| Definition | Klebsiella pneumoniae NTUH-K2044 chromosome, complete genome. |
|---|---|
| Accession | NC_012731 |
| Length | 5,248,520 |
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The map label for this gene is thrA [H]
Identifier: 238892989
GI number: 238892989
Start: 797878
End: 800382
Strand: Direct
Name: thrA [H]
Synonym: KP1_0820
Alternate gene names: 238892989
Gene position: 797878-800382 (Clockwise)
Preceding gene: 238892988
Following gene: 238892990
Centisome position: 15.2
GC content: 59.4
Gene sequence:
>2505_bases GTGCGGGCTTTTTTTTTGACAAGAGATCAAGGGGTAAGAACCATGCGAGTGTTGAAGTTCGGCGGTACATCAGTGGCAAA TGCGGAACGGTTTCTGCGGGTTGCCGATATTCTGGAGAGTAATGCCAGGCAGGGGCAGGTAGCGACGGTCCTGTCTGCCC CGGCGAAGATCACTAACCACCTGGTAGCGATGATTGAAAAGACCATTGGCGGCCAGGATGCCCTCCCCAATATTGCCGAC GCCGAACGCATTTTTGCCGAACTTCTTCAGGGCCTTGCCGACGCCCAGCCCGCTTTCCCGCTTGCCCAGTTAAAAGCCTT CGTGGAGCAGGAATTTGCTCAGATTAAGCATGTTCTGCACGGCATCAGCCTGCTGGGTCAGTGCCCGGACAGCGTCAATG CCGCGCTGATCTGCCGCGGCGAAAAGCTCTCCATCGCCATCATGGCGGGTCTGCTGGAAGCTCGTGGACATAAAGTCAGT GTCATTAACCCGGTCGAAAAACTGCTTGCCGTGGGCCACTATCTGGAATCCACCGTCGATATCGCCGAATCCACCCGCCG CATTGCCGCCAGCCAGATCCCGGCAGACCATATGATCCTGATGGCCGGGTTTACCGCCGGCAATGAGAAAGGCGAGCTGG TGGTGCTGGGGCGTAACGGCTCCGACTACTCGGCTGCGGTACTGGCCGCCTGCCTGCGCGCTGACTGCTGCGAAATCTGG ACCGATGTCGACGGAGTGTACACCTGCGATCCGCGTCAGGTGCCGGATGCGCGCCTGCTGAAATCGATGTCTTATCAGGA GGCGATGGAGCTCTCCTACTTTGGCGCGAAAGTGCTGCACCCGCGCACCATCGCCCCTATCGCCCAGTTCCAAATCCCAT GCCTGATTAAAAATACCGGCAACCCGCAGGCGCCGGGAACGCTTATCGGCGCCAGCCGCGACGAGGACGATTTGCCGGTG AAAGGCATCTCTAACCTCAACAACATGGCGATGTTCAACGTCTCCGGGCCGGGGATGAAAGGGATGGTCGGCATGGCGGC CCGCGTCTTCGCCACCATGTCCCGCGCCGGCATCTCGGTGGTGTTGATCACTCAATCTTCTTCCGAGTACAGCATCAGTT TCTGCGTGCCGCAGAGCGACTGCGCACGTGCCAAACGGGCGATGGAAGATGAGTTTTATCTGGAGCTGAAAGAGGGGCTG CTGGAGCCGCTGGCGATTATGGAGCGTCTGGCGATCATCTCCGTGGTGGGCGACGGAATGCGTACCCTGCGCGGTATCTC GGCGAAATTCTTTGCGGCACTGGCCCGCGCCAATATCAATATCGTGGCGATTGCCCAGGGCTCTTCCGAGCGCTCAATTT CGGTAGTGGTCAGCAATGACGACGCCACCACCGGCGTGCGCGTGACCCATCAGATGCTGTTCAACACCGACCAGGTGATT GAAGTGTTTGTCATCGGCGTCGGCGGCGTCGGCGGCGCGCTGCTAGAGCAGATCAAGCGCCAGCAGGGGTGGCTGAAGAA CAAACATATCGATCTGCGCGTCTGCGGTGTAGCCAATTCTCAGGCGCTGCTGACCAGCGTGCATGGCCTGAATCTGGAAA ACTGGAGTGCGGAACTGGCGGAGGCGAAAGAGCCGTTTAATCTTGGCCGCCTGATCCGCCTGGTGAAAGAGTACCACCTG CTCAATCCGGTGATCGTCGACTGTACCTCCAGCCAGGCGGTCGCCGATCAGTATGCCGACTTCCTGCGCGAAGGTTTCCA TGTGGTGACGCCGAACAAAAAGGCCAATACCTCTTCGCTGGATTACTATCACCAGCTGCGCCATGCGGCCAGCAGCTCGC GGCGTAAGTTCCTCTATGACACTAACGTTGGCGCGGGCCTGCCGGTGATTGAGAACCTGCAGAACCTGCTCAACGCCGGC GATGAGCTGCGCCATTTCTCCGGGATCCTGTCCGGCTCCCTGTCGTTTATCTTCGGCAAGCTGGACGAGGGGGTGAGTTT CTCCGCGGCGACGGCGATGGCCCGTGAGATGGGGTATACCGAGCCGGATCCGCGCGACGATTTATCCGGGGTGGATGTGG CGCGTAAACTGCTGATTCTGGCCCGTGAGACCGGGCGTGAACTGGAGCTGGCGGACATTATCGTCGAGTCGGCGCTGCCG CCGGACTTCGACGCCAGCGGCGATGTCGAGACCTTTATGGCCCGCCTGCCGTCGCTGGACGATGGTTTTGCCTCGCGGGT TGCTAAGGCGCGCGATGAAGGTAAAGTCTTGCGCTACGTCGGTAACATCGAAGAGGATGGTACCTGCCGGGTAAAAATAG CCGCGGTTGACGGCAACGATCCGCTGTTCAAAGTTAAGAATGGTGAGAACGCGCTGGCTTTTTATAGCCATTATTATCAG CCATTGCCGCTGGTGCTGCGCGGCTATGGCGCCGGGAACGACGTCACGGCGGCCGGCGTATTCGCCGACCTGCTGCGCAC CCTGTCCTGGAAGTTAGGAGTTTAA
Upstream 100 bases:
>100_bases CATCGGCATGATTACCACCATTATCACCACCACCATTACCACAGGTAACGGTGCGGGCTGACGCGTACAGGAAACACAGA AAAAAGCCCGCACCTGAACA
Downstream 100 bases:
>100_bases GATGGTCAAAGTATATGCCCCGGCTTCCAGTGCCAATATGAGCGTCGGGTTTGATGTGTTGGGCGCGGCGGTCACGCCGG TCGATGGCACGCTGCTTGGC
Product: bifunctional aspartokinase I/homoserine dehydrogenase I
Products: NA
Alternate protein names: Aspartokinase I/homoserine dehydrogenase I; AKI-HDI; Aspartokinase; Homoserine dehydrogenase [H]
Number of amino acids: Translated: 834; Mature: 834
Protein sequence:
>834_residues MRAFFLTRDQGVRTMRVLKFGGTSVANAERFLRVADILESNARQGQVATVLSAPAKITNHLVAMIEKTIGGQDALPNIAD AERIFAELLQGLADAQPAFPLAQLKAFVEQEFAQIKHVLHGISLLGQCPDSVNAALICRGEKLSIAIMAGLLEARGHKVS VINPVEKLLAVGHYLESTVDIAESTRRIAASQIPADHMILMAGFTAGNEKGELVVLGRNGSDYSAAVLAACLRADCCEIW TDVDGVYTCDPRQVPDARLLKSMSYQEAMELSYFGAKVLHPRTIAPIAQFQIPCLIKNTGNPQAPGTLIGASRDEDDLPV KGISNLNNMAMFNVSGPGMKGMVGMAARVFATMSRAGISVVLITQSSSEYSISFCVPQSDCARAKRAMEDEFYLELKEGL LEPLAIMERLAIISVVGDGMRTLRGISAKFFAALARANINIVAIAQGSSERSISVVVSNDDATTGVRVTHQMLFNTDQVI EVFVIGVGGVGGALLEQIKRQQGWLKNKHIDLRVCGVANSQALLTSVHGLNLENWSAELAEAKEPFNLGRLIRLVKEYHL LNPVIVDCTSSQAVADQYADFLREGFHVVTPNKKANTSSLDYYHQLRHAASSSRRKFLYDTNVGAGLPVIENLQNLLNAG DELRHFSGILSGSLSFIFGKLDEGVSFSAATAMAREMGYTEPDPRDDLSGVDVARKLLILARETGRELELADIIVESALP PDFDASGDVETFMARLPSLDDGFASRVAKARDEGKVLRYVGNIEEDGTCRVKIAAVDGNDPLFKVKNGENALAFYSHYYQ PLPLVLRGYGAGNDVTAAGVFADLLRTLSWKLGV
Sequences:
>Translated_834_residues MRAFFLTRDQGVRTMRVLKFGGTSVANAERFLRVADILESNARQGQVATVLSAPAKITNHLVAMIEKTIGGQDALPNIAD AERIFAELLQGLADAQPAFPLAQLKAFVEQEFAQIKHVLHGISLLGQCPDSVNAALICRGEKLSIAIMAGLLEARGHKVS VINPVEKLLAVGHYLESTVDIAESTRRIAASQIPADHMILMAGFTAGNEKGELVVLGRNGSDYSAAVLAACLRADCCEIW TDVDGVYTCDPRQVPDARLLKSMSYQEAMELSYFGAKVLHPRTIAPIAQFQIPCLIKNTGNPQAPGTLIGASRDEDDLPV KGISNLNNMAMFNVSGPGMKGMVGMAARVFATMSRAGISVVLITQSSSEYSISFCVPQSDCARAKRAMEDEFYLELKEGL LEPLAIMERLAIISVVGDGMRTLRGISAKFFAALARANINIVAIAQGSSERSISVVVSNDDATTGVRVTHQMLFNTDQVI EVFVIGVGGVGGALLEQIKRQQGWLKNKHIDLRVCGVANSQALLTSVHGLNLENWSAELAEAKEPFNLGRLIRLVKEYHL LNPVIVDCTSSQAVADQYADFLREGFHVVTPNKKANTSSLDYYHQLRHAASSSRRKFLYDTNVGAGLPVIENLQNLLNAG DELRHFSGILSGSLSFIFGKLDEGVSFSAATAMAREMGYTEPDPRDDLSGVDVARKLLILARETGRELELADIIVESALP PDFDASGDVETFMARLPSLDDGFASRVAKARDEGKVLRYVGNIEEDGTCRVKIAAVDGNDPLFKVKNGENALAFYSHYYQ PLPLVLRGYGAGNDVTAAGVFADLLRTLSWKLGV >Mature_834_residues MRAFFLTRDQGVRTMRVLKFGGTSVANAERFLRVADILESNARQGQVATVLSAPAKITNHLVAMIEKTIGGQDALPNIAD AERIFAELLQGLADAQPAFPLAQLKAFVEQEFAQIKHVLHGISLLGQCPDSVNAALICRGEKLSIAIMAGLLEARGHKVS VINPVEKLLAVGHYLESTVDIAESTRRIAASQIPADHMILMAGFTAGNEKGELVVLGRNGSDYSAAVLAACLRADCCEIW TDVDGVYTCDPRQVPDARLLKSMSYQEAMELSYFGAKVLHPRTIAPIAQFQIPCLIKNTGNPQAPGTLIGASRDEDDLPV KGISNLNNMAMFNVSGPGMKGMVGMAARVFATMSRAGISVVLITQSSSEYSISFCVPQSDCARAKRAMEDEFYLELKEGL LEPLAIMERLAIISVVGDGMRTLRGISAKFFAALARANINIVAIAQGSSERSISVVVSNDDATTGVRVTHQMLFNTDQVI EVFVIGVGGVGGALLEQIKRQQGWLKNKHIDLRVCGVANSQALLTSVHGLNLENWSAELAEAKEPFNLGRLIRLVKEYHL LNPVIVDCTSSQAVADQYADFLREGFHVVTPNKKANTSSLDYYHQLRHAASSSRRKFLYDTNVGAGLPVIENLQNLLNAG DELRHFSGILSGSLSFIFGKLDEGVSFSAATAMAREMGYTEPDPRDDLSGVDVARKLLILARETGRELELADIIVESALP PDFDASGDVETFMARLPSLDDGFASRVAKARDEGKVLRYVGNIEEDGTCRVKIAAVDGNDPLFKVKNGENALAFYSHYYQ PLPLVLRGYGAGNDVTAAGVFADLLRTLSWKLGV
Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]
COG id: COG0527
COG function: function code E; Aspartokinases
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 2 ACT domains [H]
Homologues:
Organism=Escherichia coli, GI1786183, Length=820, Percent_Identity=92.1951219512195, Blast_Score=1540, Evalue=0.0, Organism=Escherichia coli, GI1790376, Length=830, Percent_Identity=30.7228915662651, Blast_Score=336, Evalue=3e-93, Organism=Escherichia coli, GI1790455, Length=465, Percent_Identity=29.4623655913978, Blast_Score=155, Evalue=7e-39, Organism=Saccharomyces cerevisiae, GI6320893, Length=502, Percent_Identity=28.0876494023904, Blast_Score=167, Evalue=6e-42, Organism=Saccharomyces cerevisiae, GI6322599, Length=340, Percent_Identity=33.2352941176471, Blast_Score=162, Evalue=2e-40,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002912 - InterPro: IPR001048 - InterPro: IPR005106 - InterPro: IPR001341 - InterPro: IPR018042 - InterPro: IPR011147 - InterPro: IPR001342 - InterPro: IPR019811 - InterPro: IPR016040 [H]
Pfam domain/function: PF00696 AA_kinase; PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]
EC number: =2.7.2.4; =1.1.1.3 [H]
Molecular weight: Translated: 90202; Mature: 90202
Theoretical pI: Translated: 6.01; Mature: 6.01
Prosite motif: PS01042 HOMOSER_DHGENASE ; PS00324 ASPARTOKINASE
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.4 %Cys (Translated Protein) 2.5 %Met (Translated Protein) 4.0 %Cys+Met (Translated Protein) 1.4 %Cys (Mature Protein) 2.5 %Met (Mature Protein) 4.0 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MRAFFLTRDQGVRTMRVLKFGGTSVANAERFLRVADILESNARQGQVATVLSAPAKITNH CCEEEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCEEHHHHCCHHHHHH LVAMIEKTIGGQDALPNIADAERIFAELLQGLADAQPAFPLAQLKAFVEQEFAQIKHVLH HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH GISLLGQCPDSVNAALICRGEKLSIAIMAGLLEARGHKVSVINPVEKLLAVGHYLESTVD HHHHHHCCCCCCCEEEEECCCCEEHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHH IAESTRRIAASQIPADHMILMAGFTAGNEKGELVVLGRNGSDYSAAVLAACLRADCCEIW HHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHH TDVDGVYTCDPRQVPDARLLKSMSYQEAMELSYFGAKVLHPRTIAPIAQFQIPCLIKNTG CCCCCEEECCCCCCCHHHHHHHCCHHHHHHHHHHCHHHCCCCHHCCHHHEECCEEEECCC NPQAPGTLIGASRDEDDLPVKGISNLNNMAMFNVSGPGMKGMVGMAARVFATMSRAGISV CCCCCCEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCEEE VLITQSSSEYSISFCVPQSDCARAKRAMEDEFYLELKEGLLEPLAIMERLAIISVVGDGM EEEEECCCCEEEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH RTLRGISAKFFAALARANINIVAIAQGSSERSISVVVSNDDATTGVRVTHQMLFNTDQVI HHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEEECCCCCCHHHHHHHHHHCHHHEE EVFVIGVGGVGGALLEQIKRQQGWLKNKHIDLRVCGVANSQALLTSVHGLNLENWSAELA EEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHCCCCCCHHHHHHH EAKEPFNLGRLIRLVKEYHLLNPVIVDCTSSQAVADQYADFLREGFHVVTPNKKANTSSL HCCCCCCHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHCCCEEECCCCCCCCCHH DYYHQLRHAASSSRRKFLYDTNVGAGLPVIENLQNLLNAGDELRHFSGILSGSLSFIFGK HHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHH LDEGVSFSAATAMAREMGYTEPDPRDDLSGVDVARKLLILARETGRELELADIIVESALP HCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCC PDFDASGDVETFMARLPSLDDGFASRVAKARDEGKVLRYVGNIEEDGTCRVKIAAVDGND CCCCCCCCHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHCCCCCCCEEEEEEEEECCCC PLFKVKNGENALAFYSHYYQPLPLVLRGYGAGNDVTAAGVFADLLRTLSWKLGV CEEEEECCCCHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCC >Mature Secondary Structure MRAFFLTRDQGVRTMRVLKFGGTSVANAERFLRVADILESNARQGQVATVLSAPAKITNH CCEEEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCEEHHHHCCHHHHHH LVAMIEKTIGGQDALPNIADAERIFAELLQGLADAQPAFPLAQLKAFVEQEFAQIKHVLH HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH GISLLGQCPDSVNAALICRGEKLSIAIMAGLLEARGHKVSVINPVEKLLAVGHYLESTVD HHHHHHCCCCCCCEEEEECCCCEEHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHH IAESTRRIAASQIPADHMILMAGFTAGNEKGELVVLGRNGSDYSAAVLAACLRADCCEIW HHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHH TDVDGVYTCDPRQVPDARLLKSMSYQEAMELSYFGAKVLHPRTIAPIAQFQIPCLIKNTG CCCCCEEECCCCCCCHHHHHHHCCHHHHHHHHHHCHHHCCCCHHCCHHHEECCEEEECCC NPQAPGTLIGASRDEDDLPVKGISNLNNMAMFNVSGPGMKGMVGMAARVFATMSRAGISV CCCCCCEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCEEE VLITQSSSEYSISFCVPQSDCARAKRAMEDEFYLELKEGLLEPLAIMERLAIISVVGDGM EEEEECCCCEEEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH RTLRGISAKFFAALARANINIVAIAQGSSERSISVVVSNDDATTGVRVTHQMLFNTDQVI HHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEEECCCCCCHHHHHHHHHHCHHHEE EVFVIGVGGVGGALLEQIKRQQGWLKNKHIDLRVCGVANSQALLTSVHGLNLENWSAELA EEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHCCCCCCHHHHHHH EAKEPFNLGRLIRLVKEYHLLNPVIVDCTSSQAVADQYADFLREGFHVVTPNKKANTSSL HCCCCCCHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHCCCEEECCCCCCCCCHH DYYHQLRHAASSSRRKFLYDTNVGAGLPVIENLQNLLNAGDELRHFSGILSGSLSFIFGK HHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHH LDEGVSFSAATAMAREMGYTEPDPRDDLSGVDVARKLLILARETGRELELADIIVESALP HCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCC PDFDASGDVETFMARLPSLDDGFASRVAKARDEGKVLRYVGNIEEDGTCRVKIAAVDGND CCCCCCCCHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHCCCCCCCEEEEEEEEECCCC PLFKVKNGENALAFYSHYYQPLPLVLRGYGAGNDVTAAGVFADLLRTLSWKLGV CEEEEECCCCHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 7003595; 1630901; 7610040; 9278503; 6277952; 2410621; 387092; 6298218; 390305 [H]