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The map label for this gene is lysR [H]

Identifier: 238921149

GI number: 238921149

Start: 3170541

End: 3171623

Strand: Direct

Name: lysR [H]

Synonym: NT01EI_3290

Alternate gene names: 238921149

Gene position: 3170541-3171623 (Clockwise)

Preceding gene: 238921145

Following gene: 238921150

Centisome position: 83.17

GC content: 61.77

Gene sequence:

>1083_bases
ATGGTAAAAGGCTCCGGAAAAATCAGCATTACCCTCTATGTAGCAGCGCCCAGAGAGAATAAAAAATATCTATTTGTCAC
AAGTCTATTCATTTATGATATGGAATACGCCCGTTTCCTGTACGGCCGTGTGCCGCCGGAGCCCACCATGCACCGTATTT
CCCTGCGTCAGGTCGCCATCTTCCATGCCGTGATGACCAGCGGCAATCTCACCGAGGCTGCCACGCAGCTACGTACATCT
CAGCCGACCGTCAGCCGCGAACTGGCCCGCTTTGAGCAGCTGCTGGCACTGAAGCTGTTCGACCGGGTACGCGGTCGGCT
GCGGCCAACCGCCCAGGGACTACAGCTGTTTGAAGAGGTGCAGCGCGCCTACTGTGGTCTTGAGCGTATCGAGGACGCCG
CCAGCCAGATCCGCCAGTTCCGCCGCGCCACATTGGACATCGTCTGCCTGCCGGCATTCTCTCAGTCTCTGCTGCCGCAG
GTCTGCCGCCGCTTTCTTGAATGCTATCCGGAGGTCAGCCTTACCATTACCCCGCAGGAGTCTCCCCTGCTGGAAGAGTG
GCTTTCGGCCCAGCGTTACGATCTGGGACTGACGGAAGAGTGCAGCACGCCGCCGGGCTGCGAGCGCCACGCCCTGGCGA
CGCTGAATGAGGTCTGCGTCATGCCGGCCGATCACCCGCTGCTACACCATGCCATCCTGACCCCGGCGCACTTTGCGGCG
CAGCCCTATATCAGCCTGTCGGCCGGTGATAGCTATCGCCATACCCTGGATGCCCTGTTTCAACGGGCCGGGGTCGCACG
CCGGATGGTGGCAGAAACCCACAGTGCCGCCGCCGTCTGCGCCCTGGTGCGTCAGGGAATCGGGCTGTCTATCGTCAATC
CGCTGACCGCACTGGACTTCGTCGGCCGCGGGCTGGCATGGCGCCCCTTCAGCGTAGCCGTTCCCTTTACCGTCAGCCTG
ATCCGCCCGCGCCACCGTCCCGGCTCTGCCGTCGTAGATGCCCTTATCGTCTCGCTGCAGGAGGAGCTCGCGGCTGTCGC
CGAGCACCTGCGAGAGCCTTATGACAGTAACGAAAACCATTGA

Upstream 100 bases:

>100_bases
CGCTGCGTCATAAACCCACAGCGGTGTACCAAAGCGGCCCGGCAGAGCGGAAAGCAGCGTGTCATTCAGGGCATAACCGG
CCTGATTCAGGGGATAGGGC

Downstream 100 bases:

>100_bases
AAGACAAAGATCATTTATCGCACAATCTTGCTGTGCATCATTCTTTCGTTTTTATTTCTATAAAATAAAAAAAAATGCAA
TAACATGATTTATCGTTATT

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MVKGSGKISITLYVAAPRENKKYLFVTSLFIYDMEYARFLYGRVPPEPTMHRISLRQVAIFHAVMTSGNLTEAATQLRTS
QPTVSRELARFEQLLALKLFDRVRGRLRPTAQGLQLFEEVQRAYCGLERIEDAASQIRQFRRATLDIVCLPAFSQSLLPQ
VCRRFLECYPEVSLTITPQESPLLEEWLSAQRYDLGLTEECSTPPGCERHALATLNEVCVMPADHPLLHHAILTPAHFAA
QPYISLSAGDSYRHTLDALFQRAGVARRMVAETHSAAAVCALVRQGIGLSIVNPLTALDFVGRGLAWRPFSVAVPFTVSL
IRPRHRPGSAVVDALIVSLQEELAAVAEHLREPYDSNENH

Sequences:

>Translated_360_residues
MVKGSGKISITLYVAAPRENKKYLFVTSLFIYDMEYARFLYGRVPPEPTMHRISLRQVAIFHAVMTSGNLTEAATQLRTS
QPTVSRELARFEQLLALKLFDRVRGRLRPTAQGLQLFEEVQRAYCGLERIEDAASQIRQFRRATLDIVCLPAFSQSLLPQ
VCRRFLECYPEVSLTITPQESPLLEEWLSAQRYDLGLTEECSTPPGCERHALATLNEVCVMPADHPLLHHAILTPAHFAA
QPYISLSAGDSYRHTLDALFQRAGVARRMVAETHSAAAVCALVRQGIGLSIVNPLTALDFVGRGLAWRPFSVAVPFTVSL
IRPRHRPGSAVVDALIVSLQEELAAVAEHLREPYDSNENH
>Mature_360_residues
MVKGSGKISITLYVAAPRENKKYLFVTSLFIYDMEYARFLYGRVPPEPTMHRISLRQVAIFHAVMTSGNLTEAATQLRTS
QPTVSRELARFEQLLALKLFDRVRGRLRPTAQGLQLFEEVQRAYCGLERIEDAASQIRQFRRATLDIVCLPAFSQSLLPQ
VCRRFLECYPEVSLTITPQESPLLEEWLSAQRYDLGLTEECSTPPGCERHALATLNEVCVMPADHPLLHHAILTPAHFAA
QPYISLSAGDSYRHTLDALFQRAGVARRMVAETHSAAAVCALVRQGIGLSIVNPLTALDFVGRGLAWRPFSVAVPFTVSL
IRPRHRPGSAVVDALIVSLQEELAAVAEHLREPYDSNENH

Specific function: This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789204, Length=294, Percent_Identity=63.6054421768708, Blast_Score=373, Evalue=1e-105,
Organism=Escherichia coli, GI157672245, Length=230, Percent_Identity=26.9565217391304, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1788296, Length=235, Percent_Identity=29.3617021276596, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787530, Length=249, Percent_Identity=25.3012048192771, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1788481, Length=250, Percent_Identity=29.2, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1788887, Length=303, Percent_Identity=27.0627062706271, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87081904, Length=221, Percent_Identity=29.4117647058824, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1787879, Length=252, Percent_Identity=24.6031746031746, Blast_Score=65, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 40215; Mature: 40215

Theoretical pI: Translated: 7.81; Mature: 7.81

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKGSGKISITLYVAAPRENKKYLFVTSLFIYDMEYARFLYGRVPPEPTMHRISLRQVAI
CCCCCCEEEEEEEEECCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
FHAVMTSGNLTEAATQLRTSQPTVSRELARFEQLLALKLFDRVRGRLRPTAQGLQLFEEV
HHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
QRAYCGLERIEDAASQIRQFRRATLDIVCLPAFSQSLLPQVCRRFLECYPEVSLTITPQE
HHHHHHHHHHHHHHHHHHHHHHHHHEEEEECHHHHHHHHHHHHHHHHHCCCCEEEECCCC
SPLLEEWLSAQRYDLGLTEECSTPPGCERHALATLNEVCVMPADHPLLHHAILTPAHFAA
CHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHC
QPYISLSAGDSYRHTLDALFQRAGVARRMVAETHSAAAVCALVRQGIGLSIVNPLTALDF
CCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
VGRGLAWRPFSVAVPFTVSLIRPRHRPGSAVVDALIVSLQEELAAVAEHLREPYDSNENH
HCCCCCCCCEEEECCHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MVKGSGKISITLYVAAPRENKKYLFVTSLFIYDMEYARFLYGRVPPEPTMHRISLRQVAI
CCCCCCEEEEEEEEECCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
FHAVMTSGNLTEAATQLRTSQPTVSRELARFEQLLALKLFDRVRGRLRPTAQGLQLFEEV
HHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
QRAYCGLERIEDAASQIRQFRRATLDIVCLPAFSQSLLPQVCRRFLECYPEVSLTITPQE
HHHHHHHHHHHHHHHHHHHHHHHHHEEEEECHHHHHHHHHHHHHHHHHCCCCEEEECCCC
SPLLEEWLSAQRYDLGLTEECSTPPGCERHALATLNEVCVMPADHPLLHHAILTPAHFAA
CHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHC
QPYISLSAGDSYRHTLDALFQRAGVARRMVAETHSAAAVCALVRQGIGLSIVNPLTALDF
CCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
VGRGLAWRPFSVAVPFTVSLIRPRHRPGSAVVDALIVSLQEELAAVAEHLREPYDSNENH
HCCCCCCCCEEEECCHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6350602; 9278503; 2836407 [H]