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The map label for this gene is hns [H]

Identifier: 238921237

GI number: 238921237

Start: 3269766

End: 3270167

Strand: Reverse

Name: hns [H]

Synonym: NT01EI_3380

Alternate gene names: 238921237

Gene position: 3270167-3269766 (Counterclockwise)

Preceding gene: 238921240

Following gene: 238921236

Centisome position: 85.78

GC content: 50.75

Gene sequence:

>402_bases
ATGTCAGATTTGTTGAAGTCACTGAATAATATTCGTACGCTGCGTGCCTATGCACGCGAAACCCAGATTTCGGTTCTGGA
AGAGATGTTGGATAAGCTGCGTGCCGTGGTAAGCGAGCGCCGTGAAGAGGTCGAACTGGCCGAGAGCAGCCGCCGTGAGC
GCGAAGATAAGCTGAAGGCCTACCGCGAAATGTTGCTGGCTGAGGGGATCTCTCTGGATGATTTGCTGGAGATGGAAAAG
GTCACCGAGCGTAAAGTTAAGCGTGCGCCGCGTCCGGCTAAATATGAATTCCTGGATGAAAATGGCGAAATTAAGCAGTG
GACCGGTCAGGGTCGCATGCCGAAAATGGTCAAGATTGAAATCGATGCCGGTAAATCCCTGGATGATTTCCTGATCAAAT
AA

Upstream 100 bases:

>100_bases
TGTACACGGAGCGGCGATCACGGAAAATTAATTTGTCATAGGTTTGACTCGATAGACAATATAATTATAATGCCGCGGTC
TAAATTAATATAGGTTAGTT

Downstream 100 bases:

>100_bases
ATTCTCCGGCCGTCATGATGCTTCCCGTTAGTATGGGGGAATGGCGGTCGCGCTGTTATTTGCGGTGGTTCCGCACATCC
CGTTTTTTCTTACCTTATCT

Product: H-NS histone family

Products: NA

Alternate protein names: Histone-like protein HLP-II [H]

Number of amino acids: Translated: 133; Mature: 132

Protein sequence:

>133_residues
MSDLLKSLNNIRTLRAYARETQISVLEEMLDKLRAVVSERREEVELAESSRREREDKLKAYREMLLAEGISLDDLLEMEK
VTERKVKRAPRPAKYEFLDENGEIKQWTGQGRMPKMVKIEIDAGKSLDDFLIK

Sequences:

>Translated_133_residues
MSDLLKSLNNIRTLRAYARETQISVLEEMLDKLRAVVSERREEVELAESSRREREDKLKAYREMLLAEGISLDDLLEMEK
VTERKVKRAPRPAKYEFLDENGEIKQWTGQGRMPKMVKIEIDAGKSLDDFLIK
>Mature_132_residues
SDLLKSLNNIRTLRAYARETQISVLEEMLDKLRAVVSERREEVELAESSRREREDKLKAYREMLLAEGISLDDLLEMEKV
TERKVKRAPRPAKYEFLDENGEIKQWTGQGRMPKMVKIEIDAGKSLDDFLIK

Specific function: H-NS binds tightly to ds-DNA, increases its thermal stability and inhibits transcription. It also binds to ss-DNA and RNA but with a much lower affinity. H-NS has possible histone-like function. May be a global transcriptional regulator through its abilit

COG id: COG2916

COG function: function code R; DNA-binding protein H-NS

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone-like protein H-NS family [H]

Homologues:

Organism=Escherichia coli, GI1787489, Length=136, Percent_Identity=58.0882352941177, Blast_Score=128, Evalue=1e-31,
Organism=Escherichia coli, GI1789023, Length=134, Percent_Identity=53.7313432835821, Blast_Score=124, Evalue=3e-30,

Paralogues:

None

Copy number: 820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1780 Molecules/Cell In: Early Stationary Phase, Rich Media (Based on E. coli). 1020 Molecules/Cell In: Early Stationary Phase, Rich Media (Based on E. coli). 4632 Molecules/Cell In: Gr

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001801 [H]

Pfam domain/function: PF00816 Histone_HNS [H]

EC number: NA

Molecular weight: Translated: 15571; Mature: 15440

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLLKSLNNIRTLRAYARETQISVLEEMLDKLRAVVSERREEVELAESSRREREDKLKA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YREMLLAEGISLDDLLEMEKVTERKVKRAPRPAKYEFLDENGEIKQWTGQGRMPKMVKIE
HHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCHHEECCCCCEEECCCCCCCCCEEEEE
IDAGKSLDDFLIK
ECCCCCHHHHHCC
>Mature Secondary Structure 
SDLLKSLNNIRTLRAYARETQISVLEEMLDKLRAVVSERREEVELAESSRREREDKLKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YREMLLAEGISLDDLLEMEKVTERKVKRAPRPAKYEFLDENGEIKQWTGQGRMPKMVKIE
HHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCHHEECCCCCEEECCCCCCCCCEEEEE
IDAGKSLDDFLIK
ECCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2494066 [H]