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The map label for this gene is trxA [H]

Identifier: 238925336

GI number: 238925336

Start: 2870805

End: 2871161

Strand: Reverse

Name: trxA [H]

Synonym: EUBREC_2991

Alternate gene names: 238925336

Gene position: 2871161-2870805 (Counterclockwise)

Preceding gene: 238925337

Following gene: 238925334

Centisome position: 83.23

GC content: 41.18

Gene sequence:

>357_bases
ATGGGTGCAACGAAAATAATTCGTTCGACAGATGGAAGGAGAACAACTATGGTAAAGAAGATTAATAGCAGTGAATTTGA
ACAGGTTAAAAATAATAAGGCTATCATTGTTGATTTTTCGGCAGAGTGGTGCGGTCCATGCAAGATGCTTGCGCCGGTAA
TGGAGCAGCTTTCTGATGAAATCACAGATGTGGAGTTTTACAATATTGATGTGGACGAGAATCCTGATCTGGCAAGAGAG
TATCGTATAATGAATATTCCGGCAGTTATTGCAATCAAGGGCGGTCAGGTTGCCGGTCAGCAGATTGGTCTTGTGTCTAA
GGATGATATGAAAGGCTTTATAGAGGGAGTATTCTAA

Upstream 100 bases:

>100_bases
ATGTATTATAGTAGTGCTAGTACATCGAATAATAAGTTTCTGATGCATTGTTATTTCTTATTTGGTGTACTATAGTATAG
CAGTTATTTTTTATTGCTGT

Downstream 100 bases:

>100_bases
GAAGGAGTATTCAAAGAAGGAAATTCTTAAGAAGCGAGAATACACCTGCAGTGAGCTTTTGGGTGAATATGCATGGTGTG
ATTCTTAACAGTTACGATGA

Product: thiol-disulfide isomerase and thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 118; Mature: 117

Protein sequence:

>118_residues
MGATKIIRSTDGRRTTMVKKINSSEFEQVKNNKAIIVDFSAEWCGPCKMLAPVMEQLSDEITDVEFYNIDVDENPDLARE
YRIMNIPAVIAIKGGQVAGQQIGLVSKDDMKGFIEGVF

Sequences:

>Translated_118_residues
MGATKIIRSTDGRRTTMVKKINSSEFEQVKNNKAIIVDFSAEWCGPCKMLAPVMEQLSDEITDVEFYNIDVDENPDLARE
YRIMNIPAVIAIKGGQVAGQQIGLVSKDDMKGFIEGVF
>Mature_117_residues
GATKIIRSTDGRRTTMVKKINSSEFEQVKNNKAIIVDFSAEWCGPCKMLAPVMEQLSDEITDVEFYNIDVDENPDLAREY
RIMNIPAVIAIKGGQVAGQQIGLVSKDDMKGFIEGVF

Specific function: Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=88, Percent_Identity=35.2272727272727, Blast_Score=75, Evalue=1e-14,
Organism=Homo sapiens, GI50592994, Length=91, Percent_Identity=39.5604395604396, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87082331, Length=113, Percent_Identity=37.1681415929204, Blast_Score=86, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17507705, Length=92, Percent_Identity=32.6086956521739, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71998175, Length=66, Percent_Identity=40.9090909090909, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71980562, Length=101, Percent_Identity=35.6435643564356, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71980565, Length=99, Percent_Identity=35.3535353535354, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI212646193, Length=91, Percent_Identity=35.1648351648352, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319925, Length=90, Percent_Identity=41.1111111111111, Blast_Score=83, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6321648, Length=90, Percent_Identity=38.8888888888889, Blast_Score=80, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6323072, Length=83, Percent_Identity=37.3493975903614, Blast_Score=76, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321022, Length=108, Percent_Identity=29.6296296296296, Blast_Score=61, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24639068, Length=116, Percent_Identity=32.7586206896552, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28573567, Length=94, Percent_Identity=31.9148936170213, Blast_Score=73, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24639826, Length=76, Percent_Identity=39.4736842105263, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24664269, Length=74, Percent_Identity=43.2432432432432, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17648013, Length=66, Percent_Identity=42.4242424242424, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24583090, Length=66, Percent_Identity=42.4242424242424, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 13131; Mature: 13000

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGATKIIRSTDGRRTTMVKKINSSEFEQVKNNKAIIVDFSAEWCGPCKMLAPVMEQLSDE
CCCCCCEECCCCCEEEEEECCCCHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHH
ITDVEFYNIDVDENPDLAREYRIMNIPAVIAIKGGQVAGQQIGLVSKDDMKGFIEGVF
CCCEEEEEECCCCCCCHHHHEEEECCCEEEEEECCCCCCCEECCCCCCHHHHHHHCCC
>Mature Secondary Structure 
GATKIIRSTDGRRTTMVKKINSSEFEQVKNNKAIIVDFSAEWCGPCKMLAPVMEQLSDE
CCCCCEECCCCCEEEEEECCCCHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHH
ITDVEFYNIDVDENPDLAREYRIMNIPAVIAIKGGQVAGQQIGLVSKDDMKGFIEGVF
CCCEEEEEECCCCCCCHHHHEEEECCCEEEEEECCCCCCCEECCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7496529 [H]