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The map label for this gene is pepP [H]

Identifier: 238921214

GI number: 238921214

Start: 3243394

End: 3244716

Strand: Reverse

Name: pepP [H]

Synonym: NT01EI_3356

Alternate gene names: 238921214

Gene position: 3244716-3243394 (Counterclockwise)

Preceding gene: 238921215

Following gene: 238921213

Centisome position: 85.11

GC content: 61.53

Gene sequence:

>1323_bases
ATGACCCCGCAAGAGTATCAGCGTCGCCGTCAGGCGCTGCTGGCCAGAATGCAACCGGGCAGCGCCGCGCTGTTTTTCTC
GGCTCCGGTCCGCTGTCGTAATGCTGAAAACGAATACCCCTATCGCCAGAACAGCGATTTCTGGTACCTGTGCGGATTCG
ATGAGCCGGAGGCGCTGCTGGTGCTGATCAAAAGCGCCGACAACCATAGCCACAGCGTGCTGTTCAATCGGGTTCGCGAC
GTCACGGCAGAAGTTTGGTTTGGTCGTCGTCTGGGACAGGAGGCGGCGCCGACTCGGCTGAATATCGATCGCGCTCTGCC
GTACGGCGACGTAGAGGAGCAGCTGCCGTTACTGCTCAACGGTCTGGATGTGGTGTATCACGCGCAGGGCATGTATGACT
TCGCTGATGCGATGATCTTTTCCGCGCTGGAGACGCTGCGCGGCGGCGCCCGCCAGAGCCTGCGCGCGCCCGCGACCCTG
ACGGACTGGCGCCCCTGGGTACATGAGATGCGTCTGTTTAAGTCGGCGGAGGAGATCGCCGTAATGCGACGCGCCGCTGA
GATCACTGCGCTGGGCCATATCCGGGCGATGGAGAAGTGCCGCCCGGGGATGTATGAGTATCAGCTGGAGGGTGAGCTGC
TGCACGAGTTTAACCGACATGGCGCGCGGTCCCCCTCTTTTAATACCATTGTGGGCAGCGGTGGGAACGCCTGTATCCTG
CATTACACTGAAAATGAAAGTGAAATGAAAGAGGGTGATCTGGTGCTGGTGGATGCCGGTGCCGAGTTCCGCCACTATGC
CGGCGATGTTACCCGAACCTTCCCGGTCAGTGGCCGCTTTAGCGACCCCCAGCGCCAGATTTATCAGCTGGTGCTGGCAT
CAATGGAGGCGGGGCTTACCCATTACCGCCCCGGCAGCAGTCTGCGTGAGGCCCAGGAGGCCACGGTGCGGGTGATGGTG
ACCGGCCTGGTGGCGTTGGGGATACTGCAGGGAGAGGTCGATCAGCTGATCGCAGAGCAGAAGTATCGGGCGTTCTTTAT
GCACGGTCTCGGACACTGGCTGGGGCTGGATGTTCATGACGTTGGCGACTATACGACACCGGCACGCGATCGTACGCTGG
AGCCGGGAATGGTGTTGACCTGTGAGCCGGGGCTGTATATTGCGCCCGATGCCGATGTGCCGCCGATCTATCGTGGCATC
GGGGTACGGATTGAGGATGATGTGCTGATCACCGAGGCGGGCTGCGAGATCCTGACCGAGGGCGTCGTGAAATCGGTCGA
GGCGATCGAAGCCCTGATGGCGGCGGCGCGGGCGCGGGAATGA

Upstream 100 bases:

>100_bases
AATACGGCCTGGACCTATCCCGTTTTAATAACCGGTTTGTATTATGGAGACAGGGTGCAGCTGCCCTGCCGTTTGACCCG
CCTATTGTCAGGAGATGGAT

Downstream 100 bases:

>100_bases
GCATCATCATCGCCGGCGGTGGCATGGCGGGCGCGACGCTGGCGTTGGCGCTGTCGGCGCTGAGTGGCGGGCGTTGTGCG
GTAACGCTGGTGGAGGCGCT

Product: proline aminopeptidase P II

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 440; Mature: 439

Protein sequence:

>440_residues
MTPQEYQRRRQALLARMQPGSAALFFSAPVRCRNAENEYPYRQNSDFWYLCGFDEPEALLVLIKSADNHSHSVLFNRVRD
VTAEVWFGRRLGQEAAPTRLNIDRALPYGDVEEQLPLLLNGLDVVYHAQGMYDFADAMIFSALETLRGGARQSLRAPATL
TDWRPWVHEMRLFKSAEEIAVMRRAAEITALGHIRAMEKCRPGMYEYQLEGELLHEFNRHGARSPSFNTIVGSGGNACIL
HYTENESEMKEGDLVLVDAGAEFRHYAGDVTRTFPVSGRFSDPQRQIYQLVLASMEAGLTHYRPGSSLREAQEATVRVMV
TGLVALGILQGEVDQLIAEQKYRAFFMHGLGHWLGLDVHDVGDYTTPARDRTLEPGMVLTCEPGLYIAPDADVPPIYRGI
GVRIEDDVLITEAGCEILTEGVVKSVEAIEALMAAARARE

Sequences:

>Translated_440_residues
MTPQEYQRRRQALLARMQPGSAALFFSAPVRCRNAENEYPYRQNSDFWYLCGFDEPEALLVLIKSADNHSHSVLFNRVRD
VTAEVWFGRRLGQEAAPTRLNIDRALPYGDVEEQLPLLLNGLDVVYHAQGMYDFADAMIFSALETLRGGARQSLRAPATL
TDWRPWVHEMRLFKSAEEIAVMRRAAEITALGHIRAMEKCRPGMYEYQLEGELLHEFNRHGARSPSFNTIVGSGGNACIL
HYTENESEMKEGDLVLVDAGAEFRHYAGDVTRTFPVSGRFSDPQRQIYQLVLASMEAGLTHYRPGSSLREAQEATVRVMV
TGLVALGILQGEVDQLIAEQKYRAFFMHGLGHWLGLDVHDVGDYTTPARDRTLEPGMVLTCEPGLYIAPDADVPPIYRGI
GVRIEDDVLITEAGCEILTEGVVKSVEAIEALMAAARARE
>Mature_439_residues
TPQEYQRRRQALLARMQPGSAALFFSAPVRCRNAENEYPYRQNSDFWYLCGFDEPEALLVLIKSADNHSHSVLFNRVRDV
TAEVWFGRRLGQEAAPTRLNIDRALPYGDVEEQLPLLLNGLDVVYHAQGMYDFADAMIFSALETLRGGARQSLRAPATLT
DWRPWVHEMRLFKSAEEIAVMRRAAEITALGHIRAMEKCRPGMYEYQLEGELLHEFNRHGARSPSFNTIVGSGGNACILH
YTENESEMKEGDLVLVDAGAEFRHYAGDVTRTFPVSGRFSDPQRQIYQLVLASMEAGLTHYRPGSSLREAQEATVRVMVT
GLVALGILQGEVDQLIAEQKYRAFFMHGLGHWLGLDVHDVGDYTTPARDRTLEPGMVLTCEPGLYIAPDADVPPIYRGIG
VRIEDDVLITEAGCEILTEGVVKSVEAIEALMAAARARE

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=451, Percent_Identity=31.4855875831486, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI260593665, Length=310, Percent_Identity=35.8064516129032, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI149589008, Length=310, Percent_Identity=35.8064516129032, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI260593663, Length=344, Percent_Identity=31.6860465116279, Blast_Score=159, Evalue=5e-39,
Organism=Escherichia coli, GI1789275, Length=439, Percent_Identity=69.248291571754, Blast_Score=644, Evalue=0.0,
Organism=Escherichia coli, GI1788728, Length=255, Percent_Identity=32.5490196078431, Blast_Score=119, Evalue=6e-28,
Organism=Escherichia coli, GI1790282, Length=323, Percent_Identity=30.030959752322, Blast_Score=103, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17508215, Length=435, Percent_Identity=30.1149425287356, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI71989583, Length=276, Percent_Identity=32.9710144927536, Blast_Score=125, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6320922, Length=438, Percent_Identity=30.365296803653, Blast_Score=205, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6321118, Length=467, Percent_Identity=29.3361884368308, Blast_Score=175, Evalue=1e-44,
Organism=Drosophila melanogaster, GI19920384, Length=404, Percent_Identity=35.8910891089109, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI21357079, Length=447, Percent_Identity=32.4384787472036, Blast_Score=186, Evalue=4e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 49264; Mature: 49132

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPQEYQRRRQALLARMQPGSAALFFSAPVRCRNAENEYPYRQNSDFWYLCGFDEPEALL
CCCHHHHHHHHHHHHHCCCCCEEEEEECCEEECCCCCCCCCCCCCCEEEEECCCCCCEEE
VLIKSADNHSHSVLFNRVRDVTAEVWFGRRLGQEAAPTRLNIDRALPYGDVEEQLPLLLN
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHCCCCCCHHHHHHHHHC
GLDVVYHAQGMYDFADAMIFSALETLRGGARQSLRAPATLTDWRPWVHEMRLFKSAEEIA
CCHHEEECCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
VMRRAAEITALGHIRAMEKCRPGMYEYQLEGELLHEFNRHGARSPSFNTIVGSGGNACIL
HHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHCCCCCCCCCEEEECCCCEEEE
HYTENESEMKEGDLVLVDAGAEFRHYAGDVTRTFPVSGRFSDPQRQIYQLVLASMEAGLT
EEECCCCHHCCCCEEEEECCCHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCC
HYRPGSSLREAQEATVRVMVTGLVALGILQGEVDQLIAEQKYRAFFMHGLGHWLGLDVHD
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
VGDYTTPARDRTLEPGMVLTCEPGLYIAPDADVPPIYRGIGVRIEDDVLITEAGCEILTE
CCCCCCCCCCCCCCCCEEEEECCCEEECCCCCCCHHHHCCCCEEECCEEEECCCHHHHHH
GVVKSVEAIEALMAAARARE
HHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TPQEYQRRRQALLARMQPGSAALFFSAPVRCRNAENEYPYRQNSDFWYLCGFDEPEALL
CCHHHHHHHHHHHHHCCCCCEEEEEECCEEECCCCCCCCCCCCCCEEEEECCCCCCEEE
VLIKSADNHSHSVLFNRVRDVTAEVWFGRRLGQEAAPTRLNIDRALPYGDVEEQLPLLLN
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHCCCCCCHHHHHHHHHC
GLDVVYHAQGMYDFADAMIFSALETLRGGARQSLRAPATLTDWRPWVHEMRLFKSAEEIA
CCHHEEECCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
VMRRAAEITALGHIRAMEKCRPGMYEYQLEGELLHEFNRHGARSPSFNTIVGSGGNACIL
HHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHCCCCCCCCCEEEECCCCEEEE
HYTENESEMKEGDLVLVDAGAEFRHYAGDVTRTFPVSGRFSDPQRQIYQLVLASMEAGLT
EEECCCCHHCCCCEEEEECCCHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCC
HYRPGSSLREAQEATVRVMVTGLVALGILQGEVDQLIAEQKYRAFFMHGLGHWLGLDVHD
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
VGDYTTPARDRTLEPGMVLTCEPGLYIAPDADVPPIYRGIGVRIEDDVLITEAGCEILTE
CCCCCCCCCCCCCCCCEEEEECCCEEECCCCCCCHHHHCCCCEEECCEEEECCCHHHHHH
GVVKSVEAIEALMAAARARE
HHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659585; 1339425; 9278503; 9520390 [H]