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The map label for this gene is tyrB [H]

Identifier: 238892527

GI number: 238892527

Start: 309557

End: 310792

Strand: Direct

Name: tyrB [H]

Synonym: KP1_0296

Alternate gene names: 238892527

Gene position: 309557-310792 (Clockwise)

Preceding gene: 238892526

Following gene: 238892528

Centisome position: 5.9

GC content: 60.52

Gene sequence:

>1236_bases
TTGTGTAAGAACCTGCCCCATGTAAACCTGGAGATACATCGCGTGTTTCAAAAAGTTGACGCCTACGCCGGCGACCCTAT
TCTTTCTCTGATGGAACGCTTCAAAGAAGACCCGCGAAGCGACAAAGTCAACCTGAGTATCGGGCTGTACTACAACGATG
ACGGCATTATCCCGCAGCTGCAGGCGGTGGCGGAAGCGGAAGCACGCCTGAACGCCGAGCCGCATGGCGCCTCGCTGTAT
CTGCCAATGGAAGGGTTGAGCGGCTACCGTCAGGCGATTGCGCCGCTGCTGTTTGGCGCAGAGCATACCGCGCTTAAGCA
AAATCGCATTGCCTCTATTCAGACGGTCGGCGGTTCGGGCGCGCTGAAGGTCGGGGCCGACTTCCTCAAACGTTACTTTC
CTGAGTCTCATGTCTGGGTCAGCGATCCGACCTGGGAAAACCACATCGCCATTTTTGAAGGGGCTGGCTTCGAAGTAAGT
ACTTACCCCTGGTTTGATAAAGCCACCAACGGCGTGCGCTTTGAGGACCTGCTGGCGACGCTGCAAACGCTGCCGGCCCG
CGATATTGTGCTGCTGCACCCTTGCTGCCACAACCCGACCGGCGCCGACCTGACGCCAGCCCAGTGGGACCGCGTGGTTG
AGGTATTGAAAGCGCGTCAGCTGATCCCCTTCCTCGACATCGCCTACCAGGGCTTTGGCGGGGGGCTGGAAGAGGATGCC
TACGCTATTCGCGCCATCGCCAGCGCCGGGATGCCGATGCTGGTCAGCAACTCGTTCTCCAAAATTTTCTCGCTGTACGG
GGAGCGCGTCGGCGGTCTGTCCGTGGTCTGTGAAGACAGCGAAACCGCGGGCCGCGTGCTGGGGCAGCTGAAGGCCACCG
TGCGCCGCAACTACTCCAGCCCGCCGAGCTTTGGCGCGCAGGTGGTGGCGACGGTGCTGAACGATGCCGGGCTGAAAGCC
ACGTGGCAGGCGGAAGTGGACGCCATGCGCGCGCACATCCTGACCATGCGCCAGGCGCTGGTCGACGCGCTGCAGCAGGT
TGCCCCGGGCAGCAAAGTGGATTACCTGCTCAAGCAGCGCGGGATGTTCAGCTATAGCGGATTTAGCGCGGCGCAGGTGG
ATCGTCTGCGCGATGAGTTTGGCGTCTACCTGATTGCCAGCGGACGCATGTGCGTGGCGGGGTTAAACTCACGTAATGTT
CAGCAGGTAGCGAAAGCTTTTGCCGCGGTAATGTAA

Upstream 100 bases:

>100_bases
CGGTACGCACCAGGCCTGCGGCGCTCAAAAAAGCGGTTTATACCGCTGCGGGGTCACTTTCCCCTCAACATCCTCTCGAC
CTGCCGTCATATCCGGTTTA

Downstream 100 bases:

>100_bases
GCCGCTCTCCAGCAGGTTGTCTCTGCCGGTCAACGGGCAGGGGCAACCCCCTCGGATGTGATCATCCTCTTTTTCTATGA
CATCTGCGCGAAAAAGGCTT

Product: aromatic amino acid aminotransferase

Products: NA

Alternate protein names: TyrAT; Aromatic-amino-acid transaminase; Aspartate aminotransferase [H]

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MCKNLPHVNLEIHRVFQKVDAYAGDPILSLMERFKEDPRSDKVNLSIGLYYNDDGIIPQLQAVAEAEARLNAEPHGASLY
LPMEGLSGYRQAIAPLLFGAEHTALKQNRIASIQTVGGSGALKVGADFLKRYFPESHVWVSDPTWENHIAIFEGAGFEVS
TYPWFDKATNGVRFEDLLATLQTLPARDIVLLHPCCHNPTGADLTPAQWDRVVEVLKARQLIPFLDIAYQGFGGGLEEDA
YAIRAIASAGMPMLVSNSFSKIFSLYGERVGGLSVVCEDSETAGRVLGQLKATVRRNYSSPPSFGAQVVATVLNDAGLKA
TWQAEVDAMRAHILTMRQALVDALQQVAPGSKVDYLLKQRGMFSYSGFSAAQVDRLRDEFGVYLIASGRMCVAGLNSRNV
QQVAKAFAAVM

Sequences:

>Translated_411_residues
MCKNLPHVNLEIHRVFQKVDAYAGDPILSLMERFKEDPRSDKVNLSIGLYYNDDGIIPQLQAVAEAEARLNAEPHGASLY
LPMEGLSGYRQAIAPLLFGAEHTALKQNRIASIQTVGGSGALKVGADFLKRYFPESHVWVSDPTWENHIAIFEGAGFEVS
TYPWFDKATNGVRFEDLLATLQTLPARDIVLLHPCCHNPTGADLTPAQWDRVVEVLKARQLIPFLDIAYQGFGGGLEEDA
YAIRAIASAGMPMLVSNSFSKIFSLYGERVGGLSVVCEDSETAGRVLGQLKATVRRNYSSPPSFGAQVVATVLNDAGLKA
TWQAEVDAMRAHILTMRQALVDALQQVAPGSKVDYLLKQRGMFSYSGFSAAQVDRLRDEFGVYLIASGRMCVAGLNSRNV
QQVAKAFAAVM
>Mature_411_residues
MCKNLPHVNLEIHRVFQKVDAYAGDPILSLMERFKEDPRSDKVNLSIGLYYNDDGIIPQLQAVAEAEARLNAEPHGASLY
LPMEGLSGYRQAIAPLLFGAEHTALKQNRIASIQTVGGSGALKVGADFLKRYFPESHVWVSDPTWENHIAIFEGAGFEVS
TYPWFDKATNGVRFEDLLATLQTLPARDIVLLHPCCHNPTGADLTPAQWDRVVEVLKARQLIPFLDIAYQGFGGGLEEDA
YAIRAIASAGMPMLVSNSFSKIFSLYGERVGGLSVVCEDSETAGRVLGQLKATVRRNYSSPPSFGAQVVATVLNDAGLKA
TWQAEVDAMRAHILTMRQALVDALQQVAPGSKVDYLLKQRGMFSYSGFSAAQVDRLRDEFGVYLIASGRMCVAGLNSRNV
QQVAKAFAAVM

Specific function: catalyzes the formation of methionine from 2-keto-4- methylthiobutyrate (KMTB) primarily using aromatic amino acids (tyrosine, phenylalanine and tryptophan) or glutamate as the amino donors. Histidine, leucine, asparagine, or arginine are also functional

COG id: COG1448

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504067, Length=390, Percent_Identity=40.7692307692308, Blast_Score=302, Evalue=3e-82,
Organism=Homo sapiens, GI73486658, Length=388, Percent_Identity=39.9484536082474, Blast_Score=301, Evalue=1e-81,
Organism=Homo sapiens, GI117414139, Length=381, Percent_Identity=26.509186351706, Blast_Score=171, Evalue=1e-42,
Organism=Escherichia coli, GI1790488, Length=397, Percent_Identity=83.8790931989924, Blast_Score=699, Evalue=0.0,
Organism=Escherichia coli, GI1787159, Length=397, Percent_Identity=42.5692695214106, Blast_Score=341, Evalue=4e-95,
Organism=Caenorhabditis elegans, GI71981858, Length=401, Percent_Identity=36.4089775561097, Blast_Score=291, Evalue=4e-79,
Organism=Caenorhabditis elegans, GI17569539, Length=367, Percent_Identity=40.8719346049046, Blast_Score=286, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI25147133, Length=392, Percent_Identity=38.0102040816327, Blast_Score=280, Evalue=8e-76,
Organism=Caenorhabditis elegans, GI17569537, Length=390, Percent_Identity=32.0512820512821, Blast_Score=197, Evalue=9e-51,
Organism=Caenorhabditis elegans, GI17550384, Length=263, Percent_Identity=35.7414448669202, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI25147136, Length=208, Percent_Identity=36.0576923076923, Blast_Score=142, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6323055, Length=405, Percent_Identity=36.0493827160494, Blast_Score=283, Evalue=4e-77,
Organism=Saccharomyces cerevisiae, GI6322743, Length=423, Percent_Identity=32.1513002364066, Blast_Score=228, Evalue=1e-60,
Organism=Drosophila melanogaster, GI24654046, Length=409, Percent_Identity=37.6528117359413, Blast_Score=298, Evalue=6e-81,
Organism=Drosophila melanogaster, GI19922362, Length=387, Percent_Identity=39.0180878552972, Blast_Score=298, Evalue=6e-81,
Organism=Drosophila melanogaster, GI24580970, Length=397, Percent_Identity=36.5239294710327, Blast_Score=278, Evalue=5e-75,
Organism=Drosophila melanogaster, GI24580972, Length=397, Percent_Identity=36.5239294710327, Blast_Score=278, Evalue=6e-75,
Organism=Drosophila melanogaster, GI19920542, Length=388, Percent_Identity=36.8556701030928, Blast_Score=277, Evalue=1e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR000796
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.5; =2.6.1.57; =2.6.1.1 [H]

Molecular weight: Translated: 44914; Mature: 44914

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCKNLPHVNLEIHRVFQKVDAYAGDPILSLMERFKEDPRSDKVNLSIGLYYNDDGIIPQL
CCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCCHHH
QAVAEAEARLNAEPHGASLYLPMEGLSGYRQAIAPLLFGAEHTALKQNRIASIQTVGGSG
HHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCHHHHHHHCCCEEEEEECCCC
ALKVGADFLKRYFPESHVWVSDPTWENHIAIFEGAGFEVSTYPWFDKATNGVRFEDLLAT
CHHHHHHHHHHHCCCCCEEECCCCCCCCEEEEECCCCEEECCCCHHHCCCCCCHHHHHHH
LQTLPARDIVLLHPCCHNPTGADLTPAQWDRVVEVLKARQLIPFLDIAYQGFGGGLEEDA
HHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHH
YAIRAIASAGMPMLVSNSFSKIFSLYGERVGGLSVVCEDSETAGRVLGQLKATVRRNYSS
HHHHHHHHCCCCCEEHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHCCCC
PPSFGAQVVATVLNDAGLKATWQAEVDAMRAHILTMRQALVDALQQVAPGSKVDYLLKQR
CCCHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHC
GMFSYSGFSAAQVDRLRDEFGVYLIASGRMCVAGLNSRNVQQVAKAFAAVM
CCCCCCCCCHHHHHHHHHHCCEEEEECCCEEEECCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MCKNLPHVNLEIHRVFQKVDAYAGDPILSLMERFKEDPRSDKVNLSIGLYYNDDGIIPQL
CCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCCHHH
QAVAEAEARLNAEPHGASLYLPMEGLSGYRQAIAPLLFGAEHTALKQNRIASIQTVGGSG
HHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCHHHHHHHCCCEEEEEECCCC
ALKVGADFLKRYFPESHVWVSDPTWENHIAIFEGAGFEVSTYPWFDKATNGVRFEDLLAT
CHHHHHHHHHHHCCCCCEEECCCCCCCCEEEEECCCCEEECCCCHHHCCCCCCHHHHHHH
LQTLPARDIVLLHPCCHNPTGADLTPAQWDRVVEVLKARQLIPFLDIAYQGFGGGLEEDA
HHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHH
YAIRAIASAGMPMLVSNSFSKIFSLYGERVGGLSVVCEDSETAGRVLGQLKATVRRNYSS
HHHHHHHHCCCCCEEHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHCCCC
PPSFGAQVVATVLNDAGLKATWQAEVDAMRAHILTMRQALVDALQQVAPGSKVDYLLKQR
CCCHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHC
GMFSYSGFSAAQVDRLRDEFGVYLIASGRMCVAGLNSRNVQQVAKAFAAVM
CCCCCCCCCHHHHHHHHHHCCEEEEECCCEEEECCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10074065 [H]