Click here to switch to the map view.

The map label for this gene is mrdA [H]

Identifier: 238920816

GI number: 238920816

Start: 2829584

End: 2831479

Strand: Direct

Name: mrdA [H]

Synonym: NT01EI_2942

Alternate gene names: 238920816

Gene position: 2829584-2831479 (Clockwise)

Preceding gene: 238920815

Following gene: 238920817

Centisome position: 74.22

GC content: 59.34

Gene sequence:

>1896_bases
ATGAAACCAGATCGTAACCCCTTTCGTGACTATTCGGCAGAGTCCGCCCTGTTCATCCGTCGTGCGCTGTTCGCTTTCGT
CGGTGTATTGCTGCTGACCGGCGTGCTGCTCGCCAATCTGTACCACCTGCAAATTCTGCGTTTTGAAGACTACAAGACGC
GCTCTAACGAAAACCGCATCAAGTTGGTACCCATCGCCCCCAGCCGCGGCATGATCTACGATCGTAACGGTGCTCCGCTG
GCGTTTAACCGCACCATCTACCAGCTGGAGGTGATCCCGGAAAAGGTTGACGGAATGAAAGCGCAGCTCGATGCGCTGCG
CCCGATCGTCGATCTGACCGATGAGGATCTCGACAACTTCCAAAAGGAGCGTAAACGTTCACGCCGCTTCACCTCGATTC
CGCTGAAGACCGCCCTCAGCGAGGTGCAGGTGGCCCGGTTTGCCGTCAACCAGTTCCGCTTCCCCGGCTTTGAGGTCAAG
GGCTACCAGCGCCGCTACTACCCTTACGGCTCCGCCCTGACCCACGTCATCGGCTATGTCTCAAAAATCAACGACAAAGA
CATCGAGCGTCTGGACAAAGAGAGTAAACTGGCTAACTATGCCGCCACCCACGACATCGGCAAGCTGGGTATCGAACGCT
ACTATGAGGACGTGCTGCACGGCAAAACCGGCTATGAAGAGGTGGAGGTCAACAACCGCGGCAGGGTGATCCGCCAGCTG
CACGAACAACCACCCCAGGCAGGAAAAGATATCTACCTGACGCTGGATCTCAACCTGCAGCGATATATCGAACAGCTGCT
GGTCGGCAGCCGCGCCGCCGTGGTGGTCAGCGATCCGCGCAGCAGTGGGATCCTGGCGCTGGTTTCCACCCCCAGCTATG
ACCCCAACCTGTTCGTCGACGGTATCTCCGGAAAAGATTACCGCGGCCTGCTCAACGACCCCAACCGGCCGCTGATCAAC
CGCGCCACCCAGGGAGTCTATCCTCCCGCTTCGACAGTAAAACCCTACGTCGCGGTCTCGGCGCTCAGCGCCGGTGTTAT
CTCCCGCAACACCACCCTCTTCGATCCCGGCTGGTGGCAACTTCCAGGATCAGAGAAACGTTTCCGCGACTGGAAGAAGT
GGGGCCATGGGCGGCTGAGCGTCACCAAGGCGCTGGAGGAGTCGGCAGACACCTTTTTCTACCAGGTGGCCTACGATATG
GGGATCGACCGCCTGAGCGAATGGCTGTCCAAGTTCGGCTATGGCCAGTATACCGGAATCGATCTGTCCGAGGAGCGCTC
CGGCCTGATGCCGACCCGCGAATGGAAGTTCAAGCGCTACAAGAAACCCTGGTATCAGGGCGATACCATCCCGGTCGGCA
TCGGCCAGGGCTACTGGACCGCCACCCCGATCCAGATGGCCAAGGCACTCAATACCCTGATCAACGATGGCAACATCAAG
GTACCGCATCTGCTGATGAGCACCCGCATCAACGGTCAGCAGGTGCCGTTCCGCCAGCAGGAGAGTCAGCAGATAGGTGA
TATTCACTCCGGCTTCTGGGAGATCGCCAAAGATGGCATGTTCGGCGTGGCCAACCGCCCCAATGGCACCGGTTACAAGT
ATTTTGGCAGCGCACCATATAAAATCGCCGCCAAGTCCGGTACCGCCCAGGTCTTCGGCTATGAGACCTACAACGCGCAC
ACCATCGCCGAACACCTGCGCGACCATAAGCTGATGACCGCCTTTGCCCCCTATGACAACCCGCAGGTGTCGGTGGCGAT
CATCCTGGAGAACGGCGGCGCCGGACCGGCGGTGGGCACCATTATGCGCCAGATCCTGGATCACATCATGCTGGGCGACA
ACAATACCCAGCTTCCCAATGCAGCCCCCACGCCCCCCGGCGTGGAGGGCGACTGA

Upstream 100 bases:

>100_bases
TTACGGCCAATCACCCTTATCATCGTGAGTAATCGCCTGCCGGCCATGCCGGCAATAATGATGTTAATCCCGGCAGTACG
CCTGAGCATGACGGAACGGA

Downstream 100 bases:

>100_bases
CAGGCATACGGATTCACCATGACTGAGAATCAACAAAAGCGCTCAATCTGGGCCAAGATGCATATCGACCTGCCCTTCCT
GCTCTGCATTCTGGCGGTGC

Product: penicillin-binding protein 2

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 631; Mature: 631

Protein sequence:

>631_residues
MKPDRNPFRDYSAESALFIRRALFAFVGVLLLTGVLLANLYHLQILRFEDYKTRSNENRIKLVPIAPSRGMIYDRNGAPL
AFNRTIYQLEVIPEKVDGMKAQLDALRPIVDLTDEDLDNFQKERKRSRRFTSIPLKTALSEVQVARFAVNQFRFPGFEVK
GYQRRYYPYGSALTHVIGYVSKINDKDIERLDKESKLANYAATHDIGKLGIERYYEDVLHGKTGYEEVEVNNRGRVIRQL
HEQPPQAGKDIYLTLDLNLQRYIEQLLVGSRAAVVVSDPRSSGILALVSTPSYDPNLFVDGISGKDYRGLLNDPNRPLIN
RATQGVYPPASTVKPYVAVSALSAGVISRNTTLFDPGWWQLPGSEKRFRDWKKWGHGRLSVTKALEESADTFFYQVAYDM
GIDRLSEWLSKFGYGQYTGIDLSEERSGLMPTREWKFKRYKKPWYQGDTIPVGIGQGYWTATPIQMAKALNTLINDGNIK
VPHLLMSTRINGQQVPFRQQESQQIGDIHSGFWEIAKDGMFGVANRPNGTGYKYFGSAPYKIAAKSGTAQVFGYETYNAH
TIAEHLRDHKLMTAFAPYDNPQVSVAIILENGGAGPAVGTIMRQILDHIMLGDNNTQLPNAAPTPPGVEGD

Sequences:

>Translated_631_residues
MKPDRNPFRDYSAESALFIRRALFAFVGVLLLTGVLLANLYHLQILRFEDYKTRSNENRIKLVPIAPSRGMIYDRNGAPL
AFNRTIYQLEVIPEKVDGMKAQLDALRPIVDLTDEDLDNFQKERKRSRRFTSIPLKTALSEVQVARFAVNQFRFPGFEVK
GYQRRYYPYGSALTHVIGYVSKINDKDIERLDKESKLANYAATHDIGKLGIERYYEDVLHGKTGYEEVEVNNRGRVIRQL
HEQPPQAGKDIYLTLDLNLQRYIEQLLVGSRAAVVVSDPRSSGILALVSTPSYDPNLFVDGISGKDYRGLLNDPNRPLIN
RATQGVYPPASTVKPYVAVSALSAGVISRNTTLFDPGWWQLPGSEKRFRDWKKWGHGRLSVTKALEESADTFFYQVAYDM
GIDRLSEWLSKFGYGQYTGIDLSEERSGLMPTREWKFKRYKKPWYQGDTIPVGIGQGYWTATPIQMAKALNTLINDGNIK
VPHLLMSTRINGQQVPFRQQESQQIGDIHSGFWEIAKDGMFGVANRPNGTGYKYFGSAPYKIAAKSGTAQVFGYETYNAH
TIAEHLRDHKLMTAFAPYDNPQVSVAIILENGGAGPAVGTIMRQILDHIMLGDNNTQLPNAAPTPPGVEGD
>Mature_631_residues
MKPDRNPFRDYSAESALFIRRALFAFVGVLLLTGVLLANLYHLQILRFEDYKTRSNENRIKLVPIAPSRGMIYDRNGAPL
AFNRTIYQLEVIPEKVDGMKAQLDALRPIVDLTDEDLDNFQKERKRSRRFTSIPLKTALSEVQVARFAVNQFRFPGFEVK
GYQRRYYPYGSALTHVIGYVSKINDKDIERLDKESKLANYAATHDIGKLGIERYYEDVLHGKTGYEEVEVNNRGRVIRQL
HEQPPQAGKDIYLTLDLNLQRYIEQLLVGSRAAVVVSDPRSSGILALVSTPSYDPNLFVDGISGKDYRGLLNDPNRPLIN
RATQGVYPPASTVKPYVAVSALSAGVISRNTTLFDPGWWQLPGSEKRFRDWKKWGHGRLSVTKALEESADTFFYQVAYDM
GIDRLSEWLSKFGYGQYTGIDLSEERSGLMPTREWKFKRYKKPWYQGDTIPVGIGQGYWTATPIQMAKALNTLINDGNIK
VPHLLMSTRINGQQVPFRQQESQQIGDIHSGFWEIAKDGMFGVANRPNGTGYKYFGSAPYKIAAKSGTAQVFGYETYNAH
TIAEHLRDHKLMTAFAPYDNPQVSVAIILENGGAGPAVGTIMRQILDHIMLGDNNTQLPNAAPTPPGVEGD

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=628, Percent_Identity=81.8471337579618, Blast_Score=1080, Evalue=0.0,
Organism=Escherichia coli, GI1786272, Length=633, Percent_Identity=24.8025276461295, Blast_Score=142, Evalue=5e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 71092; Mature: 71092

Theoretical pI: Translated: 9.49; Mature: 9.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPDRNPFRDYSAESALFIRRALFAFVGVLLLTGVLLANLYHLQILRFEDYKTRSNENRI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCEE
KLVPIAPSRGMIYDRNGAPLAFNRTIYQLEVIPEKVDGMKAQLDALRPIVDLTDEDLDNF
EEEEECCCCCEEECCCCCCEEECCEEEEEEECCHHHCCHHHHHHHHHHHHHCCHHHHHHH
QKERKRSRRFTSIPLKTALSEVQVARFAVNQFRFPGFEVKGYQRRYYPYGSALTHVIGYV
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEECCCEEEECCCHHHHHHHHHHH
SKINDKDIERLDKESKLANYAATHDIGKLGIERYYEDVLHGKTGYEEVEVNNRGRVIRQL
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHH
HEQPPQAGKDIYLTLDLNLQRYIEQLLVGSRAAVVVSDPRSSGILALVSTPSYDPNLFVD
HHCCCCCCCEEEEEEECCHHHHHHHHHCCCCEEEEEECCCCCCEEEEEECCCCCCCEEEE
GISGKDYRGLLNDPNRPLINRATQGVYPPASTVKPYVAVSALSAGVISRNTTLFDPGWWQ
CCCCCCCCCCCCCCCCCHHHHHHCCCCCCHHHCCHHHHHHHHHHHHEECCCEEECCCCEE
LPGSEKRFRDWKKWGHGRLSVTKALEESADTFFYQVAYDMGIDRLSEWLSKFGYGQYTGI
CCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHEEEEHHHHHCHHHHHHHHHHCCCCCEECC
DLSEERSGLMPTREWKFKRYKKPWYQGDTIPVGIGQGYWTATPIQMAKALNTLINDGNIK
CCCHHHCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEE
VPHLLMSTRINGQQVPFRQQESQQIGDIHSGFWEIAKDGMFGVANRPNGTGYKYFGSAPY
ECHHHEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCEEEECCCCE
KIAAKSGTAQVFGYETYNAHTIAEHLRDHKLMTAFAPYDNPQVSVAIILENGGAGPAVGT
EEEECCCCEEEEEEECCCHHHHHHHHHCCCEEEEECCCCCCCEEEEEEEECCCCCHHHHH
IMRQILDHIMLGDNNTQLPNAAPTPPGVEGD
HHHHHHHHHEECCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKPDRNPFRDYSAESALFIRRALFAFVGVLLLTGVLLANLYHLQILRFEDYKTRSNENRI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCEE
KLVPIAPSRGMIYDRNGAPLAFNRTIYQLEVIPEKVDGMKAQLDALRPIVDLTDEDLDNF
EEEEECCCCCEEECCCCCCEEECCEEEEEEECCHHHCCHHHHHHHHHHHHHCCHHHHHHH
QKERKRSRRFTSIPLKTALSEVQVARFAVNQFRFPGFEVKGYQRRYYPYGSALTHVIGYV
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEECCCEEEECCCHHHHHHHHHHH
SKINDKDIERLDKESKLANYAATHDIGKLGIERYYEDVLHGKTGYEEVEVNNRGRVIRQL
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHH
HEQPPQAGKDIYLTLDLNLQRYIEQLLVGSRAAVVVSDPRSSGILALVSTPSYDPNLFVD
HHCCCCCCCEEEEEEECCHHHHHHHHHCCCCEEEEEECCCCCCEEEEEECCCCCCCEEEE
GISGKDYRGLLNDPNRPLINRATQGVYPPASTVKPYVAVSALSAGVISRNTTLFDPGWWQ
CCCCCCCCCCCCCCCCCHHHHHHCCCCCCHHHCCHHHHHHHHHHHHEECCCEEECCCCEE
LPGSEKRFRDWKKWGHGRLSVTKALEESADTFFYQVAYDMGIDRLSEWLSKFGYGQYTGI
CCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHEEEEHHHHHCHHHHHHHHHHCCCCCEECC
DLSEERSGLMPTREWKFKRYKKPWYQGDTIPVGIGQGYWTATPIQMAKALNTLINDGNIK
CCCHHHCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEE
VPHLLMSTRINGQQVPFRQQESQQIGDIHSGFWEIAKDGMFGVANRPNGTGYKYFGSAPY
ECHHHEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCEEEECCCCE
KIAAKSGTAQVFGYETYNAHTIAEHLRDHKLMTAFAPYDNPQVSVAIILENGGAGPAVGT
EEEECCCCEEEEEEECCCHHHHHHHHHCCCEEEEECCCCCCCEEEEEEEECCCCCHHHHH
IMRQILDHIMLGDNNTQLPNAAPTPPGVEGD
HHHHHHHHHEECCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]