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The map label for this gene is serA [H]

Identifier: 238921218

GI number: 238921218

Start: 3246935

End: 3248173

Strand: Reverse

Name: serA [H]

Synonym: NT01EI_3360

Alternate gene names: 238921218

Gene position: 3248173-3246935 (Counterclockwise)

Preceding gene: 238921219

Following gene: 238921215

Centisome position: 85.2

GC content: 59.97

Gene sequence:

>1239_bases
ATGGCAAAAGTTTCTTTGGACAAGGACAGAATTAAGTTTTTGCTGGTGGAGGGGGTGCATCAAAGCGCCGTCGATACGTT
GCGCGCCGCCGGTTATAACAATATTGAATACCATAAGGGAGCGTTGGATGACGATGCGCTGCGCGAGGCGATCCGCGATG
CCCATTTTATCGGTCTGCGCTCGCGCACCCAACTGAGTGAGGCGATGTTTTCCGCGGCGGAAAAGCTGGTGGCGGTGGGC
TGCTTTTGTATCGGGACCAATCAGGTCGATCTGGCTGCGGCGCAGCGCCGCGGTGTCCCGGTGTTCAACGCGCCGTTTTC
CAACACCCGCTCGGTGGCGGAGATGGTGCTGGGAGAGATCCTGCTGCTGCTGCGCAATATCCCGCAGGCCAATGCGTGCG
CCCACCGCGGTGAGTGGAGCAAGCAGGCGGTGGGCTGCTATGAGGCACGCGGTAAGAAGCTGGGGATCATCGGCTATGGC
CACATCGGCACGCAGCTGGGGATCCTGGCGGAGGGGATCGGAATGGATGTCTATTTCCATGACATCGAAGGTAAGCTGCC
GCTGGGTAACGCGAAGCAGGTGCGCCATCTTTCCGAATTGCTGAATATGAGCGATGTGGTATCACTGCATGTGCCGGAGA
CGCCGTCCACCCGCAATATGGTTGGTGAGGCGGAGCTGGCGAGGATGAAACCCGGCGCGATTCTGATCAATGCTGCGCGC
GGTACGGTGGTGGATATCGATGCGCTGTGTCAGGCGCTGGAGACCCGCCACTTGGGCGGTGCGGCGATCGATGTCTTTCC
GACAGAGCCGGCAACCAACAGCGATCCCTTTACCTCTCCGCTGTGCCGCTTCGACAACGTGCTGCTGACGCCGCACATCG
GCGGTTCGACCCAGGAGGCCCAGCAAAATATCGGCGTTGAGGTGGCAGGAAAGTTGGCGAAGTACTCCGACAACGGTTCG
ACCCTGTCGGCGGTGAACTTTCCGCAGGTCTCCCTGCCGATGCATGAGGATCACGTCAGCCGTCTGCTGCATACCCATGA
AAACCGCCCGGGGATGCTGAATGCCATCAACCAGATTTTTGCCGAAGAGGGGGTGAATATTGCGGCCCAGTATCTGCAGA
CCACCCCAACCATCGGCTATGTGGTGATCGACGTGGAAACGGAGACCGAGCGTGCGGAGGCTGCGCTACAGCGCATGCGC
GAGATCCCCGGTACCGTGCGGGCCCGTCTGCTGTACTAA

Upstream 100 bases:

>100_bases
GATAAAGCGGCGTTGCGCAGTGGTGGACGCTCAATGCCGTAGCTGGTGCACAGGAACCGCACATTTGCACACCATTTCCT
TTCGGACAGTAGGGCAGATC

Downstream 100 bases:

>100_bases
GCGGCGCCGGCGTCTGGCCAGCGGTAGTGGGCCTGCGGGGTGATGATCTCTGGCAGCGGCACGTCCCAGGCGGCAACGGG
CAGGGCTGCGACGCGCTGAC

Product: phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 412; Mature: 411

Protein sequence:

