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The map label for this gene is hssS [H]

Identifier: 238925635

GI number: 238925635

Start: 3126634

End: 3127674

Strand: Reverse

Name: hssS [H]

Synonym: EUBREC_3292

Alternate gene names: 238925635

Gene position: 3127674-3126634 (Counterclockwise)

Preceding gene: 238925636

Following gene: 238925634

Centisome position: 90.67

GC content: 41.11

Gene sequence:

>1041_bases
ATGGAGTATAAAAAGAAAAAAGAATTGCGTATCCGCTCATGTCTGACCGGTGCAATCTGGCTGGCACTTGCATTTTCTAT
GCTGATATCAGCCTTATTGTTTGCATTTTTGAATCATTTTTTGGATTTACCCGGGAAAATACCGGGCCTTGGCTGGCTTT
TGATTTTTAATACATTGATAGCAGGACTTATTACATCATTTATCAATGCAAGGCTGCTGGAGCCGATTACCAGGCTCGGT
AAAGCAATGAAAGCAGTTTCCCAGGGAGATTTTGAACAGCATTTGGAAACAAACAGCCGCATAGCCGAGATTGGAGAATC
CTATCAGAGCTTTAATGTCATGACAAAAGAGCTTCGTGCAACAGAGATGCTGCAAATGGATTTTGTATCCAATGTTTCCC
ATGAGTTCAAGACTCCAATCAATGCAATTGAAGGCTATACGATGCTGCTCCAGGGAGATGAGCTGTCACAGGAGCAGGAG
GGGTATGTAGAAAAAATCCTGTTTAATACTCAAAGGCTTTCCGGTCTTGTTGGAAATATTTTATTGTTATCAAGGCTGGA
AAATCAGAATATTCCAATGAAAAAAACCAAATATCGTCTGGATGAACAAATCCGTCAGGCATTTCTTTCATTGGAAGACA
AATGGACTGAAAAAGGAATTGGCTTTCAGGTGGAGATGGAGGAGGTCAGATATGTTGGAAATGAAGGGCTTTTTATGCAT
ATCTGGATGAATCTTTTGGATAATGCAATCAAGTTTAGTCCTGAAAATGGGACAATCACCATGTTTCTGAGGCGTGAAAA
TGATTCTGTGCAGTTTATTCTGGAAGACGAGGGACCGGGAATAGCGGATGATGCAAAAGCCAGAATATTTGATAAGTTTT
ATCAGGTGGATGGTTCCCATAAAGCCGAGGGAAACGGCCTTGGCCTGGCACTTGTGAAAAGAATTGTAGACATCGCCGGT
GGAACAATCAAAGCTGAAAACCGGGAATACGGTGGATGCAGATTTGTAGTACAACTGCCAATAAAGAATTATAATGAGTA
G

Upstream 100 bases:

>100_bases
TAGAGGTACATATAGGAAGAATCAGGGAGCGTTTTAAGGAAAATCCGGATTTCGAAATTGTAACAATGCGTGGTCTGGGA
TACAAGGTGGTGAAAAAATA

Downstream 100 bases:

>100_bases
CTATTTAGAACATGATAGTTACAATAATAAAATAATAAGATAAAAGATAGGAGAATTTATATGACATTTTATCAGGAACT
GCAGTTAAATCAGGCCGGCT

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MEYKKKKELRIRSCLTGAIWLALAFSMLISALLFAFLNHFLDLPGKIPGLGWLLIFNTLIAGLITSFINARLLEPITRLG
KAMKAVSQGDFEQHLETNSRIAEIGESYQSFNVMTKELRATEMLQMDFVSNVSHEFKTPINAIEGYTMLLQGDELSQEQE
GYVEKILFNTQRLSGLVGNILLLSRLENQNIPMKKTKYRLDEQIRQAFLSLEDKWTEKGIGFQVEMEEVRYVGNEGLFMH
IWMNLLDNAIKFSPENGTITMFLRRENDSVQFILEDEGPGIADDAKARIFDKFYQVDGSHKAEGNGLGLALVKRIVDIAG
GTIKAENREYGGCRFVVQLPIKNYNE

Sequences:

>Translated_346_residues
MEYKKKKELRIRSCLTGAIWLALAFSMLISALLFAFLNHFLDLPGKIPGLGWLLIFNTLIAGLITSFINARLLEPITRLG
KAMKAVSQGDFEQHLETNSRIAEIGESYQSFNVMTKELRATEMLQMDFVSNVSHEFKTPINAIEGYTMLLQGDELSQEQE
GYVEKILFNTQRLSGLVGNILLLSRLENQNIPMKKTKYRLDEQIRQAFLSLEDKWTEKGIGFQVEMEEVRYVGNEGLFMH
IWMNLLDNAIKFSPENGTITMFLRRENDSVQFILEDEGPGIADDAKARIFDKFYQVDGSHKAEGNGLGLALVKRIVDIAG
GTIKAENREYGGCRFVVQLPIKNYNE
>Mature_346_residues
MEYKKKKELRIRSCLTGAIWLALAFSMLISALLFAFLNHFLDLPGKIPGLGWLLIFNTLIAGLITSFINARLLEPITRLG
KAMKAVSQGDFEQHLETNSRIAEIGESYQSFNVMTKELRATEMLQMDFVSNVSHEFKTPINAIEGYTMLLQGDELSQEQE
GYVEKILFNTQRLSGLVGNILLLSRLENQNIPMKKTKYRLDEQIRQAFLSLEDKWTEKGIGFQVEMEEVRYVGNEGLFMH
IWMNLLDNAIKFSPENGTITMFLRRENDSVQFILEDEGPGIADDAKARIFDKFYQVDGSHKAEGNGLGLALVKRIVDIAG
GTIKAENREYGGCRFVVQLPIKNYNE

Specific function: Member of the two-component regulatory system hssS/hssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=272, Percent_Identity=27.5735294117647, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1788393, Length=274, Percent_Identity=25.5474452554745, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1790346, Length=273, Percent_Identity=27.1062271062271, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1786912, Length=234, Percent_Identity=30.3418803418803, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI1790861, Length=206, Percent_Identity=30.5825242718447, Blast_Score=101, Evalue=9e-23,
Organism=Escherichia coli, GI1789403, Length=286, Percent_Identity=25.8741258741259, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786600, Length=234, Percent_Identity=32.0512820512821, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI48994928, Length=224, Percent_Identity=31.25, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1789149, Length=272, Percent_Identity=27.5735294117647, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1788279, Length=258, Percent_Identity=28.6821705426357, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI145693157, Length=219, Percent_Identity=27.3972602739726, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788713, Length=235, Percent_Identity=26.3829787234043, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1787894, Length=318, Percent_Identity=24.5283018867925, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1789808, Length=275, Percent_Identity=25.8181818181818, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1788549, Length=218, Percent_Identity=25.6880733944954, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI87081816, Length=256, Percent_Identity=26.5625, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1787374, Length=266, Percent_Identity=23.6842105263158, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1790551, Length=285, Percent_Identity=24.5614035087719, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790436, Length=123, Percent_Identity=32.520325203252, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 39320; Mature: 39320

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYKKKKELRIRSCLTGAIWLALAFSMLISALLFAFLNHFLDLPGKIPGLGWLLIFNTLI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
AGLITSFINARLLEPITRLGKAMKAVSQGDFEQHLETNSRIAEIGESYQSFNVMTKELRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
TEMLQMDFVSNVSHEFKTPINAIEGYTMLLQGDELSQEQEGYVEKILFNTQRLSGLVGNI
HHHHHHHHHHHHHHHHCCCHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LLLSRLENQNIPMKKTKYRLDEQIRQAFLSLEDKWTEKGIGFQVEMEEVRYVGNEGLFMH
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHCCCCCHHHH
IWMNLLDNAIKFSPENGTITMFLRRENDSVQFILEDEGPGIADDAKARIFDKFYQVDGSH
HHHHHHHHHHEECCCCCEEEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCC
KAEGNGLGLALVKRIVDIAGGTIKAENREYGGCRFVVQLPIKNYNE
CCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCEEEEEEECCCCCCC
>Mature Secondary Structure
MEYKKKKELRIRSCLTGAIWLALAFSMLISALLFAFLNHFLDLPGKIPGLGWLLIFNTLI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
AGLITSFINARLLEPITRLGKAMKAVSQGDFEQHLETNSRIAEIGESYQSFNVMTKELRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
TEMLQMDFVSNVSHEFKTPINAIEGYTMLLQGDELSQEQEGYVEKILFNTQRLSGLVGNI
HHHHHHHHHHHHHHHHCCCHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LLLSRLENQNIPMKKTKYRLDEQIRQAFLSLEDKWTEKGIGFQVEMEEVRYVGNEGLFMH
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHCCCCCHHHH
IWMNLLDNAIKFSPENGTITMFLRRENDSVQFILEDEGPGIADDAKARIFDKFYQVDGSH
HHHHHHHHHHEECCCCCEEEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCC
KAEGNGLGLALVKRIVDIAGGTIKAENREYGGCRFVVQLPIKNYNE
CCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA