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The map label for this gene is mutH [H]

Identifier: 238921121

GI number: 238921121

Start: 3138332

End: 3139021

Strand: Direct

Name: mutH [H]

Synonym: NT01EI_3260

Alternate gene names: 238921121

Gene position: 3138332-3139021 (Clockwise)

Preceding gene: 238921110

Following gene: 238921122

Centisome position: 82.32

GC content: 65.65

Gene sequence:

>690_bases
ATGATGAACGAACCATTTCCTCCCCACTCGCCGCCGGTGGATCGCCAGGCGCTGCTGCAGCGCGCCCTGCGTCTGGCCGG
ATATACCTATGCCGAGCTGGCCGCGCTGGCCGGGCTGACCATACCGCGCGATCTGCGACGCGATAAGGGCTGGGTCGGCC
TGCTGCTGGAGCGCTGCCTCGGCGCCAGCTCGGGCAGTAAGGCGCAGCAGGACTTCCCCGCGCTGGGCGTCGAGTTAAAG
AGTATCCCCATCGATGCCCAGGGACGCCCCCTGGAAACCACCTTTGTCTGCGTGGCTCCGCTGACGGGAAATACCGGGTT
GACCTGGGAGCACTGTCATCTGCGCCACAAGCTACAGTGCGTTCTGTGGATCCCGGTGGAGGGGGAGCGTCAGATCCCGC
TGGCAGAGCGCCGGGTCGGTGCCCCACTGCTGTGGACCCCCTCTGCACAGGAGGAGCAGGCGCTGCGGCGAGACTGGGAG
GAGCTGATGGACCTGATCGTGCTGGGGCGGGTTGAGTCGATCACCGCCCGCCACGGCGAGGTGCTGCAGCTACGTCCCAA
GGCGGCCAACAGCCGGGCGCTGACCGAAGGCATCGGTCAGCGCGGCGAACCGATAATGACCCTGCCACGCGGCTTCTATC
TGAAAAAGAACTTCACGACGGCGCTGTTGGCCCGCTACTTTCTACTGTAA

Upstream 100 bases:

>100_bases
GAGAAAAAATTTCATTATGAATCATAATATTATTTATAGTCTGCGCCGCTTTCTCCCGCGCTGTTGATAAGCCCCGAATA
GGTGTACGTTTTTTAACCAG

Downstream 100 bases:

>100_bases
ATTCTGTTTTACACCCCGCGAGCGCTGCGCAGCGGGACACTCTCGGTGTATAATTCCAGATTATGATTTTTTTAGGTATT
TATCTCTATGTTTGCGTGGA

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: Methyl-directed mismatch repair protein [H]

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MMNEPFPPHSPPVDRQALLQRALRLAGYTYAELAALAGLTIPRDLRRDKGWVGLLLERCLGASSGSKAQQDFPALGVELK
SIPIDAQGRPLETTFVCVAPLTGNTGLTWEHCHLRHKLQCVLWIPVEGERQIPLAERRVGAPLLWTPSAQEEQALRRDWE
ELMDLIVLGRVESITARHGEVLQLRPKAANSRALTEGIGQRGEPIMTLPRGFYLKKNFTTALLARYFLL

Sequences:

>Translated_229_residues
MMNEPFPPHSPPVDRQALLQRALRLAGYTYAELAALAGLTIPRDLRRDKGWVGLLLERCLGASSGSKAQQDFPALGVELK
SIPIDAQGRPLETTFVCVAPLTGNTGLTWEHCHLRHKLQCVLWIPVEGERQIPLAERRVGAPLLWTPSAQEEQALRRDWE
ELMDLIVLGRVESITARHGEVLQLRPKAANSRALTEGIGQRGEPIMTLPRGFYLKKNFTTALLARYFLL
>Mature_229_residues
MMNEPFPPHSPPVDRQALLQRALRLAGYTYAELAALAGLTIPRDLRRDKGWVGLLLERCLGASSGSKAQQDFPALGVELK
SIPIDAQGRPLETTFVCVAPLTGNTGLTWEHCHLRHKLQCVLWIPVEGERQIPLAERRVGAPLLWTPSAQEEQALRRDWE
ELMDLIVLGRVESITARHGEVLQLRPKAANSRALTEGIGQRGEPIMTLPRGFYLKKNFTTALLARYFLL

Specific function: Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair [H]

COG id: COG3066

COG function: function code L; DNA mismatch repair protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mutH family [H]

Homologues:

Organism=Escherichia coli, GI1789196, Length=228, Percent_Identity=70.6140350877193, Blast_Score=337, Evalue=4e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004230
- InterPro:   IPR011337
- InterPro:   IPR011335 [H]

Pfam domain/function: PF02976 MutH [H]

EC number: NA

Molecular weight: Translated: 25587; Mature: 25587

Theoretical pI: Translated: 8.95; Mature: 8.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMNEPFPPHSPPVDRQALLQRALRLAGYTYAELAALAGLTIPRDLRRDKGWVGLLLERCL
CCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHH
GASSGSKAQQDFPALGVELKSIPIDAQGRPLETTFVCVAPLTGNTGLTWEHCHLRHKLQC
CCCCCCCCHHCCCHHCEEEEECCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHCCEEEE
VLWIPVEGERQIPLAERRVGAPLLWTPSAQEEQALRRDWEELMDLIVLGRVESITARHGE
EEEEECCCCCCCCHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCC
VLQLRPKAANSRALTEGIGQRGEPIMTLPRGFYLKKNFTTALLARYFLL
EEEECCCCCCCHHHHHHHCCCCCCEEECCCCEEEECCHHHHHHHHHHCC
>Mature Secondary Structure
MMNEPFPPHSPPVDRQALLQRALRLAGYTYAELAALAGLTIPRDLRRDKGWVGLLLERCL
CCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHH
GASSGSKAQQDFPALGVELKSIPIDAQGRPLETTFVCVAPLTGNTGLTWEHCHLRHKLQC
CCCCCCCCHHCCCHHCEEEEECCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHCCEEEE
VLWIPVEGERQIPLAERRVGAPLLWTPSAQEEQALRRDWEELMDLIVLGRVESITARHGE
EEEEECCCCCCCCHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCC
VLQLRPKAANSRALTEGIGQRGEPIMTLPRGFYLKKNFTTALLARYFLL
EEEECCCCCCCHHHHHHHCCCCCCEEECCCCEEEECCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA