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The map label for this gene is yjcE [H]

Identifier: 238892556

GI number: 238892556

Start: 339947

End: 341593

Strand: Direct

Name: yjcE [H]

Synonym: KP1_0329

Alternate gene names: 238892556

Gene position: 339947-341593 (Clockwise)

Preceding gene: 238892555

Following gene: 238892558

Centisome position: 6.48

GC content: 60.72

Gene sequence:

>1647_bases
ATGGAAATATTCTTTACCATCCTCATCATGACCCTTGTGGTCTCACTCTCCGGGGTAGTGACGCGCGTACTGCCCTTTCA
GGTTCCACTTCCACTGATGCAAATCGCCATTGGCGCGCTTCTGGCGTGGCCGACCTTTGGTTTGCACGTTGAATTTGATC
CAGAGCTGTTTCTGGTACTGTTTATCCCGCCGCTGCTATTCGCCGACGGCTGGAAAACGCCAACCCGCGAATTTATTGAA
CACGGGCGCGAGATCCTCGGCCTGGCGCTAGCGCTGGTGGTCGTGACGGTGGTCGGCATCGGCTTTCTGATCTACTGGAT
TGTGCCGGGCATTCCGCTGATCCCGGCGTTCGCGCTGGCGGCCGTGCTGTCGCCGACCGACGCCGTGGCGCTTTCGGGCA
TCGTTGGGGAAGGGCGGATACCGAAGAAAATCATGGGCATTCTGCAGGGGGAGGCGCTAATGAACGACGCCTCCGGCCTG
GTCTCGCTCAAGTTTGCCGTCGCGGTGGCGATGGGCACCATGGTCTTTACCGTTGGCGGCGCCACCGTAGAATTTCTGAA
GGTAGCGATTGGCGGCGTGCTGGCCGGGTTTGTGGTGAGCTGGTCGTATGGCCGCTCGATGCGCTTCCTCAGCCGCTGGG
GCGGGGATGAACCCGCCACGCAGATTGTCCTGCTGTTCCTGCTGCCGTTTGCCTCCTATCTGATTGCCGAACATATCGGT
GTCTCCGGCATCCTGGCGGCGGTGGCGGCGGGGATGACCATCACCCGTTCCGGCGTGATGCGCACCGCGCCCTTGGCCAT
GCGCCTGCGCGCCAACAGCACCTGGGCAATGTTGGAGTTTGTCTTCAACGGCATGGTCTTCCTGTTGTTGGGCCTGCAGC
TGCCGGATATCCTCTCCAGTTCGCTGGTGGCGGCGGAGGCCGACCCCAACGTTGAGACCTGGATGCTGTTTACCGACATT
ATCCTGATCTATGCCGCGCTGATGCTGGTGCGTTTTGGCTGGCTGTGGTCGATGCGTAAGCTCAGTCAGCGCTTCCTGAA
GAAGAAGCCGATGGAGTTTGGCTCCTGGACTACGCGCGAGCTGCTGATCTCCTCCGTTGCCGGGGTGCGCGGGGCGATTA
CCCTCGCCGGTGTGCTCTCCATTCCTCTGCTGCTGCCTGACGGGAATGTCTTTCCGGCGCGCTATGAGCTGATTTTCCTC
GCCGCCGGGGTGATCCTGTTCTCGCTGTTCGTCGGGGTGATTGCGCTGCCGATCCTGCTACGTCACATTGAATCGAGCGA
TAATGTGCAGCAGCGGAAAGAGGAGCGTCTGGCGCGCGCGGCAACGGCTGACGTGGCGATTGTGGCGATCCAGAAGATGG
AAGAGCGTCTGGCGGCGGATACCAAAGAGAATATCGATACCCAGCTGCTGACCGAAGTCAGTTCGCGGGTGATCGGTAAC
CTGCGCCGGCGCGCCGATGGGCGTAACGACGTGGAAACCTCTATGCTCGAAGAGAGTCTGGAACGCCGCTTCCGCCTGGC
GGCGCTGCGCTCTGAGCGCGGCGAGCTGTATCATCTGCGCGCCACCCGGCAGATCAGTAACGAGACGCTGCAGAAGCTGC
TCCACGATCTCGACCTGCTGGAAGCGCTGTTAATCGAAGATCAATAA

Upstream 100 bases:

>100_bases
AAGCCACATCCTGTTTCCATTTGCGTTAATCTGGGTAGCGTATGATTCACAGGCATGACGCCTTACAGGTATAAAAGAAA
ACGCAGCAAACAGGGAACAC

Downstream 100 bases:

>100_bases
CCTGTAATCCGGATAGCGCGACGCTTATTCGGACTACTGGCGAGACTGCAGTAAATGTGTAGCCCCGGTAAGCGTTAGCG
CGACCGGGGGAAACCCGGGC

Product: putative sodium:hydrogen antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 548; Mature: 548

Protein sequence:

>548_residues
MEIFFTILIMTLVVSLSGVVTRVLPFQVPLPLMQIAIGALLAWPTFGLHVEFDPELFLVLFIPPLLFADGWKTPTREFIE
HGREILGLALALVVVTVVGIGFLIYWIVPGIPLIPAFALAAVLSPTDAVALSGIVGEGRIPKKIMGILQGEALMNDASGL
VSLKFAVAVAMGTMVFTVGGATVEFLKVAIGGVLAGFVVSWSYGRSMRFLSRWGGDEPATQIVLLFLLPFASYLIAEHIG
VSGILAAVAAGMTITRSGVMRTAPLAMRLRANSTWAMLEFVFNGMVFLLLGLQLPDILSSSLVAAEADPNVETWMLFTDI
ILIYAALMLVRFGWLWSMRKLSQRFLKKKPMEFGSWTTRELLISSVAGVRGAITLAGVLSIPLLLPDGNVFPARYELIFL
AAGVILFSLFVGVIALPILLRHIESSDNVQQRKEERLARAATADVAIVAIQKMEERLAADTKENIDTQLLTEVSSRVIGN
LRRRADGRNDVETSMLEESLERRFRLAALRSERGELYHLRATRQISNETLQKLLHDLDLLEALLIEDQ

Sequences:

>Translated_548_residues
MEIFFTILIMTLVVSLSGVVTRVLPFQVPLPLMQIAIGALLAWPTFGLHVEFDPELFLVLFIPPLLFADGWKTPTREFIE
HGREILGLALALVVVTVVGIGFLIYWIVPGIPLIPAFALAAVLSPTDAVALSGIVGEGRIPKKIMGILQGEALMNDASGL
VSLKFAVAVAMGTMVFTVGGATVEFLKVAIGGVLAGFVVSWSYGRSMRFLSRWGGDEPATQIVLLFLLPFASYLIAEHIG
VSGILAAVAAGMTITRSGVMRTAPLAMRLRANSTWAMLEFVFNGMVFLLLGLQLPDILSSSLVAAEADPNVETWMLFTDI
ILIYAALMLVRFGWLWSMRKLSQRFLKKKPMEFGSWTTRELLISSVAGVRGAITLAGVLSIPLLLPDGNVFPARYELIFL
AAGVILFSLFVGVIALPILLRHIESSDNVQQRKEERLARAATADVAIVAIQKMEERLAADTKENIDTQLLTEVSSRVIGN
LRRRADGRNDVETSMLEESLERRFRLAALRSERGELYHLRATRQISNETLQKLLHDLDLLEALLIEDQ
>Mature_548_residues
MEIFFTILIMTLVVSLSGVVTRVLPFQVPLPLMQIAIGALLAWPTFGLHVEFDPELFLVLFIPPLLFADGWKTPTREFIE
HGREILGLALALVVVTVVGIGFLIYWIVPGIPLIPAFALAAVLSPTDAVALSGIVGEGRIPKKIMGILQGEALMNDASGL
VSLKFAVAVAMGTMVFTVGGATVEFLKVAIGGVLAGFVVSWSYGRSMRFLSRWGGDEPATQIVLLFLLPFASYLIAEHIG
VSGILAAVAAGMTITRSGVMRTAPLAMRLRANSTWAMLEFVFNGMVFLLLGLQLPDILSSSLVAAEADPNVETWMLFTDI
ILIYAALMLVRFGWLWSMRKLSQRFLKKKPMEFGSWTTRELLISSVAGVRGAITLAGVLSIPLLLPDGNVFPARYELIFL
AAGVILFSLFVGVIALPILLRHIESSDNVQQRKEERLARAATADVAIVAIQKMEERLAADTKENIDTQLLTEVSSRVIGN
LRRRADGRNDVETSMLEESLERRFRLAALRSERGELYHLRATRQISNETLQKLLHDLDLLEALLIEDQ

Specific function: Unknown

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family [H]

Homologues:

Organism=Homo sapiens, GI148727259, Length=462, Percent_Identity=24.025974025974, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI15529998, Length=459, Percent_Identity=25.4901960784314, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI27734935, Length=258, Percent_Identity=23.6434108527132, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI14211919, Length=269, Percent_Identity=24.1635687732342, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI294997330, Length=269, Percent_Identity=23.4200743494424, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI5454070, Length=292, Percent_Identity=22.6027397260274, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI110227626, Length=269, Percent_Identity=23.4200743494424, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI194239733, Length=491, Percent_Identity=23.2179226069246, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI41872703, Length=501, Percent_Identity=21.7564870259481, Blast_Score=67, Evalue=6e-11,
Organism=Escherichia coli, GI1790501, Length=548, Percent_Identity=91.6058394160584, Blast_Score=985, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71980847, Length=396, Percent_Identity=24.2424242424242, Blast_Score=85, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI25150332, Length=380, Percent_Identity=24.7368421052632, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71992101, Length=337, Percent_Identity=21.6617210682493, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71992107, Length=337, Percent_Identity=21.6617210682493, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71999819, Length=397, Percent_Identity=22.6700251889169, Blast_Score=68, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71999817, Length=397, Percent_Identity=22.6700251889169, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71999821, Length=397, Percent_Identity=22.6700251889169, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71990932, Length=395, Percent_Identity=23.5443037974684, Blast_Score=66, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI25147678, Length=396, Percent_Identity=22.4747474747475, Blast_Score=65, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6320663, Length=367, Percent_Identity=22.6158038147139, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI281364513, Length=436, Percent_Identity=21.7889908256881, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221473222, Length=436, Percent_Identity=21.7889908256881, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221510734, Length=401, Percent_Identity=22.9426433915212, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI221510738, Length=401, Percent_Identity=22.9426433915212, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI221473215, Length=442, Percent_Identity=21.4932126696833, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI221473212, Length=454, Percent_Identity=20.9251101321586, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 60106; Mature: 60106

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHCCC
>Mature Secondary Structure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HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503 [H]