATGGACAAAAAAACAGGGGTGA

Upstream 100 bases:

>100_bases
GGAGGCATAAAGAATCCCATTGGAGAATTGATCTGGAAAATTATTGAACTTCAAGAATGTCCACCAAACGATATCATCTG
TGATAGGCTGGTGAATAAAT

Downstream 100 bases:

>100_bases
GACAATTTCTCACCCCTGCTTTCTTGAAAGAAAATTACTTAACTTTCTCTTTTAATTCTTTACCGGCTCTGAACTTGGGA
ACCTTTCCTCCAGGAATCTT

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 574; Mature: 574

Protein sequence:

>574_residues
MKNKLLAKVRELPEKPGIYLFKNKKGEIIYIGKAKKLRKRVSSYFRASTHEQNGKTRELYQEIDDLEFIVVPTEKEALLL
EANLIYQHKPKFNVLLKDSKRYPYIFISDDEFPYISITRIRDRKGFYYGPYTSITLVRNLLDLLQRIFKLRSCMDNRDCK
KGRPCFLYHLKMCSAPLAGEISHAEYQKQVRGFMDFLDGKTLDVRRQLERSMQRLAENLQFEKAKEIRDVLVSFDRLYSK
QAVDVSESYTADFIVLDSGIVTLLEVRGGLLLGKLTFDFPEGNLKDFIQQFYYGQNHRKPPVLIVPGLNKSEIKEIAEDF
EYIGNPRSEEEKRLLLIASDNTIEELRIRLKVQQSLKMAKELLGLNKIPRIIEGVDISHTQGVYTVASVVVFRNGQPDKI
SYRRYRITELNEPNDFEALKILMRRRYSKHPPPDLLLVDGGAPQLAAVRESLEELGLKKIDFIGLAKEEEEIVFPDNRGR
LKLSPDHPVLRLLTTIRDESHRFAVNYHRVLRERKFSTSRLDDIPGIGPKRKRALVRAFGSVTNIKKASKEELMKVIKNR
KVVEQILAWTKKQG

Sequences:

>Translated_574_residues
MKNKLLAKVRELPEKPGIYLFKNKKGEIIYIGKAKKLRKRVSSYFRASTHEQNGKTRELYQEIDDLEFIVVPTEKEALLL
EANLIYQHKPKFNVLLKDSKRYPYIFISDDEFPYISITRIRDRKGFYYGPYTSITLVRNLLDLLQRIFKLRSCMDNRDCK
KGRPCFLYHLKMCSAPLAGEISHAEYQKQVRGFMDFLDGKTLDVRRQLERSMQRLAENLQFEKAKEIRDVLVSFDRLYSK
QAVDVSESYTADFIVLDSGIVTLLEVRGGLLLGKLTFDFPEGNLKDFIQQFYYGQNHRKPPVLIVPGLNKSEIKEIAEDF
EYIGNPRSEEEKRLLLIASDNTIEELRIRLKVQQSLKMAKELLGLNKIPRIIEGVDISHTQGVYTVASVVVFRNGQPDKI
SYRRYRITELNEPNDFEALKILMRRRYSKHPPPDLLLVDGGAPQLAAVRESLEELGLKKIDFIGLAKEEEEIVFPDNRGR
LKLSPDHPVLRLLTTIRDESHRFAVNYHRVLRERKFSTSRLDDIPGIGPKRKRALVRAFGSVTNIKKASKEELMKVIKNR
KVVEQILAWTKKQG
>Mature_574_residues
MKNKLLAKVRELPEKPGIYLFKNKKGEIIYIGKAKKLRKRVSSYFRASTHEQNGKTRELYQEIDDLEFIVVPTEKEALLL
EANLIYQHKPKFNVLLKDSKRYPYIFISDDEFPYISITRIRDRKGFYYGPYTSITLVRNLLDLLQRIFKLRSCMDNRDCK
KGRPCFLYHLKMCSAPLAGEISHAEYQKQVRGFMDFLDGKTLDVRRQLERSMQRLAENLQFEKAKEIRDVLVSFDRLYSK
QAVDVSESYTADFIVLDSGIVTLLEVRGGLLLGKLTFDFPEGNLKDFIQQFYYGQNHRKPPVLIVPGLNKSEIKEIAEDF
EYIGNPRSEEEKRLLLIASDNTIEELRIRLKVQQSLKMAKELLGLNKIPRIIEGVDISHTQGVYTVASVVVFRNGQPDKI
SYRRYRITELNEPNDFEALKILMRRRYSKHPPPDLLLVDGGAPQLAAVRESLEELGLKKIDFIGLAKEEEEIVFPDNRGR
LKLSPDHPVLRLLTTIRDESHRFAVNYHRVLRERKFSTSRLDDIPGIGPKRKRALVRAFGSVTNIKKASKEELMKVIKNR
KVVEQILAWTKKQG

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=615, Percent_Identity=34.6341463414634, Blast_Score=311, Evalue=8e-86,
Organism=Escherichia coli, GI1788037, Length=200, Percent_Identity=26, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 66695; Mature: 66695

Theoretical pI: Translated: 10.11; Mature: 10.11

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNKLLAKVRELPEKPGIYLFKNKKGEIIYIGKAKKLRKRVSSYFRASTHEQNGKTRELY
CCCHHHHHHHHCCCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHHHCCCCCCCCHHHHH
QEIDDLEFIVVPTEKEALLLEANLIYQHKPKFNVLLKDSKRYPYIFISDDEFPYISITRI
HHHCCCEEEEEECCCCEEEEEEEEEEECCCCEEEEEECCCCCCEEEECCCCCCEEEEEEE
RDRKGFYYGPYTSITLVRNLLDLLQRIFKLRSCMDNRDCKKGRPCFLYHLKMCSAPLAGE
ECCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHCCCCCCC
ISHAEYQKQVRGFMDFLDGKTLDVRRQLERSMQRLAENLQFEKAKEIRDVLVSFDRLYSK
CHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
QAVDVSESYTADFIVLDSGIVTLLEVRGGLLLGKLTFDFPEGNLKDFIQQFYYGQNHRKP
HCCCCCCCCCEEEEEECCCHHHHHHHCCCEEEEEEEEECCCCCHHHHHHHHHCCCCCCCC
PVLIVPGLNKSEIKEIAEDFEYIGNPRSEEEKRLLLIASDNTIEELRIRLKVQQSLKMAK
CEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHH
ELLGLNKIPRIIEGVDISHTQGVYTVASVVVFRNGQPDKISYRRYRITELNEPNDFEALK
HHHCCHHHHHHHCCCCCCCCCCHHHHHHHHHEECCCCCCCCEEEEEEEECCCCCHHHHHH
ILMRRRYSKHPPPDLLLVDGGAPQLAAVRESLEELGLKKIDFIGLAKEEEEIVFPDNRGR
HHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCEECCCCCCE
LKLSPDHPVLRLLTTIRDESHRFAVNYHRVLRERKFSTSRLDDIPGIGPKRKRALVRAFG
EEECCCCHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHHHH
SVTNIKKASKEELMKVIKNRKVVEQILAWTKKQG
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKNKLLAKVRELPEKPGIYLFKNKKGEIIYIGKAKKLRKRVSSYFRASTHEQNGKTRELY
CCCHHHHHHHHCCCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHHHCCCCCCCCHHHHH
QEIDDLEFIVVPTEKEALLLEANLIYQHKPKFNVLLKDSKRYPYIFISDDEFPYISITRI
HHHCCCEEEEEECCCCEEEEEEEEEEECCCCEEEEEECCCCCCEEEECCCCCCEEEEEEE
RDRKGFYYGPYTSITLVRNLLDLLQRIFKLRSCMDNRDCKKGRPCFLYHLKMCSAPLAGE
ECCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHCCCCCCC
ISHAEYQKQVRGFMDFLDGKTLDVRRQLERSMQRLAENLQFEKAKEIRDVLVSFDRLYSK
CHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
QAVDVSESYTADFIVLDSGIVTLLEVRGGLLLGKLTFDFPEGNLKDFIQQFYYGQNHRKP
HCCCCCCCCCEEEEEECCCHHHHHHHCCCEEEEEEEEECCCCCHHHHHHHHHCCCCCCCC
PVLIVPGLNKSEIKEIAEDFEYIGNPRSEEEKRLLLIASDNTIEELRIRLKVQQSLKMAK
CEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHH
ELLGLNKIPRIIEGVDISHTQGVYTVASVVVFRNGQPDKISYRRYRITELNEPNDFEALK
HHHCCHHHHHHHCCCCCCCCCCHHHHHHHHHEECCCCCCCCEEEEEEEECCCCCHHHHHH
ILMRRRYSKHPPPDLLLVDGGAPQLAAVRESLEELGLKKIDFIGLAKEEEEIVFPDNRGR
HHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCEECCCCCCE
LKLSPDHPVLRLLTTIRDESHRFAVNYHRVLRERKFSTSRLDDIPGIGPKRKRALVRAFG
EEECCCCHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHHHH
SVTNIKKASKEELMKVIKNRKVVEQILAWTKKQG
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA