Click here to switch to the map view.

The map label for this gene is parC [H]

Identifier: 238028238

GI number: 238028238

Start: 3065785

End: 3068109

Strand: Reverse

Name: parC [H]

Synonym: bglu_1g26920

Alternate gene names: 238028238

Gene position: 3068109-3065785 (Counterclockwise)

Preceding gene: 238028239

Following gene: 238028237

Centisome position: 78.54

GC content: 68.73

Gene sequence:

>2325_bases
ATGGACGACAACACTCCCGACTTTTTCGATCCGCCGCCGCCCCCGCCCGAGGGCGGCGACGTGCTGACGCTCGGCCATTA
CGCCGAGAGCGCCTACCTCGGCTACGCGGTCAGCGTGGTCAAGGGCCGTGCGCTGCCGGACGTCTGCGACGGCCAGAAGC
CGGTGCAGCGCCGGATCCTCTACGCGATGAACGAAATGGGCCTCGGCAACAACGCGAAGCCGGTGAAGTCGGCGCGCGTG
GTCGGCGACGTGCTCGGCAAGTACCACCCGCACGGCGACCAGTCGGCCTATGACGCGCTGGTGCGGCTCGCGCAGGATTT
CTCGATGCGCTATCCGCTGATCGACGGCCAGGGCAATTTCGGCTCGCGCGACGGCGACGGCGCGGCCGCGATGCGCTACA
CCGAGGCGCGGCTCACGCCGATCGCGCAGCTGCTGCTCGACGAGATCGACCAGGGCACGGTCGATTTCATGCCGAACTAC
GACGGCTCGTTCGACGAGCCGAAGCTGCTGCCGGCGCGCCTGCCGTTCGTGCTGCTCAACGGCGCCTCGGGCATCGCGGT
CGGCCTTGCCACCGAGATCCCGTCGCACAACCTGCGCGAGATCGCGGCGGCCGCGGTCGCGCTGATCCGCAACCCGAAGC
TCACCCACGCGGAGCTGATGCAGATCGTGCCGGGGCCGGATTTCCCGGGCGGCGGCCAGATCATTTCCAGCGATGCGGAA
ATCGCGGCCGCCTACGAAACCGGCCGCGGCAGCCTCAAGGTGCGCGCGCGCTGGAAGATCGAGGATCTCGCGCGCGGCCA
GTGGCAGCTGGTGGTCACCGAGCTGCCGCCGAACACCTCGGGCCAGAAGGTGCTCGAGGAGATCGAGGAGCTGACCAATC
CGAAGATCAAGGCCGGCAAGAAGACGCTGTCGCCCGAACAGGTCAATACCAAGAAGACGATGCTCGACCTGCTCGACGCG
GTGCGCGACGAGTCGGGCAAGGACGCGCCGGTGCGGCTCGTGTTCGAGCCGAAGTCGCGCAGCCTCGACCAGGCCGAGTT
CGTGCAGTCGCTGCTCGCGCACACCAGCCTCGAATCGAACGCGCCGCTCAACCTCGTGATGATCGGCAACGACGGCCGGC
CCGCGCAGAAGGGGCTCGGCACGATTCTCGGCGAATGGGTGCGGTTCCGCCAGCTCACGCTCACGCGCCGCTGCCGCCAC
CGCCTCGGCAAGGTCGATGACCGGATCCACATCCTCGAAGGGCGGATGATCGTCTTCCTCAACATCGACGAGGTGATCCG
CATCATCCGCGAGTCGGACGAGCCGAAGGCCGCGCTGATGTCGGCGTTCGGGCTGACCGAGCGGCAGGCCGACGACATTC
TCGAGATTCGGCTGCGCCAGCTCGCGCGGCTCGAGAAGATCAAGATCGAGAAGGAGCTCGAGGAGCTGCGCGCCGAGAAG
GCGAAGCTCGAAGAGCTGCTGGCCAACGAAAGCGCGATGAAGCGCCTGATGATCAAGGAGATCGAGGGCGACGCCAAGCA
GTACGGCGACGATCGCCGCACGCTGATCCAGCAGGAGAAGCGCGCGACGTTCGAGGCCAAGGTGGTGGACGAGCCGGTCA
CCGTGGTGGTCTCGCAGAAGGGCTGGGTGCGCGCGCTGAAGGGCCACGGGCTCGATCCGGCGAGCTTCACGTTCAAGGCC
GGCGACGGGCTCTACGCGGCGTTCCAGTGCCGCACGCCGGACGTGCTGATCGCCTGGGGCAGCAAGGGCCGCGTCCATTC
GGTGCCGGTGCAGGTGCTGCCCGGCGGGCGCGGTGACGGCGTGCCCGTCACCTCGCTGATCGAGCTCGAATCGGGCACCC
ATCTGATGCACTATTTCGCCGCCAACGCCGAGCAGCAGCTGTTGCTGGCCTCGAGCAACGGCTTCGGCTTCATCGCGAAG
CTCGGCGACATGGTGAGCCGCGTGAAGGCCGGCAAGGCGTTCATGACGATCGACGAAGGCGCCGAGCCGCTCGCGCCGAT
GCCGGTGATGCCGCTCGCCACGCAGGTGGCCTGCCTGTCGGGGCAGGGACGCCTGCTGGTGTTCGGCCTCGACGAGATGA
AGACGCTCTCGGCGGGCGGGCGCGGCGTGATCCTGATGGCGCTGGAGGACAAGGAGACGCTCGCGCAGGCGCTCGCGATC
GACGGCCGCGGCGTCGTGCTGCTCGGCGCGGGCCGCGGCGGCAAGGCACAGGAGGTCACGCTGGCCGGCGCGGCGCTCGC
GCCGTATCTCGGCAAGCGCGCGCGCAAGGGCCGTGCGCCCGACGTGAAGCTGAAGCCGACCGGCCTGCGGCCGATTCTCG
ACTGA

Upstream 100 bases:

>100_bases
GGCAACGAGGTCGAGGCCGACATCTGAGCGGCGGCGCGCCCGCCCGAGGTGCCCGCCTGCCGCCCCGAACCGATACGCAA
GCATACGGAAGCGATACCCG

Downstream 100 bases:

>100_bases
CGCGCGCGCGGCGCGCGGCGGCCCCCGGCGGCGCCCGTTGCGGGCGGCGCCGGGGCATGTCCACGCAGGCTGGCCGCGCC
GCGACTTCGGGGCATGCCGT

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 774; Mature: 774

Protein sequence:

>774_residues
MDDNTPDFFDPPPPPPEGGDVLTLGHYAESAYLGYAVSVVKGRALPDVCDGQKPVQRRILYAMNEMGLGNNAKPVKSARV
VGDVLGKYHPHGDQSAYDALVRLAQDFSMRYPLIDGQGNFGSRDGDGAAAMRYTEARLTPIAQLLLDEIDQGTVDFMPNY
DGSFDEPKLLPARLPFVLLNGASGIAVGLATEIPSHNLREIAAAAVALIRNPKLTHAELMQIVPGPDFPGGGQIISSDAE
IAAAYETGRGSLKVRARWKIEDLARGQWQLVVTELPPNTSGQKVLEEIEELTNPKIKAGKKTLSPEQVNTKKTMLDLLDA
VRDESGKDAPVRLVFEPKSRSLDQAEFVQSLLAHTSLESNAPLNLVMIGNDGRPAQKGLGTILGEWVRFRQLTLTRRCRH
RLGKVDDRIHILEGRMIVFLNIDEVIRIIRESDEPKAALMSAFGLTERQADDILEIRLRQLARLEKIKIEKELEELRAEK
AKLEELLANESAMKRLMIKEIEGDAKQYGDDRRTLIQQEKRATFEAKVVDEPVTVVVSQKGWVRALKGHGLDPASFTFKA
GDGLYAAFQCRTPDVLIAWGSKGRVHSVPVQVLPGGRGDGVPVTSLIELESGTHLMHYFAANAEQQLLLASSNGFGFIAK
LGDMVSRVKAGKAFMTIDEGAEPLAPMPVMPLATQVACLSGQGRLLVFGLDEMKTLSAGGRGVILMALEDKETLAQALAI
DGRGVVLLGAGRGGKAQEVTLAGAALAPYLGKRARKGRAPDVKLKPTGLRPILD

Sequences:

>Translated_774_residues
MDDNTPDFFDPPPPPPEGGDVLTLGHYAESAYLGYAVSVVKGRALPDVCDGQKPVQRRILYAMNEMGLGNNAKPVKSARV
VGDVLGKYHPHGDQSAYDALVRLAQDFSMRYPLIDGQGNFGSRDGDGAAAMRYTEARLTPIAQLLLDEIDQGTVDFMPNY
DGSFDEPKLLPARLPFVLLNGASGIAVGLATEIPSHNLREIAAAAVALIRNPKLTHAELMQIVPGPDFPGGGQIISSDAE
IAAAYETGRGSLKVRARWKIEDLARGQWQLVVTELPPNTSGQKVLEEIEELTNPKIKAGKKTLSPEQVNTKKTMLDLLDA
VRDESGKDAPVRLVFEPKSRSLDQAEFVQSLLAHTSLESNAPLNLVMIGNDGRPAQKGLGTILGEWVRFRQLTLTRRCRH
RLGKVDDRIHILEGRMIVFLNIDEVIRIIRESDEPKAALMSAFGLTERQADDILEIRLRQLARLEKIKIEKELEELRAEK
AKLEELLANESAMKRLMIKEIEGDAKQYGDDRRTLIQQEKRATFEAKVVDEPVTVVVSQKGWVRALKGHGLDPASFTFKA
GDGLYAAFQCRTPDVLIAWGSKGRVHSVPVQVLPGGRGDGVPVTSLIELESGTHLMHYFAANAEQQLLLASSNGFGFIAK
LGDMVSRVKAGKAFMTIDEGAEPLAPMPVMPLATQVACLSGQGRLLVFGLDEMKTLSAGGRGVILMALEDKETLAQALAI
DGRGVVLLGAGRGGKAQEVTLAGAALAPYLGKRARKGRAPDVKLKPTGLRPILD
>Mature_774_residues
MDDNTPDFFDPPPPPPEGGDVLTLGHYAESAYLGYAVSVVKGRALPDVCDGQKPVQRRILYAMNEMGLGNNAKPVKSARV
VGDVLGKYHPHGDQSAYDALVRLAQDFSMRYPLIDGQGNFGSRDGDGAAAMRYTEARLTPIAQLLLDEIDQGTVDFMPNY
DGSFDEPKLLPARLPFVLLNGASGIAVGLATEIPSHNLREIAAAAVALIRNPKLTHAELMQIVPGPDFPGGGQIISSDAE
IAAAYETGRGSLKVRARWKIEDLARGQWQLVVTELPPNTSGQKVLEEIEELTNPKIKAGKKTLSPEQVNTKKTMLDLLDA
VRDESGKDAPVRLVFEPKSRSLDQAEFVQSLLAHTSLESNAPLNLVMIGNDGRPAQKGLGTILGEWVRFRQLTLTRRCRH
RLGKVDDRIHILEGRMIVFLNIDEVIRIIRESDEPKAALMSAFGLTERQADDILEIRLRQLARLEKIKIEKELEELRAEK
AKLEELLANESAMKRLMIKEIEGDAKQYGDDRRTLIQQEKRATFEAKVVDEPVTVVVSQKGWVRALKGHGLDPASFTFKA
GDGLYAAFQCRTPDVLIAWGSKGRVHSVPVQVLPGGRGDGVPVTSLIELESGTHLMHYFAANAEQQLLLASSNGFGFIAK
LGDMVSRVKAGKAFMTIDEGAEPLAPMPVMPLATQVACLSGQGRLLVFGLDEMKTLSAGGRGVILMALEDKETLAQALAI
DGRGVVLLGAGRGGKAQEVTLAGAALAPYLGKRARKGRAPDVKLKPTGLRPILD

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=254, Percent_Identity=29.9212598425197, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI19913406, Length=166, Percent_Identity=34.9397590361446, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI1789396, Length=745, Percent_Identity=45.9060402684564, Blast_Score=629, Evalue=0.0,
Organism=Escherichia coli, GI1788562, Length=785, Percent_Identity=35.031847133758, Blast_Score=394, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17535065, Length=264, Percent_Identity=32.1969696969697, Blast_Score=89, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI212645845, Length=390, Percent_Identity=26.1538461538462, Blast_Score=89, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI212645657, Length=263, Percent_Identity=31.5589353612167, Blast_Score=84, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI115534553, Length=206, Percent_Identity=30.5825242718447, Blast_Score=76, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6324241, Length=248, Percent_Identity=31.4516129032258, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI17136538, Length=256, Percent_Identity=28.515625, Blast_Score=90, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 84076; Mature: 84076

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS00107 PROTEIN_KINASE_ATP ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDNTPDFFDPPPPPPEGGDVLTLGHYAESAYLGYAVSVVKGRALPDVCDGQKPVQRRIL
CCCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
YAMNEMGLGNNAKPVKSARVVGDVLGKYHPHGDQSAYDALVRLAQDFSMRYPLIDGQGNF
HHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEECCCCCC
GSRDGDGAAAMRYTEARLTPIAQLLLDEIDQGTVDFMPNYDGSFDEPKLLPARLPFVLLN
CCCCCCCHHHEEEHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCEEEEE
GASGIAVGLATEIPSHNLREIAAAAVALIRNPKLTHAELMQIVPGPDFPGGGQIISSDAE
CCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCEEECCCC
IAAAYETGRGSLKVRARWKIEDLARGQWQLVVTELPPNTSGQKVLEEIEELTNPKIKAGK
EEEEEECCCCCEEEEEEECHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCC
KTLSPEQVNTKKTMLDLLDAVRDESGKDAPVRLVFEPKSRSLDQAEFVQSLLAHTSLESN
CCCCCHHCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCC
APLNLVMIGNDGRPAQKGLGTILGEWVRFRQLTLTRRCRHRLGKVDDRIHILEGRMIVFL
CCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCEEEEE
NIDEVIRIIRESDEPKAALMSAFGLTERQADDILEIRLRQLARLEKIKIEKELEELRAEK
EHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKLEELLANESAMKRLMIKEIEGDAKQYGDDRRTLIQQEKRATFEAKVVDEPVTVVVSQK
HHHHHHHHCHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHCCEEEEECCCCEEEEEECC
GWVRALKGHGLDPASFTFKAGDGLYAAFQCRTPDVLIAWGSKGRVHSVPVQVLPGGRGDG
CHHHHHHCCCCCCCCEEEECCCCEEEEEEECCCCEEEEECCCCCEEECCEEEECCCCCCC
VPVTSLIELESGTHLMHYFAANAEQQLLLASSNGFGFIAKLGDMVSRVKAGKAFMTIDEG
CCEEEEEEECCCCEEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECCC
AEPLAPMPVMPLATQVACLSGQGRLLVFGLDEMKTLSAGGRGVILMALEDKETLAQALAI
CCCCCCCCCCHHHHHHHEECCCCCEEEEECCHHHHHCCCCCEEEEEEECCHHHHHHHHHC
DGRGVVLLGAGRGGKAQEVTLAGAALAPYLGKRARKGRAPDVKLKPTGLRPILD
CCCCEEEEECCCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCC
>Mature Secondary Structure
MDDNTPDFFDPPPPPPEGGDVLTLGHYAESAYLGYAVSVVKGRALPDVCDGQKPVQRRIL
CCCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
YAMNEMGLGNNAKPVKSARVVGDVLGKYHPHGDQSAYDALVRLAQDFSMRYPLIDGQGNF
HHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEECCCCCC
GSRDGDGAAAMRYTEARLTPIAQLLLDEIDQGTVDFMPNYDGSFDEPKLLPARLPFVLLN
CCCCCCCHHHEEEHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCEEEEE
GASGIAVGLATEIPSHNLREIAAAAVALIRNPKLTHAELMQIVPGPDFPGGGQIISSDAE
CCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCEEECCCC
IAAAYETGRGSLKVRARWKIEDLARGQWQLVVTELPPNTSGQKVLEEIEELTNPKIKAGK
EEEEEECCCCCEEEEEEECHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCC
KTLSPEQVNTKKTMLDLLDAVRDESGKDAPVRLVFEPKSRSLDQAEFVQSLLAHTSLESN
CCCCCHHCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCC
APLNLVMIGNDGRPAQKGLGTILGEWVRFRQLTLTRRCRHRLGKVDDRIHILEGRMIVFL
CCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCEEEEE
NIDEVIRIIRESDEPKAALMSAFGLTERQADDILEIRLRQLARLEKIKIEKELEELRAEK
EHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKLEELLANESAMKRLMIKEIEGDAKQYGDDRRTLIQQEKRATFEAKVVDEPVTVVVSQK
HHHHHHHHCHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHCCEEEEECCCCEEEEEECC
GWVRALKGHGLDPASFTFKAGDGLYAAFQCRTPDVLIAWGSKGRVHSVPVQVLPGGRGDG
CHHHHHHCCCCCCCCEEEECCCCEEEEEEECCCCEEEEECCCCCEEECCEEEECCCCCCC
VPVTSLIELESGTHLMHYFAANAEQQLLLASSNGFGFIAKLGDMVSRVKAGKAFMTIDEG
CCEEEEEEECCCCEEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECCC
AEPLAPMPVMPLATQVACLSGQGRLLVFGLDEMKTLSAGGRGVILMALEDKETLAQALAI
CCCCCCCCCCHHHHHHHEECCCCCEEEEECCHHHHHCCCCCEEEEEEECCHHHHHHHHHC
DGRGVVLLGAGRGGKAQEVTLAGAALAPYLGKRARKGRAPDVKLKPTGLRPILD
CCCCEEEEECCCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7830580 [H]