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The map label for this gene is ubiH [H]

Identifier: 238921213

GI number: 238921213

Start: 3242219

End: 3243397

Strand: Reverse

Name: ubiH [H]

Synonym: NT01EI_3355

Alternate gene names: 238921213

Gene position: 3243397-3242219 (Counterclockwise)

Preceding gene: 238921214

Following gene: 238921212

Centisome position: 85.08

GC content: 68.79

Gene sequence:

>1179_bases
ATGAGCATCATCATCGCCGGCGGTGGCATGGCGGGCGCGACGCTGGCGTTGGCGCTGTCGGCGCTGAGTGGCGGGCGTTG
TGCGGTAACGCTGGTGGAGGCGCTCGCCCCCGGCGCCGATGCGCATCCCGGCTTTGACGCCCGCGCCATTGCGCTGGCCC
ACGGTACCTGTCAACAGCTGGCGCAGATTGGCGTCTGGCCGGCGTTGGCCTCCTGCGCGACCGCCATTCGTCAGGTGCAG
ATAAGCGACCGCGGCCACGGCGGAGCGTTGTGGCTGGACGCCGACGCGTACGATCTCCCCGCGTTGGGGCAGGTGATCCC
GTTGCATCAGGCTGGCGCCCGCCTGTTTCAGCTGCTGGCATCGGCGCCGGGCGTGACGCTGTTCTGTCCGGCGACGCTGG
CGCGGGTGGAGCGTCGCGTCGACGGCGTGACGGCCTGGCTGGAGGATGGTCGTTGCTTACAGGGACGGCTATTGGTGGCC
GCCGATGGCGCCTCGTCGCCTCTGGCACAGATGTGCGGCATGCGGTGGCACAGCGAGGCCTATGAGCAGACGGCGCTGAT
CGCCACACTGGCCAGCAGCGAGGCGCACCGTGGACGCGCCTTTGAGCGTTTTACGCCGGATGGGCCGCTGGCGCTGCTGC
CGATGGCGGAGGAGCGGAGCTCACTGGTCTGGTGCCTGCCGCCGGTGCAGGCGACGCAGGTCGCCCGGTGGGATACGCCG
ACGTTTCTCCACCGCCTGCAGCAGGCCTTTGGCTGGCGTCTGGGGCGTTTTACGCACTGCGGTCGGCGTGATAGCTATCC
GTTGACCCTGCGTCGGGCGCATGGGCATATCGGCCACCGTTTGGCGCTGGTTGGCAATGCGGCGCAGACGCTGCACCCGA
TTGCCGGTCAAGGTTTTAACCTGGGACTGCGTGATGTGATGACGCTGGCAGAGACCTTGAATGATGCGCTGCGGCGCGGA
GACGATCCCGGCGCCTATCGGACGCTGGCGCGCTATCAGGGGCGGCGTCAGCCTGACTGCGGGGCGACCATTGCGTTGAC
CGACGGTTTGGTGCGGCTGTTCGCCAACCGCCTGCCGTCGCTGGCGCTCGGGCGTAATCTGGGACTGATGGCGCTGGCGC
TGACACCGTCGCTGCACACGCCGCTGGTGCGGCGCCTGCTGGGTCAGGTTGCCCGCTAG

Upstream 100 bases:

>100_bases
ATGTGCTGATCACCGAGGCGGGCTGCGAGATCCTGACCGAGGGCGTCGTGAAATCGGTCGAGGCGATCGAAGCCCTGATG
GCGGCGGCGCGGGCGCGGGA

Downstream 100 bases:

>100_bases
ACGGCCGTTTCTGGGGAAACAGGAAGCTATGCAATCATTCGATATTATTGTTGCCGGTGGCGGTATGGTCGGTCTGGCGC
TGGCTAACGCCCTTTCCGGC

Product: 2-polyprenyl-6-methoxyphenol 4-hydroxylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MSIIIAGGGMAGATLALALSALSGGRCAVTLVEALAPGADAHPGFDARAIALAHGTCQQLAQIGVWPALASCATAIRQVQ
ISDRGHGGALWLDADAYDLPALGQVIPLHQAGARLFQLLASAPGVTLFCPATLARVERRVDGVTAWLEDGRCLQGRLLVA
ADGASSPLAQMCGMRWHSEAYEQTALIATLASSEAHRGRAFERFTPDGPLALLPMAEERSSLVWCLPPVQATQVARWDTP
TFLHRLQQAFGWRLGRFTHCGRRDSYPLTLRRAHGHIGHRLALVGNAAQTLHPIAGQGFNLGLRDVMTLAETLNDALRRG
DDPGAYRTLARYQGRRQPDCGATIALTDGLVRLFANRLPSLALGRNLGLMALALTPSLHTPLVRRLLGQVAR

Sequences:

>Translated_392_residues
MSIIIAGGGMAGATLALALSALSGGRCAVTLVEALAPGADAHPGFDARAIALAHGTCQQLAQIGVWPALASCATAIRQVQ
ISDRGHGGALWLDADAYDLPALGQVIPLHQAGARLFQLLASAPGVTLFCPATLARVERRVDGVTAWLEDGRCLQGRLLVA
ADGASSPLAQMCGMRWHSEAYEQTALIATLASSEAHRGRAFERFTPDGPLALLPMAEERSSLVWCLPPVQATQVARWDTP
TFLHRLQQAFGWRLGRFTHCGRRDSYPLTLRRAHGHIGHRLALVGNAAQTLHPIAGQGFNLGLRDVMTLAETLNDALRRG
DDPGAYRTLARYQGRRQPDCGATIALTDGLVRLFANRLPSLALGRNLGLMALALTPSLHTPLVRRLLGQVAR
>Mature_391_residues
SIIIAGGGMAGATLALALSALSGGRCAVTLVEALAPGADAHPGFDARAIALAHGTCQQLAQIGVWPALASCATAIRQVQI
SDRGHGGALWLDADAYDLPALGQVIPLHQAGARLFQLLASAPGVTLFCPATLARVERRVDGVTAWLEDGRCLQGRLLVAA
DGASSPLAQMCGMRWHSEAYEQTALIATLASSEAHRGRAFERFTPDGPLALLPMAEERSSLVWCLPPVQATQVARWDTPT
FLHRLQQAFGWRLGRFTHCGRRDSYPLTLRRAHGHIGHRLALVGNAAQTLHPIAGQGFNLGLRDVMTLAETLNDALRRGD
DPGAYRTLARYQGRRQPDCGATIALTDGLVRLFANRLPSLALGRNLGLMALALTPSLHTPLVRRLLGQVAR

Specific function: Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone [H]

COG id: COG0654

COG function: function code HC; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiH/COQ6 family [H]

Homologues:

Organism=Homo sapiens, GI32967305, Length=384, Percent_Identity=29.9479166666667, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI32967307, Length=266, Percent_Identity=34.2105263157895, Blast_Score=127, Evalue=2e-29,
Organism=Escherichia coli, GI1789274, Length=392, Percent_Identity=60.4591836734694, Blast_Score=448, Evalue=1e-127,
Organism=Escherichia coli, GI1786883, Length=373, Percent_Identity=34.3163538873995, Blast_Score=181, Evalue=7e-47,
Organism=Escherichia coli, GI1789273, Length=391, Percent_Identity=32.4808184143223, Blast_Score=166, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI25146631, Length=418, Percent_Identity=27.511961722488, Blast_Score=132, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6321694, Length=275, Percent_Identity=28, Blast_Score=97, Evalue=3e-21,
Organism=Drosophila melanogaster, GI19920760, Length=425, Percent_Identity=27.0588235294118, Blast_Score=118, Evalue=6e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002938
- InterPro:   IPR003042
- InterPro:   IPR018168
- InterPro:   IPR010971
- InterPro:   IPR011295 [H]

Pfam domain/function: PF01494 FAD_binding_3 [H]

EC number: 1.14.13.-

Molecular weight: Translated: 41780; Mature: 41649

Theoretical pI: Translated: 9.23; Mature: 9.23

Prosite motif: PS01304 UBIH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIIIAGGGMAGATLALALSALSGGRCAVTLVEALAPGADAHPGFDARAIALAHGTCQQL
CEEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHHHHH
AQIGVWPALASCATAIRQVQISDRGHGGALWLDADAYDLPALGQVIPLHQAGARLFQLLA
HHHCCHHHHHHHHHHHHHEEECCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHH
SAPGVTLFCPATLARVERRVDGVTAWLEDGRCLQGRLLVAADGASSPLAQMCGMRWHSEA
CCCCCEEECCHHHHHHHHHHHHHHHHHCCCCEECCEEEEEECCCCCHHHHHCCCHHHHHH
YEQTALIATLASSEAHRGRAFERFTPDGPLALLPMAEERSSLVWCLPPVQATQVARWDTP
HHHHHHHHHHHCCHHHCCCCHHCCCCCCCEEEEECCCCCCCEEEEECCCCHHHHHCCCCH
TFLHRLQQAFGWRLGRFTHCGRRDSYPLTLRRAHGHIGHRLALVGNAAQTLHPIAGQGFN
HHHHHHHHHHCCHHHHHHCCCCCCCCCEEEECCCCCCCCEEEEECCHHHHHCCCCCCCCC
LGLRDVMTLAETLNDALRRGDDPGAYRTLARYQGRRQPDCGATIALTDGLVRLFANRLPS
CCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHCCC
LALGRNLGLMALALTPSLHTPLVRRLLGQVAR
HHHCCCCCEEEEEECCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SIIIAGGGMAGATLALALSALSGGRCAVTLVEALAPGADAHPGFDARAIALAHGTCQQL
EEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHHHHH
AQIGVWPALASCATAIRQVQISDRGHGGALWLDADAYDLPALGQVIPLHQAGARLFQLLA
HHHCCHHHHHHHHHHHHHEEECCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHH
SAPGVTLFCPATLARVERRVDGVTAWLEDGRCLQGRLLVAADGASSPLAQMCGMRWHSEA
CCCCCEEECCHHHHHHHHHHHHHHHHHCCCCEECCEEEEEECCCCCHHHHHCCCHHHHHH
YEQTALIATLASSEAHRGRAFERFTPDGPLALLPMAEERSSLVWCLPPVQATQVARWDTP
HHHHHHHHHHHCCHHHCCCCHHCCCCCCCEEEEECCCCCCCEEEEECCCCHHHHHCCCCH
TFLHRLQQAFGWRLGRFTHCGRRDSYPLTLRRAHGHIGHRLALVGNAAQTLHPIAGQGFN
HHHHHHHHHHCCHHHHHHCCCCCCCCCEEEECCCCCCCCEEEEECCHHHHHCCCCCCCCC
LGLRDVMTLAETLNDALRRGDDPGAYRTLARYQGRRQPDCGATIALTDGLVRLFANRLPS
CCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHCCC
LALGRNLGLMALALTPSLHTPLVRRLLGQVAR
HHHCCCCCEEEEEECCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1339425; 9278503 [H]