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The map label for this gene is dmlR [H]

Identifier: 238026873

GI number: 238026873

Start: 1357547

End: 1358449

Strand: Direct

Name: dmlR [H]

Synonym: bglu_1g12410

Alternate gene names: 238026873

Gene position: 1357547-1358449 (Clockwise)

Preceding gene: 238026871

Following gene: 238026877

Centisome position: 34.75

GC content: 69.44

Gene sequence:

>903_bases
ATGGATCGCTTCAAGCAAATCGAAACCTTCATCGCGGTGGCCGCGAAAGGCAGCCTGTCCGCCGCCGCGCACGCCGAAGG
CGTCGCGCCCGCGATCATCGGCCGCCGCATCGACGCGCTCGAGGAGCGGCTCGGCGTGAAGCTGCTGGTGCGCACCACGC
GCAAGCTGACGCTGACCTTCGAGGGCTCGGCGTTTCTCGAGGACTGCCAGCGCATCGTCAACGACATGCAGAACGCCGAG
GCCAGCGTGTCGGCCGGTGGCGTGAAGGCGAGCGGGCACCTGCGCGTATCGGGGCCGGCGGGCTTCGGCCGCCGCCACGT
CGCGCCGCTCGTGCCGGCGTTCACGGCCGCGCATCCGGACGTGTCGATCACGCTCGATCTGTCCGACCGGATGGTCGATC
TCGTCAACGAAGGGTTCGATTGCGCGGTGCGGCTCGGCGAGTTGCCCGATTCGTCGCTGGTATCGCTGAAGCTCGGCGAG
AACCGGCGCGTGTGCGTGGCCTCGCCGGCCTATCTCGCACGCGCGGGCACTCCCGCCACGCTCGACGATCTGGCCGGCCA
CCAGTGCCTTGCGCTTGCCGCGAACGCGAACCAGCAGCGCGGCTGGACCTTCCAGCACGACGGCGGGACCGTCTCGATCC
GCGTGAACGGCACCATGGAATGCTCGGACGGCGCGGTGCTGCACGAATGGTGCCTCGACGGCCACGGGCTCGCCTGGCGC
TCTTGGTGGGAGGTGGGTGCCGACATCCGGGCGGGGCGCCTCGTCAGCGTGCTCGATGCGTTCGCGGCGCCGCCGATCGG
CATCCACGCCGTGTTTGCGCAGCGCCGCCATCTGCCGCTGCGGGTGCGCTTGTTCCTCGATTTCCTCAAGCATACCTACG
ACCAGCCCGATTACTGGGGCTGA

Upstream 100 bases:

>100_bases
ATTCTATTCGTGATGTACCGGGCCTGAAAATAAGTTCTACATCACTTGATCTTTTACTTTCATCAACCTAATCTGGCCGG
CACGCCATTCTCCCGTCGTC

Downstream 100 bases:

>100_bases
GGCCGGCGCGGCGGGAAGGAAAAATCCGCGCGCCAGGGCCGGCGCGCGGATTCAACGGCCTGCGACGCCGTCGGCGTCGC
GATGCCGGGCGCGTGCGTCG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: D-malate degradation protein R [H]

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MDRFKQIETFIAVAAKGSLSAAAHAEGVAPAIIGRRIDALEERLGVKLLVRTTRKLTLTFEGSAFLEDCQRIVNDMQNAE
ASVSAGGVKASGHLRVSGPAGFGRRHVAPLVPAFTAAHPDVSITLDLSDRMVDLVNEGFDCAVRLGELPDSSLVSLKLGE
NRRVCVASPAYLARAGTPATLDDLAGHQCLALAANANQQRGWTFQHDGGTVSIRVNGTMECSDGAVLHEWCLDGHGLAWR
SWWEVGADIRAGRLVSVLDAFAAPPIGIHAVFAQRRHLPLRVRLFLDFLKHTYDQPDYWG

Sequences:

>Translated_300_residues
MDRFKQIETFIAVAAKGSLSAAAHAEGVAPAIIGRRIDALEERLGVKLLVRTTRKLTLTFEGSAFLEDCQRIVNDMQNAE
ASVSAGGVKASGHLRVSGPAGFGRRHVAPLVPAFTAAHPDVSITLDLSDRMVDLVNEGFDCAVRLGELPDSSLVSLKLGE
NRRVCVASPAYLARAGTPATLDDLAGHQCLALAANANQQRGWTFQHDGGTVSIRVNGTMECSDGAVLHEWCLDGHGLAWR
SWWEVGADIRAGRLVSVLDAFAAPPIGIHAVFAQRRHLPLRVRLFLDFLKHTYDQPDYWG
>Mature_300_residues
MDRFKQIETFIAVAAKGSLSAAAHAEGVAPAIIGRRIDALEERLGVKLLVRTTRKLTLTFEGSAFLEDCQRIVNDMQNAE
ASVSAGGVKASGHLRVSGPAGFGRRHVAPLVPAFTAAHPDVSITLDLSDRMVDLVNEGFDCAVRLGELPDSSLVSLKLGE
NRRVCVASPAYLARAGTPATLDDLAGHQCLALAANANQQRGWTFQHDGGTVSIRVNGTMECSDGAVLHEWCLDGHGLAWR
SWWEVGADIRAGRLVSVLDAFAAPPIGIHAVFAQRRHLPLRVRLFLDFLKHTYDQPDYWG

Specific function: Transcriptional regulator required for the aerobic growth on D-malate as the sole carbon source. Induces the expression of dmlA in response to D-malate or L- or meso-tartrate. Negatively regulates its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87081978, Length=290, Percent_Identity=36.551724137931, Blast_Score=195, Evalue=4e-51,
Organism=Escherichia coli, GI1789440, Length=286, Percent_Identity=30.0699300699301, Blast_Score=158, Evalue=3e-40,
Organism=Escherichia coli, GI1786401, Length=294, Percent_Identity=32.312925170068, Blast_Score=158, Evalue=3e-40,
Organism=Escherichia coli, GI145693193, Length=290, Percent_Identity=31.3793103448276, Blast_Score=155, Evalue=2e-39,
Organism=Escherichia coli, GI1787589, Length=287, Percent_Identity=29.9651567944251, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1787128, Length=283, Percent_Identity=29.3286219081272, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1789639, Length=293, Percent_Identity=27.3037542662116, Blast_Score=127, Evalue=7e-31,
Organism=Escherichia coli, GI1789173, Length=250, Percent_Identity=29.2, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1786448, Length=278, Percent_Identity=27.3381294964029, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788706, Length=215, Percent_Identity=26.5116279069767, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1790011, Length=297, Percent_Identity=22.8956228956229, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787601, Length=146, Percent_Identity=24.6575342465753, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1790208, Length=175, Percent_Identity=30.2857142857143, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32422; Mature: 32422

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRFKQIETFIAVAAKGSLSAAAHAEGVAPAIIGRRIDALEERLGVKLLVRTTRKLTLTF
CCHHHHHHHHHHHHCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHCEEEEEEECEEEEEEE
EGSAFLEDCQRIVNDMQNAEASVSAGGVKASGHLRVSGPAGFGRRHVAPLVPAFTAAHPD
CCCHHHHHHHHHHHHHHCCCCCCCCCCEEECCEEEEECCCCCCCCCCHHHHHHHHCCCCC
VSITLDLSDRMVDLVNEGFDCAVRLGELPDSSLVSLKLGENRRVCVASPAYLARAGTPAT
EEEEEECHHHHHHHHCCCCEEEEEECCCCCCCEEEEEECCCCEEEEECCHHHHCCCCCCC
LDDLAGHQCLALAANANQQRGWTFQHDGGTVSIRVNGTMECSDGAVLHEWCLDGHGLAWR
HHHHCCCEEEEEECCCCCCCCEEEEECCCEEEEEECCEEECCCCCEEHHHHCCCCCCCHH
SWWEVGADIRAGRLVSVLDAFAAPPIGIHAVFAQRRHLPLRVRLFLDFLKHTYDQPDYWG
HHHHHCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MDRFKQIETFIAVAAKGSLSAAAHAEGVAPAIIGRRIDALEERLGVKLLVRTTRKLTLTF
CCHHHHHHHHHHHHCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHCEEEEEEECEEEEEEE
EGSAFLEDCQRIVNDMQNAEASVSAGGVKASGHLRVSGPAGFGRRHVAPLVPAFTAAHPD
CCCHHHHHHHHHHHHHHCCCCCCCCCCEEECCEEEEECCCCCCCCCCHHHHHHHHCCCCC
VSITLDLSDRMVDLVNEGFDCAVRLGELPDSSLVSLKLGENRRVCVASPAYLARAGTPAT
EEEEEECHHHHHHHHCCCCEEEEEECCCCCCCEEEEEECCCCEEEEECCHHHHCCCCCCC
LDDLAGHQCLALAANANQQRGWTFQHDGGTVSIRVNGTMECSDGAVLHEWCLDGHGLAWR
HHHHCCCEEEEEECCCCCCCCEEEEECCCEEEEEECCEEECCCCCEEHHHHCCCCCCCHH
SWWEVGADIRAGRLVSVLDAFAAPPIGIHAVFAQRRHLPLRVRLFLDFLKHTYDQPDYWG
HHHHHCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]