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The map label for this gene is cycA [H]

Identifier: 238892686

GI number: 238892686

Start: 471683

End: 473086

Strand: Direct

Name: cycA [H]

Synonym: KP1_0475

Alternate gene names: 238892686

Gene position: 471683-473086 (Clockwise)

Preceding gene: 238892685

Following gene: 238892691

Centisome position: 8.99

GC content: 57.55

Gene sequence:

>1404_bases
ATGGTAGATCAGGTTAAAGTCGCTGCTGTCGAGCAGGAGCCGACTGAACAATCGCTACGGCGAAATCTCACAAACCGACA
TATTCAGCTGATCGCGATTGGCGGAGCGATCGGCACCGGGTTATTTATGGGTTCTGGCAAAACCATCAGCCTTGCCGGAC
CATCCATTATCTTTGTTTATATGATTATCGGTTTTATGCTGTTTTTCGTGATGCGTGCCATGGGCGAATTACTGCTGTCG
AACCTCGAATATAAATCCTTTAGCGACTTCGCGGCCGATCTGCTGGGGCCGTGGGCGGGCTACTTTACCGGCTGGACCTA
CTGGTTCTGCTGGGTAGTGACCGGGATGGCGGACGTTGTCGCCATCACCGCCTACGCGCAATTCTGGTTTCCCGGACTCT
CCGACTGGGTCGCCTCGCTGGCGGTGATCCTGCTGCTGCTGGGCCTGAACCTGGCCACCGTCAAGATGTTTGGCGAAATG
GAGTTCTGGTTCGCGATGATCAAAATTGTCGCCATCGTGGCGCTGATCGTGGTCGGCCTGGTAATGGTGATGATGCATTT
CAAATCGCCGACCGGGGTCGAAGCCTCTTTCGCCCACCTGTGGAATGACGGCGGCTGGTTCCCGAAAGGGCTGAGCGGCT
TCTTCGCCGGCTTCCAGATTGCGGTGTTTGCCTTCGTGGGGATTGAGCTGGTGGGGACCACCGCCGCCGAAACCAAAGAC
CCGGAAAAGTCCCTGCCGCGGGCGATTAACTCCATCCCGCTGCGTATCATTATGTTCTACGTCTTCGCGCTGATTGTGAT
TATGTCGGTGACGCCGTGGAGCTCCGTGGTGCCGAGCAAGAGCCCGTTCGTTGAGCTGTTCGTGCTGGTTGGTCTGCCGG
CGGCGGCGAGCCTGATCAACTTCGTGGTGCTGACCTCCGCGGCCTCCTCGGCCAACAGCGGCGTGTTCTCTACCAGCCGT
ATGCTGTTCGGTCTGGCGCAGGATGGTCAGGCGCCGAAGATGTTCGCCAAGCTGTCGAAGCGTGCGGTGCCGGCGAAGGG
CTTAACCTTCTCCTGCATGTGTCTGCTGGGCGGGGTGGTGATGCTGATGGTCAACCCGAGCGTGATTGCCGCCTTCACCA
TGATCACCACGGTGTCGGCGATCCTGTTTATGTTCGTCTGGACCATCATCCTTTGCTCTTACCTGGCGTATCGTAAAAAC
CGCCCTCAGCTGCATGAGAAGTCAAGCTACAAGATGCCGCTGGGTAAAGTCATGTGCTGGGTGTGCATGGCCTTCTTCGT
CTTTGTGCTGGTGCTGTTGACCCTGGAAGACGATACCCGTGAAGCGCTGATGGTCACCCCGCTGTGGTTTGTGCTGCTGG
GCGCGGGCTGGCTGTTTGCCGGCAAAAAACGGCTGGCGAAATAA

Upstream 100 bases:

>100_bases
GATTCTTACCTAATATCGACTAGCCCTTGCTGGGGTTAATGACAGACGACGGGCCATCAGAGCCTGAACAACACAGACAG
GTACAACAGGAAGAAATCAC

Downstream 100 bases:

>100_bases
ACGAAAATTTTAACGTTGCTTGCAACGGCCCGTCATAAAAAAGGCCACCCGGAGTGGCCAAATAAGACGGACAATGTCGA
GGGCGCCCGCGGGCGCCTTT

Product: D-alanine/D-serine/glycine permease

Products: D-glycine [Cytoplasm]; D-alanine [Cytoplasm]; Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MVDQVKVAAVEQEPTEQSLRRNLTNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIIFVYMIIGFMLFFVMRAMGELLLS
NLEYKSFSDFAADLLGPWAGYFTGWTYWFCWVVTGMADVVAITAYAQFWFPGLSDWVASLAVILLLLGLNLATVKMFGEM
EFWFAMIKIVAIVALIVVGLVMVMMHFKSPTGVEASFAHLWNDGGWFPKGLSGFFAGFQIAVFAFVGIELVGTTAAETKD
PEKSLPRAINSIPLRIIMFYVFALIVIMSVTPWSSVVPSKSPFVELFVLVGLPAAASLINFVVLTSAASSANSGVFSTSR
MLFGLAQDGQAPKMFAKLSKRAVPAKGLTFSCMCLLGGVVMLMVNPSVIAAFTMITTVSAILFMFVWTIILCSYLAYRKN
RPQLHEKSSYKMPLGKVMCWVCMAFFVFVLVLLTLEDDTREALMVTPLWFVLLGAGWLFAGKKRLAK

Sequences:

>Translated_467_residues
MVDQVKVAAVEQEPTEQSLRRNLTNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIIFVYMIIGFMLFFVMRAMGELLLS
NLEYKSFSDFAADLLGPWAGYFTGWTYWFCWVVTGMADVVAITAYAQFWFPGLSDWVASLAVILLLLGLNLATVKMFGEM
EFWFAMIKIVAIVALIVVGLVMVMMHFKSPTGVEASFAHLWNDGGWFPKGLSGFFAGFQIAVFAFVGIELVGTTAAETKD
PEKSLPRAINSIPLRIIMFYVFALIVIMSVTPWSSVVPSKSPFVELFVLVGLPAAASLINFVVLTSAASSANSGVFSTSR
MLFGLAQDGQAPKMFAKLSKRAVPAKGLTFSCMCLLGGVVMLMVNPSVIAAFTMITTVSAILFMFVWTIILCSYLAYRKN
RPQLHEKSSYKMPLGKVMCWVCMAFFVFVLVLLTLEDDTREALMVTPLWFVLLGAGWLFAGKKRLAK
>Mature_467_residues
MVDQVKVAAVEQEPTEQSLRRNLTNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIIFVYMIIGFMLFFVMRAMGELLLS
NLEYKSFSDFAADLLGPWAGYFTGWTYWFCWVVTGMADVVAITAYAQFWFPGLSDWVASLAVILLLLGLNLATVKMFGEM
EFWFAMIKIVAIVALIVVGLVMVMMHFKSPTGVEASFAHLWNDGGWFPKGLSGFFAGFQIAVFAFVGIELVGTTAAETKD
PEKSLPRAINSIPLRIIMFYVFALIVIMSVTPWSSVVPSKSPFVELFVLVGLPAAASLINFVVLTSAASSANSGVFSTSR
MLFGLAQDGQAPKMFAKLSKRAVPAKGLTFSCMCLLGGVVMLMVNPSVIAAFTMITTVSAILFMFVWTIILCSYLAYRKN
RPQLHEKSSYKMPLGKVMCWVCMAFFVFVLVLLTLEDDTREALMVTPLWFVLLGAGWLFAGKKRLAK

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=367, Percent_Identity=22.8882833787466, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI181337167, Length=341, Percent_Identity=22.2873900293255, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI114326544, Length=373, Percent_Identity=21.9839142091153, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI114326550, Length=373, Percent_Identity=21.9839142091153, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI258645169, Length=363, Percent_Identity=22.5895316804408, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI115648063, Length=467, Percent_Identity=25.0535331905782, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI115648022, Length=467, Percent_Identity=25.0535331905782, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1790653, Length=467, Percent_Identity=92.5053533190578, Blast_Score=873, Evalue=0.0,
Organism=Escherichia coli, GI1786302, Length=457, Percent_Identity=39.6061269146608, Blast_Score=345, Evalue=5e-96,
Organism=Escherichia coli, GI1786602, Length=457, Percent_Identity=41.1378555798687, Blast_Score=337, Evalue=7e-94,
Organism=Escherichia coli, GI1786789, Length=448, Percent_Identity=38.8392857142857, Blast_Score=335, Evalue=4e-93,
Organism=Escherichia coli, GI48994972, Length=453, Percent_Identity=38.6313465783664, Blast_Score=321, Evalue=7e-89,
Organism=Escherichia coli, GI87081915, Length=456, Percent_Identity=37.5, Blast_Score=291, Evalue=5e-80,
Organism=Escherichia coli, GI1788480, Length=453, Percent_Identity=34.4370860927152, Blast_Score=243, Evalue=1e-65,
Organism=Escherichia coli, GI87081708, Length=471, Percent_Identity=33.1210191082803, Blast_Score=241, Evalue=1e-64,
Organism=Escherichia coli, GI1789017, Length=440, Percent_Identity=30.9090909090909, Blast_Score=232, Evalue=3e-62,
Organism=Escherichia coli, GI2367353, Length=332, Percent_Identity=24.0963855421687, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI87082023, Length=409, Percent_Identity=22.2493887530562, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17532491, Length=432, Percent_Identity=23.8425925925926, Blast_Score=82, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17531343, Length=449, Percent_Identity=21.826280623608, Blast_Score=65, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6324061, Length=449, Percent_Identity=32.293986636971, Blast_Score=207, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6324924, Length=426, Percent_Identity=31.6901408450704, Blast_Score=200, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6320772, Length=446, Percent_Identity=29.8206278026906, Blast_Score=186, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6324990, Length=436, Percent_Identity=30.7339449541284, Blast_Score=172, Evalue=8e-44,
Organism=Saccharomyces cerevisiae, GI6322892, Length=419, Percent_Identity=28.6396181384248, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6321629, Length=426, Percent_Identity=28.4037558685446, Blast_Score=156, Evalue=6e-39,
Organism=Saccharomyces cerevisiae, GI6324059, Length=459, Percent_Identity=29.1938997821351, Blast_Score=152, Evalue=9e-38,
Organism=Saccharomyces cerevisiae, GI6320717, Length=414, Percent_Identity=26.0869565217391, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6324553, Length=410, Percent_Identity=28.5365853658537, Blast_Score=149, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6321053, Length=410, Percent_Identity=26.5853658536585, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6319824, Length=399, Percent_Identity=26.0651629072682, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6319542, Length=406, Percent_Identity=25.1231527093596, Blast_Score=143, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6320251, Length=402, Percent_Identity=26.3681592039801, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6319543, Length=436, Percent_Identity=25.4587155963303, Blast_Score=140, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6319608, Length=418, Percent_Identity=26.7942583732057, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6322967, Length=427, Percent_Identity=27.8688524590164, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6324981, Length=432, Percent_Identity=26.8518518518519, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6320364, Length=488, Percent_Identity=22.7459016393443, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24666159, Length=390, Percent_Identity=20.5128205128205, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI221512776, Length=390, Percent_Identity=20.5128205128205, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21357367, Length=295, Percent_Identity=26.7796610169492, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24667468, Length=429, Percent_Identity=22.6107226107226, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 51235; Mature: 51235

Theoretical pI: Translated: 9.32; Mature: 9.32

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDQVKVAAVEQEPTEQSLRRNLTNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIIFVY
CCCCEEEEECCCCCHHHHHHHHHCCCCEEEEEECCHHHHHEEECCCCEEEECCHHHHHHH
MIIGFMLFFVMRAMGELLLSNLEYKSFSDFAADLLGPWAGYFTGWTYWFCWVVTGMADVV
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AITAYAQFWFPGLSDWVASLAVILLLLGLNLATVKMFGEMEFWFAMIKIVAIVALIVVGL
HHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VMVMMHFKSPTGVEASFAHLWNDGGWFPKGLSGFFAGFQIAVFAFVGIELVGTTAAETKD
HHHHHHCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PEKSLPRAINSIPLRIIMFYVFALIVIMSVTPWSSVVPSKSPFVELFVLVGLPAAASLIN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCHHHHHHHHHCCHHHHHHHH
FVVLTSAASSANSGVFSTSRMLFGLAQDGQAPKMFAKLSKRAVPAKGLTFSCMCLLGGVV
HHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
MLMVNPSVIAAFTMITTVSAILFMFVWTIILCSYLAYRKNRPQLHEKSSYKMPLGKVMCW
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
VCMAFFVFVLVLLTLEDDTREALMVTPLWFVLLGAGWLFAGKKRLAK
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCC
>Mature Secondary Structure
MVDQVKVAAVEQEPTEQSLRRNLTNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIIFVY
CCCCEEEEECCCCCHHHHHHHHHCCCCEEEEEECCHHHHHEEECCCCEEEECCHHHHHHH
MIIGFMLFFVMRAMGELLLSNLEYKSFSDFAADLLGPWAGYFTGWTYWFCWVVTGMADVV
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AITAYAQFWFPGLSDWVASLAVILLLLGLNLATVKMFGEMEFWFAMIKIVAIVALIVVGL
HHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VMVMMHFKSPTGVEASFAHLWNDGGWFPKGLSGFFAGFQIAVFAFVGIELVGTTAAETKD
HHHHHHCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PEKSLPRAINSIPLRIIMFYVFALIVIMSVTPWSSVVPSKSPFVELFVLVGLPAAASLIN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCHHHHHHHHHCCHHHHHHHH
FVVLTSAASSANSGVFSTSRMLFGLAQDGQAPKMFAKLSKRAVPAKGLTFSCMCLLGGVV
HHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
MLMVNPSVIAAFTMITTVSAILFMFVWTIILCSYLAYRKNRPQLHEKSSYKMPLGKVMCW
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
VCMAFFVFVLVLLTLEDDTREALMVTPLWFVLLGAGWLFAGKKRLAK
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glycine [Periplasm]; D-alanine [Periplasm]; Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-glycine [Periplasm] = Proton [Cytoplasm] + D-glycine [Cytoplasm] Proton [Periplasm] + D-alanine [Periplasm] = Proton [Cytoplasm] + D-alanine [Cytoplasm] Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cyto

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]