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The map label for this gene is acrR [H]

Identifier: 238893433

GI number: 238893433

Start: 1273954

End: 1274604

Strand: Direct

Name: acrR [H]

Synonym: KP1_1321

Alternate gene names: 238893433

Gene position: 1273954-1274604 (Clockwise)

Preceding gene: 238893426

Following gene: 238893434

Centisome position: 24.27

GC content: 51.46

Gene sequence:

>651_bases
ATGGCACGAAAAACCAAACAACAGGCACGTGAAACCCGGCAACTGATTCTGGATGTTGCTCTGCGTCTGTTTTCGCAGCA
AGGCGTATCATCTACCTCGTTGGCAACAATTGCAAAAGCTGCGGGTGTAACGAGGGGGGCTATCTACTGGCATTTCAAGA
ATAAATCAGATTTATTCAACGAAATTTGGGAGCTGTCAGACGCCAGTATTAGCGATCTCGAAATTGAGTATCGGGCAAAA
TTCCCCAACGATCCACTCTCAGTTATCAGGGAGATTCTAGTCTATGTTCTTGAAGCGACAGTGACAGAAGAACGTCGACG
ATTAATGATGGAGATTATCTATCATAAGTGTGAGTTCGTCGGTGAAATGACCGTGGTGCAGCAGGCCCAGCGGCAGCTCT
CCCTGGCGAGTTATGAGCGTATCGAGCAGACCTTGAAAGAATGCATCGCGGCGAAGCTGCTGCCCGCCAATTTACTCACC
CGGCGGGCGGCCGTGTTAATGCGCAGCTACCTTTCCGGGCTGATGGAAAACTGGCTGTTTGCCCCCGATTCGTTCGACCT
GCATGCGGAAGCGCGGGACTACGTCGCTATTCTGCTGGAGATGTATCAATTCTGCCCGACGCTACGCGGCCCGGAGAGCT
TGTCAGCTTAA

Upstream 100 bases:

>100_bases
AAACAACCACAAACCCACTACAGTCTTTCTATTATGGTCATGCTATGGTACATACATTCACAAATGTATGTAAACGTAAC
CTCTGTAAAGTCATTAACCT

Downstream 100 bases:

>100_bases
AGGTAGCGCGCGGATGGGCGTGAATTTTTAGCGCCGTCCGCCGCTATTCGCCAGCGCTGAGAAGTGCTATTCTGCGCGCT
TGCGACGACCCCCGGTATTC

Product: DNA-binding transcriptional repressor AcrR

Products: NA

Alternate protein names: Potential acrAB operon repressor [H]

Number of amino acids: Translated: 216; Mature: 215

Protein sequence:

>216_residues
MARKTKQQARETRQLILDVALRLFSQQGVSSTSLATIAKAAGVTRGAIYWHFKNKSDLFNEIWELSDASISDLEIEYRAK
FPNDPLSVIREILVYVLEATVTEERRRLMMEIIYHKCEFVGEMTVVQQAQRQLSLASYERIEQTLKECIAAKLLPANLLT
RRAAVLMRSYLSGLMENWLFAPDSFDLHAEARDYVAILLEMYQFCPTLRGPESLSA

Sequences:

>Translated_216_residues
MARKTKQQARETRQLILDVALRLFSQQGVSSTSLATIAKAAGVTRGAIYWHFKNKSDLFNEIWELSDASISDLEIEYRAK
FPNDPLSVIREILVYVLEATVTEERRRLMMEIIYHKCEFVGEMTVVQQAQRQLSLASYERIEQTLKECIAAKLLPANLLT
RRAAVLMRSYLSGLMENWLFAPDSFDLHAEARDYVAILLEMYQFCPTLRGPESLSA
>Mature_215_residues
ARKTKQQARETRQLILDVALRLFSQQGVSSTSLATIAKAAGVTRGAIYWHFKNKSDLFNEIWELSDASISDLEIEYRAKF
PNDPLSVIREILVYVLEATVTEERRRLMMEIIYHKCEFVGEMTVVQQAQRQLSLASYERIEQTLKECIAAKLLPANLLTR
RAAVLMRSYLSGLMENWLFAPDSFDLHAEARDYVAILLEMYQFCPTLRGPESLSA

Specific function: Potential regulator protein for the acrAB genes [H]

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786669, Length=211, Percent_Identity=80.5687203791469, Blast_Score=364, Evalue=1e-102,
Organism=Escherichia coli, GI1789664, Length=203, Percent_Identity=36.4532019704434, Blast_Score=133, Evalue=9e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR013572
- InterPro:   IPR001647 [H]

Pfam domain/function: PF08361 TetR_C_2; PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 24756; Mature: 24625

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS01081 HTH_TETR_1 ; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARKTKQQARETRQLILDVALRLFSQQGVSSTSLATIAKAAGVTRGAIYWHFKNKSDLFN
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEECCHHHHHH
EIWELSDASISDLEIEYRAKFPNDPLSVIREILVYVLEATVTEERRRLMMEIIYHKCEFV
HHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GEMTVVQQAQRQLSLASYERIEQTLKECIAAKLLPANLLTRRAAVLMRSYLSGLMENWLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
APDSFDLHAEARDYVAILLEMYQFCPTLRGPESLSA
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
ARKTKQQARETRQLILDVALRLFSQQGVSSTSLATIAKAAGVTRGAIYWHFKNKSDLFN
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEECCHHHHHH
EIWELSDASISDLEIEYRAKFPNDPLSVIREILVYVLEATVTEERRRLMMEIIYHKCEFV
HHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GEMTVVQQAQRQLSLASYERIEQTLKECIAAKLLPANLLTRRAAVLMRSYLSGLMENWLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
APDSFDLHAEARDYVAILLEMYQFCPTLRGPESLSA
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]