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The map label for this gene is mutL [H]

Identifier: 238892654

GI number: 238892654

Start: 443253

End: 445112

Strand: Direct

Name: mutL [H]

Synonym: KP1_0438

Alternate gene names: 238892654

Gene position: 443253-445112 (Clockwise)

Preceding gene: 238892653

Following gene: 238892655

Centisome position: 8.45

GC content: 62.85

Gene sequence:

>1860_bases
ATGCCGATTCAGGTTCTGCCGCCGCAGCTCGCCAACCAGATTGCCGCCGGCGAGGTGGTGGAGCGGCCCGCGTCGGTGGT
GAAAGAGCTGGTTGAGAACAGTCTTGATGCGGGCGCCACGCGGATTGACATTGATATCGAACGCGGCGGCGCGAAGCTTA
TTCGCATCCGCGATAACGGCAGCGGCATCAAAAAAGACGAGCTGGCGCTGGCCCTAGCTCGTCATGCGACCAGCAAGATC
GCCTCGCTTGACGATCTGGAGGCCATTATCAGCCTCGGCTTTCGCGGCGAAGCGCTGGCCAGTATCAGTTCGGTAGCGCG
CTTAACGCTGACTTCGCGCACGGCGGAGCAGCAGGAAGCCTGGCAGGCGTATGCTGAAGGCCGCGATCAGGCGGTGACGG
TGAAGCCGGCGGCGCACCCGGTCGGTACCACTCTGGAAGTCCTCGATCTGTTCTATAACACCCCGGCGCGGCGCAAATTT
ATGCGCACCGAAAAGACCGAGTTCGGCCACATTGACGAGGTGGTGCGCCGCATTGCGCTGGCGCGCTTCGACGTCACTAT
CAACCTCAGCCATAACGGCAAGGTGATGCGCCAGTATCGGGCCGTCGCTCAGGATGGCCAGCGCGAGCGCCGGCTGGGGA
CAATTTGCGGCGCCGCTTTTCTCGAACATGCGCTGGCGATCGAGTGGCAGCATGGCGATCTGACCCTGCGCGGCTGGGTC
GCCGATCCGCTGCATACCACCCCGGCGCTGGCGGAAATTCAGTATTGCTACGTTAACGGGCGGATGATGCGCGATCGGCT
GATCAACCATGCTATCCGCCAGGCCTGTGAAGACAAGCTAGGGGCCGATCAGCAGCCGGCGTTTGTGCTGTATCTGGAGA
TCGATCCCCATCAGGTGGATGTAAACGTCCACCCGGCCAAGCATGAGGTGCGTTTCCATCAGTCGCGCCTGGTGCACGAC
TTTATCTACCAGGGCGTACTGAGCGTACTGCAGCAGCAGCTTGACGCGCCGCTGGCGGAAAAAGACGACCCGCCGGCGCC
GCGCCCGATGCCGGAGAACCGCATCGCCGCGGGCGGCAACCAGTTTGCGCGGCCAGCGGAAGCGCGGGAGCCTGCGACCC
GCTTCAGCATCACGCCATCGCGTGAGCCTGCGGCCTCCAGCGGCAAACCGGGCGGCGCGAGCTGGCCGCATGCGCAGCCG
GGTTACCAGAAGCAGCAGGGAGCGCTTTATCGTCAACTGCTCGACACGCCAACGGCGCCAAAGCCAGCGTTGCAGCCTCC
GGCGGCGGCAGAGTTGGCCGGTCACAGTCAGAGCTTTGGCAGAGTGCTGACGATTGTTGGCGGCGACTGCGCGCTGCTGG
AGCGCGAGGGCGGTCTGGCGCTGCTGTCGTTGACCGTTGCCGAGCGCTGGCTGCGCCAGGCGCAGTTGACCCCGGGAGCG
GAGGCGGTATGTGCTCAGCCGCTGCTGATCCCGCTGCGGTTAAAAGTTACGGAAGGGGAAAAGCAGGCGCTGGCCGCCGC
TCAGCCGGCGCTGGCGCAGCTAGGGATCGATGTGCATACCGATGCCCTGCACGTGACGGTGCGCGCGGTCCCTTTACCCT
TAAGACAACAAAATTTACAAATCTTGATTCCTGAACTGATAGGCTACCTGGCGCAGCAAAACGCATTCGACGTCGGCAAT
ATCGCCCAATGGATGGCGCGTAATCTGACGAGCGAACAGACGTCATGGAATATGGCGCAGGCGATTGCGCTGCTGGCGGA
CGTTGAGCGTCTTTGCCCGCAGCTGTTGAGAACGCCGCCGGGTGGCCTGTTACAACCTGTAGATCTCCATTCGGCGATGA
ATGCCCTGAAAGATGAATGA

Upstream 100 bases:

>100_bases
TTTATGCAGCATCCGCTGCAGTCGGCGCCTCGCGGCGAGGCGGCGCAGACCGCCAGCGCCGCGGCGCCGGGCGGGATGTT
GATTAACTAAGGAGCAGGGG

Downstream 100 bases:

>100_bases
TGTAACCGAGGCGAGCCTGCCCAAGGCAATTTTTTTAATGGGCCCGACGGCCTCCGGCAAAACCGCGCTGGCGATAGCCT
TACGTAAAGTTTTGCCAGTA

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 619; Mature: 618

Protein sequence:

>619_residues
MPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNGSGIKKDELALALARHATSKI
ASLDDLEAIISLGFRGEALASISSVARLTLTSRTAEQQEAWQAYAEGRDQAVTVKPAAHPVGTTLEVLDLFYNTPARRKF
MRTEKTEFGHIDEVVRRIALARFDVTINLSHNGKVMRQYRAVAQDGQRERRLGTICGAAFLEHALAIEWQHGDLTLRGWV
ADPLHTTPALAEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQVDVNVHPAKHEVRFHQSRLVHD
FIYQGVLSVLQQQLDAPLAEKDDPPAPRPMPENRIAAGGNQFARPAEAREPATRFSITPSREPAASSGKPGGASWPHAQP
GYQKQQGALYRQLLDTPTAPKPALQPPAAAELAGHSQSFGRVLTIVGGDCALLEREGGLALLSLTVAERWLRQAQLTPGA
EAVCAQPLLIPLRLKVTEGEKQALAAAQPALAQLGIDVHTDALHVTVRAVPLPLRQQNLQILIPELIGYLAQQNAFDVGN
IAQWMARNLTSEQTSWNMAQAIALLADVERLCPQLLRTPPGGLLQPVDLHSAMNALKDE

Sequences:

>Translated_619_residues
MPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNGSGIKKDELALALARHATSKI
ASLDDLEAIISLGFRGEALASISSVARLTLTSRTAEQQEAWQAYAEGRDQAVTVKPAAHPVGTTLEVLDLFYNTPARRKF
MRTEKTEFGHIDEVVRRIALARFDVTINLSHNGKVMRQYRAVAQDGQRERRLGTICGAAFLEHALAIEWQHGDLTLRGWV
ADPLHTTPALAEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQVDVNVHPAKHEVRFHQSRLVHD
FIYQGVLSVLQQQLDAPLAEKDDPPAPRPMPENRIAAGGNQFARPAEAREPATRFSITPSREPAASSGKPGGASWPHAQP
GYQKQQGALYRQLLDTPTAPKPALQPPAAAELAGHSQSFGRVLTIVGGDCALLEREGGLALLSLTVAERWLRQAQLTPGA
EAVCAQPLLIPLRLKVTEGEKQALAAAQPALAQLGIDVHTDALHVTVRAVPLPLRQQNLQILIPELIGYLAQQNAFDVGN
IAQWMARNLTSEQTSWNMAQAIALLADVERLCPQLLRTPPGGLLQPVDLHSAMNALKDE
>Mature_618_residues
PIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNGSGIKKDELALALARHATSKIA
SLDDLEAIISLGFRGEALASISSVARLTLTSRTAEQQEAWQAYAEGRDQAVTVKPAAHPVGTTLEVLDLFYNTPARRKFM
RTEKTEFGHIDEVVRRIALARFDVTINLSHNGKVMRQYRAVAQDGQRERRLGTICGAAFLEHALAIEWQHGDLTLRGWVA
DPLHTTPALAEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQVDVNVHPAKHEVRFHQSRLVHDF
IYQGVLSVLQQQLDAPLAEKDDPPAPRPMPENRIAAGGNQFARPAEAREPATRFSITPSREPAASSGKPGGASWPHAQPG
YQKQQGALYRQLLDTPTAPKPALQPPAAAELAGHSQSFGRVLTIVGGDCALLEREGGLALLSLTVAERWLRQAQLTPGAE
AVCAQPLLIPLRLKVTEGEKQALAAAQPALAQLGIDVHTDALHVTVRAVPLPLRQQNLQILIPELIGYLAQQNAFDVGNI
AQWMARNLTSEQTSWNMAQAIALLADVERLCPQLLRTPPGGLLQPVDLHSAMNALKDE

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=339, Percent_Identity=35.9882005899705, Blast_Score=208, Evalue=2e-53,
Organism=Homo sapiens, GI4505911, Length=318, Percent_Identity=31.7610062893082, Blast_Score=156, Evalue=7e-38,
Organism=Homo sapiens, GI189458898, Length=318, Percent_Identity=31.7610062893082, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI189458896, Length=313, Percent_Identity=30.6709265175719, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI4505913, Length=333, Percent_Identity=26.7267267267267, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI310128478, Length=333, Percent_Identity=26.7267267267267, Blast_Score=125, Evalue=2e-28,
Organism=Homo sapiens, GI263191589, Length=245, Percent_Identity=31.0204081632653, Blast_Score=110, Evalue=5e-24,
Organism=Homo sapiens, GI91992162, Length=358, Percent_Identity=23.463687150838, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI91992160, Length=358, Percent_Identity=23.463687150838, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI310128480, Length=295, Percent_Identity=23.0508474576271, Blast_Score=86, Evalue=9e-17,
Organism=Escherichia coli, GI1790612, Length=622, Percent_Identity=82.7974276527331, Blast_Score=1023, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71991825, Length=394, Percent_Identity=35.2791878172589, Blast_Score=194, Evalue=9e-50,
Organism=Caenorhabditis elegans, GI17562796, Length=351, Percent_Identity=26.7806267806268, Blast_Score=126, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6323819, Length=345, Percent_Identity=35.9420289855072, Blast_Score=187, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6324247, Length=348, Percent_Identity=27.8735632183908, Blast_Score=105, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6325093, Length=291, Percent_Identity=23.3676975945017, Blast_Score=87, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6323063, Length=403, Percent_Identity=24.5657568238213, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI17136968, Length=330, Percent_Identity=36.969696969697, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI17136970, Length=357, Percent_Identity=26.3305322128852, Blast_Score=106, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 67627; Mature: 67496

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCEEEEEEECCC
SGIKKDELALALARHATSKIASLDDLEAIISLGFRGEALASISSVARLTLTSRTAEQQEA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
WQAYAEGRDQAVTVKPAAHPVGTTLEVLDLFYNTPARRKFMRTEKTEFGHIDEVVRRIAL
HHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHH
ARFDVTINLSHNGKVMRQYRAVAQDGQRERRLGTICGAAFLEHALAIEWQHGDLTLRGWV
HHEEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHEEEEECCCEEEEEEE
ADPLHTTPALAEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQVD
CCCCCCCCHHHHEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEE
VNVHPAKHEVRFHQSRLVHDFIYQGVLSVLQQQLDAPLAEKDDPPAPRPMPENRIAAGGN
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC
QFARPAEAREPATRFSITPSREPAASSGKPGGASWPHAQPGYQKQQGALYRQLLDTPTAP
CCCCCCHHCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCC
KPALQPPAAAELAGHSQSFGRVLTIVGGDCALLEREGGLALLSLTVAERWLRQAQLTPGA
CCCCCCCCHHHHCCCCCCCCCEEEEECCCEEEEECCCCEEEEHHHHHHHHHHHHCCCCCC
EAVCAQPLLIPLRLKVTEGEKQALAAAQPALAQLGIDVHTDALHVTVRAVPLPLRQQNLQ
HHHHCCCEEEEEEEEECCCHHHHHHHHCHHHHHCCCCEECCEEEEEEEEECCCCCCCCCE
ILIPELIGYLAQQNAFDVGNIAQWMARNLTSEQTSWNMAQAIALLADVERLCPQLLRTPP
EEHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
GGLLQPVDLHSAMNALKDE
CCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
PIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCEEEEEEECCC
SGIKKDELALALARHATSKIASLDDLEAIISLGFRGEALASISSVARLTLTSRTAEQQEA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
WQAYAEGRDQAVTVKPAAHPVGTTLEVLDLFYNTPARRKFMRTEKTEFGHIDEVVRRIAL
HHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHH
ARFDVTINLSHNGKVMRQYRAVAQDGQRERRLGTICGAAFLEHALAIEWQHGDLTLRGWV
HHEEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHEEEEECCCEEEEEEE
ADPLHTTPALAEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQVD
CCCCCCCCHHHHEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEE
VNVHPAKHEVRFHQSRLVHDFIYQGVLSVLQQQLDAPLAEKDDPPAPRPMPENRIAAGGN
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC
QFARPAEAREPATRFSITPSREPAASSGKPGGASWPHAQPGYQKQQGALYRQLLDTPTAP
CCCCCCHHCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCC
KPALQPPAAAELAGHSQSFGRVLTIVGGDCALLEREGGLALLSLTVAERWLRQAQLTPGA
CCCCCCCCHHHHCCCCCCCCCEEEEECCCEEEEECCCCEEEEHHHHHHHHHHHHCCCCCC
EAVCAQPLLIPLRLKVTEGEKQALAAAQPALAQLGIDVHTDALHVTVRAVPLPLRQQNLQ
HHHHCCCEEEEEEEEECCCHHHHHHHHCHHHHHCCCCEECCEEEEEEEEECCCCCCCCCE
ILIPELIGYLAQQNAFDVGNIAQWMARNLTSEQTSWNMAQAIALLADVERLCPQLLRTPP
EEHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
GGLLQPVDLHSAMNALKDE
CCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA