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The map label for this gene is folB [H]

Identifier: 238896558

GI number: 238896558

Start: 4537863

End: 4538249

Strand: Reverse

Name: folB [H]

Synonym: KP1_4749

Alternate gene names: 238896558

Gene position: 4538249-4537863 (Counterclockwise)

Preceding gene: 238896568

Following gene: 238896557

Centisome position: 86.47

GC content: 50.9

Gene sequence:

>387_bases
GTGATGGATATTGTATTTATAGAGCAACTTTCGGTAATCACCACCATTGGTGTTTATGACTGGGAACAAACCATTGAGCA
GAAGCTGGTGTTCGATATCGAAATTGCATGGGATAACCGCAAGGCGGCCGCCAGCGATGATGTCAGCGATTGCCTCAGCT
ATGCTGATATCAGCGAGCGCGTGATTGCGCATGTGGAGGGGGGAAAATTTGCGTTAGTGGAGCGGGTGGCGGAAGAGGTG
GCCGACCTGCTGCTGGAAACATTCCAGTCGCCATGGGTGCGCATAAAAGTCAGCAAACCTGGCGCCGTGGCTCGCGCGGC
AAACGTCGGGGTGATTATTGAACGTGGCCTTAATCTGAAACAAAACTTTTCAGGTCATACTTGTTAA

Upstream 100 bases:

>100_bases
CTGTTCCGTTTTGAAAATGTCGTTGTATTCTCTGCATCTGTGGATAATACGCATAATTCGCCGGAAGTGGTATCCGGTTT
AGCTAAAAAGCAGGCAGGGC

Downstream 100 bases:

>100_bases
ACAAATTGCGTTTATACCGGTCATAGCATCCGGTCATCAGGCAATTTTACTGGCGATGTCCTTCCAGAACGGTGGACGAA
TCCGTGTGTACTTCCTGTAC

Product: bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase

Products: NA

Alternate protein names: DHNA [H]

Number of amino acids: Translated: 128; Mature: 128

Protein sequence:

>128_residues
MMDIVFIEQLSVITTIGVYDWEQTIEQKLVFDIEIAWDNRKAAASDDVSDCLSYADISERVIAHVEGGKFALVERVAEEV
ADLLLETFQSPWVRIKVSKPGAVARAANVGVIIERGLNLKQNFSGHTC

Sequences:

>Translated_128_residues
MMDIVFIEQLSVITTIGVYDWEQTIEQKLVFDIEIAWDNRKAAASDDVSDCLSYADISERVIAHVEGGKFALVERVAEEV
ADLLLETFQSPWVRIKVSKPGAVARAANVGVIIERGLNLKQNFSGHTC
>Mature_128_residues
MMDIVFIEQLSVITTIGVYDWEQTIEQKLVFDIEIAWDNRKAAASDDVSDCLSYADISERVIAHVEGGKFALVERVAEEV
ADLLLETFQSPWVRIKVSKPGAVARAANVGVIIERGLNLKQNFSGHTC

Specific function: Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. Can use L-threo-dihydroneopterin and D-erythro-dihydroneopterin as substrates for the formation of 6-hydroxymethyldihydropterin, but it can also catalyze the epimeriza

COG id: COG1539

COG function: function code H; Dihydroneopterin aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHNA family [H]

Homologues:

Organism=Escherichia coli, GI87082204, Length=121, Percent_Identity=86.7768595041322, Blast_Score=216, Evalue=3e-58,
Organism=Escherichia coli, GI1788641, Length=110, Percent_Identity=28.1818181818182, Blast_Score=62, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006156
- InterPro:   IPR006157 [H]

Pfam domain/function: PF02152 FolB [H]

EC number: =4.1.2.25 [H]

Molecular weight: Translated: 14224; Mature: 14224

Theoretical pI: Translated: 4.40; Mature: 4.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMDIVFIEQLSVITTIGVYDWEQTIEQKLVFDIEIAWDNRKAAASDDVSDCLSYADISER
CCCCHHHHHHHHHHHHCCCCHHHHHHHHEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHH
VIAHVEGGKFALVERVAEEVADLLLETFQSPWVRIKVSKPGAVARAANVGVIIERGLNLK
HHEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHCCCCEEEECCCCCC
QNFSGHTC
CCCCCCCC
>Mature Secondary Structure
MMDIVFIEQLSVITTIGVYDWEQTIEQKLVFDIEIAWDNRKAAASDDVSDCLSYADISER
CCCCHHHHHHHHHHHHCCCCHHHHHHHHEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHH
VIAHVEGGKFALVERVAEEVADLLLETFQSPWVRIKVSKPGAVARAANVGVIIERGLNLK
HHEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHCCCCEEEECCCCCC
QNFSGHTC
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]