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The map label for this gene is fkpA [H]

Identifier: 238921452

GI number: 238921452

Start: 3489934

End: 3490752

Strand: Reverse

Name: fkpA [H]

Synonym: NT01EI_3604

Alternate gene names: 238921452

Gene position: 3490752-3489934 (Counterclockwise)

Preceding gene: 238921454

Following gene: 238921451

Centisome position: 91.57

GC content: 56.17

Gene sequence:

>819_bases
ATGAAATCTTTTTTTAAAGTTACCGCGCTGGCCACGACCATGGCTCTGGCGCTGAACGCATCGGCGTTTGCAGCGGACGC
AACCAAGGCGGCTACAGCCGCACCGACTGCCGCCAATAGCCAGTTCAAGAATGACGATCAGCAGGCTGCTTACGCACTGG
GCGCCTCTCTGGGTCGTTATATGGACAACTCACTAAAAGAGCAAGAGAAGTTGGGTATCAAGCTGGATAAAGATCAGCTG
ATCGCCGGGGTACAGGATGCATTTGCCGGTAAGAGCAAACTGAGCGATCAGCAGGTCGAACAGACGCTGCAGTCTTTCGA
GAGCCGAGTGAAGAATGCTGCTCAGGCGAAGATGGAGCAGGAAGCCAAAGAAAACGCTGAGGCAGGGCAGAGGTTCCGTG
CAGAGTTTGCCAAAGAGAAAGGGGTGAAGACCACCGCCAGCGGCCTGATGTATCTGGTTCAGAAAGAGGGGACCGGGCCT
GCACCGACGGACAGCGATACCGTGGTGGTGAACTATAAGGGTTCGCTGATTAACGGTACCGAGTTCGATAACTCCTACAG
CCGCGGTGAACCGCTCTCCTTCCGCTTGGACGGGGTGATCCCGGGTTGGACCGAAGGTCTGAAGCTCATCAAGAAAGGTG
GTAAAATCAAGCTGGTTATCCCGCCGGATCTGGCCTACGGTAAAACCGGTGTTCCGGGGATCCCGGCTAACTCTACGCTG
GTCTTCGAGGTTGAGCTGCTGGACGTGAAGCCGGCGGTGAAGGCGGATGCTGCGCCGGGTGCGAAAGACAAAGCCGCTGC
CGCGACATCTGCTAAATAA

Upstream 100 bases:

>100_bases
CTGGCTTATTGATTGTTTTCTGGTAAGAGCGCCAGCTATAGTAGCCCTGTACTGTTGCTCATCGTGATTTAAGGCAAGTG
CCTTAATTTTGGAGAAATGG

Downstream 100 bases:

>100_bases
ATTGTGCATTGATTAGACCCCCTGATGGCGCCGCTCTCAGGGGGTTTTTGTTGCCTGTCTGCATCGCCTGCGGGTAAAAA
GGCATTTACCTTGGCACCAT

Product: FKBP-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 272; Mature: 272

Protein sequence:

>272_residues
MKSFFKVTALATTMALALNASAFAADATKAATAAPTAANSQFKNDDQQAAYALGASLGRYMDNSLKEQEKLGIKLDKDQL
IAGVQDAFAGKSKLSDQQVEQTLQSFESRVKNAAQAKMEQEAKENAEAGQRFRAEFAKEKGVKTTASGLMYLVQKEGTGP
APTDSDTVVVNYKGSLINGTEFDNSYSRGEPLSFRLDGVIPGWTEGLKLIKKGGKIKLVIPPDLAYGKTGVPGIPANSTL
VFEVELLDVKPAVKADAAPGAKDKAAAATSAK

Sequences:

>Translated_272_residues
MKSFFKVTALATTMALALNASAFAADATKAATAAPTAANSQFKNDDQQAAYALGASLGRYMDNSLKEQEKLGIKLDKDQL
IAGVQDAFAGKSKLSDQQVEQTLQSFESRVKNAAQAKMEQEAKENAEAGQRFRAEFAKEKGVKTTASGLMYLVQKEGTGP
APTDSDTVVVNYKGSLINGTEFDNSYSRGEPLSFRLDGVIPGWTEGLKLIKKGGKIKLVIPPDLAYGKTGVPGIPANSTL
VFEVELLDVKPAVKADAAPGAKDKAAAATSAK
>Mature_272_residues
MKSFFKVTALATTMALALNASAFAADATKAATAAPTAANSQFKNDDQQAAYALGASLGRYMDNSLKEQEKLGIKLDKDQL
IAGVQDAFAGKSKLSDQQVEQTLQSFESRVKNAAQAKMEQEAKENAEAGQRFRAEFAKEKGVKTTASGLMYLVQKEGTGP
APTDSDTVVVNYKGSLINGTEFDNSYSRGEPLSFRLDGVIPGWTEGLKLIKKGGKIKLVIPPDLAYGKTGVPGIPANSTL
VFEVELLDVKPAVKADAAPGAKDKAAAATSAK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI224809329, Length=107, Percent_Identity=44.8598130841121, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI224809327, Length=107, Percent_Identity=44.8598130841121, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI4758384, Length=107, Percent_Identity=44.8598130841121, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI224809331, Length=107, Percent_Identity=44.8598130841121, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI4503729, Length=107, Percent_Identity=41.1214953271028, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI4758380, Length=92, Percent_Identity=46.7391304347826, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI17149836, Length=92, Percent_Identity=47.8260869565217, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI4503725, Length=92, Percent_Identity=47.8260869565217, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI206725530, Length=88, Percent_Identity=47.7272727272727, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI17149844, Length=88, Percent_Identity=47.7272727272727, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI17149842, Length=88, Percent_Identity=47.7272727272727, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI4503727, Length=99, Percent_Identity=42.4242424242424, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI33469985, Length=87, Percent_Identity=39.0804597701149, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1789745, Length=259, Percent_Identity=74.5173745173745, Blast_Score=362, Evalue=1e-101,
Organism=Escherichia coli, GI87082390, Length=210, Percent_Identity=40.4761904761905, Blast_Score=139, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17561782, Length=105, Percent_Identity=44.7619047619048, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17540882, Length=87, Percent_Identity=44.8275862068966, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71993519, Length=91, Percent_Identity=48.3516483516484, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320727, Length=91, Percent_Identity=54.9450549450549, Blast_Score=86, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6324194, Length=92, Percent_Identity=46.7391304347826, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323482, Length=110, Percent_Identity=39.0909090909091, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323566, Length=96, Percent_Identity=42.7083333333333, Blast_Score=69, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24583150, Length=107, Percent_Identity=42.0560747663551, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24655568, Length=92, Percent_Identity=46.7391304347826, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21356629, Length=90, Percent_Identity=50, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI281363946, Length=88, Percent_Identity=42.0454545454545, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI17352457, Length=88, Percent_Identity=42.0454545454545, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 28699; Mature: 28699

Theoretical pI: Translated: 9.41; Mature: 9.41

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSFFKVTALATTMALALNASAFAADATKAATAAPTAANSQFKNDDQQAAYALGASLGRY
CCCHHHHHHHHHHHHHHHCCHHHHHCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH
MDNSLKEQEKLGIKLDKDQLIAGVQDAFAGKSKLSDQQVEQTLQSFESRVKNAAQAKMEQ
HHHHHHHHHHCCCEECHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EAKENAEAGQRFRAEFAKEKGVKTTASGLMYLVQKEGTGPAPTDSDTVVVNYKGSLINGT
HHHHHHHHHHHHHHHHHHHCCCCHHHHHEEEEEEECCCCCCCCCCCEEEEEECCCEECCC
EFDNSYSRGEPLSFRLDGVIPGWTEGLKLIKKGGKIKLVIPPDLAYGKTGVPGIPANSTL
CCCCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCEE
VFEVELLDVKPAVKADAAPGAKDKAAAATSAK
EEEEEEEECCCCHHCCCCCCCCCHHCCCCCCC
>Mature Secondary Structure
MKSFFKVTALATTMALALNASAFAADATKAATAAPTAANSQFKNDDQQAAYALGASLGRY
CCCHHHHHHHHHHHHHHHCCHHHHHCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH
MDNSLKEQEKLGIKLDKDQLIAGVQDAFAGKSKLSDQQVEQTLQSFESRVKNAAQAKMEQ
HHHHHHHHHHCCCEECHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EAKENAEAGQRFRAEFAKEKGVKTTASGLMYLVQKEGTGPAPTDSDTVVVNYKGSLINGT
HHHHHHHHHHHHHHHHHHHCCCCHHHHHEEEEEEECCCCCCCCCCCEEEEEECCCEECCC
EFDNSYSRGEPLSFRLDGVIPGWTEGLKLIKKGGKIKLVIPPDLAYGKTGVPGIPANSTL
CCCCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCEE
VFEVELLDVKPAVKADAAPGAKDKAAAATSAK
EEEEEEEECCCCHHCCCCCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]