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The map label for this gene is purK [H]

Identifier: 238920885

GI number: 238920885

Start: 2898109

End: 2899179

Strand: Direct

Name: purK [H]

Synonym: NT01EI_3012

Alternate gene names: 238920885

Gene position: 2898109-2899179 (Clockwise)

Preceding gene: 238920884

Following gene: 238920888

Centisome position: 76.02

GC content: 62.75

Gene sequence:

>1071_bases
ATGAAGCCGGTTTGCGTACTGGGCGACGGTCAGCTGGGGCGCATGCTGCGTCAGGCCGGAGAGCCGCTGGGGATCCCGGT
CTACCCGGTGGGTATCGAGGCCGATCCGCACAGCGTCCCCTGGCGGCAGGCGGTGATCAGTGCCGAAATCGAGCGCTGGC
CCGATACGCCACTGACCCGCGAATTGGCCCGCCACCCGGGCTTTATCAACCGCGACATCTTCCCACTGCTGGCCGATCGC
TACAGCCAAAAGCAATTGCTGGACGAACTGGGCCTGCCGACGGCGCCCTGGGCGCTGCTGGCCGCGCCAGAACAGTGGCC
CGCCCTGCTTGAACGTCTCGGCCCGCTGGCCATCGTCAAACGCCGCACCGGCGGCTATGACGGACGCGGTCAATGGCATA
TTCGTCCCGGCAATGAAACCCAGCTTGATGACGAGATCTACGGGCAGTGTATCGTCGAGCAAGGGATAAACTTCATCGGC
GAGGTCTCACTGATCGGCGCCCGCGCTCAGGATGGCCGCTGCGTCTTCTATCCCCTCACCCATAACCTGCACCAGGAGGG
CATTCTGCGCGCCAGCCTGGTCTTTCCACAGCCGGAAAGCTTTCTACAGGAGAAGGCGCAGATGATGCTACAGCGCATCA
TGCAGCATCTGGAGTACGTCGGCGTCATGGCGATGGAGTGTTTCGTGGTGGATGATGACACGCTGCTGATTAACGAACTG
GCACCGCGCGTACACAACAGCGGGCATTGGACACAGAACGGCGCTTCGATAAGCCAGTTTGAGCTGCACCTGCGTGCACT
GCTTGGCCTGCCTTTGCCGCACCCGGATGTCTCCACCCCCTCCGTGATGATCAACCTGATCGGCACCGCGCTGAATAACG
CGTGGTTGGATGGCCCGCTGGTACACCTGCACTGGTATGATAAGGCGGTCCATCCGGGACGCAAGGTGGGCCACCTCAAC
CTGAACCACTTTCAATCCCAGCGGCTGGTCAGCGCCCTGGATACCCTGCGCGGCCAGCTGCCGGCAGAGTACCGGGACAT
CCTGGCCTGGGCCAGTACACGGCTGAGCTGA

Upstream 100 bases:

>100_bases
TCCTGGCACTGCATGATGCAGACTTGAGCCGCCGCCTGACCACCTGGCGCCAGGCGCAGACAGATGAGGTACTCAACCAC
CCCGACCCGCGGGAGGACGC

Downstream 100 bases:

>100_bases
GCGTCAGCGCGCAGGGGGGCGGCGCAGCAGCCCTCTCCCCAACCCGGCGCCACACCCCCCTAACAGCAGCGCAGCACCCG
GCGGCAGCAGTAGCCACACC

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MKPVCVLGDGQLGRMLRQAGEPLGIPVYPVGIEADPHSVPWRQAVISAEIERWPDTPLTRELARHPGFINRDIFPLLADR
YSQKQLLDELGLPTAPWALLAAPEQWPALLERLGPLAIVKRRTGGYDGRGQWHIRPGNETQLDDEIYGQCIVEQGINFIG
EVSLIGARAQDGRCVFYPLTHNLHQEGILRASLVFPQPESFLQEKAQMMLQRIMQHLEYVGVMAMECFVVDDDTLLINEL
APRVHNSGHWTQNGASISQFELHLRALLGLPLPHPDVSTPSVMINLIGTALNNAWLDGPLVHLHWYDKAVHPGRKVGHLN
LNHFQSQRLVSALDTLRGQLPAEYRDILAWASTRLS

Sequences:

>Translated_356_residues
MKPVCVLGDGQLGRMLRQAGEPLGIPVYPVGIEADPHSVPWRQAVISAEIERWPDTPLTRELARHPGFINRDIFPLLADR
YSQKQLLDELGLPTAPWALLAAPEQWPALLERLGPLAIVKRRTGGYDGRGQWHIRPGNETQLDDEIYGQCIVEQGINFIG
EVSLIGARAQDGRCVFYPLTHNLHQEGILRASLVFPQPESFLQEKAQMMLQRIMQHLEYVGVMAMECFVVDDDTLLINEL
APRVHNSGHWTQNGASISQFELHLRALLGLPLPHPDVSTPSVMINLIGTALNNAWLDGPLVHLHWYDKAVHPGRKVGHLN
LNHFQSQRLVSALDTLRGQLPAEYRDILAWASTRLS
>Mature_356_residues
MKPVCVLGDGQLGRMLRQAGEPLGIPVYPVGIEADPHSVPWRQAVISAEIERWPDTPLTRELARHPGFINRDIFPLLADR
YSQKQLLDELGLPTAPWALLAAPEQWPALLERLGPLAIVKRRTGGYDGRGQWHIRPGNETQLDDEIYGQCIVEQGINFIG
EVSLIGARAQDGRCVFYPLTHNLHQEGILRASLVFPQPESFLQEKAQMMLQRIMQHLEYVGVMAMECFVVDDDTLLINEL
APRVHNSGHWTQNGASISQFELHLRALLGLPLPHPDVSTPSVMINLIGTALNNAWLDGPLVHLHWYDKAVHPGRKVGHLN
LNHFQSQRLVSALDTLRGQLPAEYRDILAWASTRLS

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=355, Percent_Identity=68.169014084507, Blast_Score=481, Evalue=1e-137,
Organism=Escherichia coli, GI1788155, Length=193, Percent_Identity=29.0155440414508, Blast_Score=70, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324702, Length=369, Percent_Identity=28.1842818428184, Blast_Score=130, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 39907; Mature: 39907

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPVCVLGDGQLGRMLRQAGEPLGIPVYPVGIEADPHSVPWRQAVISAEIERWPDTPLTR
CCCEEEECCCHHHHHHHHCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCCHHHH
ELARHPGFINRDIFPLLADRYSQKQLLDELGLPTAPWALLAAPEQWPALLERLGPLAIVK
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHEEECCHHHHHHHHHCCCEEEEE
RRTGGYDGRGQWHIRPGNETQLDDEIYGQCIVEQGINFIGEVSLIGARAQDGRCVFYPLT
ECCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCHHCCCEEEECCCCCCCEEEEECC
HNLHQEGILRASLVFPQPESFLQEKAQMMLQRIMQHLEYVGVMAMECFVVDDDTLLINEL
CCCCHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCEEEHHHH
APRVHNSGHWTQNGASISQFELHLRALLGLPLPHPDVSTPSVMINLIGTALNNAWLDGPL
HHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCE
VHLHWYDKAVHPGRKVGHLNLNHFQSQRLVSALDTLRGQLPAEYRDILAWASTRLS
EEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKPVCVLGDGQLGRMLRQAGEPLGIPVYPVGIEADPHSVPWRQAVISAEIERWPDTPLTR
CCCEEEECCCHHHHHHHHCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCCHHHH
ELARHPGFINRDIFPLLADRYSQKQLLDELGLPTAPWALLAAPEQWPALLERLGPLAIVK
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHEEECCHHHHHHHHHCCCEEEEE
RRTGGYDGRGQWHIRPGNETQLDDEIYGQCIVEQGINFIGEVSLIGARAQDGRCVFYPLT
ECCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCHHCCCEEEECCCCCCCEEEEECC
HNLHQEGILRASLVFPQPESFLQEKAQMMLQRIMQHLEYVGVMAMECFVVDDDTLLINEL
CCCCHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCEEEHHHH
APRVHNSGHWTQNGASISQFELHLRALLGLPLPHPDVSTPSVMINLIGTALNNAWLDGPL
HHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCE
VHLHWYDKAVHPGRKVGHLNLNHFQSQRLVSALDTLRGQLPAEYRDILAWASTRLS
EEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2464576; 2644189; 9278503; 1534690; 10569930 [H]