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The map label for this gene is lpxD [H]

Identifier: 238026913

GI number: 238026913

Start: 1406138

End: 1407223

Strand: Direct

Name: lpxD [H]

Synonym: bglu_1g12830

Alternate gene names: 238026913

Gene position: 1406138-1407223 (Clockwise)

Preceding gene: 238026912

Following gene: 238026914

Centisome position: 35.99

GC content: 70.72

Gene sequence:

>1086_bases
ATGGCATTGACGCTCGAGGCACTCGCCAAACGTTTCGGTGGGGACATCGCCGGAGACCCGCAATGCACGGTGGGCGGCCT
CGCGCCGCTCGACCAGGCGGGCCCCCAGCAGCTCGCGTTCCTCGCCAATCCGAAGTATCTGGCTCAGGTCGCCACGACGC
GCGCCGGCGCGGTGCTGATCGCGCCGCGCGATCTCGAGAAGCTCGGCGCGGCCGCCGAGGGCCGCAACTTCATCGTGACG
CCCAATCCCTACGCCTATTTCGCGCGCGTCGCGCAGATGTTCATCGATCTGGCCACGCCGCAGCGGCCGGCCGGCGTGCA
TCCGAGCGCGCGGGTCGACGCGGCGGCCCAGGTCGCGGCGAGCGCCGTGATCGGCCCGGGCGTGACGGTCGAGGCGGGCG
CCGTGATCGGCGAGCAGGTGCGGCTCGACGCCAACGTGTTCGTCGGTGCCGGCACGCGGATCGGCGACGGCTCGCACCTG
TATCCGAACGTGGTCGTCTATCACGGCTGCGAACTCGGCGAGCGCGCGATCGTCCATTCGGGCGCCGTGATCGGCTCGGA
CGGCTTCGGCTTCGCGCCCGATTTCGTCGGCGACGGCGCGGCGCGCACCGGCAGCTGGGTCAAGATCCCGCAGGTCGGCG
GCGTGAAGATCGGCCCCGACGTCGAGATCGGCGCGAATACCACGATCGACCGCGGCGCGATGGCCGACACCGTCATCGAG
GAAGGCGTGAAGATCGACAACCTCGTGCAGATCGCGCACAACTGCCGGATCGGCGCCTACACGGTGATCGCGGGCTGCGC
GGGCATCGCCGGCAGCACCACGATCGGCCGCCACTGCATGATCGGCGGCGCGGTCGGGATCGCCGGGCACCTCACGCTCG
GCGACTACGTGATCATCACCGCGCAGTCGGGCGTATCGAAGTCGCTGCCCAAGGCCGGCATGTACACGAGCGCGTTTCCG
GCCGTCGAACACGGCGACTGGAACCGCAGCGCGGCGCTCGTGCGCAATCTCGACAAGCTTCGCGACCGGATTCGTGCGCT
CGAGACCTCGCTCGCCGCGCGCGACGCGGGCCCCGCGCAGGACTGA

Upstream 100 bases:

>100_bases
AGGAAGCGGTCTACGTCAGTCCGCGCATCGACATCACCGACAAGGTGCTGAAGGCGCTCGCGTCGCCTTCCGGTTCGCTG
AACTGACGGGGGTCGAACGC

Downstream 100 bases:

>100_bases
GCGTCGCCAGGGCGCGGCGGCGCGGCCGGACCGGCCGCCGCGATCACGAGGGCCGCTCGGCGCGGCCCGTACCAGCATTT
GCAGTTACCACCGCGCAGCG

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: UDP-2,3-Bis(3-Hydroxytetradecanoyl)Glucosamine; [Acyl-Carrier Protein]. [C]

Alternate protein names: NA

Number of amino acids: Translated: 361; Mature: 360

Protein sequence:

>361_residues
MALTLEALAKRFGGDIAGDPQCTVGGLAPLDQAGPQQLAFLANPKYLAQVATTRAGAVLIAPRDLEKLGAAAEGRNFIVT
PNPYAYFARVAQMFIDLATPQRPAGVHPSARVDAAAQVAASAVIGPGVTVEAGAVIGEQVRLDANVFVGAGTRIGDGSHL
YPNVVVYHGCELGERAIVHSGAVIGSDGFGFAPDFVGDGAARTGSWVKIPQVGGVKIGPDVEIGANTTIDRGAMADTVIE
EGVKIDNLVQIAHNCRIGAYTVIAGCAGIAGSTTIGRHCMIGGAVGIAGHLTLGDYVIITAQSGVSKSLPKAGMYTSAFP
AVEHGDWNRSAALVRNLDKLRDRIRALETSLAARDAGPAQD

Sequences:

