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The map label for this gene is lhgO [H]

Identifier: 238026743

GI number: 238026743

Start: 1210374

End: 1211498

Strand: Direct

Name: lhgO [H]

Synonym: bglu_1g11010

Alternate gene names: 238026743

Gene position: 1210374-1211498 (Clockwise)

Preceding gene: 238026742

Following gene: 238026745

Centisome position: 30.98

GC content: 73.16

Gene sequence:

>1125_bases
ATGACGGAGATGGTCGATTGCGTCGTGATCGGCGCGGGAGTGGTCGGCCTGGCGGCCGCGCGCGCCAGTGCGCGGCGCGG
CTGGGAGACGGTGATCGTCGAGTCGGAATCGATGATCGGCACCGGCACGAGCTCGCGCAACAGCGAGGTGATCCATGCCG
GCATTTACTATTCGGCCGGTTCGCTGAAGGCGCGGCTCTGCGTCGAGGGGCGCGAGCGGCTCTATGCATTCTGCGAGGAG
CACCAGGTGCCGTACCGGCGCAGCGGCAAGCTGATCGTGGCCGCCGAGGACGCGCAGCGCGGCACGCTCGCCGAGCTCGA
GGCGGCCGCGCGCGCCAACGGCGTGACCGACCTGCGGCGCCTGAGCGGCGACCAGGCGCGCGCGCTCGAACCGGCCCTGC
GCTGCGTGGCGGCGCTCGAATCGCCGTCCACCGGCATCGTCGACAGCCACGCGCTGATGCTCGCGCTGCTCGGCGACGCC
GAGCGCGCCGGCGCCGTGATCGCCTATCGTTCGCCCGTGATCGGCGGCCAGGTGCTGCACGACGGCGGCCCCGCGATCGA
GCTCGAGGTGGGCGGCGCCGAGCCGATGACGCTGCGCGCGCGGCGCGTGGTGAACGCGGCCGGGCTCTACGCCCAGACGG
TGGCCGGCGGGCTGCGCGGCCTGCCGCCCGAGTCGGTGCCGCGCGCGCGCTACGCGAAGGGCAACTACTATTCGCTGGCG
GGCCGCGCGCCGTTCTCGCGGCTCATCTATCCGGTGCCGGAGCCGGGCGGGCTCGGTGTCCATCTGACGCTCGATCTGGC
CAATCAGGCGCGCTTCGGCCCCGACGTCGAATGGATCGACGAGATCGACTTCCGCGTCGATCCGGCCCGCGCCGCGCGCT
TCTACGATGCGATCCGCAGCTACTGGCCGGAGCTGCCCGACGAGGCATTGCAGCCGGCCTACGCCGGCGTGCGGCCGAAG
CTGGCGCACCCGCCCGGCGGCGGCGACGACTTCGTGATCCAGTCGGCGCGCGCGCACGGCGTGGCCGGCCTCGTCAACCT
GTACGGCATCGAGTCGCCGGGGCTGACGGCCTCGCTCGCGATCGCCGAGCAGGTGATCGCGGCGCTCGACGACGCTACGC
AGTGA

Upstream 100 bases:

>100_bases
GCCAGGCGCTGCGGTATGCTGCGGGGCTGCGCCGCCGCGTGCCGGCCCGCGCCATGCGGCGCCGGGCGCGCCGGCGATTC
CAAGAAAGGAGCCTGAGAAG

Downstream 100 bases:

>100_bases
CCGTCAACACCGCATCGACCGCCGCCAAGGCATGACGACGCGTCACGAGACGGCGAGGATCGAGGGGCGTTGAGCGCGGG
CGCGACGAGGTGAGCCGCGG

Product: FAD dependent oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 374; Mature: 373

Protein sequence:

>374_residues
MTEMVDCVVIGAGVVGLAAARASARRGWETVIVESESMIGTGTSSRNSEVIHAGIYYSAGSLKARLCVEGRERLYAFCEE
HQVPYRRSGKLIVAAEDAQRGTLAELEAAARANGVTDLRRLSGDQARALEPALRCVAALESPSTGIVDSHALMLALLGDA
ERAGAVIAYRSPVIGGQVLHDGGPAIELEVGGAEPMTLRARRVVNAAGLYAQTVAGGLRGLPPESVPRARYAKGNYYSLA
GRAPFSRLIYPVPEPGGLGVHLTLDLANQARFGPDVEWIDEIDFRVDPARAARFYDAIRSYWPELPDEALQPAYAGVRPK
LAHPPGGGDDFVIQSARAHGVAGLVNLYGIESPGLTASLAIAEQVIAALDDATQ

Sequences:

>Translated_374_residues
MTEMVDCVVIGAGVVGLAAARASARRGWETVIVESESMIGTGTSSRNSEVIHAGIYYSAGSLKARLCVEGRERLYAFCEE
HQVPYRRSGKLIVAAEDAQRGTLAELEAAARANGVTDLRRLSGDQARALEPALRCVAALESPSTGIVDSHALMLALLGDA
ERAGAVIAYRSPVIGGQVLHDGGPAIELEVGGAEPMTLRARRVVNAAGLYAQTVAGGLRGLPPESVPRARYAKGNYYSLA
GRAPFSRLIYPVPEPGGLGVHLTLDLANQARFGPDVEWIDEIDFRVDPARAARFYDAIRSYWPELPDEALQPAYAGVRPK
LAHPPGGGDDFVIQSARAHGVAGLVNLYGIESPGLTASLAIAEQVIAALDDATQ
>Mature_373_residues
TEMVDCVVIGAGVVGLAAARASARRGWETVIVESESMIGTGTSSRNSEVIHAGIYYSAGSLKARLCVEGRERLYAFCEEH
QVPYRRSGKLIVAAEDAQRGTLAELEAAARANGVTDLRRLSGDQARALEPALRCVAALESPSTGIVDSHALMLALLGDAE
RAGAVIAYRSPVIGGQVLHDGGPAIELEVGGAEPMTLRARRVVNAAGLYAQTVAGGLRGLPPESVPRARYAKGNYYSLAG
RAPFSRLIYPVPEPGGLGVHLTLDLANQARFGPDVEWIDEIDFRVDPARAARFYDAIRSYWPELPDEALQPAYAGVRPKL
AHPPGGGDDFVIQSARAHGVAGLVNLYGIESPGLTASLAIAEQVIAALDDATQ

Specific function: Oxidizes L-2-hydroxyglutarate, probably to recover alpha-ketoglutarate mistakenly reduced by other enzymes or formed during growth on propionate [H]

COG id: COG0579

COG function: function code R; Predicted dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the L2HGDH family [H]

Homologues:

Organism=Homo sapiens, GI13376331, Length=271, Percent_Identity=32.1033210332103, Blast_Score=120, Evalue=2e-27,
Organism=Escherichia coli, GI87082148, Length=377, Percent_Identity=27.0557029177719, Blast_Score=108, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17565764, Length=403, Percent_Identity=31.5136476426799, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI24585081, Length=385, Percent_Identity=30.3896103896104, Blast_Score=145, Evalue=5e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015657
- InterPro:   IPR006076 [H]

Pfam domain/function: PF01266 DAO [H]

EC number: =1.1.3.15 [H]

Molecular weight: Translated: 39516; Mature: 39385

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEMVDCVVIGAGVVGLAAARASARRGWETVIVESESMIGTGTSSRNSEVIHAGIYYSAG
CCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCCCCEEEEEEEEECC
SLKARLCVEGRERLYAFCEEHQVPYRRSGKLIVAAEDAQRGTLAELEAAARANGVTDLRR
CCEEEEEHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCHHHHHH
LSGDQARALEPALRCVAALESPSTGIVDSHALMLALLGDAERAGAVIAYRSPVIGGQVLH
HCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHCCEEEEECCCCCCCEEEE
DGGPAIELEVGGAEPMTLRARRVVNAAGLYAQTVAGGLRGLPPESVPRARYAKGNYYSLA
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEC
GRAPFSRLIYPVPEPGGLGVHLTLDLANQARFGPDVEWIDEIDFRVDPARAARFYDAIRS
CCCCHHHCEECCCCCCCCEEEEEEEECCCCCCCCCCHHHHCCCCEECHHHHHHHHHHHHH
YWPELPDEALQPAYAGVRPKLAHPPGGGDDFVIQSARAHGVAGLVNLYGIESPGLTASLA
HCCCCCHHHHCCHHCCCCCCCCCCCCCCCCCEEECCHHCCHHHHHHHEECCCCCCCHHHH
IAEQVIAALDDATQ
HHHHHHHHHHCCCC
>Mature Secondary Structure 
TEMVDCVVIGAGVVGLAAARASARRGWETVIVESESMIGTGTSSRNSEVIHAGIYYSAG
CCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCCCCEEEEEEEEECC
SLKARLCVEGRERLYAFCEEHQVPYRRSGKLIVAAEDAQRGTLAELEAAARANGVTDLRR
CCEEEEEHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCHHHHHH
LSGDQARALEPALRCVAALESPSTGIVDSHALMLALLGDAERAGAVIAYRSPVIGGQVLH
HCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHCCEEEEECCCCCCCEEEE
DGGPAIELEVGGAEPMTLRARRVVNAAGLYAQTVAGGLRGLPPESVPRARYAKGNYYSLA
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEC
GRAPFSRLIYPVPEPGGLGVHLTLDLANQARFGPDVEWIDEIDFRVDPARAARFYDAIRS
CCCCHHHCEECCCCCCCCEEEEEEEECCCCCCCCCCHHHHCCCCEECHHHHHHHHHHHHH
YWPELPDEALQPAYAGVRPKLAHPPGGGDDFVIQSARAHGVAGLVNLYGIESPGLTASLA
HCCCCCHHHHCCHHCCCCCCCCCCCCCCCCCEEECCHHCCHHHHHHHEECCCCCCCHHHH
IAEQVIAALDDATQ
HHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 8297211; 7984428 [H]