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The map label for this gene is pepP [H]

Identifier: 238925337

GI number: 238925337

Start: 2871320

End: 2872573

Strand: Reverse

Name: pepP [H]

Synonym: EUBREC_2992

Alternate gene names: 238925337

Gene position: 2872573-2871320 (Counterclockwise)

Preceding gene: 238925338

Following gene: 238925336

Centisome position: 83.27

GC content: 45.06

Gene sequence:

>1254_bases
ATGGATTTTGAAAGCAGAAGACAAAGAATTTTAGACAAGATGGAGGACAATTCTATAGCAATATTGTACTCAGGCATCGA
GCACCATGTGAGTGCAGATGAGTATGATTTATTTACAGCACAGGCTAACCGTAATTTCTTCTATCTGACCGGACTTAGAC
GTGACAACATGGTCCTTGTCCTGGATAAATGTGTAGAGCCTGCTAAGACGATGCTCTTCATAGAGGAGGCAGACCCTACG
ATGGAGCGCTGGTACGGCAGAAAGGTGACTATGGAGGAAGCCGAGGAAATATCAGGAATTGATGAGATAGAATATATTTA
TGAGCTTGAGAGCACACTGGACAGGATAATGACGCGTGAGGATGTATACACAGCATATTTCGACACGTATCGTCATCAGA
AAGTGGATTTGCCGGATTACAATGTGGTAAAAGCCAATGAATTTCGGACAGATTATCCGGGAGTTGCTGTGAAGAATCTT
TTCCCGCTTGTGGCAGAGGAGCGTATGCAGAAGGATGAGGATGAGATTGAGCTGACCAAAAAGGCAATCGCTCTCACAAA
GGACGGACTCTGCAATGTGATGGCTAATTTAAAGCCGGGCATGAAGGAATATCAGGCACAGGCAGATTTTGAATATATCA
TAAGACGCGGTGGGGCAGAGTGGACAGCTTTTCCTACAATTGCCGGAAGCGGAATGAATGGAACGATGCTTCACTATGAC
ACAAATCGTGAGACGATGGAGGATGGAACACTGGTGCTTCTTGACCTTGGAGCCAGAATAGATGGCTACAATTCGGATAT
TACGAGAACATATCCGGTAAATGGCAGGTTCACCGAGCGCCAGAAACAGGTATATGATATTGTGCTTGCCGCAAACCGAA
AGATTGTCGAGGTTGCAAAGCCGGGAATGACTACAAAGGAATTAAATGAAGTATGTAAGGATGTGCTTGCAGACGGGCTT
ATGAAGCTTGGACTGATAAAGAATTCGGTAGAGATTTCTAAGTATTACATGCATGGCGTGTCACACCATCTGGGAATTGA
TGTGCATGACGTGACAGTTGACTCAAACAGCAGGCTTCGTCCGGGGGCAATCATCAGTGATGAGCCGGGGCTGTATATAG
ATGAATGGGAAATTGGTATCAGGATTGAGGATGATGTACTTATCACCGAGGATGGTGCAGTGTGTCTGTCGGAGGATATC
ATCAGAACCACAGAGGATATAGAGGCCTACATGGCAGAGCACAAAAAGAATTAA

Upstream 100 bases:

>100_bases
ATGGCTTGTAAAAATACATATATTGTGATAACGTAAGGGCGTATGAATGTCAGCGATTTTTGAAGACAGGCATTACAAAT
AATGAATAAGAGGCAGCAAA

Downstream 100 bases:

>100_bases
TCGTGATAAATGATAAATTTTGCGGTTTATAATATTTTTATGTGACATAATCTGATTTATGTATTATAGTAGTGCTAGTA
CATCGAATAATAAGTTTCTG

Product: Xaa-Pro aminopeptidase, putative

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MDFESRRQRILDKMEDNSIAILYSGIEHHVSADEYDLFTAQANRNFFYLTGLRRDNMVLVLDKCVEPAKTMLFIEEADPT
MERWYGRKVTMEEAEEISGIDEIEYIYELESTLDRIMTREDVYTAYFDTYRHQKVDLPDYNVVKANEFRTDYPGVAVKNL
FPLVAEERMQKDEDEIELTKKAIALTKDGLCNVMANLKPGMKEYQAQADFEYIIRRGGAEWTAFPTIAGSGMNGTMLHYD
TNRETMEDGTLVLLDLGARIDGYNSDITRTYPVNGRFTERQKQVYDIVLAANRKIVEVAKPGMTTKELNEVCKDVLADGL
MKLGLIKNSVEISKYYMHGVSHHLGIDVHDVTVDSNSRLRPGAIISDEPGLYIDEWEIGIRIEDDVLITEDGAVCLSEDI
IRTTEDIEAYMAEHKKN

Sequences:

>Translated_417_residues
MDFESRRQRILDKMEDNSIAILYSGIEHHVSADEYDLFTAQANRNFFYLTGLRRDNMVLVLDKCVEPAKTMLFIEEADPT
MERWYGRKVTMEEAEEISGIDEIEYIYELESTLDRIMTREDVYTAYFDTYRHQKVDLPDYNVVKANEFRTDYPGVAVKNL
FPLVAEERMQKDEDEIELTKKAIALTKDGLCNVMANLKPGMKEYQAQADFEYIIRRGGAEWTAFPTIAGSGMNGTMLHYD
TNRETMEDGTLVLLDLGARIDGYNSDITRTYPVNGRFTERQKQVYDIVLAANRKIVEVAKPGMTTKELNEVCKDVLADGL
MKLGLIKNSVEISKYYMHGVSHHLGIDVHDVTVDSNSRLRPGAIISDEPGLYIDEWEIGIRIEDDVLITEDGAVCLSEDI
IRTTEDIEAYMAEHKKN
>Mature_417_residues
MDFESRRQRILDKMEDNSIAILYSGIEHHVSADEYDLFTAQANRNFFYLTGLRRDNMVLVLDKCVEPAKTMLFIEEADPT
MERWYGRKVTMEEAEEISGIDEIEYIYELESTLDRIMTREDVYTAYFDTYRHQKVDLPDYNVVKANEFRTDYPGVAVKNL
FPLVAEERMQKDEDEIELTKKAIALTKDGLCNVMANLKPGMKEYQAQADFEYIIRRGGAEWTAFPTIAGSGMNGTMLHYD
TNRETMEDGTLVLLDLGARIDGYNSDITRTYPVNGRFTERQKQVYDIVLAANRKIVEVAKPGMTTKELNEVCKDVLADGL
MKLGLIKNSVEISKYYMHGVSHHLGIDVHDVTVDSNSRLRPGAIISDEPGLYIDEWEIGIRIEDDVLITEDGAVCLSEDI
IRTTEDIEAYMAEHKKN

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=396, Percent_Identity=31.3131313131313, Blast_Score=192, Evalue=3e-49,
Organism=Homo sapiens, GI149589008, Length=475, Percent_Identity=28, Blast_Score=165, Evalue=8e-41,
Organism=Homo sapiens, GI260593665, Length=306, Percent_Identity=31.6993464052288, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI260593663, Length=254, Percent_Identity=31.496062992126, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI264681563, Length=237, Percent_Identity=30.379746835443, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1789275, Length=442, Percent_Identity=34.3891402714932, Blast_Score=244, Evalue=1e-65,
Organism=Escherichia coli, GI1788728, Length=236, Percent_Identity=30.5084745762712, Blast_Score=118, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI17508215, Length=475, Percent_Identity=28.2105263157895, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71989583, Length=341, Percent_Identity=24.9266862170088, Blast_Score=106, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6320922, Length=435, Percent_Identity=28.0459770114943, Blast_Score=160, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6321118, Length=401, Percent_Identity=28.927680798005, Blast_Score=151, Evalue=2e-37,
Organism=Drosophila melanogaster, GI19920384, Length=406, Percent_Identity=32.0197044334975, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI21357079, Length=422, Percent_Identity=28.1990521327014, Blast_Score=160, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 47765; Mature: 47765

Theoretical pI: Translated: 4.43; Mature: 4.43

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFESRRQRILDKMEDNSIAILYSGIEHHVSADEYDLFTAQANRNFFYLTGLRRDNMVLV
CCHHHHHHHHHHHHCCCCEEEEEECHHHCCCCCCEEEEEEECCCCEEEEEECCCCCEEEE
LDKCVEPAKTMLFIEEADPTMERWYGRKVTMEEAEEISGIDEIEYIYELESTLDRIMTRE
EHHCCCCCCEEEEEECCCCHHHHHCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
DVYTAYFDTYRHQKVDLPDYNVVKANEFRTDYPGVAVKNLFPLVAEERMQKDEDEIELTK
HHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHH
KAIALTKDGLCNVMANLKPGMKEYQAQADFEYIIRRGGAEWTAFPTIAGSGMNGTMLHYD
HHHHHCCCCHHHHHHHCCCCHHHHHHHCCHHHHHHCCCCCEEEECCEECCCCCCCEEEEE
TNRETMEDGTLVLLDLGARIDGYNSDITRTYPVNGRFTERQKQVYDIVLAANRKIVEVAK
CCCCCCCCCCEEEEEECCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCEEEEECC
PGMTTKELNEVCKDVLADGLMKLGLIKNSVEISKYYMHGVSHHLGIDVHDVTVDSNSRLR
CCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCHHHCCCEEEEEEECCCCCCC
PGAIISDEPGLYIDEWEIGIRIEDDVLITEDGAVCLSEDIIRTTEDIEAYMAEHKKN
CCEEECCCCCCEEEEEEEEEEEECCEEEECCCCEEECHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDFESRRQRILDKMEDNSIAILYSGIEHHVSADEYDLFTAQANRNFFYLTGLRRDNMVLV
CCHHHHHHHHHHHHCCCCEEEEEECHHHCCCCCCEEEEEEECCCCEEEEEECCCCCEEEE
LDKCVEPAKTMLFIEEADPTMERWYGRKVTMEEAEEISGIDEIEYIYELESTLDRIMTRE
EHHCCCCCCEEEEEECCCCHHHHHCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
DVYTAYFDTYRHQKVDLPDYNVVKANEFRTDYPGVAVKNLFPLVAEERMQKDEDEIELTK
HHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHH
KAIALTKDGLCNVMANLKPGMKEYQAQADFEYIIRRGGAEWTAFPTIAGSGMNGTMLHYD
HHHHHCCCCHHHHHHHCCCCHHHHHHHCCHHHHHHCCCCCEEEECCEECCCCCCCEEEEE
TNRETMEDGTLVLLDLGARIDGYNSDITRTYPVNGRFTERQKQVYDIVLAANRKIVEVAK
CCCCCCCCCCEEEEEECCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCEEEEECC
PGMTTKELNEVCKDVLADGLMKLGLIKNSVEISKYYMHGVSHHLGIDVHDVTVDSNSRLR
CCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCHHHCCCEEEEEEECCCCCCC
PGAIISDEPGLYIDEWEIGIRIEDDVLITEDGAVCLSEDIIRTTEDIEAYMAEHKKN
CCEEECCCCCCEEEEEEEEEEEECCEEEECCCCEEECHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659585; 1339425; 9278503; 9520390 [H]