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The map label for this gene is fadA [H]

Identifier: 238026995

GI number: 238026995

Start: 1514929

End: 1516107

Strand: Direct

Name: fadA [H]

Synonym: bglu_1g13730

Alternate gene names: 238026995

Gene position: 1514929-1516107 (Clockwise)

Preceding gene: 238026994

Following gene: 238026996

Centisome position: 38.78

GC content: 71.42

Gene sequence:

>1179_bases
ATGACCGAAGCCGTAATCGTATCCACCGCCCGCACCGCGCTTGCCAAATCGTGGCGCGGCGCGCTCAACATGACGCATGG
CGCGACGCTCGGCGGCCACGTGGTCGCCGCGGCCGTGGCGCGCGCGAAGCTCGACCCGGCGCGCGTCGAGGACGTGCTGA
TGGGCTGCGCGAATCCCGAAGGCGCGACGGGCGCCAACATCGCGCGCCAGATCGCGCTGCGCGCCGGCCTGCCGGTATCG
GTGCCGGGCATGACGATCAACCGCTTCTGCTCGTCGGGGCTGCAGACCATCGCGCTCGCCGCGCAGCGCGTGATCGCGGG
CGAGGGCGAGGTGTTCGTGGCGGGCGGGGTGGAGTCGATCTCGTGCGTGCAGAACGAGATGAACCACCATATGCTGCAGG
AGGGCTGGCTCAGGGAGCACAAGCCGGAGATCTACTGGAGCATGCTGCAGACCGCCGAGAACGTCGCGAAGCGCTACGGC
ATCGACAGGCAGCGCCAGGACGAGTACGGCGTGCAATCGCAGCAGCGCGCGGCCGCCGCGCAGGCGGCCGGCCGGTTCGA
CGACGAGATCGTGCCGATCACGGTGCTGGCCGGCGTGGCCGACAAGGCGAGCGGGCGGCTCTCGACGCGCGAGCTCACGC
TCGCGGCCGACGAGGGGATTCGCCCCGACACCACGCTCGAGGGCGTCTCGAAGATCCGTTCGGCGCTGCCGGGCGGCGTG
ATCACGGCCGGCAACGCGAGCCAGTTCTCCGACGGCGCCTCGGCCTGCGTGGTGATGAGCGCGAAGCTGGCCGAGCGCGA
GGGGCTGCAGCCGCTCGGCATCTTCCGCGGCTTCGCGGTGGCCGGCTGCGAGCCCGACGAGATGGGCATCGGCCCGGTGT
TCGCGGTGCCGAAGCTGCTGAAGCAGGCCGGCCTGACGGTGGCCGACATCGACCTGTGGGAGCTGAACGAGGCGTTCGCG
GTGCAGGTGCTCTATTGCCGCGACACGCTCGGCATCCCGAACGAGCGGCTCAACGTGAACGGCGGCGCGATCGCGGTCGG
CCATCCCTACGGCGTGTCGGGCGCGCGGCTCACCGGCCATGCGCTGATCGAAGGCAAGCGGCGCGGCGCGAAGCGCGTGG
TGGTGACGATGTGCATCGGCGGCGGCCAGGGCGCGGCGGGGCTGTTCGAGATCGCCTGA

Upstream 100 bases:

>100_bases
GGCGCGGGCGTGGCCCGCGTGCATGCGGACGCGGTGCCGCTCTGAGCCCGCCGGCGCGCGCCGCGTTCCGTCTACAAGCA
ATTCGAACCAGGAGACTGGC

Downstream 100 bases:

>100_bases
GGGCGCCCGGTCCGGCCACGATCTGCGGTGGCGGTCGATGGGCGCCGATGGGCGCGCCCGACGCATCGCTTCGCCGCGGC
GGCAAGTTTGGTAGGCTTCG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MTEAVIVSTARTALAKSWRGALNMTHGATLGGHVVAAAVARAKLDPARVEDVLMGCANPEGATGANIARQIALRAGLPVS
VPGMTINRFCSSGLQTIALAAQRVIAGEGEVFVAGGVESISCVQNEMNHHMLQEGWLREHKPEIYWSMLQTAENVAKRYG
IDRQRQDEYGVQSQQRAAAAQAAGRFDDEIVPITVLAGVADKASGRLSTRELTLAADEGIRPDTTLEGVSKIRSALPGGV
ITAGNASQFSDGASACVVMSAKLAEREGLQPLGIFRGFAVAGCEPDEMGIGPVFAVPKLLKQAGLTVADIDLWELNEAFA
VQVLYCRDTLGIPNERLNVNGGAIAVGHPYGVSGARLTGHALIEGKRRGAKRVVVTMCIGGGQGAAGLFEIA

Sequences:

>Translated_392_residues
MTEAVIVSTARTALAKSWRGALNMTHGATLGGHVVAAAVARAKLDPARVEDVLMGCANPEGATGANIARQIALRAGLPVS
VPGMTINRFCSSGLQTIALAAQRVIAGEGEVFVAGGVESISCVQNEMNHHMLQEGWLREHKPEIYWSMLQTAENVAKRYG
IDRQRQDEYGVQSQQRAAAAQAAGRFDDEIVPITVLAGVADKASGRLSTRELTLAADEGIRPDTTLEGVSKIRSALPGGV
ITAGNASQFSDGASACVVMSAKLAEREGLQPLGIFRGFAVAGCEPDEMGIGPVFAVPKLLKQAGLTVADIDLWELNEAFA
VQVLYCRDTLGIPNERLNVNGGAIAVGHPYGVSGARLTGHALIEGKRRGAKRVVVTMCIGGGQGAAGLFEIA
>Mature_391_residues
TEAVIVSTARTALAKSWRGALNMTHGATLGGHVVAAAVARAKLDPARVEDVLMGCANPEGATGANIARQIALRAGLPVSV
PGMTINRFCSSGLQTIALAAQRVIAGEGEVFVAGGVESISCVQNEMNHHMLQEGWLREHKPEIYWSMLQTAENVAKRYGI
DRQRQDEYGVQSQQRAAAAQAAGRFDDEIVPITVLAGVADKASGRLSTRELTLAADEGIRPDTTLEGVSKIRSALPGGVI
TAGNASQFSDGASACVVMSAKLAEREGLQPLGIFRGFAVAGCEPDEMGIGPVFAVPKLLKQAGLTVADIDLWELNEAFAV
QVLYCRDTLGIPNERLNVNGGAIAVGHPYGVSGARLTGHALIEGKRRGAKRVVVTMCIGGGQGAAGLFEIA

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=390, Percent_Identity=42.5641025641026, Blast_Score=278, Evalue=4e-75,
Organism=Homo sapiens, GI167614485, Length=397, Percent_Identity=38.5390428211587, Blast_Score=259, Evalue=3e-69,
Organism=Homo sapiens, GI4557237, Length=401, Percent_Identity=36.1596009975062, Blast_Score=225, Evalue=5e-59,
Organism=Homo sapiens, GI148539872, Length=397, Percent_Identity=36.5239294710327, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI4504327, Length=389, Percent_Identity=30.8483290488432, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI194353979, Length=389, Percent_Identity=31.6195372750643, Blast_Score=159, Evalue=4e-39,
Organism=Escherichia coli, GI1787663, Length=412, Percent_Identity=41.0194174757282, Blast_Score=258, Evalue=6e-70,
Organism=Escherichia coli, GI48994986, Length=396, Percent_Identity=39.1414141414141, Blast_Score=247, Evalue=8e-67,
Organism=Escherichia coli, GI1788554, Length=405, Percent_Identity=41.4814814814815, Blast_Score=247, Evalue=1e-66,
Organism=Escherichia coli, GI87082165, Length=402, Percent_Identity=38.8059701492537, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI1788683, Length=413, Percent_Identity=30.0242130750605, Blast_Score=162, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI133906874, Length=397, Percent_Identity=37.7833753148615, Blast_Score=236, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI17535921, Length=408, Percent_Identity=35.2941176470588, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI25147385, Length=398, Percent_Identity=32.4120603015075, Blast_Score=187, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI17551802, Length=437, Percent_Identity=28.604118993135, Blast_Score=175, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI17535917, Length=393, Percent_Identity=27.2264631043257, Blast_Score=131, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6322031, Length=396, Percent_Identity=37.1212121212121, Blast_Score=224, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6325229, Length=403, Percent_Identity=33.2506203473945, Blast_Score=191, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24655093, Length=400, Percent_Identity=40.5, Blast_Score=264, Evalue=8e-71,
Organism=Drosophila melanogaster, GI17648125, Length=400, Percent_Identity=37.25, Blast_Score=237, Evalue=1e-62,
Organism=Drosophila melanogaster, GI24640423, Length=401, Percent_Identity=34.9127182044888, Blast_Score=218, Evalue=7e-57,
Organism=Drosophila melanogaster, GI17137578, Length=411, Percent_Identity=31.6301703163017, Blast_Score=181, Evalue=1e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 40987; Mature: 40856

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEAVIVSTARTALAKSWRGALNMTHGATLGGHVVAAAVARAKLDPARVEDVLMGCANPE
CCCEEEEHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCC
GATGANIARQIALRAGLPVSVPGMTINRFCSSGLQTIALAAQRVIAGEGEVFVAGGVESI
CCCHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHH
SCVQNEMNHHMLQEGWLREHKPEIYWSMLQTAENVAKRYGIDRQRQDEYGVQSQQRAAAA
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCHHHHHHHH
QAAGRFDDEIVPITVLAGVADKASGRLSTRELTLAADEGIRPDTTLEGVSKIRSALPGGV
HHCCCCCCCEEEEEEEECCCCCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHCCCCE
ITAGNASQFSDGASACVVMSAKLAEREGLQPLGIFRGFAVAGCEPDEMGIGPVFAVPKLL
EECCCCCCCCCCCCEEEEEHHHHHHHCCCCHHHHHHCCEEECCCCCCCCCCHHHHHHHHH
KQAGLTVADIDLWELNEAFAVQVLYCRDTLGIPNERLNVNGGAIAVGHPYGVSGARLTGH
HHCCCEEEECCHHHCCCCCEEEEEEEECCCCCCCCEEECCCCEEEECCCCCCCCCEEECH
ALIEGKRRGAKRVVVTMCIGGGQGAAGLFEIA
HEEECCCCCCCEEEEEEEECCCCCCCCEEECC
>Mature Secondary Structure 
TEAVIVSTARTALAKSWRGALNMTHGATLGGHVVAAAVARAKLDPARVEDVLMGCANPE
CCEEEEHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCC
GATGANIARQIALRAGLPVSVPGMTINRFCSSGLQTIALAAQRVIAGEGEVFVAGGVESI
CCCHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHH
SCVQNEMNHHMLQEGWLREHKPEIYWSMLQTAENVAKRYGIDRQRQDEYGVQSQQRAAAA
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCHHHHHHHH
QAAGRFDDEIVPITVLAGVADKASGRLSTRELTLAADEGIRPDTTLEGVSKIRSALPGGV
HHCCCCCCCEEEEEEEECCCCCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHCCCCE
ITAGNASQFSDGASACVVMSAKLAEREGLQPLGIFRGFAVAGCEPDEMGIGPVFAVPKLL
EECCCCCCCCCCCCEEEEEHHHHHHHCCCCHHHHHHCCEEECCCCCCCCCCHHHHHHHHH
KQAGLTVADIDLWELNEAFAVQVLYCRDTLGIPNERLNVNGGAIAVGHPYGVSGARLTGH
HHCCCEEEECCHHHCCCCCEEEEEEEECCCCCCCCEEECCCCEEEECCCCCCCCCEEECH
ALIEGKRRGAKRVVVTMCIGGGQGAAGLFEIA
HEEECCCCCCCEEEEEEEECCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]