>Translated_361_residues
MALTLEALAKRFGGDIAGDPQCTVGGLAPLDQAGPQQLAFLANPKYLAQVATTRAGAVLIAPRDLEKLGAAAEGRNFIVT
PNPYAYFARVAQMFIDLATPQRPAGVHPSARVDAAAQVAASAVIGPGVTVEAGAVIGEQVRLDANVFVGAGTRIGDGSHL
YPNVVVYHGCELGERAIVHSGAVIGSDGFGFAPDFVGDGAARTGSWVKIPQVGGVKIGPDVEIGANTTIDRGAMADTVIE
EGVKIDNLVQIAHNCRIGAYTVIAGCAGIAGSTTIGRHCMIGGAVGIAGHLTLGDYVIITAQSGVSKSLPKAGMYTSAFP
AVEHGDWNRSAALVRNLDKLRDRIRALETSLAARDAGPAQD
>Mature_360_residues
ALTLEALAKRFGGDIAGDPQCTVGGLAPLDQAGPQQLAFLANPKYLAQVATTRAGAVLIAPRDLEKLGAAAEGRNFIVTP
NPYAYFARVAQMFIDLATPQRPAGVHPSARVDAAAQVAASAVIGPGVTVEAGAVIGEQVRLDANVFVGAGTRIGDGSHLY
PNVVVYHGCELGERAIVHSGAVIGSDGFGFAPDFVGDGAARTGSWVKIPQVGGVKIGPDVEIGANTTIDRGAMADTVIEE
GVKIDNLVQIAHNCRIGAYTVIAGCAGIAGSTTIGRHCMIGGAVGIAGHLTLGDYVIITAQSGVSKSLPKAGMYTSAFPA
VEHGDWNRSAALVRNLDKLRDRIRALETSLAARDAGPAQD

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=354, Percent_Identity=40.1129943502825, Blast_Score=262, Evalue=3e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF04613 LpxD [H]

EC number: 2.3.1.- [C]

Molecular weight: Translated: 37008; Mature: 36876

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALTLEALAKRFGGDIAGDPQCTVGGLAPLDQAGPQQLAFLANPKYLAQVATTRAGAVLI
CEEEHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCHHEEEECCCHHHHHHHHCCCCEEEE
APRDLEKLGAAAEGRNFIVTPNPYAYFARVAQMFIDLATPQRPAGVHPSARVDAAAQVAA
CCCCHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
SAVIGPGVTVEAGAVIGEQVRLDANVFVGAGTRIGDGSHLYPNVVVYHGCELGERAIVHS
HHHCCCCCEEECCCEECCEEEEECEEEEECCCEECCCCCCCCCEEEEECCCCCCHHEEEC
GAVIGSDGFGFAPDFVGDGAARTGSWVKIPQVGGVKIGPDVEIGANTTIDRGAMADTVIE
CCEECCCCCCCCCHHCCCCCCCCCCEEECCCCCCEEECCCCEECCCCCCCCCHHHHHHHH
EGVKIDNLVQIAHNCRIGAYTVIAGCAGIAGSTTIGRHCMIGGAVGIAGHLTLGDYVIIT
CCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCEEEECCCCCEEEEEEECCEEEEE
AQSGVSKSLPKAGMYTSAFPAVEHGDWNRSAALVRNLDKLRDRIRALETSLAARDAGPAQ
ECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
D
C
>Mature Secondary Structure 
ALTLEALAKRFGGDIAGDPQCTVGGLAPLDQAGPQQLAFLANPKYLAQVATTRAGAVLI
EEEHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCHHEEEECCCHHHHHHHHCCCCEEEE
APRDLEKLGAAAEGRNFIVTPNPYAYFARVAQMFIDLATPQRPAGVHPSARVDAAAQVAA
CCCCHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
SAVIGPGVTVEAGAVIGEQVRLDANVFVGAGTRIGDGSHLYPNVVVYHGCELGERAIVHS
HHHCCCCCEEECCCEECCEEEEECEEEEECCCEECCCCCCCCCEEEEECCCCCCHHEEEC
GAVIGSDGFGFAPDFVGDGAARTGSWVKIPQVGGVKIGPDVEIGANTTIDRGAMADTVIE
CCEECCCCCCCCCHHCCCCCCCCCCEEECCCCCCEEECCCCEECCCCCCCCCHHHHHHHH
EGVKIDNLVQIAHNCRIGAYTVIAGCAGIAGSTTIGRHCMIGGAVGIAGHLTLGDYVIIT
CCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCEEEECCCCCEEEEEEECCEEEEE
AQSGVSKSLPKAGMYTSAFPAVEHGDWNRSAALVRNLDKLRDRIRALETSLAARDAGPAQ
ECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
D
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-3-O-(3-Hydroxytetradecanoyl)Glucosamine; (R)-3-Hydroxytetradecanoyl-[Acyl-Carrier Protein] [C]

Specific reaction: UDP-3-O-(3-Hydroxytetradecanoyl)Glucosamine + (R)-3-Hydroxytetradecanoyl-[Acyl-Carrier Protein] = UDP-2,3-Bis(3-Hydroxytetradecanoyl)Glucosamine + [Acyl-Carrier Protein]. [C]

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA