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The map label for this gene is lysC [H]

Identifier: 238892496

GI number: 238892496

Start: 279307

End: 280656

Strand: Reverse

Name: lysC [H]

Synonym: KP1_0263

Alternate gene names: 238892496

Gene position: 280656-279307 (Counterclockwise)

Preceding gene: 238892498

Following gene: 238892495

Centisome position: 5.35

GC content: 60.81

Gene sequence:

>1350_bases
ATGACAGATCTAGTCGTCGCCAAATTTGGCGGCACCAGCGTTGCTGATTTTGACGCAATGAACCGCAGCATCGATGTGGC
GCTGCTCGATGCCAATACCCGTATTGTTGTGCTCTCCGCCTCTGCCGGCGTGACCAACATTCTGGTGGCCTTAGCGGGAG
GGCTGGAACCCACCGAACGTTTTTCCCAGCTGGACGCTCTGCGTCAGATCCAGTTCAATATTCTGGAGCGTTTGCGTTAT
CCCAACGTGATCCGCGAAGAGATTGAGCGCTTGCTGGAAAATATCACGACGCTGGCGGAAGCCGCCGCGCTCGCCTCCTC
AACCGCCCTGACCGACGAACTGGTCAGCCATGGCGAACTGATGTCCACCCTGCTGTTTGTGGAAATTCTGCGTGAACGCG
GTATTCAGGCGCAGTGGTTTGACGCCCGTAAAGTGCTGCGCACTAACGATCGCTTTGGCCGCGCCGAACCGGACATCGCC
GCCGTCGCCGAACTGACCCAGCAGCAGCTGGCGCCGCGCCTGGCGGAAGGCCTGGTGGTGACCCAGGGCTTTATCGGCAG
CGAAGCGAAAGGCCGTACCACCACCCTCGGCCGCGGCGGCAGCGATTATACCGCCGCTCTGCTCGGCGAAGCGCTGAATG
CCACCCGCGTCGATATCTGGACCGATGTCCCGGGGATCTATACTACCGACCCGCGCGTCGCGCCGGCGGCGAAACGCATC
GACGTCATCGCCTTTGAAGAGGCAGCGGAAATGGCCACCTTTGGCGCCAAAGTGCTGCATCCGGCGACCCTGCTGCCTGC
CGTGCGCAGCGATATCCCGGTGTTTGTCGGCTCCAGTAAAGAGCCTAAAGCGGGCGGTACGCTGGTGTGTAAAACCACCG
AGAACCCGCCGCTGTTCCGCGCGCTGGCGCTGCGTCGCCGGCAAACGCTGCTGACGCTGCACAGCCTGAATATGCTGCAC
TCCCGCGGCTTCCTCGCCGAAGTGTTCGGTATTCTGGCGCGCCATAACATCTCAGTTGATTTGATCACCACCTCCGAAGT
GAGCGTGGCCCTGACCATGGACACCACCGGCTCGACCTCTGCGGGCGATACCCTGCTGACCCAGGCGCTGCTGACCGAGC
TCTCTTCGCTGTGCCGCGTGGAAGTGGAAGAAAATCTGGCGCTGGTCGCCCTGATTGGCAATGAGCTGTCGAAAGCCTGC
GGCGTCGGCAAAGAGGTCTTTGGCGTCCTCGAGCCGTTTAACATCCGCATGATCTGCTATGGCGCCTCCAGCCACAACCT
GTGCTTCCTGGTGCCGGGCGACGATGCGGAGAAGGTTGTGCAGAAGCTGCATCATAATTTGTTTGAATAA

Upstream 100 bases:

>100_bases
TATTAAGACATTTTGTTGCGATCCGGCGGCGTCCAGCCCCTGCCAGGATCGGTGCTCAGGAATCGTTTTAATAAGTCAGG
CCCCCTGACACGAGGTTGTT

Downstream 100 bases:

>100_bases
AATTCCTTAGCACGATAAACAATACCTATAGCCGGGCTCGAACCCGGCTTTTTTATAACAACATCAACACAACCAGCTGA
CCTGCTCGCCGCCCATCGGG

Product: aspartate kinase III

Products: NA

Alternate protein names: Aspartate kinase III; AKIII; Lysine-sensitive aspartokinase III [H]

Number of amino acids: Translated: 449; Mature: 448

Protein sequence:

>449_residues
MTDLVVAKFGGTSVADFDAMNRSIDVALLDANTRIVVLSASAGVTNILVALAGGLEPTERFSQLDALRQIQFNILERLRY
PNVIREEIERLLENITTLAEAAALASSTALTDELVSHGELMSTLLFVEILRERGIQAQWFDARKVLRTNDRFGRAEPDIA
AVAELTQQQLAPRLAEGLVVTQGFIGSEAKGRTTTLGRGGSDYTAALLGEALNATRVDIWTDVPGIYTTDPRVAPAAKRI
DVIAFEEAAEMATFGAKVLHPATLLPAVRSDIPVFVGSSKEPKAGGTLVCKTTENPPLFRALALRRRQTLLTLHSLNMLH
SRGFLAEVFGILARHNISVDLITTSEVSVALTMDTTGSTSAGDTLLTQALLTELSSLCRVEVEENLALVALIGNELSKAC
GVGKEVFGVLEPFNIRMICYGASSHNLCFLVPGDDAEKVVQKLHHNLFE

Sequences:

>Translated_449_residues
MTDLVVAKFGGTSVADFDAMNRSIDVALLDANTRIVVLSASAGVTNILVALAGGLEPTERFSQLDALRQIQFNILERLRY
PNVIREEIERLLENITTLAEAAALASSTALTDELVSHGELMSTLLFVEILRERGIQAQWFDARKVLRTNDRFGRAEPDIA
AVAELTQQQLAPRLAEGLVVTQGFIGSEAKGRTTTLGRGGSDYTAALLGEALNATRVDIWTDVPGIYTTDPRVAPAAKRI
DVIAFEEAAEMATFGAKVLHPATLLPAVRSDIPVFVGSSKEPKAGGTLVCKTTENPPLFRALALRRRQTLLTLHSLNMLH
SRGFLAEVFGILARHNISVDLITTSEVSVALTMDTTGSTSAGDTLLTQALLTELSSLCRVEVEENLALVALIGNELSKAC
GVGKEVFGVLEPFNIRMICYGASSHNLCFLVPGDDAEKVVQKLHHNLFE
>Mature_448_residues
TDLVVAKFGGTSVADFDAMNRSIDVALLDANTRIVVLSASAGVTNILVALAGGLEPTERFSQLDALRQIQFNILERLRYP
NVIREEIERLLENITTLAEAAALASSTALTDELVSHGELMSTLLFVEILRERGIQAQWFDARKVLRTNDRFGRAEPDIAA
VAELTQQQLAPRLAEGLVVTQGFIGSEAKGRTTTLGRGGSDYTAALLGEALNATRVDIWTDVPGIYTTDPRVAPAAKRID
VIAFEEAAEMATFGAKVLHPATLLPAVRSDIPVFVGSSKEPKAGGTLVCKTTENPPLFRALALRRRQTLLTLHSLNMLHS
RGFLAEVFGILARHNISVDLITTSEVSVALTMDTTGSTSAGDTLLTQALLTELSSLCRVEVEENLALVALIGNELSKACG
VGKEVFGVLEPFNIRMICYGASSHNLCFLVPGDDAEKVVQKLHHNLFE

Specific function: Lysine biosynthesis; first step. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1790455, Length=449, Percent_Identity=87.5278396436526, Blast_Score=747, Evalue=0.0,
Organism=Escherichia coli, GI1786183, Length=474, Percent_Identity=30.5907172995781, Blast_Score=177, Evalue=2e-45,
Organism=Escherichia coli, GI1790376, Length=290, Percent_Identity=34.8275862068965, Blast_Score=132, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6320893, Length=495, Percent_Identity=27.8787878787879, Blast_Score=167, Evalue=3e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 48432; Mature: 48301

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLVVAKFGGTSVADFDAMNRSIDVALLDANTRIVVLSASAGVTNILVALAGGLEPTER
CCCEEEEECCCCCCHHHHHCCCEEEEEEEECCCEEEEEECCCCHHHHHHHHHCCCCHHHH
FSQLDALRQIQFNILERLRYPNVIREEIERLLENITTLAEAAALASSTALTDELVSHGEL
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MSTLLFVEILRERGIQAQWFDARKVLRTNDRFGRAEPDIAAVAELTQQQLAPRLAEGLVV
HHHHHHHHHHHHCCCCEEHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEE
TQGFIGSEAKGRTTTLGRGGSDYTAALLGEALNATRVDIWTDVPGIYTTDPRVAPAAKRI
ECCCCCCCCCCCEEECCCCCCHHHHHHHHHHCCCCEEEEEECCCCCEECCCCCCCHHHHE
DVIAFEEAAEMATFGAKVLHPATLLPAVRSDIPVFVGSSKEPKAGGTLVCKTTENPPLFR
EEEEHHHHHHHHHHHHHHHCHHHHHHHHHCCCCEEECCCCCCCCCCEEEEEECCCCHHHH
ALALRRRQTLLTLHSLNMLHSRGFLAEVFGILARHNISVDLITTSEVSVALTMDTTGSTS
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEEEECCEEEEEEECCCCCCC
AGDTLLTQALLTELSSLCRVEVEENLALVALIGNELSKACGVGKEVFGVLEPFNIRMICY
CCHHHHHHHHHHHHHHHHEEECCCCEEEEEEECHHHHHHHCCCHHHHHHCCCCCEEEEEE
GASSHNLCFLVPGDDAEKVVQKLHHNLFE
ECCCCCEEEEECCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
TDLVVAKFGGTSVADFDAMNRSIDVALLDANTRIVVLSASAGVTNILVALAGGLEPTER
CCEEEEECCCCCCHHHHHCCCEEEEEEEECCCEEEEEECCCCHHHHHHHHHCCCCHHHH
FSQLDALRQIQFNILERLRYPNVIREEIERLLENITTLAEAAALASSTALTDELVSHGEL
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MSTLLFVEILRERGIQAQWFDARKVLRTNDRFGRAEPDIAAVAELTQQQLAPRLAEGLVV
HHHHHHHHHHHHCCCCEEHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEE
TQGFIGSEAKGRTTTLGRGGSDYTAALLGEALNATRVDIWTDVPGIYTTDPRVAPAAKRI
ECCCCCCCCCCCEEECCCCCCHHHHHHHHHHCCCCEEEEEECCCCCEECCCCCCCHHHHE
DVIAFEEAAEMATFGAKVLHPATLLPAVRSDIPVFVGSSKEPKAGGTLVCKTTENPPLFR
EEEEHHHHHHHHHHHHHHHCHHHHHHHHHCCCCEEECCCCCCCCCCEEEEEECCCCHHHH
ALALRRRQTLLTLHSLNMLHSRGFLAEVFGILARHNISVDLITTSEVSVALTMDTTGSTS
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEEEECCEEEEEEECCCCCCC
AGDTLLTQALLTELSSLCRVEVEENLALVALIGNELSKACGVGKEVFGVLEPFNIRMICY
CCHHHHHHHHHHHHHHHHEEECCCCEEEEEEECHHHHHHHCCCHHHHHHCCCCCEEEEEE
GASSHNLCFLVPGDDAEKVVQKLHHNLFE
ECCCCCEEEEECCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3003049; 8265357; 9278503; 6312411 [H]