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The map label for this gene is msrA [H]

Identifier: 238892698

GI number: 238892698

Start: 483023

End: 483721

Strand: Reverse

Name: msrA [H]

Synonym: KP1_0489

Alternate gene names: 238892698

Gene position: 483721-483023 (Counterclockwise)

Preceding gene: 238892702

Following gene: 238892697

Centisome position: 9.22

GC content: 59.51

Gene sequence:

>699_bases
GTGTTAAAAGACACGCTTCGTTACAACCTTAACGACGATTTCTGTATTGAGAGGCCAACCGTGAGTCTATTTGATAAAAC
GCATCTTGTCGCCCAGGCGGATGCGCTGCCTGGACGCAATACCCCCATGCCAGTGGCGACGCTCCACGCAGTTAACGGCC
ACTCGATGACCAACGTCCCGGCGGGGATGGAAGTGGCGCTGTTCGCCATGGGCTGCTTCTGGGGAGTTGAGCGCCTGTTC
TGGCAATTGCCGGGGGTTTACAGCACCGCCGCAGGTTACACTGGCGGCTATACGCCCAATCCGACCTATCGCGAAGTATG
CAGCGGCCAGACCGGTCACGCGGAAGCGGTACGCGTGGTTTATGATCCGCAGGTGATTAGCTATGAGCAGTTATTGCAGG
TGTTCTGGGAAAATCACGACCCGGCGCAGGGTATGCGGCAGGGTAACGACCACGGCACCCAGTACCGCTCGGCGATTTAC
CCGCTGACCCCGGAACAGACGGAGGCGGCAAAGGGCAGCCTCGCGCGCTTCCAGGCGGCGATGAACGACGCGCACGATAC
CCGTCACATCACCACCGAGATCGCCACCGCCAAACCGTTCTACTATGCCGAGGACGATCACCAGCAGTATCTGTATAAAA
ACCCGCACGGCTATTGCGGCATCGGCGGCATTGGCGTCTGCCTGCCGCCTCAGGCGTAA

Upstream 100 bases:

>100_bases
CTCCACGGCTTAACAAAACCCTAACAACATAGGGTTGAAAAAGTGGCAATAACCCAAATAATTCTTATGTATTAATCTAG
ACGTATTACGCGTATTTATT

Downstream 100 bases:

>100_bases
TTCTGATTTCCGCCTCAACAGCGAGGCGGTCAATGAACGCTCTGGCGGCTTTACATTCCCTTACGCTATACTAGCCAGTG
TGACAGCCGGTCCAGCGCCT

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MLKDTLRYNLNDDFCIERPTVSLFDKTHLVAQADALPGRNTPMPVATLHAVNGHSMTNVPAGMEVALFAMGCFWGVERLF
WQLPGVYSTAAGYTGGYTPNPTYREVCSGQTGHAEAVRVVYDPQVISYEQLLQVFWENHDPAQGMRQGNDHGTQYRSAIY
PLTPEQTEAAKGSLARFQAAMNDAHDTRHITTEIATAKPFYYAEDDHQQYLYKNPHGYCGIGGIGVCLPPQA

Sequences:

>Translated_232_residues
MLKDTLRYNLNDDFCIERPTVSLFDKTHLVAQADALPGRNTPMPVATLHAVNGHSMTNVPAGMEVALFAMGCFWGVERLF
WQLPGVYSTAAGYTGGYTPNPTYREVCSGQTGHAEAVRVVYDPQVISYEQLLQVFWENHDPAQGMRQGNDHGTQYRSAIY
PLTPEQTEAAKGSLARFQAAMNDAHDTRHITTEIATAKPFYYAEDDHQQYLYKNPHGYCGIGGIGVCLPPQA
>Mature_232_residues
MLKDTLRYNLNDDFCIERPTVSLFDKTHLVAQADALPGRNTPMPVATLHAVNGHSMTNVPAGMEVALFAMGCFWGVERLF
WQLPGVYSTAAGYTGGYTPNPTYREVCSGQTGHAEAVRVVYDPQVISYEQLLQVFWENHDPAQGMRQGNDHGTQYRSAIY
PLTPEQTEAAKGSLARFQAAMNDAHDTRHITTEIATAKPFYYAEDDHQQYLYKNPHGYCGIGGIGVCLPPQA

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=204, Percent_Identity=59.8039215686275, Blast_Score=257, Evalue=6e-69,
Organism=Homo sapiens, GI208609995, Length=182, Percent_Identity=62.0879120879121, Blast_Score=238, Evalue=3e-63,
Organism=Homo sapiens, GI208609993, Length=204, Percent_Identity=45.5882352941176, Blast_Score=171, Evalue=4e-43,
Organism=Escherichia coli, GI1790665, Length=212, Percent_Identity=88.6792452830189, Blast_Score=376, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17533973, Length=153, Percent_Identity=36.6013071895425, Blast_Score=97, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6320881, Length=167, Percent_Identity=34.7305389221557, Blast_Score=97, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24664627, Length=153, Percent_Identity=38.562091503268, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI45553131, Length=141, Percent_Identity=39.7163120567376, Blast_Score=87, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24664631, Length=153, Percent_Identity=37.2549019607843, Blast_Score=84, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 25703; Mature: 25703

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKDTLRYNLNDDFCIERPTVSLFDKTHLVAQADALPGRNTPMPVATLHAVNGHSMTNVP
CCCCCEEECCCCCEEEECCCHHHHHHHHHEEECCCCCCCCCCCCEEEEEEECCCCCCCCC
AGMEVALFAMGCFWGVERLFWQLPGVYSTAAGYTGGYTPNPTYREVCSGQTGHAEAVRVV
CCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCHHHHHCCCCCCCEEEEEE
YDPQVISYEQLLQVFWENHDPAQGMRQGNDHGTQYRSAIYPLTPEQTEAAKGSLARFQAA
ECCCEECHHHHHHHHHCCCCHHHHHHCCCCCCHHHHHEECCCCCCHHHHHHHHHHHHHHH
MNDAHDTRHITTEIATAKPFYYAEDDHQQYLYKNPHGYCGIGGIGVCLPPQA
HHHCCCHHHHHHHHHCCCCEEEECCCCHHHHHCCCCCEECCCCCEEECCCCC
>Mature Secondary Structure
MLKDTLRYNLNDDFCIERPTVSLFDKTHLVAQADALPGRNTPMPVATLHAVNGHSMTNVP
CCCCCEEECCCCCEEEECCCHHHHHHHHHEEECCCCCCCCCCCCEEEEEEECCCCCCCCC
AGMEVALFAMGCFWGVERLFWQLPGVYSTAAGYTGGYTPNPTYREVCSGQTGHAEAVRVV
CCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCHHHHHCCCCCCCEEEEEE
YDPQVISYEQLLQVFWENHDPAQGMRQGNDHGTQYRSAIYPLTPEQTEAAKGSLARFQAA
ECCCEECHHHHHHHHHCCCCHHHHHHCCCCCCHHHHHEECCCCCCHHHHHHHHHHHHHHH
MNDAHDTRHITTEIATAKPFYYAEDDHQQYLYKNPHGYCGIGGIGVCLPPQA
HHHCCCHHHHHHHHHCCCCEEEECCCCHHHHHCCCCCEECCCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA