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The map label for this gene is hssR [H]

Identifier: 238925636

GI number: 238925636

Start: 3127674

End: 3128345

Strand: Reverse

Name: hssR [H]

Synonym: EUBREC_3293

Alternate gene names: 238925636

Gene position: 3128345-3127674 (Counterclockwise)

Preceding gene: 238925637

Following gene: 238925635

Centisome position: 90.68

GC content: 42.71

Gene sequence:

>672_bases
GTGTTTAAGATATTAATTGTAGAAGATGATAAGGAATTAAGTCTGTTATTCCAAAAGGTGCTTGAAAAGAGCGGATATCA
GGTCAAAAGTGCGTCGGATGGAGCACAGGCACTGGAGGTATTGGACAGAGAATATATTGATTTAATCATTTCCGATATAA
TGATGCCGGTTATGGATGGATATGAACTTGTGTCGGAGCTTCGTTCGGCGGGATATCAGATACCGGTGCTTATGATTACT
GCAAAAAGCAGCTTCGATGATATGCGTCAGGGCTTTCTTTCGGGAAGTGACGACTATATGGTAAAACCTGTAAATGTCAA
TGAAATGGTTTTAAGGGTAGGGGCACTGCTTCGTCGTGCACAGATACTGAACGAACACAAAATTGTGATTGGCTCAACCG
AGCTTGATTATGATGCAATGACAGTTGTGACCGGTGATGAAGCGCTTGTCCTGCCAAAAAAAGAATTTCTGCTTTTATAC
AAGCTGGCAGCTTCACCGGGCAGGACATTTACGAAGCAGCAGCTAATGGATGAGGTATGGGGATATGAGACGGAGGCAGA
CCCACATACGATAGAGGTACATATAGGAAGAATCAGGGAGCGTTTTAAGGAAAATCCGGATTTCGAAATTGTAACAATGC
GTGGTCTGGGATACAAGGTGGTGAAAAAATAA

Upstream 100 bases:

>100_bases
CCGATTGAATTAACAGAAAAACGTAAAAGAAAGGTGTTTCTGGTACAGCATCTGCTTGGATGGGCAAGGGATTTGTTTTG
ATTAAAGGAGAACATAAAGC

Downstream 100 bases:

>100_bases
TGGAGTATAAAAAGAAAAAAGAATTGCGTATCCGCTCATGTCTGACCGGTGCAATCTGGCTGGCACTTGCATTTTCTATG
CTGATATCAGCCTTATTGTT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MFKILIVEDDKELSLLFQKVLEKSGYQVKSASDGAQALEVLDREYIDLIISDIMMPVMDGYELVSELRSAGYQIPVLMIT
AKSSFDDMRQGFLSGSDDYMVKPVNVNEMVLRVGALLRRAQILNEHKIVIGSTELDYDAMTVVTGDEALVLPKKEFLLLY
KLAASPGRTFTKQQLMDEVWGYETEADPHTIEVHIGRIRERFKENPDFEIVTMRGLGYKVVKK

Sequences:

>Translated_223_residues
MFKILIVEDDKELSLLFQKVLEKSGYQVKSASDGAQALEVLDREYIDLIISDIMMPVMDGYELVSELRSAGYQIPVLMIT
AKSSFDDMRQGFLSGSDDYMVKPVNVNEMVLRVGALLRRAQILNEHKIVIGSTELDYDAMTVVTGDEALVLPKKEFLLLY
KLAASPGRTFTKQQLMDEVWGYETEADPHTIEVHIGRIRERFKENPDFEIVTMRGLGYKVVKK
>Mature_223_residues
MFKILIVEDDKELSLLFQKVLEKSGYQVKSASDGAQALEVLDREYIDLIISDIMMPVMDGYELVSELRSAGYQIPVLMIT
AKSSFDDMRQGFLSGSDDYMVKPVNVNEMVLRVGALLRRAQILNEHKIVIGSTELDYDAMTVVTGDEALVLPKKEFLLLY
KLAASPGRTFTKQQLMDEVWGYETEADPHTIEVHIGRIRERFKENPDFEIVTMRGLGYKVVKK

Specific function: Member of the two-component regulatory system hssS/hssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. Phosphorylated hssR binds to a direct repeat sequence within hrtAB promoter and activates the expression of hrtAB

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI87082012, Length=221, Percent_Identity=35.2941176470588, Blast_Score=139, Evalue=1e-34,
Organism=Escherichia coli, GI1786599, Length=221, Percent_Identity=33.4841628959276, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1789809, Length=229, Percent_Identity=34.061135371179, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1790552, Length=223, Percent_Identity=32.7354260089686, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1790860, Length=221, Percent_Identity=34.3891402714932, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1786784, Length=220, Percent_Identity=33.1818181818182, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1789402, Length=222, Percent_Identity=30.6306306306306, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI2367329, Length=231, Percent_Identity=35.9307359307359, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1787375, Length=218, Percent_Identity=29.8165137614679, Blast_Score=111, Evalue=4e-26,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=31.4410480349345, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=29.1479820627803, Blast_Score=104, Evalue=4e-24,
Organism=Escherichia coli, GI1788394, Length=223, Percent_Identity=33.6322869955157, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI1787229, Length=223, Percent_Identity=27.8026905829596, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI145693157, Length=104, Percent_Identity=38.4615384615385, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1790437, Length=161, Percent_Identity=27.9503105590062, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790299, Length=117, Percent_Identity=31.6239316239316, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI145693140, Length=233, Percent_Identity=27.0386266094421, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1787487, Length=102, Percent_Identity=38.2352941176471, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1788713, Length=160, Percent_Identity=28.125, Blast_Score=70, Evalue=9e-14,
Organism=Escherichia coli, GI1788905, Length=102, Percent_Identity=38.2352941176471, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788550, Length=109, Percent_Identity=29.3577981651376, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1788191, Length=105, Percent_Identity=34.2857142857143, Blast_Score=61, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=102, Percent_Identity=34.3137254901961, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25347; Mature: 25347

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKILIVEDDKELSLLFQKVLEKSGYQVKSASDGAQALEVLDREYIDLIISDIMMPVMDG
CEEEEEEECCHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
YELVSELRSAGYQIPVLMITAKSSFDDMRQGFLSGSDDYMVKPVNVNEMVLRVGALLRRA
HHHHHHHHHCCCEEEEEEEEECCCHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHH
QILNEHKIVIGSTELDYDAMTVVTGDEALVLPKKEFLLLYKLAASPGRTFTKQQLMDEVW
HHHCCCEEEEECCCCCCCEEEEEECCCEEEECHHHHEEEEEECCCCCCCHHHHHHHHHHC
GYETEADPHTIEVHIGRIRERFKENPDFEIVTMRGLGYKVVKK
CCCCCCCCEEEEEEHHHHHHHHHCCCCEEEEEECCCCCHHHCC
>Mature Secondary Structure
MFKILIVEDDKELSLLFQKVLEKSGYQVKSASDGAQALEVLDREYIDLIISDIMMPVMDG
CEEEEEEECCHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
YELVSELRSAGYQIPVLMITAKSSFDDMRQGFLSGSDDYMVKPVNVNEMVLRVGALLRRA
HHHHHHHHHCCCEEEEEEEEECCCHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHH
QILNEHKIVIGSTELDYDAMTVVTGDEALVLPKKEFLLLYKLAASPGRTFTKQQLMDEVW
HHHCCCEEEEECCCCCCCEEEEEECCCEEEECHHHHEEEEEECCCCCCCHHHHHHHHHHC
GYETEADPHTIEVHIGRIRERFKENPDFEIVTMRGLGYKVVKK
CCCCCCCCEEEEEEHHHHHHHHHCCCCEEEEEECCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA