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The map label for this gene is ppiB [H]

Identifier: 238920880

GI number: 238920880

Start: 2894525

End: 2895019

Strand: Direct

Name: ppiB [H]

Synonym: NT01EI_3007

Alternate gene names: 238920880

Gene position: 2894525-2895019 (Clockwise)

Preceding gene: 238920878

Following gene: 238920881

Centisome position: 75.93

GC content: 56.16

Gene sequence:

>495_bases
ATGGTTACTTTCCACACCAATCATGGTGACATCGTCATCAAAACCTTTGACGACAAAGCGCCGGCTACCGTTGCCAACTT
CCTGGAATACTGCCGTGACGGCTTCTACGACAACACCATCTTTCACCGCGTGATCGATGGCTTCATGATCCAGGGCGGCG
GTTTCGAGCCGGGCATGAAACAGAAAGCCACCAAGGCACCGATCAAGAATGAAGCCAACAATGGCCTGAAGAATACCCGC
GGCACGCTATCCATGGCGCGCACCAACGATCCGCACTCTGCCACCGCCCAGTTCTTCATCAACGTCGTTGATAACGACTT
CCTCAACTTCCGCTCCGAGCGCCCGGACGGCTGGGGCTATGCCGTATTCGCCGAAGTGGCGGAAGGCATGGACGTGGTCG
ACAAGATCAAGGGCGTCTCCACCGGCCGTAACGGCATGCACCAGGATGTTCCGCGTGAAGACGTGATCATCCAAAGCGTT
ACCGTGAGCGAATAA

Upstream 100 bases:

>100_bases
GGCGCCCGGCGAATATTCCCGGAGAAAGAGGTGCCAGCGGCAGGGGCATCGGCTACAATCATTCCGCTTGCTTCAATCAT
CATAAAACAGGATTATTGTT

Downstream 100 bases:

>100_bases
TCGCCCGGATGGCAACGCTGTTCATCGCTGATTTACACCTCAGCCAACAGGAACCGGCGATCACCGCCGGTTTTCTGCGT
TTTCTTGCCGAAGAGGCCCC

Product: peptidyl-prolyl cis-trans isomerase B (rotamase B)

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 164; Mature: 164

Protein sequence:

>164_residues
MVTFHTNHGDIVIKTFDDKAPATVANFLEYCRDGFYDNTIFHRVIDGFMIQGGGFEPGMKQKATKAPIKNEANNGLKNTR
GTLSMARTNDPHSATAQFFINVVDNDFLNFRSERPDGWGYAVFAEVAEGMDVVDKIKGVSTGRNGMHQDVPREDVIIQSV
TVSE

Sequences:

>Translated_164_residues
MVTFHTNHGDIVIKTFDDKAPATVANFLEYCRDGFYDNTIFHRVIDGFMIQGGGFEPGMKQKATKAPIKNEANNGLKNTR
GTLSMARTNDPHSATAQFFINVVDNDFLNFRSERPDGWGYAVFAEVAEGMDVVDKIKGVSTGRNGMHQDVPREDVIIQSV
TVSE
>Mature_164_residues
MVTFHTNHGDIVIKTFDDKAPATVANFLEYCRDGFYDNTIFHRVIDGFMIQGGGFEPGMKQKATKAPIKNEANNGLKNTR
GTLSMARTNDPHSATAQFFINVVDNDFLNFRSERPDGWGYAVFAEVAEGMDVVDKIKGVSTGRNGMHQDVPREDVIIQSV
TVSE

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=166, Percent_Identity=32.5301204819277, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI24308049, Length=163, Percent_Identity=36.8098159509202, Blast_Score=80, Evalue=8e-16,
Organism=Homo sapiens, GI22547212, Length=164, Percent_Identity=33.5365853658537, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI7657473, Length=164, Percent_Identity=33.5365853658537, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI22547215, Length=164, Percent_Identity=33.5365853658537, Blast_Score=77, Evalue=8e-15,
Organism=Homo sapiens, GI64276486, Length=112, Percent_Identity=39.2857142857143, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI7706339, Length=159, Percent_Identity=32.0754716981132, Blast_Score=70, Evalue=8e-13,
Organism=Homo sapiens, GI310110104, Length=144, Percent_Identity=36.8055555555556, Blast_Score=70, Evalue=8e-13,
Organism=Homo sapiens, GI310129267, Length=143, Percent_Identity=35.6643356643357, Blast_Score=67, Evalue=6e-12,
Organism=Homo sapiens, GI310120620, Length=143, Percent_Identity=35.6643356643357, Blast_Score=67, Evalue=6e-12,
Organism=Homo sapiens, GI5454154, Length=163, Percent_Identity=31.9018404907975, Blast_Score=67, Evalue=9e-12,
Organism=Escherichia coli, GI1786736, Length=164, Percent_Identity=86.5853658536585, Blast_Score=300, Evalue=3e-83,
Organism=Escherichia coli, GI1789763, Length=161, Percent_Identity=55.2795031055901, Blast_Score=171, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17506311, Length=165, Percent_Identity=35.1515151515151, Blast_Score=83, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI71980590, Length=143, Percent_Identity=34.965034965035, Blast_Score=80, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71980594, Length=143, Percent_Identity=34.965034965035, Blast_Score=80, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17532641, Length=165, Percent_Identity=30.9090909090909, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17532643, Length=150, Percent_Identity=38, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17539496, Length=168, Percent_Identity=30.3571428571429, Blast_Score=66, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17506307, Length=158, Percent_Identity=34.8101265822785, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17552780, Length=155, Percent_Identity=34.1935483870968, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320510, Length=168, Percent_Identity=37.5, Blast_Score=68, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6320359, Length=141, Percent_Identity=33.3333333333333, Blast_Score=62, Evalue=5e-11,
Organism=Drosophila melanogaster, GI17986117, Length=146, Percent_Identity=34.2465753424658, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI19922376, Length=165, Percent_Identity=31.5151515151515, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI19922912, Length=165, Percent_Identity=32.7272727272727, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24652460, Length=166, Percent_Identity=29.5180722891566, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18192; Mature: 18192

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTFHTNHGDIVIKTFDDKAPATVANFLEYCRDGFYDNTIFHRVIDGFMIQGGGFEPGMK
CEEEECCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHEEECCCCCCCCCH
QKATKAPIKNEANNGLKNTRGTLSMARTNDPHSATAQFFINVVDNDFLNFRSERPDGWGY
HHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCHHHHHCCCCCCCCCH
AVFAEVAEGMDVVDKIKGVSTGRNGMHQDVPREDVIIQSVTVSE
HHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCC
>Mature Secondary Structure
MVTFHTNHGDIVIKTFDDKAPATVANFLEYCRDGFYDNTIFHRVIDGFMIQGGGFEPGMK
CEEEECCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHEEECCCCCCCCCH
QKATKAPIKNEANNGLKNTRGTLSMARTNDPHSATAQFFINVVDNDFLNFRSERPDGWGY
HHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCHHHHHCCCCCCCCCH
AVFAEVAEGMDVVDKIKGVSTGRNGMHQDVPREDVIIQSVTVSE
HHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2007139; 9278503; 1864365; 9298646; 9600841; 1606970; 8601841 [H]