>412_residues
MAKVSLDKDRIKFLLVEGVHQSAVDTLRAAGYNNIEYHKGALDDDALREAIRDAHFIGLRSRTQLSEAMFSAAEKLVAVG
CFCIGTNQVDLAAAQRRGVPVFNAPFSNTRSVAEMVLGEILLLLRNIPQANACAHRGEWSKQAVGCYEARGKKLGIIGYG
HIGTQLGILAEGIGMDVYFHDIEGKLPLGNAKQVRHLSELLNMSDVVSLHVPETPSTRNMVGEAELARMKPGAILINAAR
GTVVDIDALCQALETRHLGGAAIDVFPTEPATNSDPFTSPLCRFDNVLLTPHIGGSTQEAQQNIGVEVAGKLAKYSDNGS
TLSAVNFPQVSLPMHEDHVSRLLHTHENRPGMLNAINQIFAEEGVNIAAQYLQTTPTIGYVVIDVETETERAEAALQRMR
EIPGTVRARLLY

Sequences:

>Translated_412_residues
MAKVSLDKDRIKFLLVEGVHQSAVDTLRAAGYNNIEYHKGALDDDALREAIRDAHFIGLRSRTQLSEAMFSAAEKLVAVG
CFCIGTNQVDLAAAQRRGVPVFNAPFSNTRSVAEMVLGEILLLLRNIPQANACAHRGEWSKQAVGCYEARGKKLGIIGYG
HIGTQLGILAEGIGMDVYFHDIEGKLPLGNAKQVRHLSELLNMSDVVSLHVPETPSTRNMVGEAELARMKPGAILINAAR
GTVVDIDALCQALETRHLGGAAIDVFPTEPATNSDPFTSPLCRFDNVLLTPHIGGSTQEAQQNIGVEVAGKLAKYSDNGS
TLSAVNFPQVSLPMHEDHVSRLLHTHENRPGMLNAINQIFAEEGVNIAAQYLQTTPTIGYVVIDVETETERAEAALQRMR
EIPGTVRARLLY
>Mature_411_residues
AKVSLDKDRIKFLLVEGVHQSAVDTLRAAGYNNIEYHKGALDDDALREAIRDAHFIGLRSRTQLSEAMFSAAEKLVAVGC
FCIGTNQVDLAAAQRRGVPVFNAPFSNTRSVAEMVLGEILLLLRNIPQANACAHRGEWSKQAVGCYEARGKKLGIIGYGH
IGTQLGILAEGIGMDVYFHDIEGKLPLGNAKQVRHLSELLNMSDVVSLHVPETPSTRNMVGEAELARMKPGAILINAARG
TVVDIDALCQALETRHLGGAAIDVFPTEPATNSDPFTSPLCRFDNVLLTPHIGGSTQEAQQNIGVEVAGKLAKYSDNGST
LSAVNFPQVSLPMHEDHVSRLLHTHENRPGMLNAINQIFAEEGVNIAAQYLQTTPTIGYVVIDVETETERAEAALQRMRE
IPGTVRARLLY

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=317, Percent_Identity=33.7539432176656, Blast_Score=169, Evalue=5e-42,
Organism=Homo sapiens, GI145580578, Length=244, Percent_Identity=32.7868852459016, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI4557499, Length=244, Percent_Identity=32.7868852459016, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI61743967, Length=258, Percent_Identity=30.2325581395349, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI4557497, Length=258, Percent_Identity=30.2325581395349, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI145580575, Length=254, Percent_Identity=31.1023622047244, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI6912396, Length=248, Percent_Identity=27.8225806451613, Blast_Score=89, Evalue=9e-18,
Organism=Escherichia coli, GI1789279, Length=412, Percent_Identity=77.1844660194175, Blast_Score=666, Evalue=0.0,
Organism=Escherichia coli, GI87082289, Length=251, Percent_Identity=31.8725099601594, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1787645, Length=234, Percent_Identity=31.6239316239316, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1788660, Length=304, Percent_Identity=28.6184210526316, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87081824, Length=190, Percent_Identity=25.7894736842105, Blast_Score=62, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=322, Percent_Identity=31.9875776397516, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI25147481, Length=241, Percent_Identity=27.8008298755187, Blast_Score=92, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6322116, Length=414, Percent_Identity=45.6521739130435, Blast_Score=380, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6320925, Length=414, Percent_Identity=45.1690821256039, Blast_Score=377, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6324055, Length=281, Percent_Identity=25.9786476868327, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6324964, Length=256, Percent_Identity=28.515625, Blast_Score=94, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6321253, Length=162, Percent_Identity=29.6296296296296, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6325144, Length=174, Percent_Identity=30.4597701149425, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI19921140, Length=306, Percent_Identity=30.0653594771242, Blast_Score=138, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24646446, Length=235, Percent_Identity=32.7659574468085, Blast_Score=105, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24646448, Length=235, Percent_Identity=32.7659574468085, Blast_Score=105, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24646452, Length=235, Percent_Identity=32.7659574468085, Blast_Score=105, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24646450, Length=235, Percent_Identity=32.7659574468085, Blast_Score=105, Evalue=8e-23,
Organism=Drosophila melanogaster, GI28571528, Length=259, Percent_Identity=28.957528957529, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI62472511, Length=235, Percent_Identity=32.7659574468085, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI28574286, Length=265, Percent_Identity=28.3018867924528, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24585514, Length=250, Percent_Identity=26.4, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI28574282, Length=250, Percent_Identity=26.4, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI28574284, Length=250, Percent_Identity=26.4, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI45551003, Length=250, Percent_Identity=26.4, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI45552429, Length=250, Percent_Identity=26.4, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24585516, Length=301, Percent_Identity=24.2524916943522, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 44704; Mature: 44572

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKVSLDKDRIKFLLVEGVHQSAVDTLRAAGYNNIEYHKGALDDDALREAIRDAHFIGLR
CCCCCCCHHHHHEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCC
SRTQLSEAMFSAAEKLVAVGCFCIGTNQVDLAAAQRRGVPVFNAPFSNTRSVAEMVLGEI
CHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHCCCCEEECCCCCHHHHHHHHHHHH
LLLLRNIPQANACAHRGEWSKQAVGCYEARGKKLGIIGYGHIGTQLGILAEGIGMDVYFH
HHHHHCCCCCHHHHHCCCCCHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHCCCCEEEEE
DIEGKLPLGNAKQVRHLSELLNMSDVVSLHVPETPSTRNMVGEAELARMKPGAILINAAR
ECCCCCCCCCHHHHHHHHHHHCHHHEEEEECCCCCCHHCCCCHHHHHHCCCCEEEEECCC
GTVVDIDALCQALETRHLGGAAIDVFPTEPATNSDPFTSPLCRFDNVLLTPHIGGSTQEA
CCEEEHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHCCCEEEECCCCCCHHHH
QQNIGVEVAGKLAKYSDNGSTLSAVNFPQVSLPMHEDHVSRLLHTHENRPGMLNAINQIF
HHHCCHHEEHHHHEECCCCCEEEEECCCCEECCCCHHHHHHHHHHCCCCCHHHHHHHHHH
AEEGVNIAAQYLQTTPTIGYVVIDVETETERAEAALQRMREIPGTVRARLLY
HHCCCHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCHHHHEECC
>Mature Secondary Structure 
AKVSLDKDRIKFLLVEGVHQSAVDTLRAAGYNNIEYHKGALDDDALREAIRDAHFIGLR
CCCCCCHHHHHEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCC
SRTQLSEAMFSAAEKLVAVGCFCIGTNQVDLAAAQRRGVPVFNAPFSNTRSVAEMVLGEI
CHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHCCCCEEECCCCCHHHHHHHHHHHH
LLLLRNIPQANACAHRGEWSKQAVGCYEARGKKLGIIGYGHIGTQLGILAEGIGMDVYFH
HHHHHCCCCCHHHHHCCCCCHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHCCCCEEEEE
DIEGKLPLGNAKQVRHLSELLNMSDVVSLHVPETPSTRNMVGEAELARMKPGAILINAAR
ECCCCCCCCCHHHHHHHHHHHCHHHEEEEECCCCCCHHCCCCHHHHHHCCCCEEEEECCC
GTVVDIDALCQALETRHLGGAAIDVFPTEPATNSDPFTSPLCRFDNVLLTPHIGGSTQEA
CCEEEHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHCCCEEEECCCCCCHHHH
QQNIGVEVAGKLAKYSDNGSTLSAVNFPQVSLPMHEDHVSRLLHTHENRPGMLNAINQIF
HHHCCHHEEHHHHEECCCCCEEEEECCCCEECCCCHHHHHHHHHHCCCCCHHHHHHHHHH
AEEGVNIAAQYLQTTPTIGYVVIDVETETERAEAALQRMREIPGTVRARLLY
HHCCCHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]