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The map label for this gene is thiD [H]

Identifier: 238026881

GI number: 238026881

Start: 1366451

End: 1367260

Strand: Reverse

Name: thiD [H]

Synonym: bglu_1g12490

Alternate gene names: 238026881

Gene position: 1367260-1366451 (Counterclockwise)

Preceding gene: 238026882

Following gene: 238026876

Centisome position: 35.0

GC content: 72.59

Gene sequence:

>810_bases
ATGACCCGACCCATTCCGAATGCCCTGACCATCGCCGGCTCCGATTCGGGCGGCGGCGCCGGCATCCAGGCCGACCTGAA
GGCCTTCTCCGCGCTCGGCGCCTACGGCGCGAGCGTGATTACCGCGCTGACCGCGCAGAACACGCGCGGCGTCACGGCCG
TGCATGCCCCCGAGGCCGACTTCATTCGCGCCCAGCTCGACGCCGTGTTCGACGACATCCGGATCGACGCCGTGAAGATC
GGCATGCTCGCCAACGCCTCGATCGTGGGCGCGGTGGCGGCGGCCCTCGAACGGTACGCGCCGCCGTTCGTCGTGCTCGA
CACCGTGATGATCTCGAAAAGCCGGCACGCGCTGCTCGCGCCCGACGCCGTGGCCGCGCTGCGCGACACGCTGCTGCCGC
GCGCGGACCTGGTCACGCCGAACCTGCCCGAGGCAGCCGCCCTGCTAGGCTGCGACGAGGCGGCGAACGAGGCCGAAATG
GTCGAACAGGGGCGCGCGCTCGTCGCGCGCGGCGCGCGCGCGGTGCTGATGAAGGGCGGCCATCTGGCAGGCGCCGCGGA
CTGTCCCGACTGGCTGATCCGCACCGACGGCGAACTGCGCATCGGCGGCGAGCGGATCGCCGTCGCCCATACCCACGGCA
CCGGCTGCACGCTGTCGGCGGCGATCGCGGCGCTGCGGCCGCAGCGCGCCGACCTCGCGGCGGCCGTGGCCGACGCGAAA
CGCTATCTGGCCGAGGCGATCGCCGCGAGCACGCGACTGGCGATCGGACACGGCATCGGGCCGGTCCATCATTTCCATCG
CTGGTGGTGA

Upstream 100 bases:

>100_bases
CCGTCCCGATCTGCCGCAGTCCGGCTCGATCGGCCCGTCCGGACGCCGTCCGGCCTTGTGCGTTTCCGATCCGCCGGCCC
GCGCGACCGGCCCCTGCACG

Downstream 100 bases:

>100_bases
GCCCCCGCTGACGCAGCGGCCGGTGCGGCGGCGGGCATTGGCCGGCTGCGAGCCGCCTCTACCGCCTCTACCGCCGGATC
GCACCGGATCGCACCGGATC

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 269; Mature: 268

Protein sequence:

>269_residues
MTRPIPNALTIAGSDSGGGAGIQADLKAFSALGAYGASVITALTAQNTRGVTAVHAPEADFIRAQLDAVFDDIRIDAVKI
GMLANASIVGAVAAALERYAPPFVVLDTVMISKSRHALLAPDAVAALRDTLLPRADLVTPNLPEAAALLGCDEAANEAEM
VEQGRALVARGARAVLMKGGHLAGAADCPDWLIRTDGELRIGGERIAVAHTHGTGCTLSAAIAALRPQRADLAAAVADAK
RYLAEAIAASTRLAIGHGIGPVHHFHRWW

Sequences:

>Translated_269_residues
MTRPIPNALTIAGSDSGGGAGIQADLKAFSALGAYGASVITALTAQNTRGVTAVHAPEADFIRAQLDAVFDDIRIDAVKI
GMLANASIVGAVAAALERYAPPFVVLDTVMISKSRHALLAPDAVAALRDTLLPRADLVTPNLPEAAALLGCDEAANEAEM
VEQGRALVARGARAVLMKGGHLAGAADCPDWLIRTDGELRIGGERIAVAHTHGTGCTLSAAIAALRPQRADLAAAVADAK
RYLAEAIAASTRLAIGHGIGPVHHFHRWW
>Mature_268_residues
TRPIPNALTIAGSDSGGGAGIQADLKAFSALGAYGASVITALTAQNTRGVTAVHAPEADFIRAQLDAVFDDIRIDAVKIG
MLANASIVGAVAAALERYAPPFVVLDTVMISKSRHALLAPDAVAALRDTLLPRADLVTPNLPEAAALLGCDEAANEAEMV
EQGRALVARGARAVLMKGGHLAGAADCPDWLIRTDGELRIGGERIAVAHTHGTGCTLSAAIAALRPQRADLAAAVADAKR
YLAEAIAASTRLAIGHGIGPVHHFHRWW

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. Shows no activity with pyridoxal, pyridoxamine or pyridoxine [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=263, Percent_Identity=62.7376425855513, Blast_Score=321, Evalue=3e-89,
Organism=Saccharomyces cerevisiae, GI6325378, Length=282, Percent_Identity=29.0780141843972, Blast_Score=115, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6324997, Length=181, Percent_Identity=33.7016574585635, Blast_Score=101, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6324517, Length=181, Percent_Identity=32.5966850828729, Blast_Score=100, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 27760; Mature: 27629

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRPIPNALTIAGSDSGGGAGIQADLKAFSALGAYGASVITALTAQNTRGVTAVHAPEAD
CCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHH
FIRAQLDAVFDDIRIDAVKIGMLANASIVGAVAAALERYAPPFVVLDTVMISKSRHALLA
HHHHHHHHHHHHHEEEEEEEEHHCCHHHHHHHHHHHHHHCCCEEEEHHHHHCCCCCEEEC
PDAVAALRDTLLPRADLVTPNLPEAAALLGCDEAANEAEMVEQGRALVARGARAVLMKGG
CHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEEEECC
HLAGAADCPDWLIRTDGELRIGGERIAVAHTHGTGCTLSAAIAALRPQRADLAAAVADAK
CCCCCCCCCCCEEECCCCEEECCCEEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHH
RYLAEAIAASTRLAIGHGIGPVHHFHRWW
HHHHHHHHHHHHHHHHCCCCHHHHHHCCC
>Mature Secondary Structure 
TRPIPNALTIAGSDSGGGAGIQADLKAFSALGAYGASVITALTAQNTRGVTAVHAPEAD
CCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHH
FIRAQLDAVFDDIRIDAVKIGMLANASIVGAVAAALERYAPPFVVLDTVMISKSRHALLA
HHHHHHHHHHHHHEEEEEEEEHHCCHHHHHHHHHHHHHHCCCEEEEHHHHHCCCCCEEEC
PDAVAALRDTLLPRADLVTPNLPEAAALLGCDEAANEAEMVEQGRALVARGARAVLMKGG
CHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEEEECC
HLAGAADCPDWLIRTDGELRIGGERIAVAHTHGTGCTLSAAIAALRPQRADLAAAVADAK
CCCCCCCCCCCEEECCCCEEECCCEEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHH
RYLAEAIAASTRLAIGHGIGPVHHFHRWW
HHHHHHHHHHHHHHHHCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10075431; 9097040; 9278503 [H]