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The map label for this gene is lpxB [H]

Identifier: 238026916

GI number: 238026916

Start: 1408656

End: 1409825

Strand: Direct

Name: lpxB [H]

Synonym: bglu_1g12860

Alternate gene names: 238026916

Gene position: 1408656-1409825 (Clockwise)

Preceding gene: 238026915

Following gene: 238026917

Centisome position: 36.06

GC content: 69.91

Gene sequence:

>1170_bases
ATGGCGCTCCCACCGAAACCGTTGCGAATCGCGCTCGCGGCCGGCGAGCCGTCGGGCGACCTGCTGGCCGCGTCGCTGCT
GGGCGGCCTGCACGCACGGTTGCCGGCGGCGTCGCACTATTACGGCATCGGCGGCCCGCGCATGATCTCGGCCGGCTTCG
AATCGCACTGGCCGATGGACCGGCTGACGGTGCGCGGCTATGTCGAGGCGCTCAAGGAAATCCCGGCGATCCTGCGGATC
CGCGGCGAGCTGAAGCGCCAGCTGCTGACCGAGCCGCCCGATGCGTTCATCGGCGTCGACGCGCCCGATTTCAATTTCGG
CGTCGAGCAGGCACTGCGCGAGGCCGGCATCCCGACCGTCCACTTCGTCTGCCCGTCGATCTGGGCATGGCGCGGCGGGC
GCATCAAGAAGATCGTGAAGTCGGTCGATCACATGCTGTGCCTGTTCCCGTTCGAGCCGGCGCTGCTCGAAAAATCGGGC
GTGGCCTCGACCTACGTCGGCCATCCGCTCGCCGACGAGATCCCGCTCGAACCCGACACGCACGGTGCGCGCATCGCGCT
CGGGCTGCCCGAGCACGGTCCCGTGATCGCGGTGCTGCCCGGCAGCCGGCGTTCGGAGATCGCGCTGATCGGGCCGACCT
TCTTCGCCGCGATGGCGCTGATGCACCAGCGCGAGCCCGGCCTGCGCTTCGTGATGCCGGCCGCGACGCCGGCCCTGCGC
GCGCTGCTGCAGCCGCTCGTCGACGCGCATCCGCAACTGCCGCTCACGCTGACCGACGGCCGCTCGCAGGTGGCGATGAC
GGCTGCCGACGCGATTCTCGTCAAGAGCGGGACGGTGACGCTCGAGGCCGCGCTGCTGAAGAAGCCGATGGTGATCTCGT
ACAAGGTGCCCTGGCTGACGGGGCAGATCATGCGCCGGCAAGGCTACCAGCCCTATGTCGGGCTGCCGAACATCCTGGCC
GGCCGCTTCGTGGTGCCGGAACTGCTGCAGCACTTCGCGACCCCGCAGGCGTTGGCCGACGCGACGCTCACGCAGCTGCG
CGACGACGCGAACCGCCGCACGCTGACCGAAATCTTCACGCAGCTGCATCTGTCGCTGCGTCAGAACACCGCCGTGCGCG
CCGCGGAGGCGGTCGAGCGCGTGATCGCGAGCCGGAAGCCACGCGCATGA

Upstream 100 bases:

>100_bases
TTGCGCGAATTGATCGCGGCGGGCGGCGAGCACCTGGCCGACGTGAAGACGTTCGTCGATTTCATCGGCGCGTCGCAGCG
CGGCATCATCCGCTGACGCG

Downstream 100 bases:

>100_bases
AGGCCGTCCGTACCAGGCGCACCGCCGCGTCGCTGGCCGCCGAGCAGGCCGGCTTCAGCTTCGACGCGCCGGGCGAGATC
GTCTGCGGCGTCGACGAGGC

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MALPPKPLRIALAAGEPSGDLLAASLLGGLHARLPAASHYYGIGGPRMISAGFESHWPMDRLTVRGYVEALKEIPAILRI
RGELKRQLLTEPPDAFIGVDAPDFNFGVEQALREAGIPTVHFVCPSIWAWRGGRIKKIVKSVDHMLCLFPFEPALLEKSG
VASTYVGHPLADEIPLEPDTHGARIALGLPEHGPVIAVLPGSRRSEIALIGPTFFAAMALMHQREPGLRFVMPAATPALR
ALLQPLVDAHPQLPLTLTDGRSQVAMTAADAILVKSGTVTLEAALLKKPMVISYKVPWLTGQIMRRQGYQPYVGLPNILA
GRFVVPELLQHFATPQALADATLTQLRDDANRRTLTEIFTQLHLSLRQNTAVRAAEAVERVIASRKPRA

Sequences:

>Translated_389_residues
MALPPKPLRIALAAGEPSGDLLAASLLGGLHARLPAASHYYGIGGPRMISAGFESHWPMDRLTVRGYVEALKEIPAILRI
RGELKRQLLTEPPDAFIGVDAPDFNFGVEQALREAGIPTVHFVCPSIWAWRGGRIKKIVKSVDHMLCLFPFEPALLEKSG
VASTYVGHPLADEIPLEPDTHGARIALGLPEHGPVIAVLPGSRRSEIALIGPTFFAAMALMHQREPGLRFVMPAATPALR
ALLQPLVDAHPQLPLTLTDGRSQVAMTAADAILVKSGTVTLEAALLKKPMVISYKVPWLTGQIMRRQGYQPYVGLPNILA
GRFVVPELLQHFATPQALADATLTQLRDDANRRTLTEIFTQLHLSLRQNTAVRAAEAVERVIASRKPRA
>Mature_388_residues
ALPPKPLRIALAAGEPSGDLLAASLLGGLHARLPAASHYYGIGGPRMISAGFESHWPMDRLTVRGYVEALKEIPAILRIR
GELKRQLLTEPPDAFIGVDAPDFNFGVEQALREAGIPTVHFVCPSIWAWRGGRIKKIVKSVDHMLCLFPFEPALLEKSGV
ASTYVGHPLADEIPLEPDTHGARIALGLPEHGPVIAVLPGSRRSEIALIGPTFFAAMALMHQREPGLRFVMPAATPALRA
LLQPLVDAHPQLPLTLTDGRSQVAMTAADAILVKSGTVTLEAALLKKPMVISYKVPWLTGQIMRRQGYQPYVGLPNILAG
RFVVPELLQHFATPQALADATLTQLRDDANRRTLTEIFTQLHLSLRQNTAVRAAEAVERVIASRKPRA

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=374, Percent_Identity=40.3743315508021, Blast_Score=276, Evalue=1e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 42256; Mature: 42125

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALPPKPLRIALAAGEPSGDLLAASLLGGLHARLPAASHYYGIGGPRMISAGFESHWPMD
CCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEECCCCCCEEECCCCCCCCHH
RLTVRGYVEALKEIPAILRIRGELKRQLLTEPPDAFIGVDAPDFNFGVEQALREAGIPTV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCHHHHHHHCCCCEE
HFVCPSIWAWRGGRIKKIVKSVDHMLCLFPFEPALLEKSGVASTYVGHPLADEIPLEPDT
EEECCHHHHCCCCHHHHHHHHHHHEEEECCCCHHHHCCCCCCHHHCCCCCCCCCCCCCCC
HGARIALGLPEHGPVIAVLPGSRRSEIALIGPTFFAAMALMHQREPGLRFVMPAATPALR
CCCEEEEECCCCCCEEEEECCCCCCCEEEECHHHHHHHHHHHCCCCCCEEEECCCCHHHH
ALLQPLVDAHPQLPLTLTDGRSQVAMTAADAILVKSGTVTLEAALLKKPMVISYKVPWLT
HHHHHHHHCCCCCCEEECCCCCEEEHHHHCEEEEECCCEEEEHHHHCCCEEEEEECCHHH
GQIMRRQGYQPYVGLPNILAGRFVVPELLQHFATPQALADATLTQLRDDANRRTLTEIFT
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHH
QLHLSLRQNTAVRAAEAVERVIASRKPRA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
ALPPKPLRIALAAGEPSGDLLAASLLGGLHARLPAASHYYGIGGPRMISAGFESHWPMD
CCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEECCCCCCEEECCCCCCCCHH
RLTVRGYVEALKEIPAILRIRGELKRQLLTEPPDAFIGVDAPDFNFGVEQALREAGIPTV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCHHHHHHHCCCCEE
HFVCPSIWAWRGGRIKKIVKSVDHMLCLFPFEPALLEKSGVASTYVGHPLADEIPLEPDT
EEECCHHHHCCCCHHHHHHHHHHHEEEECCCCHHHHCCCCCCHHHCCCCCCCCCCCCCCC
HGARIALGLPEHGPVIAVLPGSRRSEIALIGPTFFAAMALMHQREPGLRFVMPAATPALR
CCCEEEEECCCCCCEEEEECCCCCCCEEEECHHHHHHHHHHHCCCCCCEEEECCCCHHHH
ALLQPLVDAHPQLPLTLTDGRSQVAMTAADAILVKSGTVTLEAALLKKPMVISYKVPWLT
HHHHHHHHCCCCCCEEECCCCCEEEHHHHCEEEEECCCEEEEHHHHCCCEEEEEECCHHH
GQIMRRQGYQPYVGLPNILAGRFVVPELLQHFATPQALADATLTQLRDDANRRTLTEIFT
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHH
QLHLSLRQNTAVRAAEAVERVIASRKPRA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA