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The map label for this gene is lpxD [C]

Identifier: 238892498

GI number: 238892498

Start: 283120

End: 283725

Strand: Reverse

Name: lpxD [C]

Synonym: KP1_0265

Alternate gene names: 238892498

Gene position: 283725-283120 (Counterclockwise)

Preceding gene: 238892499

Following gene: 238892496

Centisome position: 5.41

GC content: 57.59

Gene sequence:

>606_bases
TTGGCTGTGGCTGGAAGTACTCGCCGCGAATCCCGCCGCGCGCCGTTTTTACGAACGCCAGGGAATGCAGCACATCAGAG
ACACGACTTTCCACTCCGCCAGCCAGCAAAGCACCTTACATATTCTGGCCAAACCTATTTGAGAGGAACTATGCCTGAGC
TTCGTGATACCGGTGTACGTAACGTCGTTTGTGGGGAAAATGTCGTTATTTACCAGCCCGCCAACCTCTATGATTGCCAG
CTCGGCGATAACGTCTTCGTCGGGCCGTTCGTTGAGATCCAGGGGAATACCCGCATCGGCGCGAACAGTAAAATTCAATC
CCATACCTTTATCTGCGAGTACGTCACCATCGGCCAGCGCTGCTTTATCGGTCACGGCGTGATGTTTGCCAACGACCTGT
TTCGCGAGGGTAAACCAAACGCCGACCGCGCCAGCTGGGGGCGGATCGAGATTGGCGATGACGTGTCGATCGGCAGCGGC
GCCACGATTCTGGCCGTCAGCATCTGCGATGGGGTGGTGATAGGCGCGGGCAGCGTGGTAACGAAGTCCATTACCGAGAA
AGGCGTGTGGGCGGGGAATCCGGCGAGGCTGCTGCGGCGGCTATAA

Upstream 100 bases:

>100_bases
GCTGCTGCATAAGCTCTACCTGATGCCGGGGAAGACTGGCCACCGCTACGGCGAGCATATTTTTCACGCCGTCGAGGCGA
GCAAAAACGGCCGGTGAAAG

Downstream 100 bases:

>100_bases
ATAAAAATGCCGACCAAAGGGTCGGCATTCCGTCTTAGCTGCGCAAGCGTTATGCGCGCCAGGCTTTATAACGGTTAATC
AGGCCGTTAGTAGAGCTGTC

Product: UDP-3-O-(3-hydroxymyristoyl)-glucosamine N-acyltransferase

Products: UDP-2,3-Bis(3-Hydroxytetradecanoyl)Glucosamine; [Acyl-Carrier Protein]. [C]

Alternate protein names: Hexapaptide Repeat-Containing Transferase; Transferase Hexapeptide Repeat Containing Protein; UDP-3-O-(3-Hydroxymyristoyl)-Glucosamine N-Acyltransferase; Acyltransferase; Acetyltransferase Protein; Hexapeptide Repeat-Containing Acetyltransferase; Hexapeptide Repeat Acetyltransferase; Acetyl/Acyl Transferase Related Protein

Number of amino acids: Translated: 201; Mature: 200

Protein sequence:

>201_residues
MAVAGSTRRESRRAPFLRTPGNAAHQRHDFPLRQPAKHLTYSGQTYLRGTMPELRDTGVRNVVCGENVVIYQPANLYDCQ
LGDNVFVGPFVEIQGNTRIGANSKIQSHTFICEYVTIGQRCFIGHGVMFANDLFREGKPNADRASWGRIEIGDDVSIGSG
ATILAVSICDGVVIGAGSVVTKSITEKGVWAGNPARLLRRL

Sequences:

>Translated_201_residues
MAVAGSTRRESRRAPFLRTPGNAAHQRHDFPLRQPAKHLTYSGQTYLRGTMPELRDTGVRNVVCGENVVIYQPANLYDCQ
LGDNVFVGPFVEIQGNTRIGANSKIQSHTFICEYVTIGQRCFIGHGVMFANDLFREGKPNADRASWGRIEIGDDVSIGSG
ATILAVSICDGVVIGAGSVVTKSITEKGVWAGNPARLLRRL
>Mature_200_residues
AVAGSTRRESRRAPFLRTPGNAAHQRHDFPLRQPAKHLTYSGQTYLRGTMPELRDTGVRNVVCGENVVIYQPANLYDCQL
GDNVFVGPFVEIQGNTRIGANSKIQSHTFICEYVTIGQRCFIGHGVMFANDLFREGKPNADRASWGRIEIGDDVSIGSGA
TILAVSICDGVVIGAGSVVTKSITEKGVWAGNPARLLRRL

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG0110

COG function: function code R; Acetyltransferase (isoleucine patch superfamily)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 2.3.1.- [C]

Molecular weight: Translated: 21887; Mature: 21756

Theoretical pI: Translated: 9.30; Mature: 9.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVAGSTRRESRRAPFLRTPGNAAHQRHDFPLRQPAKHLTYSGQTYLRGTMPELRDTGVR
CCCCCCCCHHHHCCCEEECCCCCHHHCCCCCCCCCHHHCEECCCEEEECCCCHHHHCCCC
NVVCGENVVIYQPANLYDCQLGDNVFVGPFVEIQGNTRIGANSKIQSHTFICEYVTIGQR
EEEECCCEEEECCCCEEEEECCCCEEECCEEEECCCEEECCCCCCCCCEEEEEEEECCCE
CFIGHGVMFANDLFREGKPNADRASWGRIEIGDDVSIGSGATILAVSICDGVVIGAGSVV
EEECCCHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCEEEEEEECCCEEECCCHHH
TKSITEKGVWAGNPARLLRRL
HHHHHHCCCCCCCHHHHHHCC
>Mature Secondary Structure 
AVAGSTRRESRRAPFLRTPGNAAHQRHDFPLRQPAKHLTYSGQTYLRGTMPELRDTGVR
CCCCCCCHHHHCCCEEECCCCCHHHCCCCCCCCCHHHCEECCCEEEECCCCHHHHCCCC
NVVCGENVVIYQPANLYDCQLGDNVFVGPFVEIQGNTRIGANSKIQSHTFICEYVTIGQR
EEEECCCEEEECCCCEEEEECCCCEEECCEEEECCCEEECCCCCCCCCEEEEEEEECCCE
CFIGHGVMFANDLFREGKPNADRASWGRIEIGDDVSIGSGATILAVSICDGVVIGAGSVV
EEECCCHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCEEEEEEECCCEEECCCHHH
TKSITEKGVWAGNPARLLRRL
HHHHHHCCCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-3-O-(3-Hydroxytetradecanoyl)Glucosamine; (R)-3-Hydroxytetradecanoyl-[Acyl-Carrier Protein] [C]

Specific reaction: UDP-3-O-(3-Hydroxytetradecanoyl)Glucosamine + (R)-3-Hydroxytetradecanoyl-[Acyl-Carrier Protein] = UDP-2,3-Bis(3-Hydroxytetradecanoyl)Glucosamine + [Acyl-Carrier Protein]. [C]

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA