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The map label for this gene is fklB [H]

Identifier: 238892685

GI number: 238892685

Start: 470698

End: 471378

Strand: Direct

Name: fklB [H]

Synonym: KP1_0474

Alternate gene names: 238892685

Gene position: 470698-471378 (Clockwise)

Preceding gene: 238892683

Following gene: 238892686

Centisome position: 8.97

GC content: 58.88

Gene sequence:

>681_bases
ATGGCTGTTATGCTTTCGCACGCTTTTATCTTGATGTTTATCACCCAAAAAGGAACAACGATGGCAACCCCAACTTTTGA
CACTATCGAAGCGCAGGCAAGTTACGGTATCGGCTTGCAGGTTGGACAACAGCTGAGCGAATCCGGCCTGCAGGGGCTGC
TGCCGGAAGCGCTGGTGGCGGGTATCGCCGATGCGCTGGAAGGTAACCAGCCGCAGGTGCCGGTGGAAGCCGTTCACCGC
GCGCTGCGTGAAATCCACGAGCGTGCTGACGCTGTGCGTCTCGAGCGTTTTCAGGCCATGGCCGCTGACGGCCAAAAATA
CCTTGATGAAAACCGCGAGAAAGAGGGTGTGAACAGCACCGAGTCTGGTCTGCAGTTCCGCGTACTGACCCAGGGCGAAG
GCCCGATCCCGGCGCGTACTGACCGCGTTCGCGTGCACTACACTGGCAAACTGATCGACGGCACCGTCTTCGACAGCTCC
GTCGCTCGCGGTGAACCGGCTGAATTCCCGGTGACCGGCGTGATCGGCGGCTGGATTGAAGCGCTGACTCTGATGCCGGT
CGGTTCTAAATGGGAACTGACGATCCCGCACAACCTCGCCTACGGTGAGCGCGGCGCTGGCGCATCGATTCCTCCGTTCA
GCACCCTGATCTTCGAAGTTGAACTGCTGGACATTATCTAA

Upstream 100 bases:

>100_bases
CTGATGACCGGAACAAAGTGAAGTTAACCTGCTGCCGCCTATTGTTTCTTTTTCGCTGAGATTTGTCATCATTCGCCGAC
AAAGTTTTACCCATTTCGCT

Downstream 100 bases:

>100_bases
ACAGCAGCGGCTTCCTCTTCCCCGCGGCAGGGGAAGCCATAAAAATAGCGTAAAATCCTTAAGTTAAAAATTAATTGGAA
TTATGTTTTGCATTCATCAC

Product: peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: FKBP22; PPIase; Rotamase [H]

Number of amino acids: Translated: 226; Mature: 225

Protein sequence:

>226_residues
MAVMLSHAFILMFITQKGTTMATPTFDTIEAQASYGIGLQVGQQLSESGLQGLLPEALVAGIADALEGNQPQVPVEAVHR
ALREIHERADAVRLERFQAMAADGQKYLDENREKEGVNSTESGLQFRVLTQGEGPIPARTDRVRVHYTGKLIDGTVFDSS
VARGEPAEFPVTGVIGGWIEALTLMPVGSKWELTIPHNLAYGERGAGASIPPFSTLIFEVELLDII

Sequences:

>Translated_226_residues
MAVMLSHAFILMFITQKGTTMATPTFDTIEAQASYGIGLQVGQQLSESGLQGLLPEALVAGIADALEGNQPQVPVEAVHR
ALREIHERADAVRLERFQAMAADGQKYLDENREKEGVNSTESGLQFRVLTQGEGPIPARTDRVRVHYTGKLIDGTVFDSS
VARGEPAEFPVTGVIGGWIEALTLMPVGSKWELTIPHNLAYGERGAGASIPPFSTLIFEVELLDII
>Mature_225_residues
AVMLSHAFILMFITQKGTTMATPTFDTIEAQASYGIGLQVGQQLSESGLQGLLPEALVAGIADALEGNQPQVPVEAVHRA
LREIHERADAVRLERFQAMAADGQKYLDENREKEGVNSTESGLQFRVLTQGEGPIPARTDRVRVHYTGKLIDGTVFDSSV
ARGEPAEFPVTGVIGGWIEALTLMPVGSKWELTIPHNLAYGERGAGASIPPFSTLIFEVELLDII

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cytoplasm. Periplasm. Note=According to PubMed:7610040 it is periplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI206725530, Length=114, Percent_Identity=48.2456140350877, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI17149844, Length=114, Percent_Identity=48.2456140350877, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI17149842, Length=114, Percent_Identity=48.2456140350877, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI17149836, Length=106, Percent_Identity=43.3962264150943, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI4503725, Length=106, Percent_Identity=43.3962264150943, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI4503729, Length=92, Percent_Identity=44.5652173913043, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI4503727, Length=156, Percent_Identity=35.8974358974359, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI4758380, Length=106, Percent_Identity=38.6792452830189, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI192448443, Length=90, Percent_Identity=42.2222222222222, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI33469985, Length=110, Percent_Identity=41.8181818181818, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI87082390, Length=206, Percent_Identity=88.3495145631068, Blast_Score=370, Evalue=1e-104,
Organism=Escherichia coli, GI1789745, Length=211, Percent_Identity=35.5450236966825, Blast_Score=120, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI17540882, Length=106, Percent_Identity=45.2830188679245, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71993519, Length=106, Percent_Identity=39.622641509434, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17561782, Length=100, Percent_Identity=40, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320727, Length=88, Percent_Identity=53.4090909090909, Blast_Score=90, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6324194, Length=108, Percent_Identity=44.4444444444444, Blast_Score=80, Evalue=3e-16,
Organism=Drosophila melanogaster, GI281363946, Length=88, Percent_Identity=50, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI17352457, Length=88, Percent_Identity=50, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24583150, Length=108, Percent_Identity=41.6666666666667, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24655568, Length=106, Percent_Identity=43.3962264150943, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24647110, Length=93, Percent_Identity=41.9354838709677, Blast_Score=67, Evalue=7e-12,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 24427; Mature: 24296

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVMLSHAFILMFITQKGTTMATPTFDTIEAQASYGIGLQVGQQLSESGLQGLLPEALVA
CEEEHHHHEEEEEEECCCCEEECCCCHHHECCCCCCCCHHHHHHHHHHHHHCCCHHHHHH
GIADALEGNQPQVPVEAVHRALREIHERADAVRLERFQAMAADGQKYLDENREKEGVNST
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHCCCCCC
ESGLQFRVLTQGEGPIPARTDRVRVHYTGKLIDGTVFDSSVARGEPAEFPVTGVIGGWIE
CCCCEEEEEECCCCCCCCCCCEEEEEEECEEEECEEECCHHCCCCCCCCCHHHHHHHHHH
ALTLMPVGSKWELTIPHNLAYGERGAGASIPPFSTLIFEVELLDII
HHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHEEEEEECCC
>Mature Secondary Structure 
AVMLSHAFILMFITQKGTTMATPTFDTIEAQASYGIGLQVGQQLSESGLQGLLPEALVA
EEEHHHHEEEEEEECCCCEEECCCCHHHECCCCCCCCHHHHHHHHHHHHHCCCHHHHHH
GIADALEGNQPQVPVEAVHRALREIHERADAVRLERFQAMAADGQKYLDENREKEGVNST
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHCCCCCC
ESGLQFRVLTQGEGPIPARTDRVRVHYTGKLIDGTVFDSSVARGEPAEFPVTGVIGGWIE
CCCCEEEEEECCCCCCCCCCCEEEEEEECEEEECEEECCHHCCCCCCCCCHHHHHHHHHH
ALTLMPVGSKWELTIPHNLAYGERGAGASIPPFSTLIFEVELLDII
HHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503; 8703024; 9298646 [H]