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The map label for this gene is lpxH

Identifier: 238920881

GI number: 238920881

Start: 2895028

End: 2895807

Strand: Direct

Name: lpxH

Synonym: NT01EI_3008

Alternate gene names: 238920881

Gene position: 2895028-2895807 (Clockwise)

Preceding gene: 238920880

Following gene: 238920883

Centisome position: 75.94

GC content: 61.92

Gene sequence:

>780_bases
ATGGCAACGCTGTTCATCGCTGATTTACACCTCAGCCAACAGGAACCGGCGATCACCGCCGGTTTTCTGCGTTTTCTTGC
CGAAGAGGCCCCCAAGGCAGAAGCCCTGTACATTCTGGGCGACTTTTTCGACTACTGGATAGGTGATGATGACCCCCAGC
CACTGCACCGGCAAGTCGCCGGGGCGCTGCGCCAGCTGAGCGACAACGGCGTTCCCTGTTACTTCATCTGCGGCAACCGC
GATTTTTTACTGGGTAAGTCCTATGCCAAGCGCTGCGGCATGACCCTGCTGCCCGACGAACAGATCATTACGCTGTACGG
TCAGCCTATTCTGCTGCTGCACGGCGATACCCTGTGTAGCGACGATCGCGACTACCAGCGCTACCGACGCCGGGTTCACA
ACCCCCTGCTACAATGGCTGTTCCGCCGCCTTCCCCTGCGCCTGCGCCTGAAGATCGCCGTCGGCATGCGCCAACAGAGC
CAGCGCAGCAACAGCGCCAAGGCGATGACCATCATGGACGTCAACCAGGAGACGGTCTGCGCCACCCTGCGGCGCCACGG
CGTTCAGCGCATGATCCACGGCCATACCCACCGCCCGGCCCTGCACCACTTCAGTCTCGACGATGGCCGTTGCGCCCTGC
GTGCGGTACTGGGTGCCTGGCATACCCACGGTTCGATGATCCGGGTCGATGCACAGGGGATACATCTGATCGAGCTGCCT
GCTCACCCCGCCGAGGACGAGATCATCACGACGCGATTGCGCTCCGCCAACCTGGTCTGA

Upstream 100 bases:

>100_bases
AGATCAAGGGCGTCTCCACCGGCCGTAACGGCATGCACCAGGATGTTCCGCGTGAAGACGTGATCATCCAAAGCGTTACC
GTGAGCGAATAATCGCCCGG

Downstream 100 bases:

>100_bases
TACAACGTTATGTCTGCCTGCACCATGCCCGTCCGGTGCTCATCCTGTCCTTCCCGCAGACAAAACCAGCGAAGCTGAGG
GTCATACCCGGCGGAGTATT

Product: UDP-2,3-diacylglucosamine hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 259; Mature: 258

Protein sequence:

>259_residues
MATLFIADLHLSQQEPAITAGFLRFLAEEAPKAEALYILGDFFDYWIGDDDPQPLHRQVAGALRQLSDNGVPCYFICGNR
DFLLGKSYAKRCGMTLLPDEQIITLYGQPILLLHGDTLCSDDRDYQRYRRRVHNPLLQWLFRRLPLRLRLKIAVGMRQQS
QRSNSAKAMTIMDVNQETVCATLRRHGVQRMIHGHTHRPALHHFSLDDGRCALRAVLGAWHTHGSMIRVDAQGIHLIELP
AHPAEDEIITTRLRSANLV

Sequences:

>Translated_259_residues
MATLFIADLHLSQQEPAITAGFLRFLAEEAPKAEALYILGDFFDYWIGDDDPQPLHRQVAGALRQLSDNGVPCYFICGNR
DFLLGKSYAKRCGMTLLPDEQIITLYGQPILLLHGDTLCSDDRDYQRYRRRVHNPLLQWLFRRLPLRLRLKIAVGMRQQS
QRSNSAKAMTIMDVNQETVCATLRRHGVQRMIHGHTHRPALHHFSLDDGRCALRAVLGAWHTHGSMIRVDAQGIHLIELP
AHPAEDEIITTRLRSANLV
>Mature_258_residues
ATLFIADLHLSQQEPAITAGFLRFLAEEAPKAEALYILGDFFDYWIGDDDPQPLHRQVAGALRQLSDNGVPCYFICGNRD
FLLGKSYAKRCGMTLLPDEQIITLYGQPILLLHGDTLCSDDRDYQRYRRRVHNPLLQWLFRRLPLRLRLKIAVGMRQQSQ
RSNSAKAMTIMDVNQETVCATLRRHGVQRMIHGHTHRPALHHFSLDDGRCALRAVLGAWHTHGSMIRVDAQGIHLIELPA
HPAEDEIITTRLRSANLV

Specific function: Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP

COG id: COG2908

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxH family

Homologues:

Organism=Escherichia coli, GI1786735, Length=240, Percent_Identity=60.8333333333333, Blast_Score=315, Evalue=2e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXH_EDWI9 (C5B8V8)

Other databases:

- EMBL:   CP001600
- RefSeq:   YP_002934396.1
- ProteinModelPortal:   C5B8V8
- GeneID:   7960286
- GenomeReviews:   CP001600_GR
- KEGG:   eic:NT01EI_3008
- OMA:   CHGDTLC
- GO:   GO:0005737
- HAMAP:   MF_00575
- InterPro:   IPR004843
- InterPro:   IPR010138
- TIGRFAMs:   TIGR01854

Pfam domain/function: PF00149 Metallophos

EC number: 3.6.1.-

Molecular weight: Translated: 29503; Mature: 29372

Theoretical pI: Translated: 8.39; Mature: 8.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATLFIADLHLSQQEPAITAGFLRFLAEEAPKAEALYILGDFFDYWIGDDDPQPLHRQVA
CCEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEEHHHHHHCCCCCCCHHHHHHH
GALRQLSDNGVPCYFICGNRDFLLGKSYAKRCGMTLLPDEQIITLYGQPILLLHGDTLCS
HHHHHHCCCCCEEEEEECCCCEEECCHHHHHCCCEECCCCCEEEEECCEEEEEECCCCCC
DDRDYQRYRRRVHNPLLQWLFRRLPLRLRLKIAVGMRQQSQRSNSAKAMTIMDVNQETVC
CCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCHHHHHCCCCCCEEEEEECCHHHHH
ATLRRHGVQRMIHGHTHRPALHHFSLDDGRCALRAVLGAWHTHGSMIRVDAQGIHLIELP
HHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHCCCCEEEEECCCEEEEEEC
AHPAEDEIITTRLRSANLV
CCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure 
ATLFIADLHLSQQEPAITAGFLRFLAEEAPKAEALYILGDFFDYWIGDDDPQPLHRQVA
CEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEEHHHHHHCCCCCCCHHHHHHH
GALRQLSDNGVPCYFICGNRDFLLGKSYAKRCGMTLLPDEQIITLYGQPILLLHGDTLCS
HHHHHHCCCCCEEEEEECCCCEEECCHHHHHCCCEECCCCCEEEEECCEEEEEECCCCCC
DDRDYQRYRRRVHNPLLQWLFRRLPLRLRLKIAVGMRQQSQRSNSAKAMTIMDVNQETVC
CCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCHHHHHCCCCCCEEEEEECCHHHHH
ATLRRHGVQRMIHGHTHRPALHHFSLDDGRCALRAVLGAWHTHGSMIRVDAQGIHLIELP
HHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHCCCCEEEEECCCEEEEEEC
AHPAEDEIITTRLRSANLV
CCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA