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The map label for this gene is ytfL [H]

Identifier: 238892697

GI number: 238892697

Start: 481505

End: 482842

Strand: Reverse

Name: ytfL [H]

Synonym: KP1_0488

Alternate gene names: 238892697

Gene position: 482842-481505 (Counterclockwise)

Preceding gene: 238892698

Following gene: 238892696

Centisome position: 9.2

GC content: 55.01

Gene sequence:

>1338_bases
ATGTTAAACAGTATTTTAGTAATACTCTGTCTGATAGCCGTCAGTGCGTTTTTTTCGATATCGGAAATTTCACTGGCAGC
CTCACGTAAAATCAAACTGAAACTGCTGGCCGATGAAGGCAACGTCAACGCACAGCGGGTGCTGAAGATGCAGGAGAACC
CGGGCACCTTCTTTACCGTCGTGCAGATTGGCCTCAACGCCGTCGCCATTCTTGGCGGTATTGTGGGCGACGCGGCTTTC
TCACCGGCGTTTCATAGCCTGCTCAGCGGGTATTTGTCGCCGGAGCTCTCCGAGCAGCTGAGCTTCATCATCTCTTTTAC
CCTGGTCACCAGCTTGTTCATCCTGTTTGCTGACCTGACTCCGAAACGCATCGGTATGATTGCGCCCGAAACAGTGGCCC
TGCGCATCATCAACCCGATGCGCTTCTGCCTGTTAGTCTTCCGCCCGCTGGTGTGGTTGTTTAACGGCATGGCCAACATG
ATCTTCCGCATCTTCAAACTGCCGATGGTGCGGAAAGACGATATCACTTCCGATGATATCTATGCCGTGGTCGAGGCCGG
CGCGCTGGCCGGGGTGCTGCGCAAGCAGGAGCATGAGCTAATTGAGAACGTGTTCGAGCTGGAGTCCCGCACCGTTCCTT
CCTCCATGACCCCGCGTGAAAGCGTCATTTGGTTTGATTTGCACGAAGACGAGCAGAGCCTGAAGAATAAAGTGGCCGAA
CATCCGCACTCGAAGTTCCTCGTCTGTAATGAAGATATCGACCACATTATCGGTTACGTCGATTCAAAAGATCTGCTGAA
CCGCGTGCTGGCGAACCAGAGCCTGGTGCTGACCGGCGGCGTACAGATCCGCAACACGTTGATCGTGCCGGACACCCTGA
CCCTGTCGGAAGCGCTGGAAAGCTTCAAAACCGCCGGGGAAGACTTCGCGGTGATCATGAATGAATACGCGCTGGTGGTC
GGGATCATCACTCTCAACGACGTAATGACCACCCTGATGGGCGACCTCGTCGGCCAGGGGCTGGAAGAGCAGATTGTCGC
CCGCGATGAAAACTCGTGGCTGATCGATGGCGGTACGCCGATTGATGACGTGATGCGCGTGCTGGATATCGACGAGTTCC
CGCAGTCCGGGAATTACGAGACCATCGGCGGCTTTATGATGTTTATGCTGCGTAAAATCCCCAAACGCACCGACGCGGTG
AAGTTCTCCGGCTATAAGTTTGAGGTCGTGGATATCGATAACTACCGTATCGACCAGCTGCTGGTGACCCGCATCGATAA
CAAGCCAACGGTGCTGGTGCCGAAGCAGGCGGAAACGGCGGAAAGCCAGAACGCCTGA

Upstream 100 bases:

>100_bases
TGACAGCCGGTCCAGCGCCTTCGGACCGGTTTTTTATGTATTCCACATTTGAGTTATCAACTTCCCTTCCGAGGATCTGG
CCTCAACGGTCAGAAAAGAT

Downstream 100 bases:

>100_bases
GCGTAATCTTTTCTCTCTCCTAAGGGCGGATGACCATCCGTCCTTTTTTATGGCCCAAATGGTTATCCCACACTCCCACT
TAACAAAATTGCTTTATCGG

Product: putative hemolysin-related membrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MLNSILVILCLIAVSAFFSISEISLAASRKIKLKLLADEGNVNAQRVLKMQENPGTFFTVVQIGLNAVAILGGIVGDAAF
SPAFHSLLSGYLSPELSEQLSFIISFTLVTSLFILFADLTPKRIGMIAPETVALRIINPMRFCLLVFRPLVWLFNGMANM
IFRIFKLPMVRKDDITSDDIYAVVEAGALAGVLRKQEHELIENVFELESRTVPSSMTPRESVIWFDLHEDEQSLKNKVAE
HPHSKFLVCNEDIDHIIGYVDSKDLLNRVLANQSLVLTGGVQIRNTLIVPDTLTLSEALESFKTAGEDFAVIMNEYALVV
GIITLNDVMTTLMGDLVGQGLEEQIVARDENSWLIDGGTPIDDVMRVLDIDEFPQSGNYETIGGFMMFMLRKIPKRTDAV
KFSGYKFEVVDIDNYRIDQLLVTRIDNKPTVLVPKQAETAESQNA

Sequences:

>Translated_445_residues
MLNSILVILCLIAVSAFFSISEISLAASRKIKLKLLADEGNVNAQRVLKMQENPGTFFTVVQIGLNAVAILGGIVGDAAF
SPAFHSLLSGYLSPELSEQLSFIISFTLVTSLFILFADLTPKRIGMIAPETVALRIINPMRFCLLVFRPLVWLFNGMANM
IFRIFKLPMVRKDDITSDDIYAVVEAGALAGVLRKQEHELIENVFELESRTVPSSMTPRESVIWFDLHEDEQSLKNKVAE
HPHSKFLVCNEDIDHIIGYVDSKDLLNRVLANQSLVLTGGVQIRNTLIVPDTLTLSEALESFKTAGEDFAVIMNEYALVV
GIITLNDVMTTLMGDLVGQGLEEQIVARDENSWLIDGGTPIDDVMRVLDIDEFPQSGNYETIGGFMMFMLRKIPKRTDAV
KFSGYKFEVVDIDNYRIDQLLVTRIDNKPTVLVPKQAETAESQNA
>Mature_445_residues
MLNSILVILCLIAVSAFFSISEISLAASRKIKLKLLADEGNVNAQRVLKMQENPGTFFTVVQIGLNAVAILGGIVGDAAF
SPAFHSLLSGYLSPELSEQLSFIISFTLVTSLFILFADLTPKRIGMIAPETVALRIINPMRFCLLVFRPLVWLFNGMANM
IFRIFKLPMVRKDDITSDDIYAVVEAGALAGVLRKQEHELIENVFELESRTVPSSMTPRESVIWFDLHEDEQSLKNKVAE
HPHSKFLVCNEDIDHIIGYVDSKDLLNRVLANQSLVLTGGVQIRNTLIVPDTLTLSEALESFKTAGEDFAVIMNEYALVV
GIITLNDVMTTLMGDLVGQGLEEQIVARDENSWLIDGGTPIDDVMRVLDIDEFPQSGNYETIGGFMMFMLRKIPKRTDAV
KFSGYKFEVVDIDNYRIDQLLVTRIDNKPTVLVPKQAETAESQNA

Specific function: Unknown

COG id: COG1253

COG function: function code R; Hemolysins and related proteins containing CBS domains

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI310128564, Length=380, Percent_Identity=25.7894736842105, Blast_Score=155, Evalue=6e-38,
Organism=Escherichia coli, GI1790664, Length=445, Percent_Identity=91.2359550561798, Blast_Score=834, Evalue=0.0,
Organism=Escherichia coli, GI145693175, Length=423, Percent_Identity=24.3498817966903, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI87082033, Length=238, Percent_Identity=32.3529411764706, Blast_Score=121, Evalue=7e-29,
Organism=Escherichia coli, GI1788119, Length=240, Percent_Identity=26.6666666666667, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1786879, Length=255, Percent_Identity=23.921568627451, Blast_Score=83, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR002550
- InterPro:   IPR005170 [H]

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC; PF01595 DUF21 [H]

EC number: NA

Molecular weight: Translated: 49495; Mature: 49495

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNSILVILCLIAVSAFFSISEISLAASRKIKLKLLADEGNVNAQRVLKMQENPGTFFTV
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCHHHHEEEECCCCCEEEH
VQIGLNAVAILGGIVGDAAFSPAFHSLLSGYLSPELSEQLSFIISFTLVTSLFILFADLT
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
PKRIGMIAPETVALRIINPMRFCLLVFRPLVWLFNGMANMIFRIFKLPMVRKDDITSDDI
HHHHCCCCCCHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHH
YAVVEAGALAGVLRKQEHELIENVFELESRTVPSSMTPRESVIWFDLHEDEQSLKNKVAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCHHHHHHHHHHH
HPHSKFLVCNEDIDHIIGYVDSKDLLNRVLANQSLVLTGGVQIRNTLIVPDTLTLSEALE
CCCCEEEEECCCHHHHHHCCCCHHHHHHHHCCCCEEEECCEEEEEEEECCCCHHHHHHHH
SFKTAGEDFAVIMNEYALVVGIITLNDVMTTLMGDLVGQGLEEQIVARDENSWLIDGGTP
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHEECCCCEEEECCCC
IDDVMRVLDIDEFPQSGNYETIGGFMMFMLRKIPKRTDAVKFSGYKFEVVDIDNYRIDQL
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEECCEEEEEEECCCCCHHHH
LVTRIDNKPTVLVPKQAETAESQNA
HHHHCCCCCEEEECCCCCCCCCCCC
>Mature Secondary Structure
MLNSILVILCLIAVSAFFSISEISLAASRKIKLKLLADEGNVNAQRVLKMQENPGTFFTV
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCHHHHEEEECCCCCEEEH
VQIGLNAVAILGGIVGDAAFSPAFHSLLSGYLSPELSEQLSFIISFTLVTSLFILFADLT
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
PKRIGMIAPETVALRIINPMRFCLLVFRPLVWLFNGMANMIFRIFKLPMVRKDDITSDDI
HHHHCCCCCCHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHH
YAVVEAGALAGVLRKQEHELIENVFELESRTVPSSMTPRESVIWFDLHEDEQSLKNKVAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCHHHHHHHHHHH
HPHSKFLVCNEDIDHIIGYVDSKDLLNRVLANQSLVLTGGVQIRNTLIVPDTLTLSEALE
CCCCEEEEECCCHHHHHHCCCCHHHHHHHHCCCCEEEECCEEEEEEEECCCCHHHHHHHH
SFKTAGEDFAVIMNEYALVVGIITLNDVMTTLMGDLVGQGLEEQIVARDENSWLIDGGTP
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHEECCCCEEEECCCC
IDDVMRVLDIDEFPQSGNYETIGGFMMFMLRKIPKRTDAVKFSGYKFEVVDIDNYRIDQL
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEECCEEEEEEECCCCCHHHH
LVTRIDNKPTVLVPKQAETAESQNA
HHHHCCCCCEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]