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The map label for this gene is ygjF [H]

Identifier: 238896572

GI number: 238896572

Start: 4551608

End: 4552114

Strand: Reverse

Name: ygjF [H]

Synonym: KP1_4767

Alternate gene names: 238896572

Gene position: 4552114-4551608 (Counterclockwise)

Preceding gene: 238896574

Following gene: 238896568

Centisome position: 86.73

GC content: 63.31

Gene sequence:

>507_bases
ATGATTAGCGATATCCTTGCGCCGGGCCTGCGCGTTGTCTTTTGCGGTATCAACCCGGGGAAGTCCTCCGCCCATACCGG
CTTTCATTTTGCCCATCCTGGCAATCGCTTCTGGAAGGTCATCCATCAGGCCGGGTTCACCGATCGGCAGCTCAGGCCGG
AAGAGGAGCTGCAGCTGCTGGATACGCGCTGCGGCATCACCATGCTGGTAGAGCGTCCGACGGTGCAGGCCAGCGAGGTC
GCCTTGCAGGAGTTACGCAGCGGCGGCCGTGAGCTGGTGCGGAAGATTGAGGAGTATCAGCCGCAGGCGCTGGCGGTGCT
CGGCAAGCAGGCCTTCGAGCTGGCCTTTAACCAGCGCGGCGCGAAGTGGGGGAAACAGGCCATGACCATCGGGACGACCC
AGGTGTGGGTGCTGCCTAATCCCAGCGGCTTAAACCGGGCGACGCTCGATAAGCTGGTGGCGGCCTATCGTGAACTGGAC
GATGCCCTGGCAACCCGCGGCCAGTAG

Upstream 100 bases:

>100_bases
GGCGATTGCAATCCAGCGTAAAGCGCGCAGCTGCTGTTTTTATAAACAATGCATTTTCAATCCTTTATAATCATGTTTTA
GCCATACAGCCGGAGAAAAC

Downstream 100 bases:

>100_bases
CGGAGAGAGGCGACTTTCCCGGGATGGCCACCTGAACGCCATAAAAAAAGCTCCCCGCAGGGAGCTTTTTAACAGGCTGT
AGACGATGCCCCGCGACGAT

Product: G/U mismatch-specific DNA glycosylase

Products: NA

Alternate protein names: Double-strand-specific uracil glycosylase; Mismatch-specific uracil DNA-glycosylase; MUG [H]

Number of amino acids: Translated: 168; Mature: 168

Protein sequence:

>168_residues
MISDILAPGLRVVFCGINPGKSSAHTGFHFAHPGNRFWKVIHQAGFTDRQLRPEEELQLLDTRCGITMLVERPTVQASEV
ALQELRSGGRELVRKIEEYQPQALAVLGKQAFELAFNQRGAKWGKQAMTIGTTQVWVLPNPSGLNRATLDKLVAAYRELD
DALATRGQ

Sequences:

>Translated_168_residues
MISDILAPGLRVVFCGINPGKSSAHTGFHFAHPGNRFWKVIHQAGFTDRQLRPEEELQLLDTRCGITMLVERPTVQASEV
ALQELRSGGRELVRKIEEYQPQALAVLGKQAFELAFNQRGAKWGKQAMTIGTTQVWVLPNPSGLNRATLDKLVAAYRELD
DALATRGQ
>Mature_168_residues
MISDILAPGLRVVFCGINPGKSSAHTGFHFAHPGNRFWKVIHQAGFTDRQLRPEEELQLLDTRCGITMLVERPTVQASEV
ALQELRSGGRELVRKIEEYQPQALAVLGKQAFELAFNQRGAKWGKQAMTIGTTQVWVLPNPSGLNRATLDKLVAAYRELD
DALATRGQ

Specific function: Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone o

COG id: COG3663

COG function: function code L; G:T/U mismatch-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TDG/mug DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI59853162, Length=151, Percent_Identity=33.112582781457, Blast_Score=86, Evalue=2e-17,
Organism=Escherichia coli, GI1789449, Length=168, Percent_Identity=73.8095238095238, Blast_Score=270, Evalue=3e-74,
Organism=Drosophila melanogaster, GI21356805, Length=144, Percent_Identity=33.3333333333333, Blast_Score=97, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015637
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.28 [H]

Molecular weight: Translated: 18636; Mature: 18636

Theoretical pI: Translated: 9.27; Mature: 9.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISDILAPGLRVVFCGINPGKSSAHTGFHFAHPGNRFWKVIHQAGFTDRQLRPEEELQLL
CCCHHHCCCCEEEEECCCCCCCCCCCCEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHH
DTRCGITMLVERPTVQASEVALQELRSGGRELVRKIEEYQPQALAVLGKQAFELAFNQRG
HHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
AKWGKQAMTIGTTQVWVLPNPSGLNRATLDKLVAAYRELDDALATRGQ
HHHCCHHEEECCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MISDILAPGLRVVFCGINPGKSSAHTGFHFAHPGNRFWKVIHQAGFTDRQLRPEEELQLL
CCCHHHCCCCEEEEECCCCCCCCCCCCEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHH
DTRCGITMLVERPTVQASEVALQELRSGGRELVRKIEEYQPQALAVLGKQAFELAFNQRG
HHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
AKWGKQAMTIGTTQVWVLPNPSGLNRATLDKLVAAYRELDDALATRGQ
HHHCCHHEEECCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA