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The map label for this gene is ung [H]

Identifier: 238920933

GI number: 238920933

Start: 2956201

End: 2956971

Strand: Direct

Name: ung [H]

Synonym: NT01EI_3061

Alternate gene names: 238920933

Gene position: 2956201-2956971 (Clockwise)

Preceding gene: 238920932

Following gene: 238920935

Centisome position: 77.54

GC content: 60.05

Gene sequence:

>771_bases
ATGCACCGGAAAACCGGGCGCGCACCGGCGCTGCAACCACATGAGAATCAACGAATAAAAACAAAGGAAGTACAGATGAC
CACGTCACTCACCTGGCATGACGTAATCGGTGCCGAGAAAGATCAGCCCTATTTCCGCGACACACTGACCTTTGTTGCCA
CTGAGCGCAGTAATGGTAAGACCATTTATCCTCCGCAGCAGGATGTGTTCAACGCATTCCGCTTTACCGAGTTCAACGAC
GTGAAGGTGGTGATCCTGGGGCAGGATCCCTATCATGGCCCGAATCAGGCGCACGGCCTCTCCTTTTCGGTACTGCCCGG
CGTGCCGACCCCGCCCTCCCTGCAGAATATGTACAAAGAGCTGAAGAGCGACATCCCCGGCTTTGAGATCCCCAGCCATG
GCTATCTGAAAAGCTGGGCCGATCAGGGGGTGCTGCTGCTCAACACCGTACTGACCGTCGAGCGCGGCCAGGCGCACTCT
CACGCCCAGTTGGGCTGGGAGCAGTTTACCGATCGGGTGGTTGAGGCGCTGAACAGCCAGCGCAGCGGCATCGTCTTTCT
GCTGTGGGGCGCCCATGCCCAGAAGAAGGGACGCATCATCGATACCCAGCGCCACCGCGTGCTGAAGGCGCCGCACCCCT
CCCCGCTGTCGGCTCACCGCGGCTTTTTGGGCTGCAGACACTTCTCCATGACCAACCAGCTGCTGCAGGAGCAGGGGATG
GCACCCATCGACTGGCAGCCGCACCTGCCGCAGGATGAGGCGCAGGCATAA

Upstream 100 bases:

>100_bases
AGGGGGTTTTTGCTAAGGAGACGGCGTGAAATGCGCCGCTGGGCGGTTCCCCTGCTAGCGGGGACAGGGTAAGCTACCTT
TAAGGCAGCCCAAAGCCGCA

Downstream 100 bases:

>100_bases
AAAAACCAGCCCGCGGGCTGGTTTTTGCGCCTATTCTGAACCGAATCAGCCTTTCGAGACTGCGACCATCGCCGGGCGGA
TCAGGCGACCGTTCAGGGTA

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG [H]

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MHRKTGRAPALQPHENQRIKTKEVQMTTSLTWHDVIGAEKDQPYFRDTLTFVATERSNGKTIYPPQQDVFNAFRFTEFND
VKVVILGQDPYHGPNQAHGLSFSVLPGVPTPPSLQNMYKELKSDIPGFEIPSHGYLKSWADQGVLLLNTVLTVERGQAHS
HAQLGWEQFTDRVVEALNSQRSGIVFLLWGAHAQKKGRIIDTQRHRVLKAPHPSPLSAHRGFLGCRHFSMTNQLLQEQGM
APIDWQPHLPQDEAQA

Sequences:

>Translated_256_residues
MHRKTGRAPALQPHENQRIKTKEVQMTTSLTWHDVIGAEKDQPYFRDTLTFVATERSNGKTIYPPQQDVFNAFRFTEFND
VKVVILGQDPYHGPNQAHGLSFSVLPGVPTPPSLQNMYKELKSDIPGFEIPSHGYLKSWADQGVLLLNTVLTVERGQAHS
HAQLGWEQFTDRVVEALNSQRSGIVFLLWGAHAQKKGRIIDTQRHRVLKAPHPSPLSAHRGFLGCRHFSMTNQLLQEQGM
APIDWQPHLPQDEAQA
>Mature_256_residues
MHRKTGRAPALQPHENQRIKTKEVQMTTSLTWHDVIGAEKDQPYFRDTLTFVATERSNGKTIYPPQQDVFNAFRFTEFND
VKVVILGQDPYHGPNQAHGLSFSVLPGVPTPPSLQNMYKELKSDIPGFEIPSHGYLKSWADQGVLLLNTVLTVERGQAHS
HAQLGWEQFTDRVVEALNSQRSGIVFLLWGAHAQKKGRIIDTQRHRVLKAPHPSPLSAHRGFLGCRHFSMTNQLLQEQGM
APIDWQPHLPQDEAQA

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI19718751, Length=216, Percent_Identity=59.7222222222222, Blast_Score=263, Evalue=8e-71,
Organism=Homo sapiens, GI6224979, Length=216, Percent_Identity=59.7222222222222, Blast_Score=263, Evalue=1e-70,
Organism=Escherichia coli, GI1788934, Length=227, Percent_Identity=71.3656387665198, Blast_Score=350, Evalue=5e-98,
Organism=Caenorhabditis elegans, GI17556304, Length=244, Percent_Identity=45.4918032786885, Blast_Score=223, Evalue=5e-59,
Organism=Saccharomyces cerevisiae, GI6323620, Length=231, Percent_Identity=47.6190476190476, Blast_Score=192, Evalue=5e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 28949; Mature: 28949

Theoretical pI: Translated: 9.01; Mature: 9.01

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHRKTGRAPALQPHENQRIKTKEVQMTTSLTWHDVIGAEKDQPYFRDTLTFVATERSNGK
CCCCCCCCCCCCCCCCCCCEEEEEEEEECCCHHHHCCCCCCCCHHHHHEEEEEEECCCCC
TIYPPQQDVFNAFRFTEFNDVKVVILGQDPYHGPNQAHGLSFSVLPGVPTPPSLQNMYKE
EECCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHH
LKSDIPGFEIPSHGYLKSWADQGVLLLNTVLTVERGQAHSHAQLGWEQFTDRVVEALNSQ
HHHCCCCCCCCCCCHHHHHHCCCEEEEHHHHHHCCCCCCCHHHHCHHHHHHHHHHHHCCC
RSGIVFLLWGAHAQKKGRIIDTQRHRVLKAPHPSPLSAHRGFLGCRHFSMTNQLLQEQGM
CCCEEEEEECCCCCCCCCEEECCCHHEEECCCCCCCHHHCCHHHHHHHHHHHHHHHHCCC
APIDWQPHLPQDEAQA
CCCCCCCCCCCHHCCC
>Mature Secondary Structure
MHRKTGRAPALQPHENQRIKTKEVQMTTSLTWHDVIGAEKDQPYFRDTLTFVATERSNGK
CCCCCCCCCCCCCCCCCCCEEEEEEEEECCCHHHHCCCCCCCCHHHHHEEEEEEECCCCC
TIYPPQQDVFNAFRFTEFNDVKVVILGQDPYHGPNQAHGLSFSVLPGVPTPPSLQNMYKE
EECCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHH
LKSDIPGFEIPSHGYLKSWADQGVLLLNTVLTVERGQAHSHAQLGWEQFTDRVVEALNSQ
HHHCCCCCCCCCCCHHHHHHCCCEEEEHHHHHHCCCCCCCHHHHCHHHHHHHHHHHHCCC
RSGIVFLLWGAHAQKKGRIIDTQRHRVLKAPHPSPLSAHRGFLGCRHFSMTNQLLQEQGM
CCCEEEEEECCCCCCCCCEEECCCHHEEECCCCCCCHHHCCHHHHHHHHHHHHHHHHCCC
APIDWQPHLPQDEAQA
CCCCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA