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The map label for this gene is thrB [H]

Identifier: 238892990

GI number: 238892990

Start: 800384

End: 801313

Strand: Direct

Name: thrB [H]

Synonym: KP1_0822

Alternate gene names: 238892990

Gene position: 800384-801313 (Clockwise)

Preceding gene: 238892989

Following gene: 238892991

Centisome position: 15.25

GC content: 60.11

Gene sequence:

>930_bases
ATGGTCAAAGTATATGCCCCGGCTTCCAGTGCCAATATGAGCGTCGGGTTTGATGTGTTGGGCGCGGCGGTCACGCCGGT
CGATGGCACGCTGCTTGGCGACAACGTCACTGTCGAAGCGGCGGAGCAATTTAGCCTGCAGAATCTTGGACGCTTCGCCA
GCAAACTGCCGACGGCGCCGCAGGAGAACATTGTTTACCAGTGCTGGGAAAGCTTTTGCCGGGAGATCGGCAAGACGGTG
CCGGTGGCGATGACGCTGGAAAAAAACATGCCGATTGGCTCCGGGCTGGGTTCCAGCGCCTGCTCGGTGGTCGCTGCGCT
GGTGGCCATGAACGAGTTCTGCGGCAAGCCGCTGAACGAGACGCGCATGCTGGCGCTGATGGGAGAGATGGAAGGGCGTA
TCTCCGGCAGCATTCACTACGACAACGTGGCGCCGTGCTATCTTGGCGGCATGCAGTTGATGATCGAAGAGAATGGGATT
ATCAGTCAGCAGGTGCCCGGGTTTGATGAGTGGCTGTGGGTGCTGGCCTATCCGGGGATTAAAGTTTCTACTGCTGAAGC
GCGGGCGATTCTGCCGGCGCAGTATCGCCGCCAGGATTGTATCGCCCATGGTCGCCACCTCGCGGGCTTTATTCACGCCT
GCTACACCCGCCAGCCGCAGCTGGCGGCAAAATTGATGAAAGATGTGATTGCCGAACCGTACCGAACCAAACTGCTGCCG
GGCTTTAGCGAAGCGCGTCAGGCGGCCATGGAGATGGGCGCCCAGGCTTGCGGCATCTCCGGCTCTGGCCCAACGCTGTT
CGCGTTGTGTGATAAACCGGATACCGCACAGCGCGTCGCCGACTGGCTTGGCGCGCACTATCTGCAGAATCAGGAAGGCT
TTGTTCATATTTGCCGGCTGGACACGGCGGGCGCACGCGTAGTGGGATAA

Upstream 100 bases:

>100_bases
CCGCTGGTGCTGCGCGGCTATGGCGCCGGGAACGACGTCACGGCGGCCGGCGTATTCGCCGACCTGCTGCGCACCCTGTC
CTGGAAGTTAGGAGTTTAAG

Downstream 100 bases:

>100_bases
CCAATGAAACTGTATAACTTAAAAGATCATAACGAGCAGGTCAGCTTTGCGCAGGCCGTCACCCAGGGACTTGGCAAGCA
TCAGGGCCTGTTCTTTCCGC

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MVKVYAPASSANMSVGFDVLGAAVTPVDGTLLGDNVTVEAAEQFSLQNLGRFASKLPTAPQENIVYQCWESFCREIGKTV
PVAMTLEKNMPIGSGLGSSACSVVAALVAMNEFCGKPLNETRMLALMGEMEGRISGSIHYDNVAPCYLGGMQLMIEENGI
ISQQVPGFDEWLWVLAYPGIKVSTAEARAILPAQYRRQDCIAHGRHLAGFIHACYTRQPQLAAKLMKDVIAEPYRTKLLP
GFSEARQAAMEMGAQACGISGSGPTLFALCDKPDTAQRVADWLGAHYLQNQEGFVHICRLDTAGARVVG

Sequences:

>Translated_309_residues
MVKVYAPASSANMSVGFDVLGAAVTPVDGTLLGDNVTVEAAEQFSLQNLGRFASKLPTAPQENIVYQCWESFCREIGKTV
PVAMTLEKNMPIGSGLGSSACSVVAALVAMNEFCGKPLNETRMLALMGEMEGRISGSIHYDNVAPCYLGGMQLMIEENGI
ISQQVPGFDEWLWVLAYPGIKVSTAEARAILPAQYRRQDCIAHGRHLAGFIHACYTRQPQLAAKLMKDVIAEPYRTKLLP
GFSEARQAAMEMGAQACGISGSGPTLFALCDKPDTAQRVADWLGAHYLQNQEGFVHICRLDTAGARVVG
>Mature_309_residues
MVKVYAPASSANMSVGFDVLGAAVTPVDGTLLGDNVTVEAAEQFSLQNLGRFASKLPTAPQENIVYQCWESFCREIGKTV
PVAMTLEKNMPIGSGLGSSACSVVAALVAMNEFCGKPLNETRMLALMGEMEGRISGSIHYDNVAPCYLGGMQLMIEENGI
ISQQVPGFDEWLWVLAYPGIKVSTAEARAILPAQYRRQDCIAHGRHLAGFIHACYTRQPQLAAKLMKDVIAEPYRTKLLP
GFSEARQAAMEMGAQACGISGSGPTLFALCDKPDTAQRVADWLGAHYLQNQEGFVHICRLDTAGARVVG

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate [H]

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786184, Length=308, Percent_Identity=88.6363636363636, Blast_Score=576, Evalue=1e-166,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 33250; Mature: 33250

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
7.4 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
7.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKVYAPASSANMSVGFDVLGAAVTPVDGTLLGDNVTVEAAEQFSLQNLGRFASKLPTAP
CEEEECCCCCCCCEECHHHHHCEECCCCCEEECCCEEEHHHHHHHHHHHHHHHHHCCCCC
QENIVYQCWESFCREIGKTVPVAMTLEKNMPIGSGLGSSACSVVAALVAMNEFCGKPLNE
HHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCH
TRMLALMGEMEGRISGSIHYDNVAPCYLGGMQLMIEENGIISQQVPGFDEWLWVLAYPGI
HHHHHHHHHHCCCEECEEEECCCCCHHHCCEEEEEECCCCCCCCCCCHHHHHHEEECCCC
KVSTAEARAILPAQYRRQDCIAHGRHLAGFIHACYTRQPQLAAKLMKDVIAEPYRTKLLP
EEECCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHCCC
GFSEARQAAMEMGAQACGISGSGPTLFALCDKPDTAQRVADWLGAHYLQNQEGFVHICRL
CHHHHHHHHHHCCHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEEE
DTAGARVVG
CCCCCCCCC
>Mature Secondary Structure
MVKVYAPASSANMSVGFDVLGAAVTPVDGTLLGDNVTVEAAEQFSLQNLGRFASKLPTAP
CEEEECCCCCCCCEECHHHHHCEECCCCCEEECCCEEEHHHHHHHHHHHHHHHHHCCCCC
QENIVYQCWESFCREIGKTVPVAMTLEKNMPIGSGLGSSACSVVAALVAMNEFCGKPLNE
HHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCH
TRMLALMGEMEGRISGSIHYDNVAPCYLGGMQLMIEENGIISQQVPGFDEWLWVLAYPGI
HHHHHHHHHHCCCEECEEEECCCCCHHHCCEEEEEECCCCCCCCCCCHHHHHHEEECCCC
KVSTAEARAILPAQYRRQDCIAHGRHLAGFIHACYTRQPQLAAKLMKDVIAEPYRTKLLP
EEECCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHCCC
GFSEARQAAMEMGAQACGISGSGPTLFALCDKPDTAQRVADWLGAHYLQNQEGFVHICRL
CHHHHHHHHHHCCHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEEE
DTAGARVVG
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA