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The map label for this gene is parE [H]

Identifier: 238028239

GI number: 238028239

Start: 3068183

End: 3070165

Strand: Reverse

Name: parE [H]

Synonym: bglu_1g26930

Alternate gene names: 238028239

Gene position: 3070165-3068183 (Counterclockwise)

Preceding gene: 238028240

Following gene: 238028238

Centisome position: 78.59

GC content: 67.52

Gene sequence:

>1983_bases
ATGTCCACGAAAAAGCCCGCAGCGGCATATAGCGAAGCATCGATCAAGGTGCTGAAGGGCCTCGAGCCCGTCAAGCAGCG
GCCCGGTATGTATACGCGTACCGAAAACCCGCTGCACATCATTCAGGAAGTGATCGACAACGCCTCGGACGAGGCGCTCG
GCGGCCACGGCAAGCAGATCACGGTCACCCTGCATGCGGACCAGTCGGTCTCGGTGGAGGACGACGGCCGCGGCATTCCG
TTCGGCCTGCATCCGGACGAAGGCGTGCCGGTGGTGGAGATCGTGTTCACGCGGCTGCACGCGGGCGGCAAGTTCGACAA
GGCCGCGGGCGGCGCCTACACCTTCTCGGGCGGCCTGCACGGGGTGGGCGTGTCGGTCACGAACGCGCTCGCCACGCGGC
TCGACGTCACGGTCTGGCGCGAGGGCAAATGCGCCGAGCTCGGCTTCGCGCACGGCGACGTGGTCAAGCCGCTCGTCACG
CAGCCGGCCGGCCGCGGCGAGAAGAAGTCGGGCACGCGGGTGCGCGTCTGGCCCGACGGCAAGTATTTCGATTCGCCGAA
CCTGCCGCTCGGCGAGCTGCAGCGGCTGCTGCGCTCGAAGGCGGTGCTGCTGCCGGGCGTGGAAGTGGTGCTCGTCATCG
AGAAGTCGGGCGAACGGCAGAGCTGGAAGTACGAGGACGGCCTGCGCGGCTACCTGCTCGACGAGATGAACGGCAGCGAG
CTGCTGATTCCGCTGTTCGAGGGCGAGCGCTTCGCCGATTCGAAGTCGGGCGACGACAGCTTCGCCGACGGCGAGGGCGC
CTCGTGGGTGGTGGCCTGGAGCGAGGAAGGCTCGCTCACGCGCGAATCCTACGTGAACCTGATCCCCACGCCTGCCGGCG
GCACGCACGAGTCGGGCTTGCGCGACGGGCTCTACCAGGCGGTCAAGAGCTTCGTCGAGCTGCACAATCTGCAGCCGAAA
GGCGTCAAGCTGCTGGCCGAGGACGTGTTCGCGCGCGTCTCGTTCGTGCTGTCGGCGAAGGTGCTCGACCCGCAGTTCCA
AGGGCAGATCAAGGAGCGGCTCAACAGCCGGGACGCGGTGAAGCTGGTCTCGTCGTTCACGCGCCCGGCGCTCGAGCTGT
GGCTGAACCAGCACGTCGAGCACGGCAAGAAGCTCGCCGAGCTCGTGATCAAGCAGGCGCAGGCGCGCACGCGCGCGGGC
CAGAAGGTGGAGAAGCGCAAGAGCTCGGGCGTGGCGGTGCTGCCGGGCAAGCTGACCGACTGCGAGACGCAGGACATCAC
GCGCAACGAGCTGTTCCTGGTCGAGGGCGATTCGGCGGGCGGCTCGGCCAAGATGGGGCGCGACAAGGAGTATCAGGCGA
TCCTGCCGCTGCGCGGCAAGGTGCTCAACACCTGGGAAACCGAGCGCGATCGGCTGTTCGCGAACAACGAGGTGCACGAC
ATCTCGGTGGCGATCGGCGTCGATCCGCACGGTCCCGACGACAACGTCGACCTGTCGAACCTGCGCTACGGCAAGATCTG
CATCCTCTCGGACGCGGACGTGGACGGCGCGCACATCCAGGTGCTGCTGCTCACGCTGTTCTTCAAGCATTTCCCGCAGC
TGATCGAGCGCGGCAACGTGTTCGTGGCGCGCCCGCCGCTGTTTCGCGTCGACGCGCCGGCGCGCGGCAAGAAGCCCGCG
CAGAAGCTCTACGCGCTCGACGACGGCGAGCTCGAGGCGATCCTCGACAAGCTGCGCAAGGACGGCGTGCGCGACACGCA
GTGGACCATCAGCCGCTTCAAGGGCCTCGGCGAGATGAGCGCCGAGCAGCTGTGGGACACCACCATGAATCCCGACACGC
GGCGCCTGATGCCGGTGGCGCTCGGCCAGCTCGACTACGACGCGACCGTCTCGCGCATGACGATGCTGATGGGCAAGGGC
GAAGCCGCGGCGCGCCGCAGCTGGCTGGAAGAAAAGGGCAACGAGGTCGAGGCCGACATCTGA

Upstream 100 bases:

>100_bases
AGGTTCCGAGCGGCGCGTTCATCGAATTCAACGTTTTGTCCATGCGCTTGTCGGCCCCGGCGGCCGGCGATCACCCGGAC
GATTGACGAAACTGGCGCCT

Downstream 100 bases:

>100_bases
GCGGCGGCGCGCCCGCCCGAGGTGCCCGCCTGCCGCCCCGAACCGATACGCAAGCATACGGAAGCGATACCCGATGGACG
ACAACACTCCCGACTTTTTC

Product: DNA topoisomerase IV subunit B

Products: NA

Alternate protein names: Topoisomerase IV subunit B [H]

Number of amino acids: Translated: 660; Mature: 659

Protein sequence:

>660_residues
MSTKKPAAAYSEASIKVLKGLEPVKQRPGMYTRTENPLHIIQEVIDNASDEALGGHGKQITVTLHADQSVSVEDDGRGIP
FGLHPDEGVPVVEIVFTRLHAGGKFDKAAGGAYTFSGGLHGVGVSVTNALATRLDVTVWREGKCAELGFAHGDVVKPLVT
QPAGRGEKKSGTRVRVWPDGKYFDSPNLPLGELQRLLRSKAVLLPGVEVVLVIEKSGERQSWKYEDGLRGYLLDEMNGSE
LLIPLFEGERFADSKSGDDSFADGEGASWVVAWSEEGSLTRESYVNLIPTPAGGTHESGLRDGLYQAVKSFVELHNLQPK
GVKLLAEDVFARVSFVLSAKVLDPQFQGQIKERLNSRDAVKLVSSFTRPALELWLNQHVEHGKKLAELVIKQAQARTRAG
QKVEKRKSSGVAVLPGKLTDCETQDITRNELFLVEGDSAGGSAKMGRDKEYQAILPLRGKVLNTWETERDRLFANNEVHD
ISVAIGVDPHGPDDNVDLSNLRYGKICILSDADVDGAHIQVLLLTLFFKHFPQLIERGNVFVARPPLFRVDAPARGKKPA
QKLYALDDGELEAILDKLRKDGVRDTQWTISRFKGLGEMSAEQLWDTTMNPDTRRLMPVALGQLDYDATVSRMTMLMGKG
EAAARRSWLEEKGNEVEADI

Sequences:

>Translated_660_residues
MSTKKPAAAYSEASIKVLKGLEPVKQRPGMYTRTENPLHIIQEVIDNASDEALGGHGKQITVTLHADQSVSVEDDGRGIP
FGLHPDEGVPVVEIVFTRLHAGGKFDKAAGGAYTFSGGLHGVGVSVTNALATRLDVTVWREGKCAELGFAHGDVVKPLVT
QPAGRGEKKSGTRVRVWPDGKYFDSPNLPLGELQRLLRSKAVLLPGVEVVLVIEKSGERQSWKYEDGLRGYLLDEMNGSE
LLIPLFEGERFADSKSGDDSFADGEGASWVVAWSEEGSLTRESYVNLIPTPAGGTHESGLRDGLYQAVKSFVELHNLQPK
GVKLLAEDVFARVSFVLSAKVLDPQFQGQIKERLNSRDAVKLVSSFTRPALELWLNQHVEHGKKLAELVIKQAQARTRAG
QKVEKRKSSGVAVLPGKLTDCETQDITRNELFLVEGDSAGGSAKMGRDKEYQAILPLRGKVLNTWETERDRLFANNEVHD
ISVAIGVDPHGPDDNVDLSNLRYGKICILSDADVDGAHIQVLLLTLFFKHFPQLIERGNVFVARPPLFRVDAPARGKKPA
QKLYALDDGELEAILDKLRKDGVRDTQWTISRFKGLGEMSAEQLWDTTMNPDTRRLMPVALGQLDYDATVSRMTMLMGKG
EAAARRSWLEEKGNEVEADI
>Mature_659_residues
STKKPAAAYSEASIKVLKGLEPVKQRPGMYTRTENPLHIIQEVIDNASDEALGGHGKQITVTLHADQSVSVEDDGRGIPF
GLHPDEGVPVVEIVFTRLHAGGKFDKAAGGAYTFSGGLHGVGVSVTNALATRLDVTVWREGKCAELGFAHGDVVKPLVTQ
PAGRGEKKSGTRVRVWPDGKYFDSPNLPLGELQRLLRSKAVLLPGVEVVLVIEKSGERQSWKYEDGLRGYLLDEMNGSEL
LIPLFEGERFADSKSGDDSFADGEGASWVVAWSEEGSLTRESYVNLIPTPAGGTHESGLRDGLYQAVKSFVELHNLQPKG
VKLLAEDVFARVSFVLSAKVLDPQFQGQIKERLNSRDAVKLVSSFTRPALELWLNQHVEHGKKLAELVIKQAQARTRAGQ
KVEKRKSSGVAVLPGKLTDCETQDITRNELFLVEGDSAGGSAKMGRDKEYQAILPLRGKVLNTWETERDRLFANNEVHDI
SVAIGVDPHGPDDNVDLSNLRYGKICILSDADVDGAHIQVLLLTLFFKHFPQLIERGNVFVARPPLFRVDAPARGKKPAQ
KLYALDDGELEAILDKLRKDGVRDTQWTISRFKGLGEMSAEQLWDTTMNPDTRRLMPVALGQLDYDATVSRMTMLMGKGE
AAARRSWLEEKGNEVEADI

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=651, Percent_Identity=23.963133640553, Blast_Score=123, Evalue=6e-28,
Organism=Homo sapiens, GI19913406, Length=648, Percent_Identity=23.7654320987654, Blast_Score=118, Evalue=2e-26,
Organism=Escherichia coli, GI1789408, Length=655, Percent_Identity=50.8396946564886, Blast_Score=635, Evalue=0.0,
Organism=Escherichia coli, GI48994957, Length=657, Percent_Identity=36.6818873668189, Blast_Score=364, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI212645845, Length=626, Percent_Identity=24.4408945686901, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17535065, Length=645, Percent_Identity=23.7209302325581, Blast_Score=106, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI212645657, Length=215, Percent_Identity=29.3023255813954, Blast_Score=72, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=643, Percent_Identity=25.3499222395023, Blast_Score=135, Evalue=2e-32,
Organism=Drosophila melanogaster, GI17136538, Length=658, Percent_Identity=24.9240121580547, Blast_Score=117, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005737 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: 5.99.1.-

Molecular weight: Translated: 72467; Mature: 72336

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTKKPAAAYSEASIKVLKGLEPVKQRPGMYTRTENPLHIIQEVIDNASDEALGGHGKQI
CCCCCCCCHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCEE
TVTLHADQSVSVEDDGRGIPFGLHPDEGVPVVEIVFTRLHAGGKFDKAAGGAYTFSGGLH
EEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEECCCCC
GVGVSVTNALATRLDVTVWREGKCAELGFAHGDVVKPLVTQPAGRGEKKSGTRVRVWPDG
CCCHHHHHHHHHHHEEEEECCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCEEEECCCC
KYFDSPNLPLGELQRLLRSKAVLLPGVEVVLVIEKSGERQSWKYEDGLRGYLLDEMNGSE
CCCCCCCCCHHHHHHHHHHCCEECCCCEEEEEEECCCCCCCCCCCCCCCEEEEECCCCCE
LLIPLFEGERFADSKSGDDSFADGEGASWVVAWSEEGSLTRESYVNLIPTPAGGTHESGL
EEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHCCEEEECCCCCCCCHHH
RDGLYQAVKSFVELHNLQPKGVKLLAEDVFARVSFVLSAKVLDPQFQGQIKERLNSRDAV
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHH
KLVSSFTRPALELWLNQHVEHGKKLAELVIKQAQARTRAGQKVEKRKSSGVAVLPGKLTD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCC
CETQDITRNELFLVEGDSAGGSAKMGRDKEYQAILPLRGKVLNTWETERDRLFANNEVHD
CCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEECCCCCEEECCCCCCHHHEECCCCEEE
ISVAIGVDPHGPDDNVDLSNLRYGKICILSDADVDGAHIQVLLLTLFFKHFPQLIERGNV
EEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCE
FVARPPLFRVDAPARGKKPAQKLYALDDGELEAILDKLRKDGVRDTQWTISRFKGLGEMS
EEECCCCEEECCCCCCCCHHHHHEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCHH
AEQLWDTTMNPDTRRLMPVALGQLDYDATVSRMTMLMGKGEAAARRSWLEEKGNEVEADI
HHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCEECCCC
>Mature Secondary Structure 
STKKPAAAYSEASIKVLKGLEPVKQRPGMYTRTENPLHIIQEVIDNASDEALGGHGKQI
CCCCCCCHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCEE
TVTLHADQSVSVEDDGRGIPFGLHPDEGVPVVEIVFTRLHAGGKFDKAAGGAYTFSGGLH
EEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEECCCCC
GVGVSVTNALATRLDVTVWREGKCAELGFAHGDVVKPLVTQPAGRGEKKSGTRVRVWPDG
CCCHHHHHHHHHHHEEEEECCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCEEEECCCC
KYFDSPNLPLGELQRLLRSKAVLLPGVEVVLVIEKSGERQSWKYEDGLRGYLLDEMNGSE
CCCCCCCCCHHHHHHHHHHCCEECCCCEEEEEEECCCCCCCCCCCCCCCEEEEECCCCCE
LLIPLFEGERFADSKSGDDSFADGEGASWVVAWSEEGSLTRESYVNLIPTPAGGTHESGL
EEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHCCEEEECCCCCCCCHHH
RDGLYQAVKSFVELHNLQPKGVKLLAEDVFARVSFVLSAKVLDPQFQGQIKERLNSRDAV
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHH
KLVSSFTRPALELWLNQHVEHGKKLAELVIKQAQARTRAGQKVEKRKSSGVAVLPGKLTD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCC
CETQDITRNELFLVEGDSAGGSAKMGRDKEYQAILPLRGKVLNTWETERDRLFANNEVHD
CCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEECCCCCEEECCCCCCHHHEECCCCEEE
ISVAIGVDPHGPDDNVDLSNLRYGKICILSDADVDGAHIQVLLLTLFFKHFPQLIERGNV
EEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCE
FVARPPLFRVDAPARGKKPAQKLYALDDGELEAILDKLRKDGVRDTQWTISRFKGLGEMS
EEECCCCEEECCCCCCCCHHHHHEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCHH
AEQLWDTTMNPDTRRLMPVALGQLDYDATVSRMTMLMGKGEAAARRSWLEEKGNEVEADI
HHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2170028; 8388096; 9278503; 8227000; 8980775 [H]