Click here to switch to the map view.

The map label for this gene is guaB [H]

Identifier: 238026926

GI number: 238026926

Start: 1419534

End: 1420994

Strand: Direct

Name: guaB [H]

Synonym: bglu_1g12980

Alternate gene names: 238026926

Gene position: 1419534-1420994 (Clockwise)

Preceding gene: 238026925

Following gene: 238026927

Centisome position: 36.34

GC content: 67.9

Gene sequence:

>1461_bases
ATGCGTCTCATCCAAAAAGCACTCACTTTCGATGACGTGCTCCTCGTCCCGGCGTTCTCCGACGTCCTGCCGCGCGACAC
CAGCCTCAAGACCCGACTCACCCGCAACATCGCCCTGAACATGCCGCTCGTGTCCGCCGCCATGGATACGGTGACGGAAG
GCCGTCTCGCGATCGCGATGGCGCAGCAGGGCGGCGTGGGGATCGTCCACAAGAACCTGACGCCTGCCGAGCAGGCGCGC
GAGGTCGCCAAGGTCAAGCGCTTCGAATCGGGCGTGGTGCGCGATCCGATCACGGTGCCGCCCACCATGAAGGTGCGCGA
CGTGATCGCGCTGTCGCGCCAGCATGGCATTTCCGGCTTCCCGGTCGTCGAGGGGGCGCAACTCGTCGGCATCGTCACGA
ACCGCGATCTGCGCTTCGAAAGCCGCCTCGACGACGTGGTGCAGTCGATCATGACGCCGCGCGAGCGTCTCGTGACGGTC
AAGGAAGGCACGCCGCTCGCCGACGCCAAGGCGCTCATGCACAGCCACCGCCTCGAGCGCGTGCTGGTGGTGAACGACGC
GTTCGAGCTGCGCGGCCTGATGACGGTGAAGGACATCACGAAGCAGACCGAGCACCCGGACGCCTGCAAGGACGAGCACG
GCAAGCTGCGCGTGGGCGCCGCCGTGGGCGTGGGCGCCGACAACGAGGAGCGCGTCGAGCTGCTGGTGCAGGCCGGGGTC
GACGTGATCGTCGTCGATACCGCGCACGGCCACAGCAAGGGCGTGCTCGAGCGGGTGCGCTGGGTCAAGCAGAATTTCCC
GCGGGTCGAGGTGATCGGCGGCAACATCGCCACCGCCGCCGCCGCGAAGGCGCTGGTCGACTACGGCGCGGACGCCGTCA
AGGTCGGCATCGGCCCCGGCTCGATCTGCACCACGCGGATCGTGGCTGGCGTGGGCGTGCCGCAGATCAGCGCGATCGCC
AACGTCTCCGAGGCGCTGCGCGGCACCGGCGTGCCCTGCATCGCCGACGGCGGCGTGCGCTTCTCGGGCGACGTGTCGAA
GGCGCTGGCCGCCGGCGCGAACGCGGTGATGATGGGCAGCATGCTGGCCGGCACCGAGGAAGCGCCGGGCGACGTGTTCC
TGTACCAGGGCCGCCAGTACAAGTCGTACCGCGGCATGGGCTCGGTGGGTGCGATGAAGGACGGCGCTGCCGACCGCTAC
TTCCAGGACAATTCCGCGAACATCGACAAGCTCGTGCCCGAAGGTATCGAAGGGCGCGTCGCCTACAAGGGTTCGGTCAA
CGCGATCCTGTTCCAGCTCGTCGGCGGCGTGCGCGCGAGCATGGGCTACTGCGGTTGCCGCACCATCGAGGAATTGCACG
ACAAGGCCGAGTTCGTCCAGATCACGGCGGCCGGCATGCGCGAATCTCACGTCCACGACGTGCAGATCACCAAGGAAGCC
CCCAACTACCACGTGGACTGA

Upstream 100 bases:

>100_bases
GAAGCGAATGGCTGCCTGGGAAGGCGCTAAGCCGTTGTTCGTGTTGTGAAAATCTGCCGCGCATCGCGTATAATTCGGCT
TTGCGCCCATAGGATCTGCC

Downstream 100 bases:

>100_bases
ACGCCAATGAAACCACTGCTGCGCGTCGTACTCGTCATCGATGCCCTGCTGCTGCTGGCAGGGGGTGTGCTGTTCGTGCT
GACGCCCTGGAAGGGGCTTT

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 486; Mature: 486

Protein sequence:

>486_residues
MRLIQKALTFDDVLLVPAFSDVLPRDTSLKTRLTRNIALNMPLVSAAMDTVTEGRLAIAMAQQGGVGIVHKNLTPAEQAR
EVAKVKRFESGVVRDPITVPPTMKVRDVIALSRQHGISGFPVVEGAQLVGIVTNRDLRFESRLDDVVQSIMTPRERLVTV
KEGTPLADAKALMHSHRLERVLVVNDAFELRGLMTVKDITKQTEHPDACKDEHGKLRVGAAVGVGADNEERVELLVQAGV
DVIVVDTAHGHSKGVLERVRWVKQNFPRVEVIGGNIATAAAAKALVDYGADAVKVGIGPGSICTTRIVAGVGVPQISAIA
NVSEALRGTGVPCIADGGVRFSGDVSKALAAGANAVMMGSMLAGTEEAPGDVFLYQGRQYKSYRGMGSVGAMKDGAADRY
FQDNSANIDKLVPEGIEGRVAYKGSVNAILFQLVGGVRASMGYCGCRTIEELHDKAEFVQITAAGMRESHVHDVQITKEA
PNYHVD

Sequences:

>Translated_486_residues
MRLIQKALTFDDVLLVPAFSDVLPRDTSLKTRLTRNIALNMPLVSAAMDTVTEGRLAIAMAQQGGVGIVHKNLTPAEQAR
EVAKVKRFESGVVRDPITVPPTMKVRDVIALSRQHGISGFPVVEGAQLVGIVTNRDLRFESRLDDVVQSIMTPRERLVTV
KEGTPLADAKALMHSHRLERVLVVNDAFELRGLMTVKDITKQTEHPDACKDEHGKLRVGAAVGVGADNEERVELLVQAGV
DVIVVDTAHGHSKGVLERVRWVKQNFPRVEVIGGNIATAAAAKALVDYGADAVKVGIGPGSICTTRIVAGVGVPQISAIA
NVSEALRGTGVPCIADGGVRFSGDVSKALAAGANAVMMGSMLAGTEEAPGDVFLYQGRQYKSYRGMGSVGAMKDGAADRY
FQDNSANIDKLVPEGIEGRVAYKGSVNAILFQLVGGVRASMGYCGCRTIEELHDKAEFVQITAAGMRESHVHDVQITKEA
PNYHVD
>Mature_486_residues
MRLIQKALTFDDVLLVPAFSDVLPRDTSLKTRLTRNIALNMPLVSAAMDTVTEGRLAIAMAQQGGVGIVHKNLTPAEQAR
EVAKVKRFESGVVRDPITVPPTMKVRDVIALSRQHGISGFPVVEGAQLVGIVTNRDLRFESRLDDVVQSIMTPRERLVTV
KEGTPLADAKALMHSHRLERVLVVNDAFELRGLMTVKDITKQTEHPDACKDEHGKLRVGAAVGVGADNEERVELLVQAGV
DVIVVDTAHGHSKGVLERVRWVKQNFPRVEVIGGNIATAAAAKALVDYGADAVKVGIGPGSICTTRIVAGVGVPQISAIA
NVSEALRGTGVPCIADGGVRFSGDVSKALAAGANAVMMGSMLAGTEEAPGDVFLYQGRQYKSYRGMGSVGAMKDGAADRY
FQDNSANIDKLVPEGIEGRVAYKGSVNAILFQLVGGVRASMGYCGCRTIEELHDKAEFVQITAAGMRESHVHDVQITKEA
PNYHVD

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=479, Percent_Identity=41.9624217118998, Blast_Score=368, Evalue=1e-102,
Organism=Homo sapiens, GI156616279, Length=479, Percent_Identity=41.9624217118998, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI34328928, Length=479, Percent_Identity=41.9624217118998, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI34328930, Length=479, Percent_Identity=41.9624217118998, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI66933016, Length=482, Percent_Identity=40.4564315352697, Blast_Score=361, Evalue=1e-100,
Organism=Homo sapiens, GI217035152, Length=475, Percent_Identity=41.8947368421053, Blast_Score=361, Evalue=1e-100,
Organism=Homo sapiens, GI217035148, Length=479, Percent_Identity=41.1273486430063, Blast_Score=355, Evalue=4e-98,
Organism=Homo sapiens, GI217035150, Length=479, Percent_Identity=39.0396659707724, Blast_Score=326, Evalue=3e-89,
Organism=Homo sapiens, GI156104880, Length=262, Percent_Identity=35.1145038167939, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI50541956, Length=261, Percent_Identity=36.3984674329502, Blast_Score=162, Evalue=9e-40,
Organism=Homo sapiens, GI50541954, Length=261, Percent_Identity=36.3984674329502, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI50541952, Length=261, Percent_Identity=36.3984674329502, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI50541948, Length=261, Percent_Identity=36.3984674329502, Blast_Score=161, Evalue=1e-39,
Organism=Escherichia coli, GI1788855, Length=487, Percent_Identity=62.4229979466119, Blast_Score=573, Evalue=1e-165,
Organism=Escherichia coli, GI1786293, Length=239, Percent_Identity=33.8912133891213, Blast_Score=140, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI71994385, Length=477, Percent_Identity=37.9454926624738, Blast_Score=304, Evalue=8e-83,
Organism=Caenorhabditis elegans, GI71994389, Length=424, Percent_Identity=39.622641509434, Blast_Score=288, Evalue=4e-78,
Organism=Caenorhabditis elegans, GI17560440, Length=239, Percent_Identity=35.1464435146443, Blast_Score=160, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6322012, Length=488, Percent_Identity=39.344262295082, Blast_Score=358, Evalue=1e-99,
Organism=Saccharomyces cerevisiae, GI6323585, Length=484, Percent_Identity=39.4628099173554, Blast_Score=352, Evalue=8e-98,
Organism=Saccharomyces cerevisiae, GI6323464, Length=484, Percent_Identity=39.0495867768595, Blast_Score=343, Evalue=3e-95,
Organism=Saccharomyces cerevisiae, GI6319352, Length=342, Percent_Identity=39.1812865497076, Blast_Score=265, Evalue=1e-71,
Organism=Saccharomyces cerevisiae, GI6319353, Length=142, Percent_Identity=35.9154929577465, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24641071, Length=483, Percent_Identity=41.407867494824, Blast_Score=361, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24641073, Length=483, Percent_Identity=41.407867494824, Blast_Score=361, Evalue=1e-100,
Organism=Drosophila melanogaster, GI28571163, Length=441, Percent_Identity=42.1768707482993, Blast_Score=328, Evalue=6e-90,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 51926; Mature: 51926

Theoretical pI: Translated: 7.38; Mature: 7.38

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLIQKALTFDDVLLVPAFSDVLPRDTSLKTRLTRNIALNMPLVSAAMDTVTEGRLAIAM
CCHHHHHCCCCCEEEECCHHHHCCCCCCHHHHHHHHEEECCCHHHHHHHHHCCCCEEEEE
AQQGGVGIVHKNLTPAEQAREVAKVKRFESGVVRDPITVPPTMKVRDVIALSRQHGISGF
ECCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCC
PVVEGAQLVGIVTNRDLRFESRLDDVVQSIMTPRERLVTVKEGTPLADAKALMHSHRLER
CEECCCEEEEEEECCCCCHHHHHHHHHHHHHCCHHHEEEEECCCCHHHHHHHHHHHHCCE
VLVVNDAFELRGLMTVKDITKQTEHPDACKDEHGKLRVGAAVGVGADNEERVELLVQAGV
EEEEECHHHHHCCHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHCCC
DVIVVDTAHGHSKGVLERVRWVKQNFPRVEVIGGNIATAAAAKALVDYGADAVKVGIGPG
CEEEEECCCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCC
SICTTRIVAGVGVPQISAIANVSEALRGTGVPCIADGGVRFSGDVSKALAAGANAVMMGS
HHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEECCCEEECCCHHHHHHCCCCCEEHHH
MLAGTEEAPGDVFLYQGRQYKSYRGMGSVGAMKDGAADRYFQDNSANIDKLVPEGIEGRV
HHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCEE
AYKGSVNAILFQLVGGVRASMGYCGCRTIEELHDKAEFVQITAAGMRESHVHDVQITKEA
EECCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCHHHEEEEEECCCCCCCCCEEEEEECC
PNYHVD
CCCCCC
>Mature Secondary Structure
MRLIQKALTFDDVLLVPAFSDVLPRDTSLKTRLTRNIALNMPLVSAAMDTVTEGRLAIAM
CCHHHHHCCCCCEEEECCHHHHCCCCCCHHHHHHHHEEECCCHHHHHHHHHCCCCEEEEE
AQQGGVGIVHKNLTPAEQAREVAKVKRFESGVVRDPITVPPTMKVRDVIALSRQHGISGF
ECCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCC
PVVEGAQLVGIVTNRDLRFESRLDDVVQSIMTPRERLVTVKEGTPLADAKALMHSHRLER
CEECCCEEEEEEECCCCCHHHHHHHHHHHHHCCHHHEEEEECCCCHHHHHHHHHHHHCCE
VLVVNDAFELRGLMTVKDITKQTEHPDACKDEHGKLRVGAAVGVGADNEERVELLVQAGV
EEEEECHHHHHCCHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHCCC
DVIVVDTAHGHSKGVLERVRWVKQNFPRVEVIGGNIATAAAAKALVDYGADAVKVGIGPG
CEEEEECCCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCC
SICTTRIVAGVGVPQISAIANVSEALRGTGVPCIADGGVRFSGDVSKALAAGANAVMMGS
HHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEECCCEEECCCHHHHHHCCCCCEEHHH
MLAGTEEAPGDVFLYQGRQYKSYRGMGSVGAMKDGAADRYFQDNSANIDKLVPEGIEGRV
HHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCEE
AYKGSVNAILFQLVGGVRASMGYCGCRTIEELHDKAEFVQITAAGMRESHVHDVQITKEA
EECCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCHHHEEEEEECCCCCCCCCEEEEEECC
PNYHVD
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA