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The map label for this gene is yogA [H]

Identifier: 238026737

GI number: 238026737

Start: 1200831

End: 1201844

Strand: Direct

Name: yogA [H]

Synonym: bglu_1g10950

Alternate gene names: 238026737

Gene position: 1200831-1201844 (Clockwise)

Preceding gene: 238026735

Following gene: 238026739

Centisome position: 30.74

GC content: 72.78

Gene sequence:

>1014_bases
ATGAAGGCCGCCGTGTTTCGCGCACCCGGCGGCCTCGATCGCATCGAGATCCTCGAGGTGGCCGACCCGGGCCGGCCGGG
GCCGGGTCAGATCCGCGTCGCGCTGCACGCCACCTCGCTCAATTTCCACGACCTGATCGTCGCCAAGGGCGGCATGGGAA
CCGACGACGGCCGCGTGCTGATGTCCGACGGCGCCGGCGTGGTCGAGGCGGTGGGCGAGGGCGTGACCGAATTCGCGCCG
GGCGACCACGTGGTCTCGCTGTTCTTCCCGCAATGGGCCGACGGCGCGCCGTGCCCGCCGGTCGGCGATTTCGCCGGCAC
GCCCGGTGACGGCATCGACGGCTTCGCGACCGAGGTGGTGGTGCGCGCGGCCGGCGCGTTCACGCACGCGCCGCGCGGCT
GGCGCCATGCCGAGAGCGCGACCATCACCACCGCCGGGCTGACCGCCTGGCGCGCGCTGGTCGGCGACGCGGGCCTGAAG
GCCGGCGACGTGGTGCTCACGCTCGGCACCGGCGGGGTGTCGATCGCGGCGCTGCAGATCGCCAAGGCGTCGGGCGCGAC
CGTGATCGTCACCTCGTCGTCGGACGAAAAACTCAGCCGCGCCAGCGCGCTCGGCGCCGATCACACCGTCAACTACCGGC
ATACGCCCGACTGGGGCCGCGTGGCGCGCGAGCTGACGGGCGGGCGCGGTGTCGATCACGTGATCGAGCTGGGCGGGCCG
GGCACGCTCGCGCAGTCGATCGACGCGGTGCGCGTGGGCGGCCACATCTCGCTGATCGGCGTGCTGACCGGCATGCAGGG
CGAGGTGCCGACGGCCGCGCTGATGAGCAAGCAGGCGCGGCTGCAGGGATTGATCGTCGGCAGCCGGCGCCAGCAGCAGG
ATTACGTGGCCGCGCTCGAGGCCACCGGCATCCGCCCGGTGATCGACCGCAGCTTCGGCTTCGGCGAACTGGCCGAGGCG
TTCCGCTGGCAGGAGCAAGGCGGCCACTTCGGCAAGATCGTGGTGGAGTGGTAA

Upstream 100 bases:

>100_bases
ATCCGATCTTCAGGGAGTCCAGCATGCCTTCATTCGCTATCGTTTCCGTTTCGCGCGGGTTCGCCCCCGCGCCGGCCGTC
ATCGTGCGCCGGAGGTTCGC

Downstream 100 bases:

>100_bases
GGGCAACGGCGCGCGGGCGAGGGCAGGGCAGCGTGCCGTGCCCGCGCCGCGCGCTGCTTACTTCGCGGTCGGCATGGCGA
ACTCGGCGCCCTTCTCGATG

Product: alcohol dehydrogenase, zinc-binding domain-containing protein

Products: Glycerol; Nicotinamide adenine dinucleotide [C]

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MKAAVFRAPGGLDRIEILEVADPGRPGPGQIRVALHATSLNFHDLIVAKGGMGTDDGRVLMSDGAGVVEAVGEGVTEFAP
GDHVVSLFFPQWADGAPCPPVGDFAGTPGDGIDGFATEVVVRAAGAFTHAPRGWRHAESATITTAGLTAWRALVGDAGLK
AGDVVLTLGTGGVSIAALQIAKASGATVIVTSSSDEKLSRASALGADHTVNYRHTPDWGRVARELTGGRGVDHVIELGGP
GTLAQSIDAVRVGGHISLIGVLTGMQGEVPTAALMSKQARLQGLIVGSRRQQQDYVAALEATGIRPVIDRSFGFGELAEA
FRWQEQGGHFGKIVVEW

Sequences:

>Translated_337_residues
MKAAVFRAPGGLDRIEILEVADPGRPGPGQIRVALHATSLNFHDLIVAKGGMGTDDGRVLMSDGAGVVEAVGEGVTEFAP
GDHVVSLFFPQWADGAPCPPVGDFAGTPGDGIDGFATEVVVRAAGAFTHAPRGWRHAESATITTAGLTAWRALVGDAGLK
AGDVVLTLGTGGVSIAALQIAKASGATVIVTSSSDEKLSRASALGADHTVNYRHTPDWGRVARELTGGRGVDHVIELGGP
GTLAQSIDAVRVGGHISLIGVLTGMQGEVPTAALMSKQARLQGLIVGSRRQQQDYVAALEATGIRPVIDRSFGFGELAEA
FRWQEQGGHFGKIVVEW
>Mature_337_residues
MKAAVFRAPGGLDRIEILEVADPGRPGPGQIRVALHATSLNFHDLIVAKGGMGTDDGRVLMSDGAGVVEAVGEGVTEFAP
GDHVVSLFFPQWADGAPCPPVGDFAGTPGDGIDGFATEVVVRAAGAFTHAPRGWRHAESATITTAGLTAWRALVGDAGLK
AGDVVLTLGTGGVSIAALQIAKASGATVIVTSSSDEKLSRASALGADHTVNYRHTPDWGRVARELTGGRGVDHVIELGGP
GTLAQSIDAVRVGGHISLIGVLTGMQGEVPTAALMSKQARLQGLIVGSRRQQQDYVAALEATGIRPVIDRSFGFGELAEA
FRWQEQGGHFGKIVVEW

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI22538446, Length=354, Percent_Identity=26.8361581920904, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI22538444, Length=354, Percent_Identity=26.8361581920904, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI194239674, Length=307, Percent_Identity=26.7100977198697, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI13236495, Length=307, Percent_Identity=26.7100977198697, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI47519420, Length=351, Percent_Identity=25.9259259259259, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI28557745, Length=248, Percent_Identity=30.241935483871, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI156627571, Length=352, Percent_Identity=26.4204545454545, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI41872631, Length=325, Percent_Identity=27.3846153846154, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI194239676, Length=305, Percent_Identity=26.2295081967213, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI87081918, Length=325, Percent_Identity=28.3076923076923, Blast_Score=82, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17507255, Length=346, Percent_Identity=26.878612716763, Blast_Score=78, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6319955, Length=338, Percent_Identity=27.2189349112426, Blast_Score=73, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6322619, Length=338, Percent_Identity=27.2189349112426, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323729, Length=286, Percent_Identity=27.2727272727273, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6323961, Length=352, Percent_Identity=25.5681818181818, Blast_Score=66, Evalue=8e-12,
Organism=Drosophila melanogaster, GI19920632, Length=220, Percent_Identity=30.4545454545455, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI221330659, Length=220, Percent_Identity=30.4545454545455, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24581345, Length=220, Percent_Identity=29.5454545454545, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.1 [C]

Molecular weight: Translated: 34803; Mature: 34803

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAAVFRAPGGLDRIEILEVADPGRPGPGQIRVALHATSLNFHDLIVAKGGMGTDDGRVL
CCCEEEECCCCCCEEEEEEECCCCCCCCCEEEEEEEEECCCEEEEEEECCCCCCCCCEEE
MSDGAGVVEAVGEGVTEFAPGDHVVSLFFPQWADGAPCPPVGDFAGTPGDGIDGFATEVV
EECCCCHHHHHHCCHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
VRAAGAFTHAPRGWRHAESATITTAGLTAWRALVGDAGLKAGDVVLTLGTGGVSIAALQI
HHHHCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEEEEEE
AKASGATVIVTSSSDEKLSRASALGADHTVNYRHTPDWGRVARELTGGRGVDHVIELGGP
EECCCCEEEEECCCCHHHHHHHHCCCCCEECCCCCCCHHHHHHHHCCCCCCCCEEEECCC
GTLAQSIDAVRVGGHISLIGVLTGMQGEVPTAALMSKQARLQGLIVGSRRQQQDYVAALE
CHHHHCCCEEEECCCEEEEEEEECCCCCCCHHHHHHHHHHHEEEEECCCCCHHHHHHHHH
ATGIRPVIDRSFGFGELAEAFRWQEQGGHFGKIVVEW
HCCCCHHHHCCCCHHHHHHHHHHHHCCCCEEEEEEEC
>Mature Secondary Structure
MKAAVFRAPGGLDRIEILEVADPGRPGPGQIRVALHATSLNFHDLIVAKGGMGTDDGRVL
CCCEEEECCCCCCEEEEEEECCCCCCCCCEEEEEEEEECCCEEEEEEECCCCCCCCCEEE
MSDGAGVVEAVGEGVTEFAPGDHVVSLFFPQWADGAPCPPVGDFAGTPGDGIDGFATEVV
EECCCCHHHHHHCCHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
VRAAGAFTHAPRGWRHAESATITTAGLTAWRALVGDAGLKAGDVVLTLGTGGVSIAALQI
HHHHCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEEEEEE
AKASGATVIVTSSSDEKLSRASALGADHTVNYRHTPDWGRVARELTGGRGVDHVIELGGP
EECCCCEEEEECCCCHHHHHHHHCCCCCEECCCCCCCHHHHHHHHCCCCCCCCEEEECCC
GTLAQSIDAVRVGGHISLIGVLTGMQGEVPTAALMSKQARLQGLIVGSRRQQQDYVAALE
CHHHHCCCEEEECCCEEEEEEEECCCCCCCHHHHHHHHHHHEEEEECCCCCHHHHHHHHH
ATGIRPVIDRSFGFGELAEAFRWQEQGGHFGKIVVEW
HCCCCHHHHCCCCHHHHHHHHHHHHCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD+; NADH [C]

Metal ions: Co2+ Zn2+-depleted [C]

Kcat value (1/min): 150 [C]

Specific activity: 19

Km value (mM): 0.2 {tryptophol}} 0.0074 {NAD+}} 0.0069 {NAD+}} 13 {ethylene} 6 {methanol}} 27 {pentanol}} 0.44 {1-butanol}} 120 {ethanol}} 0.91 {acetaldehyde}} 0.1 {acetaldehyde}} 0.005 {1-octanol}} 0.004 {benzyl} 0.005 {cyclohe

Substrates: D-Glyceraldehyde; H+; Nicotinamide adenine dinucleotide - reduced [C]

Specific reaction: D-Glyceraldehyde + H+ + Nicotinamide adenine dinucleotide - reduced <==> Glycerol + Nicotinamide adenine dinucleotide [C]

General reaction: Redox reaction [C]

Inhibitor: 2, 2'-Bipyridyl; 4-Methyl pyrazole acetaldehyde; 8-Amino-6-methoxyquinoline; 8-Hydroxy quinoline-5-sulfonic acid; Acetaldehyde; Dipicolinic acid; EDTA; Ethanol; GSH; Heptafluorbutanol; Imidazole; Iodoacetamide; Iodoacetate; Isobutyramide EDTA; NAD+; NADH;

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]